Mitophagy defects arising from BNip3 loss promote mammary tumor progression to metastasis

EMBO Reports

Volumn 16, Issue 9, 2015, Pages 1145-1163

  Chourasia, Aparajita H ^a,b   Tracy, Kristin ^a,b   Frankenberger, Casey ^a   Boland, Michelle L ^a,c   Sharifi, Marina N ^a,b   Drake, Lauren E ^a,d   Sachleben, Joseph R ^e   Asara, John M ^f   Locasale, Jason W ^g   Karczmar, Gregory S ^e   Macleod, Kay F ^a,b,c  

^a UNIVERSITY OF CHICAGO   (United States)

^b Committee on Cancer Biology ^*  (United States)

^c Committee on Molecular Metabolism and Nutrition ^*  (United States)

^d Committee on Molecular Pathogenesis and Molecular Medicine ^*  (United States)

^e UNIVERSITY OF CHICAGO   (United States)

^f HARVARD MEDICAL SCHOOL   (United States)

^g Department of Obstetrics Gynecology   (United States)

Author keywords

BNip3; breast cancer; glycolysis; HIF 1 ; invasive carcinoma; mitophagy; ROS

Indexed keywords

CYTOCHROME C OXIDASE; ESTROGEN RECEPTOR ALPHA; FRUCTOSE BISPHOSPHATE; GLYCERALDEHYDE 3 PHOSPHATE; PROTEIN BNIP3; REACTIVE OXYGEN METABOLITE; VOLTAGE DEPENDENT ANION CHANNEL 1; BNIP3 PROTEIN, MOUSE; HYPOXIA INDUCIBLE FACTOR 1ALPHA; MEMBRANE PROTEIN; MITOCHONDRIAL PROTEIN; TUMOR MARKER;

AEROBIC METABOLISM; ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOPHAGY; BREAST EPITHELIUM CELL; BREAST TUMOR; CANCER PROGNOSIS; CARCINOGENESIS; CELL METABOLISM; CELL MIGRATION; CELL VIABILITY; CONTROLLED STUDY; FEMALE; GLUCOSE TRANSPORT; GLUTATHIONE METABOLISM; GLYCOLYSIS; HUMAN; HUMAN CELL; IN VITRO STUDY; LUNG METASTASIS; MASS SPECTROMETRY; METASTASIS; MITOCHONDRION; MITOPHAGY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN EXPRESSION; TRANSMISSION ELECTRON MICROSCOPY; TRIPLE NEGATIVE BREAST CANCER; TUMOR GROWTH; TUMOR VOLUME; ANIMAL; DEFICIENCY; DISEASE COURSE; EXPERIMENTAL MAMMARY NEOPLASM; GENETICS; LUNG TUMOR; METABOLISM; NEOVASCULARIZATION (PATHOLOGY); PATHOLOGY; PROGNOSIS; SECONDARY;

ANIMALS; BIOMARKERS, TUMOR; DISEASE PROGRESSION; FEMALE; GLYCOLYSIS; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; LUNG NEOPLASMS; MAMMARY NEOPLASMS, EXPERIMENTAL; MEMBRANE PROTEINS; MICE; MITOCHONDRIAL DEGRADATION; MITOCHONDRIAL PROTEINS; NEOPLASM METASTASIS; NEOVASCULARIZATION, PATHOLOGIC; PROGNOSIS; REACTIVE OXYGEN SPECIES; TRIPLE NEGATIVE BREAST NEOPLASMS;

EID: 84940796811     PISSN: 1469221X     EISSN: 14693178     Source Type: Journal    
DOI: 10.15252/embr.201540759     Document Type: Article

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