Expression of the cell death genes BNip3 and NIX in ductal carcinoma in situ of the breast; correlation of BNip3 levels with necrosis and grade

Journal of Pathology

Volumn 201, Issue 4, 2003, Pages 573-580

  Sowter, Heidi Michelle ^a   Ferguson, Mary ^a   Pym, Caroline ^a   Watson, Peter ^b   Fox, Stephen B ^a   Han, Cheng ^c   Harris, Adrian L ^a  

^a JOHN RADCLIFFE HOSPITAL   (United Kingdom)

^b UNIVERSITY OF MANITOBA   (Canada)

^c CHURCHILL HOSPITAL   (United Kingdom)

Author keywords

BNip3; Cell death; Ductal carcinoma in situ of the breast; Hypoxia; Necrosis

Indexed keywords

NIX PROTEIN; ONCOPROTEIN; PROTEIN BNIP3; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; BREAST CARCINOMA; CANCER CELL; CANCER GRADING; CANCER INVASION; CARCINOMA IN SITU; CELL DEATH; CONTROLLED STUDY; CORRELATION ANALYSIS; DISEASE COURSE; HUMAN; HUMAN CELL; HUMAN TISSUE; HYPOXIA; MACROPHAGE; METAPLASIA; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; UPREGULATION;

BREAST NEOPLASMS; CARCINOMA IN SITU; CARCINOMA, DUCTAL, BREAST; CELL DEATH; EPITHELIUM; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; MACROPHAGES; MEMBRANE PROTEINS; NECROSIS; NEOPLASM INVASIVENESS; OXYGEN; PROTO-ONCOGENE PROTEINS; RNA, MESSENGER; RNA, NEOPLASM; TUMOR SUPPRESSOR PROTEINS;

EID: 1342333155     PISSN: 00223417     EISSN: None     Source Type: Journal    
DOI: 10.1002/path.1486     Document Type: Article

References (23)

1. Fonseca R, Hartmann LC, Petersen IA, Donohue JH, Crotty TB, Gisvold JJ. Ductal carcinoma in situ of the breast. Ann Intern Med 1997; 127: 1013-1022.
2. Fisher ER, Dignam J, Tan-Chiu E, et al. Pathologic findings from the National Surgical Adjuvant Breast Project (NSABP) eight year update of Protocol B17: intraductal carcinoma. Cancer 1999; 86: 429-438.
3. Graeber TG, Osmanian C, Jacks T, et al. Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours [see comments]. Nature 1996; 379: 88-91.
4. Shimizu S, Eguchi Y, Kamiike W, et al. Induction of apoptosis as well as necrosis by hypoxia and predominant prevention of apoptosis by Bcl-2 and Bcl-XL. Cancer Res 1996; 56: 2161-2166.
5. Schmaltz C, Hardenbergh PH, Wells A, Fisher DE. Regulation of proliferation-survival decisions during tumor cell hypoxia. Mol Cell Biol 1998; 18: 2845-2854.
6. Zaugg K, Bodis S. Is there a role for molecular prognostic factors in the clinical management of ductal carcinoma (DCIS) of the breast. Radiother Oncol 2000; 55: 95-99.
7. Chen G, Cizeau J, Vande Velde C, et al. NIX and Nip3 form a subfamily of pro-apoptotic mitochondrial proteins. J Biol Chem 1999; 274: 7-10.
8. Bruik RK. Expression of the gene encoding the proapoptotic Nip3 protein is induced by hypoxia. Proc Natl Acad Sci U S A 2000; 97: 9082-9087.
9. Sowter HM, Ratcliffe PJ, Watson P, Greenberg AH, Harris AL. HIF-1-dependent regulation of hypoxic induction of the cell death factors BNIP3 and NIX in human tumours. Cancer Res 2001; 61: 6669-6673.
10. Wykoff CC, Beasley NJP, Watson PH, et al. Hypoxia inducible expression of tumor-associated carbonic anhydrases. Cancer Res 2000; 60: 7075-7083.
11. Silverstein MJ, Lagois MD, Craig PH, et al. A prognostic index for ductal carcinoma in situ of the breast. Cancer 1996; 77: 2267-2274.
12. Leake R, Barnes D, Pinder S, et al. Immunohistochemical detection of steroid receptors in breast cancer: a working protocol. J Clin Pathol 2000; 53: 634-635.
13. Zhang HT, Scott PA, Ziche M, Weich HA, Harris AL, Bicknell R. Enhancement of tumour growth and vascular density by transfection of vascular endothelial cell growth factor into MCF-7 human breast carcinoma cells. J Natl Cancer Inst 1995; 87: 219-231.
14. Talks KL, Turley H, Gatter KC, et al. The expression and distribution of the hypoxia-inducible factors HIF-1a and HIF-2a in normal human tissues, cancers and tumour-associated macrophages. Am J Pathol 2000; 157: 411-421.
15. Ray R, Chen G, Vande Velde C, et al. BNIP3 heterodimerizes with Bcl-2/Bcl-XL and induces cell death independent of a Bcl-2 homology 3 (BH3) domain at both mitochondrial and nonmitochondrial sites. J Biol Chem 2000; 275: 1439-1448.
16. Vande Velde C, Cizeau J, Dubik D, et al. BNIP3 and genetic control of necrosis-like cell death through the mitochondrial permeability transition pore. Mol Cell Biol 2000; 20: 5454-5468.
17. Imazu T, Shimizu S, Tagami S, et al. Bcl-2/E1B 19 kDa-interacting protein 3-like protein (Bnip3L) interacts with Bcl-2/Bcl-xl and induces apoptosis by altering mitochondrial membrane permeability. Oncogene 1999; 18: 4523-4529.
18. Ahmed A. Apocrine metaplasia in cystic hyperplastic mastopathy. Histochemical and ultrastructural observations. J Pathol 1975; 115: 211-214.
19. Kiener HR, Davis PM, Starling GC, et al. Differential induction of apoptosis by Fas-Fas ligand interactions in human monocytes and macrophages. J Exp Med 1997; 185: 1511-1516.
20. Xaus J, Comalada M, Valledor AF, et al. Molecular mechanisms involved in macrophage survival, proliferation, activation or apoptosis. Immunology 2001; 204: 543-550.
21. Lewis JS, Lee JA, Underwood JCE, Harris AL, Lewis CE. Macrophage responses to hypoxia: relevance to disease mechanisms. J Leukocyte Biol 1999; 66: 889-900.
22. Pennacchietti S, Michieli P, Galluzzo M, Mazzone M, Giordano S, Comoglio PM. Hypoxia promotes invasive growth by transcriptional activation of the met protooncogene. Cancer Cell 2003; 3: 347-361.
23. Helczynska K, Kronblad A, Jogi A, et al. Hypoxia promotes a dedifferentiated phenotype in ductal breast carcinoma in situ. Cancer Res 2003; 63: 1441-1444.