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Volumn 48, Issue 6, 2015, Pages 353-361

Interleukin-17 in systemic lupus erythematosus: A comprehensive review

Author keywords

Anti IL17 agents; immune tolerance; interleukin 17; lupus nephritis; systemic lupus erythematosus; Th17 cell

Indexed keywords

INTERLEUKIN 17; ANTIINFLAMMATORY AGENT; IMMUNOLOGIC FACTOR; MONOCLONAL ANTIBODY;

EID: 84940556353     PISSN: 08916934     EISSN: 1607842X     Source Type: Journal    
DOI: 10.3109/08916934.2015.1037441     Document Type: Review
Times cited : (82)

References (106)
  • 1
    • 58149215075 scopus 로고    scopus 로고
    • Epigenetic regulation and the pathogenesis of systemic lupus erythematosus
    • Pan, Y., and A. H. Sawalha. 2009. Epigenetic regulation and the pathogenesis of systemic lupus erythematosus. Transl. Res. 153: 4-10.
    • (2009) Transl. Res. , vol.153 , pp. 4-10
    • Pan, Y.1    Sawalha, A.H.2
  • 2
    • 84875751473 scopus 로고    scopus 로고
    • The role of cytokines in the pathogenesis of systemic lupus erythematosus-from bench to bedside
    • Yap, D. Y., and K. N. Lai. 2013. The role of cytokines in the pathogenesis of systemic lupus erythematosus-from bench to bedside. Nephrology. 18: 243-255.
    • (2013) Nephrology. , vol.18 , pp. 243-255
    • Yap, D.Y.1    Lai, K.N.2
  • 3
    • 84867197977 scopus 로고    scopus 로고
    • TH17 cells in autoimmunity and immunodeficiency: Protective or pathogenic?
    • Marwaha, A. K., N. J. Leung, A. N. McMurchy, and M. K. Levings. 2012. TH17 cells in autoimmunity and immunodeficiency: protective or pathogenic? Front. Immunol. 3: 129.
    • (2012) Front. Immunol. , vol.3 , pp. 129
    • Marwaha, A.K.1    Leung, N.J.2    McMurchy, A.N.3    Levings, M.K.4
  • 4
    • 40649126762 scopus 로고    scopus 로고
    • The inflammatory Th 17 subset in immunity against self and non-self antigens
    • Jin, D., L. Zhang, J. Zheng, and Y. Zhao. 2008. The inflammatory Th 17 subset in immunity against self and non-self antigens. Autoimmunity. 41: 154-162.
    • (2008) Autoimmunity. , vol.41 , pp. 154-162
    • Jin, D.1    Zhang, L.2    Zheng, J.3    Zhao, Y.4
  • 7
    • 84867021009 scopus 로고    scopus 로고
    • Brodalumab and ixekizumab, antiinterleukin-17-receptor antibodies for psoriasis: A critical appraisal
    • discussion 714-715
    • Spuls, P. I., and L. Hooft. 2012. Brodalumab and ixekizumab, antiinterleukin-17-receptor antibodies for psoriasis: a critical appraisal. Br. J. Dermatol. 167: 710-713; discussion 714-715.
    • (2012) Br. J. Dermatol. , vol.167 , pp. 710-713
    • Spuls, P.I.1    Hooft, L.2
  • 8
    • 84877603562 scopus 로고    scopus 로고
    • Efficacy and safety of secukinumab in patients with rheumatoid arthritis: A phase II, dose-finding, double-blind, randomised, placebo controlled study
    • Genovese, M. C., P. Durez, H. B. Richards, et al. 2013. Efficacy and safety of secukinumab in patients with rheumatoid arthritis: a phase II, dose-finding, double-blind, randomised, placebo controlled study. Ann. Rheum. Dis. 72: 863-869.
    • (2013) Ann. Rheum. Dis. , vol.72 , pp. 863-869
    • Genovese, M.C.1    Durez, P.2    Richards, H.B.3
  • 9
    • 84887992906 scopus 로고    scopus 로고
    • Anti-interleukin-17A monoclonal antibody secukinumab in treatment of ankylosing spondylitis: A randomised, double-blind, placebo-controlled trial
    • Baeten, D., X. Baraliakos, J. Braun, et al. 2013. Anti-interleukin-17A monoclonal antibody secukinumab in treatment of ankylosing spondylitis: a randomised, double-blind, placebo-controlled trial. Lancet. 382: 1705-1713.
    • (2013) Lancet. , vol.382 , pp. 1705-1713
    • Baeten, D.1    Baraliakos, X.2    Braun, J.3
  • 10
    • 0027215897 scopus 로고
    • CTLA-8, cloned from an activated T cell, bearing AU-rich messenger RNA instability sequences, and homologous to a herpesvirus saimiri gene
    • Rouvier, E., M. F. Luciani, M. G. Mattei, et al. 1993. CTLA-8, cloned from an activated T cell, bearing AU-rich messenger RNA instability sequences, and homologous to a herpesvirus saimiri gene. J. Immunol. 150: 5445-5456.
    • (1993) J. Immunol. , vol.150 , pp. 5445-5456
    • Rouvier, E.1    Luciani, M.F.2    Mattei, M.G.3
  • 11
    • 5644277476 scopus 로고    scopus 로고
    • Interleukin-17 family members and inflammation
    • Kolls, J. K., and A. Linden. 2004. Interleukin-17 family members and inflammation. Immunity. 21: 467-476.
    • (2004) Immunity. , vol.21 , pp. 467-476
    • Kolls, J.K.1    Linden, A.2
  • 12
    • 0031282513 scopus 로고    scopus 로고
    • Molecular characterization of the human interleukin (IL)-17 receptor
    • Yao, Z., M. K. Spriggs, J. M. Derry, et al. 1997. Molecular characterization of the human interleukin (IL)-17 receptor. Cytokine. 9: 794-800.
    • (1997) Cytokine. , vol.9 , pp. 794-800
    • Yao, Z.1    Spriggs, M.K.2    Derry, J.M.3
  • 13
    • 0037449737 scopus 로고    scopus 로고
    • Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin-17
    • Aggarwal, S., N. Ghilardi, M. H. Xie, et al. 2003. Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin-17. J. Biol. Chem. 278: 1910-1914.
    • (2003) J. Biol. Chem. , vol.278 , pp. 1910-1914
    • Aggarwal, S.1    Ghilardi, N.2    Xie, M.H.3
  • 14
    • 0028858556 scopus 로고
    • Human IL-17: A novel cytokine derived from T cells
    • Yao, Z., S. L. Painter, W. C. Fanslow, et al. 1995. Human IL-17: a novel cytokine derived from T cells. J. Immunol. 155: 5483-5486.
    • (1995) J. Immunol. , vol.155 , pp. 5483-5486
    • Yao, Z.1    Painter, S.L.2    Fanslow, W.C.3
  • 15
    • 66149120713 scopus 로고    scopus 로고
    • Th17 cells in rheumatoid arthritis and systemic lupus erythematosus
    • Pernis, A. B. 2009. Th17 cells in rheumatoid arthritis and systemic lupus erythematosus. J. Intern. Med. 265: 644-652.
    • (2009) J. Intern. Med. , vol.265 , pp. 644-652
    • Pernis, A.B.1
  • 16
    • 0033758344 scopus 로고    scopus 로고
    • Increased interleukin-17 production in patients with systemic sclerosis
    • Kurasawa, K., K. Hirose, H. Sano, et al. 2000. Increased interleukin-17 production in patients with systemic sclerosis. Arthritis Rheum. 43: 2455-2463.
    • (2000) Arthritis Rheum. , vol.43 , pp. 2455-2463
    • Kurasawa, K.1    Hirose, K.2    Sano, H.3
  • 18
    • 46749151286 scopus 로고    scopus 로고
    • Generation of T follicular helper cells is mediated by interleukin-21 but independent of T helper 1, 2, or 17 cell lineages
    • Nurieva, R. I., Y. Chung, D. Hwang, et al. 2008. Generation of T follicular helper cells is mediated by interleukin-21 but independent of T helper 1, 2, or 17 cell lineages. Immunity. 29: 138-149.
    • (2008) Immunity. , vol.29 , pp. 138-149
    • Nurieva, R.I.1    Chung, Y.2    Hwang, D.3
  • 19
    • 0024353079 scopus 로고
    • TH1 and TH2 cells: Different patterns of lymphokine secretion lead to different functional properties
    • Mosmann, T. R., and R. L. Coffman. 1989. TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties. Annu. Rev. Immunol. 7: 145-173.
    • (1989) Annu. Rev. Immunol. , vol.7 , pp. 145-173
    • Mosmann, T.R.1    Coffman, R.L.2
  • 20
    • 16844363097 scopus 로고    scopus 로고
    • A well adapted regulatory contrivance: Regulatory T cell development and the forkhead family transcription factor Foxp3
    • Fontenot, J. D., and A. Y. Rudensky. 2005. A well adapted regulatory contrivance: regulatory T cell development and the forkhead family transcription factor Foxp3. Nat. Immunol. 6: 331-337.
    • (2005) Nat. Immunol. , vol.6 , pp. 331-337
    • Fontenot, J.D.1    Rudensky, A.Y.2
  • 21
    • 27544490377 scopus 로고    scopus 로고
    • Interleukin 17-producing CD4+effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages
    • Harrington, L. E., R. D. Hatton, P. R. Mangan, et al. 2005. Interleukin 17-producing CD4+effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages. Nat. Immunol. 6: 1123-1132.
    • (2005) Nat. Immunol. , vol.6 , pp. 1123-1132
    • Harrington, L.E.1    Hatton, R.D.2    Mangan, P.R.3
  • 22
    • 39449087338 scopus 로고    scopus 로고
    • Th17 cells: Effector T cells with inflammatory properties
    • Korn, T., M. Oukka, V. Kuchroo, and E. Bettelli. 2007. Th17 cells: effector T cells with inflammatory properties. Semin. Immunol. 19: 362-371.
    • (2007) Semin. Immunol. , vol.19 , pp. 362-371
    • Korn, T.1    Oukka, M.2    Kuchroo, V.3    Bettelli, E.4
  • 23
    • 58849162766 scopus 로고    scopus 로고
    • Expanded double negative T cells in patients with systemic lupus erythematosus produce IL-17 and infiltrate the kidneys
    • Crispin, J. C., M. Oukka, G. Bayliss, et al. 2008. Expanded double negative T cells in patients with systemic lupus erythematosus produce IL-17 and infiltrate the kidneys. J. Immunol. 181: 8761-8766.
    • (2008) J. Immunol. , vol.181 , pp. 8761-8766
    • Crispin, J.C.1    Oukka, M.2    Bayliss, G.3
  • 24
    • 84859784038 scopus 로고    scopus 로고
    • Th17 cells in systemic lupus erythematosus share functional features with Th17 cells from normal bone marrow and peripheral tissues
    • Henriques, A., L. Ines, M. L. Pais, et al. 2012. Th17 cells in systemic lupus erythematosus share functional features with Th17 cells from normal bone marrow and peripheral tissues. Clin. Rheumatol. 31: 483-491.
    • (2012) Clin. Rheumatol. , vol.31 , pp. 483-491
    • Henriques, A.1    Ines, L.2    Pais, M.L.3
  • 25
    • 80155211500 scopus 로고    scopus 로고
    • Copy number variations of interleukin-17F, interleukin-21, and interleukin-22 are associated with systemic lupus erythematosus
    • Yu, B., M. Guan, Y. Peng, et al. 2011. Copy number variations of interleukin-17F, interleukin-21, and interleukin-22 are associated with systemic lupus erythematosus. Arthritis Rheum. 63: 3487-3492.
    • (2011) Arthritis Rheum. , vol.63 , pp. 3487-3492
    • Yu, B.1    Guan, M.2    Peng, Y.3
  • 27
    • 84865068306 scopus 로고    scopus 로고
    • Gene expression of cytokines (TNF-alpha, IFN-gamma), serum profiles of IL-17 and IL-23 in paediatric systemic lupus erythematosus
    • Rana, A., R. W. Minz, R. Aggarwal, et al. 2012. Gene expression of cytokines (TNF-alpha, IFN-gamma), serum profiles of IL-17 and IL-23 in paediatric systemic lupus erythematosus. Lupus. 21: 1105-1112.
    • (2012) Lupus. , vol.21 , pp. 1105-1112
    • Rana, A.1    Minz, R.W.2    Aggarwal, R.3
  • 28
    • 79960187365 scopus 로고    scopus 로고
    • High levels of maternal serum IL-17 and activin A in pregnant women affected by systemic lupus erythematosus
    • Torricelli, M., F. Bellisai, R. Novembri, et al. 2011. High levels of maternal serum IL-17 and activin A in pregnant women affected by systemic lupus erythematosus. Am. J. Reprod. Immunol. 66: 84-89.
    • (2011) Am. J. Reprod. Immunol. , vol.66 , pp. 84-89
    • Torricelli, M.1    Bellisai, F.2    Novembri, R.3
  • 29
    • 77953536871 scopus 로고    scopus 로고
    • Plasma IL-17A is increased in new-onset SLE patients and associated with disease activity
    • Chen, X. Q., Y. C. Yu, H. H. Deng, et al. 2010. Plasma IL-17A is increased in new-onset SLE patients and associated with disease activity. J. Clin. Immunol. 30: 221-225.
    • (2010) J. Clin. Immunol. , vol.30 , pp. 221-225
    • Chen, X.Q.1    Yu, Y.C.2    Deng, H.H.3
  • 30
    • 84892386145 scopus 로고    scopus 로고
    • The proinflammatory potential of T cells in juvenile-onset systemic lupus erythematosus
    • Ballantine, L. E., J. Ong, A. Midgley, et al. 2014. The proinflammatory potential of T cells in juvenile-onset systemic lupus erythematosus. Pediatr. Rheumatol. Online J. 12: 4.
    • (2014) Pediatr. Rheumatol. Online J. , vol.12 , pp. 4
    • Ballantine, L.E.1    Ong, J.2    Midgley, A.3
  • 31
    • 77954795855 scopus 로고    scopus 로고
    • Increased expression of costimulatory markers CD134 and CD80 on interleukin-17 producing T cells in patients with systemic lupus erythematosus
    • Dolff, S., D. Quandt, B. Wilde, et al. 2010. Increased expression of costimulatory markers CD134 and CD80 on interleukin-17 producing T cells in patients with systemic lupus erythematosus. Arthritis Res. Ther. 12: R150.
    • (2010) Arthritis Res. Ther. , vol.12 , pp. R150
    • Dolff, S.1    Quandt, D.2    Wilde, B.3
  • 32
    • 84882529537 scopus 로고    scopus 로고
    • Clinical associations of serum interleukin-17 in systemic lupus erythematosus
    • Vincent, F. B., M. Northcott, A. Hoi, et al. 2013. Clinical associations of serum interleukin-17 in systemic lupus erythematosus. Arthritis Res. Ther. 15: R97.
    • (2013) Arthritis Res. Ther. , vol.15 , pp. R97
    • Vincent, F.B.1    Northcott, M.2    Hoi, A.3
  • 33
    • 77957867731 scopus 로고    scopus 로고
    • The relation of interleukin 17 (IL-17) and IL-23 to Th1/Th2 cytokines and disease activity in systemic lupus erythematosus
    • Mok, M. Y., H. J. Wu, Y. Lo, and C. S. Lau. 2010. The relation of interleukin 17 (IL-17) and IL-23 to Th1/Th2 cytokines and disease activity in systemic lupus erythematosus. J. Rheumatol. 37: 2046-2052.
    • (2010) J. Rheumatol. , vol.37 , pp. 2046-2052
    • Mok, M.Y.1    Wu, H.J.2    Lo, Y.3    Lau, C.S.4
  • 34
    • 84868593854 scopus 로고    scopus 로고
    • A murine autoimmune model of rheumatoid arthritis and systemic lupus erythematosus associated with deregulated production of IL-17 and IL-21
    • Biswas, P. S., K. Kang, S. Gupta, et al. 2012. A murine autoimmune model of rheumatoid arthritis and systemic lupus erythematosus associated with deregulated production of IL-17 and IL-21. Methods Mol. Biol. 900: 233-251.
    • (2012) Methods Mol. Biol. , vol.900 , pp. 233-251
    • Biswas, P.S.1    Kang, K.2    Gupta, S.3
  • 35
    • 84874611415 scopus 로고    scopus 로고
    • Interleukin-17 expression positively correlates with disease severity of lupus nephritis by increasing anti-double-stranded DNA antibody production in a lupus model induced by activated lymphocyte derived DNA
    • Wen, Z., L. Xu, W. Xu, et al. 2013. Interleukin-17 expression positively correlates with disease severity of lupus nephritis by increasing anti-double-stranded DNA antibody production in a lupus model induced by activated lymphocyte derived DNA. PLoS One. 8: e58161.
    • (2013) PLoS One. , vol.8
    • Wen, Z.1    Xu, L.2    Xu, W.3
  • 36
    • 33745297345 scopus 로고    scopus 로고
    • Cutting edge: Interleukin 17 signals through a heteromeric receptor complex
    • Toy, D., D. Kugler, M. Wolfson, et al. 2006. Cutting edge: interleukin 17 signals through a heteromeric receptor complex. J. Immunol. 177: 36-39.
    • (2006) J. Immunol. , vol.177 , pp. 36-39
    • Toy, D.1    Kugler, D.2    Wolfson, M.3
  • 37
    • 38949155203 scopus 로고    scopus 로고
    • Regulation of IL-17 production in human lymphocytes
    • Chen, Z., and J. J. O'Shea. 2008. Regulation of IL-17 production in human lymphocytes. Cytokine. 41: 71-78.
    • (2008) Cytokine. , vol.41 , pp. 71-78
    • Chen, Z.1    O'Shea, J.J.2
  • 38
    • 84878073363 scopus 로고    scopus 로고
    • Correlations between concentrations of interleukin (IL)-17A, IL-17B and IL-17F, and endothelial cells and proangiogenic cytokines in systemic lupus erythematosus patients
    • Robak, E., L. Kulczycka-Siennicka, Z. Gerlicz, et al. 2013. Correlations between concentrations of interleukin (IL)-17A, IL-17B and IL-17F, and endothelial cells and proangiogenic cytokines in systemic lupus erythematosus patients. Eur. Cytokine Network. 24: 60-68.
    • (2013) Eur. Cytokine Network. , vol.24 , pp. 60-68
    • Robak, E.1    Kulczycka-Siennicka, L.2    Gerlicz, Z.3
  • 40
    • 84856880805 scopus 로고    scopus 로고
    • CAMPresponsive element modulator alpha (CREMalpha) suppresses IL-17F protein expression in T lymphocytes from patients with systemic lupus erythematosus (SLE)
    • Hedrich, C. M., T. Rauen, K. Kis-Toth, et al. 2012. cAMPresponsive element modulator alpha (CREMalpha) suppresses IL-17F protein expression in T lymphocytes from patients with systemic lupus erythematosus (SLE). J. Biol. Chem. 287: 4715-4725.
    • (2012) J. Biol. Chem. , vol.287 , pp. 4715-4725
    • Hedrich, C.M.1    Rauen, T.2    Kis-Toth, K.3
  • 41
    • 84867755386 scopus 로고    scopus 로고
    • The potential role of Th17 cells and Th17-related cytokines in the pathogenesis of lupus nephritis
    • Chen, D. Y., Y. M. Chen, M. C. Wen, et al. 2012. The potential role of Th17 cells and Th17-related cytokines in the pathogenesis of lupus nephritis. Lupus. 21: 1385-1396.
    • (2012) Lupus. , vol.21 , pp. 1385-1396
    • Chen, D.Y.1    Chen, Y.M.2    Wen, M.C.3
  • 42
    • 70749113527 scopus 로고    scopus 로고
    • Laser microdissection-based analysis of cytokine balance in the kidneys of patients with lupus nephritis
    • Wang, Y., S. Ito, Y. Chino, et al. 2010. Laser microdissection-based analysis of cytokine balance in the kidneys of patients with lupus nephritis. Clin. Exp. Immunol. 159: 1-10.
    • (2010) Clin. Exp. Immunol. , vol.159 , pp. 1-10
    • Wang, Y.1    Ito, S.2    Chino, Y.3
  • 43
    • 77951250725 scopus 로고    scopus 로고
    • Intrathecal cytokine and chemokine profiling in neuropsychiatric lupus or lupus complicated with central nervous system infection
    • Lu, X. Y., C. Q. Zhu, J. Qian, et al. 2010. Intrathecal cytokine and chemokine profiling in neuropsychiatric lupus or lupus complicated with central nervous system infection. Lupus. 19: 689-695.
    • (2010) Lupus. , vol.19 , pp. 689-695
    • Lu, X.Y.1    Zhu, C.Q.2    Qian, J.3
  • 44
    • 84863517147 scopus 로고    scopus 로고
    • Elevated Th17 cells are accompanied by FoxP3+Treg cells decrease in patients with lupus nephritis
    • Xing, Q., B. Wang, H. Su, et al. 2012. Elevated Th17 cells are accompanied by FoxP3+Treg cells decrease in patients with lupus nephritis. Rheumatol. Int. 32: 949-958.
    • (2012) Rheumatol. Int. , vol.32 , pp. 949-958
    • Xing, Q.1    Wang, B.2    Su, H.3
  • 45
    • 75649142843 scopus 로고    scopus 로고
    • The gene expression of type 17 T-helper cell-related cytokines in the urinary sediment of patients with systemic lupus erythematosus
    • Kwan, B. C., L. S. Tam, K. B. Lai, et al. 2009. The gene expression of type 17 T-helper cell-related cytokines in the urinary sediment of patients with systemic lupus erythematosus. Rheumatology. 48: 1491-1497.
    • (2009) Rheumatology. , vol.48 , pp. 1491-1497
    • Kwan, B.C.1    Tam, L.S.2    Lai, K.B.3
  • 46
    • 64049089798 scopus 로고    scopus 로고
    • Critical regulation of early Th17 cell differentiation by interleukin-1 signaling
    • Chung, Y., S. H. Chang, G. J. Martinez, et al. 2009. Critical regulation of early Th17 cell differentiation by interleukin-1 signaling. Immunity. 30: 576-587.
    • (2009) Immunity. , vol.30 , pp. 576-587
    • Chung, Y.1    Chang, S.H.2    Martinez, G.J.3
  • 47
    • 42649115767 scopus 로고    scopus 로고
    • TH17 cells in development: An updated view of their molecular identity and genetic programming
    • Dong, C. 2008. TH17 cells in development: an updated view of their molecular identity and genetic programming. Nat. Rev. Immunol. 8: 337-348.
    • (2008) Nat. Rev. Immunol. , vol.8 , pp. 337-348
    • Dong, C.1
  • 48
    • 44049104564 scopus 로고    scopus 로고
    • The differentiation of human T(H)-17 cells requires transforming growth factorbeta and induction of the nuclear receptor RORgammat
    • Manel, N., D. Unutmaz, and D. R. Littman. 2008. The differentiation of human T(H)-17 cells requires transforming growth factorbeta and induction of the nuclear receptor RORgammat. Nat. Immunol. 9: 641-649.
    • (2008) Nat. Immunol. , vol.9 , pp. 641-649
    • Manel, N.1    Unutmaz, D.2    Littman, D.R.3
  • 49
    • 0032076183 scopus 로고    scopus 로고
    • Disruption of the Jak1 gene demonstrates obligatory and nonredundant roles of the Jaks in cytokine-induced biologic responses
    • Rodig, S. J., M. A. Meraz, J. M. White, et al. 1998. Disruption of the Jak1 gene demonstrates obligatory and nonredundant roles of the Jaks in cytokine-induced biologic responses. Cell. 93: 373-383.
    • (1998) Cell. , vol.93 , pp. 373-383
    • Rodig, S.J.1    Meraz, M.A.2    White, J.M.3
  • 50
    • 0032168152 scopus 로고    scopus 로고
    • Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway
    • Heinrich, P. C., I. Behrmann, G. Muller-Newen, et al. 1998. Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway. Biochem. J. 334: 297-314.
    • (1998) Biochem. J. , vol.334 , pp. 297-314
    • Heinrich, P.C.1    Behrmann, I.2    Muller-Newen, G.3
  • 51
    • 33744479688 scopus 로고    scopus 로고
    • Selective regulatory function of Socs3 in the formation of IL-17-secreting T cells
    • Chen, Z., A. Laurence, Y. Kanno, et al. 2006. Selective regulatory function of Socs3 in the formation of IL-17-secreting T cells. Proc. Natl. Acad. Sci. USA 103: 8137-8142.
    • (2006) Proc. Natl. Acad. Sci. USA , vol.103 , pp. 8137-8142
    • Chen, Z.1    Laurence, A.2    Kanno, Y.3
  • 52
    • 34247593586 scopus 로고    scopus 로고
    • STAT3 regulates cytokine-mediated generation of inflammatory helper T cells
    • Yang, X. O., A. D. Panopoulos, R. Nurieva, et al. 2007. STAT3 regulates cytokine-mediated generation of inflammatory helper T cells. J. Biol. Chem. 282: 9358-9363.
    • (2007) J. Biol. Chem. , vol.282 , pp. 9358-9363
    • Yang, X.O.1    Panopoulos, A.D.2    Nurieva, R.3
  • 53
    • 35348960243 scopus 로고    scopus 로고
    • Th17: The third member of the effector T cell trilogy
    • Bettelli, E., T. Korn, and V. K. Kuchroo. 2007. Th17: the third member of the effector T cell trilogy. Curr. Opin. Immunol. 19: 652-657.
    • (2007) Curr. Opin. Immunol. , vol.19 , pp. 652-657
    • Bettelli, E.1    Korn, T.2    Kuchroo, V.K.3
  • 54
    • 80053173155 scopus 로고    scopus 로고
    • Increase in IL-21 producing T-cells in patients with systemic lupus erythematosus
    • Dolff, S., W. H. Abdulahad, J. Westra, et al. 2011. Increase in IL-21 producing T-cells in patients with systemic lupus erythematosus. Arthritis Res. Ther. 13: R157.
    • (2011) Arthritis Res. Ther. , vol.13 , pp. R157
    • Dolff, S.1    Abdulahad, W.H.2    Westra, J.3
  • 55
    • 74649086985 scopus 로고    scopus 로고
    • The receptor SIGIRR suppresses Th17 cell proliferation via inhibition of the interleukin-1 receptor pathway and mTOR kinase activation
    • Gulen, M. F., Z. Kang, K. Bulek, et al. 2010. The receptor SIGIRR suppresses Th17 cell proliferation via inhibition of the interleukin-1 receptor pathway and mTOR kinase activation. Immunity. 32: 54-66.
    • (2010) Immunity. , vol.32 , pp. 54-66
    • Gulen, M.F.1    Kang, Z.2    Bulek, K.3
  • 56
    • 84863151799 scopus 로고    scopus 로고
    • Microbiota-induced IL-1beta, but not IL-6, is critical for the development of steady-state TH17 cells in the intestine
    • Shaw, M. H., N. Kamada, Y. G. Kim, and G. Nunez. 2012. Microbiota-induced IL-1beta, but not IL-6, is critical for the development of steady-state TH17 cells in the intestine. J. Exp. Med. 209: 251-258.
    • (2012) J. Exp. Med. , vol.209 , pp. 251-258
    • Shaw, M.H.1    Kamada, N.2    Kim, Y.G.3    Nunez, G.4
  • 57
    • 84875610850 scopus 로고    scopus 로고
    • Recent advances in understanding the molecular mechanisms of the development and function of Th17 cells
    • Kurebayashi, Y., S. Nagai, A. Ikejiri, and S. Koyasu. 2013. Recent advances in understanding the molecular mechanisms of the development and function of Th17 cells. Genes Cells: Devot. Mol. Cell. Mech. 18: 247-265.
    • (2013) Genes Cells: Devot. Mol. Cell. Mech. , vol.18 , pp. 247-265
    • Kurebayashi, Y.1    Nagai, S.2    Ikejiri, A.3    Koyasu, S.4
  • 58
    • 84880028487 scopus 로고    scopus 로고
    • ERK differentially regulates Th17-and Treg-cell development and contributes to the pathogenesis of colitis
    • Liu, H., S. Yao, S. M. Dann, et al. 2013. ERK differentially regulates Th17-and Treg-cell development and contributes to the pathogenesis of colitis. Eur. J. Immunol. 43: 1716-1726.
    • (2013) Eur. J. Immunol. , vol.43 , pp. 1716-1726
    • Liu, H.1    Yao, S.2    Dann, S.M.3
  • 59
    • 84861134382 scopus 로고    scopus 로고
    • PI3K-AktmTORC1-S6K1/2 axis controls Th17 differentiation by regulating Gfi1 expression and nuclear translocation of RORgamma
    • Kurebayashi, Y., S. Nagai, A. Ikejiri, et al. 2012. PI3K-AktmTORC1-S6K1/2 axis controls Th17 differentiation by regulating Gfi1 expression and nuclear translocation of RORgamma. Cell. Rep. 1: 360-373.
    • (2012) Cell. Rep. , vol.1 , pp. 360-373
    • Kurebayashi, Y.1    Nagai, S.2    Ikejiri, A.3
  • 60
    • 84868548958 scopus 로고    scopus 로고
    • T cell receptor/CARMA1/NF-kappaB signaling controls T-helper (Th) 17 differentiation
    • Molinero, L. L., A. Cubre, C. Mora-Solano, et al. 2012. T cell receptor/CARMA1/NF-kappaB signaling controls T-helper (Th) 17 differentiation. Proc. Natl. Acad. Sci. USA 109: 18529-18534.
    • (2012) Proc. Natl. Acad. Sci. USA , vol.109 , pp. 18529-18534
    • Molinero, L.L.1    Cubre, A.2    Mora-Solano, C.3
  • 61
    • 79251589323 scopus 로고    scopus 로고
    • Profiling of CD4+T cells with epigenetic immune lineage analysis
    • Janson, P. C., L. B. Linton, E. A. Bergman, et al. 2011. Profiling of CD4+T cells with epigenetic immune lineage analysis. J. Immunol. 186: 92-102.
    • (2011) J. Immunol. , vol.186 , pp. 92-102
    • Janson, P.C.1    Linton, L.B.2    Bergman, E.A.3
  • 62
    • 83355166923 scopus 로고    scopus 로고
    • CAMPresponsive element modulator (CREM)alpha protein induces interleukin 17A expression and mediates epigenetic alterations at the interleukin-17A gene locus in patients with systemic lupus erythematosus
    • Rauen, T., C. M. Hedrich, Y. T. Juang, et al. 2011. cAMPresponsive element modulator (CREM)alpha protein induces interleukin 17A expression and mediates epigenetic alterations at the interleukin-17A gene locus in patients with systemic lupus erythematosus. J. Biol. Chem. 286: 43437-43446.
    • (2011) J. Biol. Chem. , vol.286 , pp. 43437-43446
    • Rauen, T.1    Hedrich, C.M.2    Juang, Y.T.3
  • 63
    • 84861473517 scopus 로고    scopus 로고
    • Plasticity of DNA methylation in mouse T cell activation and differentiation
    • Li, Y., G. Chen, L. Ma, et al. 2012. Plasticity of DNA methylation in mouse T cell activation and differentiation. BMC Mol. Biol. 13: 16.
    • (2012) BMC Mol. Biol. , vol.13 , pp. 16
    • Li, Y.1    Chen, G.2    Ma, L.3
  • 64
    • 34147138648 scopus 로고    scopus 로고
    • Chromatin remodeling of interleukin-17 (IL-17)-IL-17F cytokine gene locus during inflammatory helper T cell differentiation
    • Akimzhanov, A. M., X. O. Yang, and C. Dong. 2007. Chromatin remodeling of interleukin-17 (IL-17)-IL-17F cytokine gene locus during inflammatory helper T cell differentiation. J. Biol. Chem. 282: 5969-5972.
    • (2007) J. Biol. Chem. , vol.282 , pp. 5969-5972
    • Akimzhanov, A.M.1    Yang, X.O.2    Dong, C.3
  • 65
    • 58149214356 scopus 로고    scopus 로고
    • Global mapping of H3K4me3 and H3K27me3 reveals specificity and plasticity in lineage fate determination of differentiating CD4+T cells
    • Wei, G., L. Wei, J. Zhu, et al. 2009. Global mapping of H3K4me3 and H3K27me3 reveals specificity and plasticity in lineage fate determination of differentiating CD4+T cells. Immunity. 30: 155-167.
    • (2009) Immunity. , vol.30 , pp. 155-167
    • Wei, G.1    Wei, L.2    Zhu, J.3
  • 66
    • 84867351076 scopus 로고    scopus 로고
    • CAMP response element modulator alpha controls IL2 and IL17A expression during CD4 lineage commitment and subset distribution in lupus
    • Hedrich, C. M., J. C. Crispin, T. Rauen, et al. 2012. cAMP response element modulator alpha controls IL2 and IL17A expression during CD4 lineage commitment and subset distribution in lupus. Proc. Natl. Acad. Sci. USA. 109: 16606-16611.
    • (2012) Proc. Natl. Acad. Sci. USA. , vol.109 , pp. 16606-16611
    • Hedrich, C.M.1    Crispin, J.C.2    Rauen, T.3
  • 67
    • 84899760423 scopus 로고    scopus 로고
    • CaMK4-dependent activation of AKT/mTOR and CREM-alpha underlies autoimmunity-associated Th17 imbalance
    • Koga, T., C. M. Hedrich, M. Mizui, et al. 2014. CaMK4-dependent activation of AKT/mTOR and CREM-alpha underlies autoimmunity-associated Th17 imbalance. J. Clin. Investig. 124: 2234-2245.
    • (2014) J. Clin. Investig. , vol.124 , pp. 2234-2245
    • Koga, T.1    Hedrich, C.M.2    Mizui, M.3
  • 68
    • 84884197375 scopus 로고    scopus 로고
    • Protein phosphatase 2A enables expression of interleukin 17 (IL-17) through chromatin remodeling
    • Apostolidis, S. A., T. Rauen, C. M. Hedrich, et al. 2013. Protein phosphatase 2A enables expression of interleukin 17 (IL-17) through chromatin remodeling. J. Biol. Chem. 288: 26775-26784.
    • (2013) J. Biol. Chem. , vol.288 , pp. 26775-26784
    • Apostolidis, S.A.1    Rauen, T.2    Hedrich, C.M.3
  • 69
    • 84878579250 scopus 로고    scopus 로고
    • Enhanced rho-associated protein kinase activation in patients with systemic lupus erythematosus
    • Isgro, J., S. Gupta, E. Jacek, et al. 2013. Enhanced rho-associated protein kinase activation in patients with systemic lupus erythematosus. Arthritis Rheum. 65: 1592-1602.
    • (2013) Arthritis Rheum. , vol.65 , pp. 1592-1602
    • Isgro, J.1    Gupta, S.2    Jacek, E.3
  • 70
    • 33847206969 scopus 로고    scopus 로고
    • IL-17 family cytokines and the expanding diversity of effector T cell lineages
    • Weaver, C. T., R. D. Hatton, P. R. Mangan, and L. E. Harrington. 2007. IL-17 family cytokines and the expanding diversity of effector T cell lineages. Annu. Rev. Immunol. 25: 821-852.
    • (2007) Annu. Rev. Immunol. , vol.25 , pp. 821-852
    • Weaver, C.T.1    Hatton, R.D.2    Mangan, P.R.3    Harrington, L.E.4
  • 71
    • 0033765333 scopus 로고    scopus 로고
    • Interleukin-17 and CD40-ligand synergistically enhance cytokine and chemokine production by renal epithelial cells
    • Woltman, A. M., S. de Haij, J. G. Boonstra, et al. 2000. Interleukin-17 and CD40-ligand synergistically enhance cytokine and chemokine production by renal epithelial cells. J. Am. Soc. Nephrol.: JASN. 11: 2044-2055.
    • (2000) J. Am. Soc. Nephrol.: JASN. , vol.11 , pp. 2044-2055
    • Woltman, A.M.1    De Haij, S.2    Boonstra, J.G.3
  • 72
    • 51349111163 scopus 로고    scopus 로고
    • An overview of IL-17 function and signaling
    • Gaffen, S. L. 2008. An overview of IL-17 function and signaling. Cytokine. 43: 402-407.
    • (2008) Cytokine. , vol.43 , pp. 402-407
    • Gaffen, S.L.1
  • 73
    • 75949102667 scopus 로고    scopus 로고
    • Interleukin-17 and its target genes: Mechanisms of interleukin-17 function in disease
    • Onishi, R. M., and S. L. Gaffen. 2010. Interleukin-17 and its target genes: mechanisms of interleukin-17 function in disease. Immunology. 129: 311-321.
    • (2010) Immunology. , vol.129 , pp. 311-321
    • Onishi, R.M.1    Gaffen, S.L.2
  • 74
    • 0038281377 scopus 로고    scopus 로고
    • IL-17 induces autoantibody overproduction and peripheral blood mononuclear cell overexpression of IL-6 in lupus nephritis patients
    • Dong, G., R. Ye, W. Shi, et al. 2003. IL-17 induces autoantibody overproduction and peripheral blood mononuclear cell overexpression of IL-6 in lupus nephritis patients. Chin. Med. J. 116: 543-548.
    • (2003) Chin. Med. J. , vol.116 , pp. 543-548
    • Dong, G.1    Ye, R.2    Shi, W.3
  • 75
    • 67649197343 scopus 로고    scopus 로고
    • Interleukin 17 acts in synergy with B cell-activating factor to influence B cell biology and the pathophysiology of systemic lupus erythematosus
    • Doreau, A., A. Belot, J. Bastid, et al. 2009. Interleukin 17 acts in synergy with B cell-activating factor to influence B cell biology and the pathophysiology of systemic lupus erythematosus. Nat. Immunol. 10: 778-785.
    • (2009) Nat. Immunol. , vol.10 , pp. 778-785
    • Doreau, A.1    Belot, A.2    Bastid, J.3
  • 76
    • 77349093568 scopus 로고    scopus 로고
    • B-cell biology and related therapies in systemic lupus erythematosus
    • viii-ix
    • Ahmed, S., and J. H. Anolik. 2010. B-cell biology and related therapies in systemic lupus erythematosus. Rheum. Dis. Clin. N. Am. 36: 109-130, viii-ix.
    • (2010) Rheum. Dis. Clin. N. Am. , vol.36 , pp. 109-130
    • Ahmed, S.1    Anolik, J.H.2
  • 77
    • 0032939560 scopus 로고    scopus 로고
    • IL-17 is produced by nickel-specific T lymphocytes and regulates ICAM-1 expression and chemokine production in human keratinocytes: Synergistic or antagonist effects with IFN-gamma and TNF-alpha
    • Albanesi, C., A. Cavani, and G. Girolomoni. 1999. IL-17 is produced by nickel-specific T lymphocytes and regulates ICAM-1 expression and chemokine production in human keratinocytes: synergistic or antagonist effects with IFN-gamma and TNF-alpha. J. Immunol. 162: 494-502.
    • (1999) J. Immunol. , vol.162 , pp. 494-502
    • Albanesi, C.1    Cavani, A.2    Girolomoni, G.3
  • 78
    • 0034193959 scopus 로고    scopus 로고
    • Requirement of endogenous stem cell factor and granulocyte-colony-stimulating factor for IL-17-mediated granulopoiesis
    • Schwarzenberger, P., W. Huang, P. Ye, et al. 2000. Requirement of endogenous stem cell factor and granulocyte-colony-stimulating factor for IL-17-mediated granulopoiesis. J. Immunol. 164: 4783-4789.
    • (2000) J. Immunol. , vol.164 , pp. 4783-4789
    • Schwarzenberger, P.1    Huang, W.2    Ye, P.3
  • 79
    • 44949195816 scopus 로고    scopus 로고
    • T cells and in situ cryoglobulin deposition in the pathogenesis of lupus nephritis
    • Cohen, R. A., G. Bayliss, J. C. Crispin, et al. 2008. T cells and in situ cryoglobulin deposition in the pathogenesis of lupus nephritis. Clin. Immunol. 128: 1-7.
    • (2008) Clin. Immunol. , vol.128 , pp. 1-7
    • Cohen, R.A.1    Bayliss, G.2    Crispin, J.C.3
  • 80
    • 66049151440 scopus 로고    scopus 로고
    • Th17 and natural Treg cell population dynamics in systemic lupus erythematosus
    • Yang, J., Y. Chu, X. Yang, et al. 2009. Th17 and natural Treg cell population dynamics in systemic lupus erythematosus. Arthritis Rheum. 60: 1472-1483.
    • (2009) Arthritis Rheum. , vol.60 , pp. 1472-1483
    • Yang, J.1    Chu, Y.2    Yang, X.3
  • 81
    • 84887350775 scopus 로고    scopus 로고
    • Inhibition of IL-17 as a pharmacological approach for IBD
    • Fitzpatrick, L. R. 2013. Inhibition of IL-17 as a pharmacological approach for IBD. Int. Rev. Immunol. 32: 544-555.
    • (2013) Int. Rev. Immunol. , vol.32 , pp. 544-555
    • Fitzpatrick, L.R.1
  • 82
    • 13244283212 scopus 로고    scopus 로고
    • IL-23 drives a pathogenic T cell population that induces autoimmune inflammation
    • Langrish, C. L., Y. Chen, W. M. Blumenschein, et al. 2005. IL-23 drives a pathogenic T cell population that induces autoimmune inflammation. J. Exp. Med. 201: 233-240.
    • (2005) J. Exp. Med. , vol.201 , pp. 233-240
    • Langrish, C.L.1    Chen, Y.2    Blumenschein, W.M.3
  • 83
    • 33751521013 scopus 로고    scopus 로고
    • Th17 functions as an osteoclastogenic helper T cell subset that links T cell activation and bone destruction
    • Sato, K., A. Suematsu, K. Okamoto, et al. 2006. Th17 functions as an osteoclastogenic helper T cell subset that links T cell activation and bone destruction. J. Exp. Med. 203: 2673-2682.
    • (2006) J. Exp. Med. , vol.203 , pp. 2673-2682
    • Sato, K.1    Suematsu, A.2    Okamoto, K.3
  • 84
    • 0344585384 scopus 로고    scopus 로고
    • Suppression of immune induction of collagen-induced arthritis in IL-17-deficient mice
    • Nakae, S., A. Nambu, K. Sudo, and Y. Iwakura. 2003. Suppression of immune induction of collagen-induced arthritis in IL-17-deficient mice. J. Immunol. 171: 6173-6177.
    • (2003) J. Immunol. , vol.171 , pp. 6173-6177
    • Nakae, S.1    Nambu, A.2    Sudo, K.3    Iwakura, Y.4
  • 85
    • 84929718360 scopus 로고    scopus 로고
    • Interleukin-17 is a critical target for the treatment of ankylosing enthesitis and psoriasis-like dermatitis in mice
    • [Epub ahead of print]
    • Ebihara, S., F. Date, Y. Dong, and M. Ono. 2014. Interleukin-17 is a critical target for the treatment of ankylosing enthesitis and psoriasis-like dermatitis in mice. Autoimmunity. 1-8. [Epub ahead of print]. doi: 10.3109/08916934.2014.976630.
    • (2014) Autoimmunity. , pp. 1-8
    • Ebihara, S.1    Date, F.2    Dong, Y.3    Ono, M.4
  • 86
    • 79953073305 scopus 로고    scopus 로고
    • Anti-IL-17A therapy protects against bone erosion in experimental models of rheumatoid arthritis
    • Chao, C. C., S. J. Chen, I. E. Adamopoulos, et al. 2011. Anti-IL-17A therapy protects against bone erosion in experimental models of rheumatoid arthritis. Autoimmunity. 44: 243-252.
    • (2011) Autoimmunity. , vol.44 , pp. 243-252
    • Chao, C.C.1    Chen, S.J.2    Adamopoulos, I.E.3
  • 87
    • 84873124241 scopus 로고    scopus 로고
    • Efficacy and safety of secukinumab in the treatment of moderate-to-severe plaque psoriasis: A randomized, double-blind, placebo-controlled phase II dose-ranging study
    • Papp, K. A., R. G. Langley, B. Sigurgeirsson, et al. 2013. Efficacy and safety of secukinumab in the treatment of moderate-to-severe plaque psoriasis: a randomized, double-blind, placebo-controlled phase II dose-ranging study. Br. J. Dermatol. 168: 412-421.
    • (2013) Br. J. Dermatol. , vol.168 , pp. 412-421
    • Papp, K.A.1    Langley, R.G.2    Sigurgeirsson, B.3
  • 88
    • 84873168729 scopus 로고    scopus 로고
    • Secukinumab induction and maintenance therapy in moderate-to-severe plaque psoriasis: A randomized, double-blind, placebo-controlled, phase II regimen-finding study
    • Rich, P., B. Sigurgeirsson, D. Thaci, et al. 2013. Secukinumab induction and maintenance therapy in moderate-to-severe plaque psoriasis: a randomized, double-blind, placebo-controlled, phase II regimen-finding study. Br. J. Dermatol. 168: 402-411.
    • (2013) Br. J. Dermatol. , vol.168 , pp. 402-411
    • Rich, P.1    Sigurgeirsson, B.2    Thaci, D.3
  • 89
    • 84912024938 scopus 로고    scopus 로고
    • Secukinumab improves hand, foot and nail lesions in moderate-to-severe plaque psoriasis: Subanalysis of a randomized, double-blind, placebocontrolled, regimen-finding phase 2 trial
    • Paul, C., K. Reich, A. B. Gottlieb, et al. 2014. Secukinumab improves hand, foot and nail lesions in moderate-to-severe plaque psoriasis: subanalysis of a randomized, double-blind, placebocontrolled, regimen-finding phase 2 trial. J. Eur. Acad. Dermatol. Venereol.: JEADV. 28: 1670-1675.
    • (2014) J. Eur. Acad. Dermatol. Venereol.: JEADV. , vol.28 , pp. 1670-1675
    • Paul, C.1    Reich, K.2    Gottlieb, A.B.3
  • 90
    • 84905862282 scopus 로고    scopus 로고
    • Secukinumab improves the signs and symptoms of moderate-to-severe plaque psoriasis in subjects with involvement of hands and/or feet: Subanalysis of a randomized, double-blind, placebo-controlled, phase 2 dose-ranging study
    • Sigurgeirsson, B., L. Kircik, O. Nemoto, et al. 2014. Secukinumab improves the signs and symptoms of moderate-to-severe plaque psoriasis in subjects with involvement of hands and/or feet: subanalysis of a randomized, double-blind, placebo-controlled, phase 2 dose-ranging study. J. Eur. Acad. Dermatol. Venereol.: JEADV. 28: 1127-1129.
    • (2014) J. Eur. Acad. Dermatol. Venereol.: JEADV. , vol.28 , pp. 1127-1129
    • Sigurgeirsson, B.1    Kircik, L.2    Nemoto, O.3
  • 91
    • 84891740105 scopus 로고    scopus 로고
    • Efficacy and safety of secukinumab, a fully human anti-interleukin-17A monoclonal antibody, in patients with moderate-to-severe psoriatic arthritis: A 24-week, randomised, double-blind, placebo-controlled, phase II proof-of-concept trial
    • McInnes, I. B., J. Sieper, J. Braun, et al. 2014. Efficacy and safety of secukinumab, a fully human anti-interleukin-17A monoclonal antibody, in patients with moderate-to-severe psoriatic arthritis: a 24-week, randomised, double-blind, placebo-controlled, phase II proof-of-concept trial. Ann. Rheum. Dis. 73: 349-356.
    • (2014) Ann. Rheum. Dis. , vol.73 , pp. 349-356
    • McInnes, I.B.1    Sieper, J.2    Braun, J.3
  • 92
    • 84903581591 scopus 로고    scopus 로고
    • Antibodies to watch in 2014: Mid-year update
    • Reichert, J. M. 2014. Antibodies to watch in 2014: mid-year update. mAbs. 6: 799-802.
    • (2014) MAbs. , vol.6 , pp. 799-802
    • Reichert, J.M.1
  • 94
    • 84897954122 scopus 로고    scopus 로고
    • Secukinumab treatment in rheumatoid arthritis is associated with incremental benefit in the clinical outcomes and HRQoL improvements that exceed minimally important thresholds
    • Strand, V., M. Kosinski, A. Gnanasakthy, et al. 2014. Secukinumab treatment in rheumatoid arthritis is associated with incremental benefit in the clinical outcomes and HRQoL improvements that exceed minimally important thresholds. Health Qual. Life. Outcomes. 12: 31.
    • (2014) Health Qual. Life. Outcomes. , vol.12 , pp. 31
    • Strand, V.1    Kosinski, M.2    Gnanasakthy, A.3
  • 95
    • 84895465850 scopus 로고    scopus 로고
    • One-year efficacy and safety results of secukinumab in patients with rheumatoid arthritis: Phase II, dose-finding, double-blind, randomized, placebo-controlled study
    • Genovese, M. C., P. Durez, H. B. Richards, et al. 2014. One-year efficacy and safety results of secukinumab in patients with rheumatoid arthritis: phase II, dose-finding, double-blind, randomized, placebo-controlled study. J. Rheumatol. 41: 414-421.
    • (2014) J. Rheumatol. , vol.41 , pp. 414-421
    • Genovese, M.C.1    Durez, P.2    Richards, H.B.3
  • 96
    • 84887444732 scopus 로고    scopus 로고
    • Targeting interleukin-17 in patients with active rheumatoid arthritis: Rationale and clinical potential
    • Kellner, H. 2013. Targeting interleukin-17 in patients with active rheumatoid arthritis: rationale and clinical potential. Ther. Adv. Musculoskelet. Dis. 5: 141-152.
    • (2013) Ther. Adv. Musculoskelet. Dis. , vol.5 , pp. 141-152
    • Kellner, H.1
  • 97
    • 84879890395 scopus 로고    scopus 로고
    • Treatment of spondyloarthropathy: The potential for agents other than TNF inhibitors
    • Her, M., and A. Kavanaugh. 2013. Treatment of spondyloarthropathy: the potential for agents other than TNF inhibitors. Curr. Opin. Rheumatol. 25: 455-459.
    • (2013) Curr. Opin. Rheumatol. , vol.25 , pp. 455-459
    • Her, M.1    Kavanaugh, A.2
  • 98
    • 84874592146 scopus 로고    scopus 로고
    • Treating multiple sclerosis with monoclonal antibodies: A 2013 update
    • Deiss, A., I. Brecht, A. Haarmann, and M. Buttmann. 2013. Treating multiple sclerosis with monoclonal antibodies: a 2013 update. Expert. Rev. Neurother. 13: 313-335.
    • (2013) Expert. Rev. Neurother. , vol.13 , pp. 313-335
    • Deiss, A.1    Brecht, I.2    Haarmann, A.3    Buttmann, M.4
  • 99
    • 84875697084 scopus 로고    scopus 로고
    • Secukinumab in the treatment of noninfectious uveitis: Results of three randomized, controlled clinical trials
    • Dick, A. D., I. Tugal-Tutkun, S. Foster, et al. 2013. Secukinumab in the treatment of noninfectious uveitis: results of three randomized, controlled clinical trials. Ophthalmology. 120: 777-787.
    • (2013) Ophthalmology. , vol.120 , pp. 777-787
    • Dick, A.D.1    Tugal-Tutkun, I.2    Foster, S.3
  • 100
    • 84896314616 scopus 로고    scopus 로고
    • The selective anti-IL17A monoclonal antibody secukinumab (AIN457) attenuates IL17A-induced levels of IL6 in human astrocytes
    • Elain, G., K. Jeanneau, A. Rutkowska, et al. 2014. The selective anti-IL17A monoclonal antibody secukinumab (AIN457) attenuates IL17A-induced levels of IL6 in human astrocytes. Glia. 62: 725-735.
    • (2014) Glia. , vol.62 , pp. 725-735
    • Elain, G.1    Jeanneau, K.2    Rutkowska, A.3
  • 101
    • 84902266081 scopus 로고    scopus 로고
    • Not all monoclonals are created equal-lessons from failed drug trials in Crohn's disease
    • Kaser, A. 2014. Not all monoclonals are created equal-lessons from failed drug trials in Crohn's disease. Best. Pract. Res. Clin. Gastroenterol. 28: 437-449.
    • (2014) Best. Pract. Res. Clin. Gastroenterol. , vol.28 , pp. 437-449
    • Kaser, A.1
  • 102
    • 84883591833 scopus 로고    scopus 로고
    • Combined blockade of IL-17A and IL-17F may prevent the development of experimental colitis
    • McLean, L. P., R. K. Cross, and T. Shea-Donohue. 2013. Combined blockade of IL-17A and IL-17F may prevent the development of experimental colitis. Immunotherapy. 5: 923-925.
    • (2013) Immunotherapy. , vol.5 , pp. 923-925
    • McLean, L.P.1    Cross, R.K.2    Shea-Donohue, T.3
  • 103
    • 84883571248 scopus 로고    scopus 로고
    • TH17 cell induction and effects of IL-17A and IL-17F blockade in experimental colitis
    • Wedebye Schmidt, E. G., H. L. Larsen, N. N. Kristensen, et al. 2013. TH17 cell induction and effects of IL-17A and IL-17F blockade in experimental colitis. Inflamm. Bowel. Dis. 19: 1567-1576.
    • (2013) Inflamm. Bowel. Dis. , vol.19 , pp. 1567-1576
    • Wedebye Schmidt, E.G.1    Larsen, H.L.2    Kristensen, N.N.3
  • 104
    • 38349178776 scopus 로고    scopus 로고
    • Interleukin 17-producing T helper cells and interleukin 17 orchestrate autoreactive germinal center development in autoimmune BXD2 mice
    • Hsu, H. C., P. Yang, J. Wang, et al. 2008. Interleukin 17-producing T helper cells and interleukin 17 orchestrate autoreactive germinal center development in autoimmune BXD2 mice. Nat. Immunol. 9: 166-175.
    • (2008) Nat. Immunol. , vol.9 , pp. 166-175
    • Hsu, H.C.1    Yang, P.2    Wang, J.3
  • 105
    • 59249101944 scopus 로고    scopus 로고
    • IL-17 producing CD4+T cells mediate accelerated ischemia/reperfusion-induced injury in autoimmunity-prone mice
    • Edgerton, C., J. C. Crispin, C. M. Moratz, et al. 2009. IL-17 producing CD4+T cells mediate accelerated ischemia/reperfusion-induced injury in autoimmunity-prone mice. Clin. Immunol. 130: 313-321.
    • (2009) Clin. Immunol. , vol.130 , pp. 313-321
    • Edgerton, C.1    Crispin, J.C.2    Moratz, C.M.3
  • 106
    • 84895107356 scopus 로고    scopus 로고
    • Pragmatic approaches to therapy for systemic lupus erythematosus
    • Xiong, W., and R. G. Lahita. 2014. Pragmatic approaches to therapy for systemic lupus erythematosus. Nat. Rev. Rheumatol. 10: 97-107.
    • (2014) Nat. Rev. Rheumatol. , vol.10 , pp. 97-107
    • Xiong, W.1    Lahita, R.G.2


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