The potential role of Th17 cells and Th17-related cytokines in the pathogenesis of lupus nephritis

Lupus

Volumn 21, Issue 13, 2012, Pages 1385-1396

  Chen, D Y ^a,b,c   Chen, Y M ^a   Wen, M C ^a   Hsieh, T Y ^a,b   Hung, W T ^a   Lan, J L ^a,b,c  

^a TAICHUNG VETERANS GENERAL HOSPITAL   (Taiwan)

^b CHUNG SHAN MEDICAL UNIVERSITY   (Taiwan)

^c NATIONAL CHUNG HSING UNIVERSITY   (Taiwan)

Author keywords

lupus nephritis; pathogenesis; systemic lupus erythematosus; Th17 cell; Th17 related cytokines

Indexed keywords

ALISAMYCIN; INTERLEUKIN 17; INTERLEUKIN 23; INTERLEUKIN 6;

ARTICLE; CELL PROLIFERATION; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; FEMALE; FLOW CYTOMETRY; HUMAN; IMMUNOHISTOCHEMISTRY; LUPUS ERYTHEMATOSUS NEPHRITIS; MALE; PATHOGENESIS; PRIORITY JOURNAL; SYSTEMIC LUPUS ERYTHEMATOSUS; TH17 CELL;

ADULT; BIOPSY; CASE-CONTROL STUDIES; CYTOKINES; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; FLOW CYTOMETRY; HUMANS; IMMUNOHISTOCHEMISTRY; INTERLEUKIN-17; INTERLEUKIN-18; INTERLEUKIN-23; INTERLEUKIN-6; KIDNEY GLOMERULUS; LUPUS NEPHRITIS; MALE; MIDDLE AGED; NEPHROSIS, LIPOID; PROGNOSIS; TH17 CELLS;

EID: 84867755386     PISSN: 09612033     EISSN: 14770962     Source Type: Journal    
DOI: 10.1177/0961203312457718     Document Type: Article

References (57)

1. Cameron JS, Turner DR, Ogg CS, et al. Systemic lupus with nephritis: a long-term study. QJM. 1979 ; 48: 1-24
2. Korbet SM, Lewis EJ, Schwartz MM. Factors predictive of outcome in severe lupus nephritis. Lupus Nephritis Collaborative Study Group. Am J Kidney Dis. 2000 ; 35: 904-914
3. Waldman M, Appel GB. Update on the treatment of lupus nephritis. Kidney Int. 2006 ; 70: 1403-1412
4. Lee YH, Woo JH, Choi SJ, et al. Induction and maintenance therapy for lupus nephritis: a systematic review and meta-analysis. Lupus. 2009 ; 18: 1-8
5. Grande JP, Balow JE. Renal biopsy in lupus nephritis. Lupus. 1998 ; 7: 611-617
6. Weening JJ, D'Agati VD, Schwartz MM, et al. The classification of glomerulonephritis in systemic lupus erythematosus revised. J Am Soc Nephrol. 2004 ; 15: 241-250
7. Moroni G, Pasquali S, Quaglini S, et al. Clinical and prognostic value of serial renal biopsies in lupus nephritis. Am J Kidney Dis. 1999 ; 34: 530-539
8. Najafi CC, Korbet SM, Lewis EJ, et al. Significance of histological patterns of glomerular injury upon long-term prognosis in severe lupus glomerulonephritis. Kidney Int. 2001 ; 59: 2156-2163
9. Kelley VR, Wuthrich RP. Cytokines in the pathogenesis of systemic lupus erythematosus. Semin Nephrol. 1999 ; 19: 57-66
10. Akahoshi M, Nakashima H, Tanaka Y, et al. Th1/Th2 balance of peripheral T helper cells in systemic lupus erythematosus. Arthritis Rheum. 1999 ; 42: 1644-1688
11. Masutani K, Akahoshi M, Tsuruya K, et al. Predominance of Th1 immune response in diffuse proliferative lupus nephritis. Arthritis Rheum. 2001 ; 44: 2097-2106
12. Bettelli E, Oukka M, Kuchroo VK. Th-17 cells in the circle of immunity and autoimmunity. Nat Immunol. 2007 ; 8: 345-350
13. Harrington LE, Hatton RD, Mangan PR, et al. Interleukin17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineage. Nat Immunol. 2005 ; 6: 1123-1132
14. Park H, Li Z, Yang XO, et al. A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17. Nat Immunol. 2005 ; 6: 1133-1141
15. Jovanovic DV, Di Battista JA, Martel-Pelletier J, et al. IL-17 stimulates the production of proinflammatory cytokines, IL-1β and TNF-α, by human macrophages. J Immunol. 1998 ; 160: 3513-3521
16. Laan M, Cui AH, Hoshino H, et al. Neutrophil recruitment by human IL-17 via CXC chemokine release in the airways. J Immunol. 1999 ; 162: 2347-2352
17. Agarwal S, Misra R, Aggarwal A. Interleukin 17 levels are increased in juvenile idiopathic arthritis synovial fluid and induce synovial fibroblasts to produce proinflammatory cytokines and matrix metalloproteinases. J Rheumatol. 2008 ; 35: 515-519
18. Wong CK, Lit LCW, Tam LS, et al. Hyperproduction of IL-23 and IL-17 in patients with systemic lupus erythematosus: implications for Th17-mediated inflammation in auto-immunity. Clin Immunol. 2008 ; 127: 385-393
19. Yang J, Chu Y, Yang X, et al. Th17 and natural Treg cell population dynamics in systemic lupus erythematosus. Arthritis Rheum. 2009 ; 60: 1472-1483
20. Garrett-Sinha LA, John S, Gaffen SL. IL-17 and the Th17 lineage in systemic lupus erythematosus. Curr Opin Rheumatol. 2008 ; 20: 519-525
21. Chen XQ, Yu YC, Deng HH, et al. Plasma IL-17A is increased in new-onset SLE patients and associated with disease activity. J Clin Immunol. 2010 ; 30: 221-225
22. Wong CK, Ho CY, Li EK, et al. Elevation of proinflammatory cytokines (IL-18, IL-17, IL-12) and Th 2 cytokine (IL-4) concentrations in patients with systemic lupus erythematosus. Lupus. 2000 ; 9: 589-593
23. Huang X, Hua J, Shen N, et al. Dysregulated expression of interleukin-23 and interleukin-12 subunits in systemic lupus erythematosus patients. Mod Rheumatol. 2007 ; 17: 220-223
24. Zhou L, Ivanov II, Spolski R, et al. IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways. Nat Immunol. 2007 ; 8: 967-974
25. Uhm WS, Na K, Song GW, et al. Cytokine balances in kidney tissue from lupus nephritis patients. Rheumatology (Oxford). 2003 ; 42: 935-938
26. Chen Z, Tato CM, Muul L, et al. Distinct regulation of interleukin-17 in human T helper lymphocytes. Arthritis Rheum. 2007 ; 56: 2936-2946
27. Kang HK, Ecklund D, Liu M, et al. Apigenin, a non-mutagenic dietary flavonoid, suppresses lupus by inhibiting autoantigen presentation for expansion of autoreactive Th1 and Th17 cells. Arthritis Res Ther. 2009 ; 11: R59 - R59
28. Crispin JC, Oukka M, Bayliss G, et al. Expanded double negative T cells in patients with systemic lupus erythematosus produce IL-17 and infiltrate the kidneys. J Immunol. 2008 ; 181: 8761-8766
29. Wang Y, Ito S, Chino Y, et al. Laser microdissection-based analysis of cytokine balance in the kidneys of patients with lupus nephritis. Clin Exp Immunol. 2009 ; 159: 1-10
30. Hochberg MC. Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus [letter]. Arthritis Rheum. 1997 ; 40: 1725-1725
31. Bombaridier C, Gladman DD, Urowitz MB, et al. Derivation of the SLEDAI: a disease activity index for lupus patients. The Committee on Prognosis Studies in SLE. Arthritis Rheum. 1992 ; 35: 630-640
32. Yamada H, Nakashima Y, Okazaki K, et al. Th1 but not Th17 cells predominate in the joints of patients with rheumatoid arthritis. Ann Rheum Dis. 2008 ; 67: 1299-1304
33. Chen DY, Chen YM, Lan JL, et al. Potential role of Th17 cells in the pathogenesis of adult-onset Still's disease. Rheumatology (Oxford). 2010 ; 49: 2305-2312
34. Makino H, Yamasaki Y, Shikata K, et al. Transition of morphologic features in lupus nephritis: does steroid therapy accelerate glomerulosclerosis?. Intern Med. 1995 ; 34: 982-987
35. Calvani N, Richard HB, Tucci M, et al. Up-regulation of IL-18 and predominance of a Th1 immune response is a hallmark of lupus nephritis. Clin Exp Immunol. 2004 ; 138: 171-178
36. Gueret G, Lion F, Guriec N, et al. Acute renal dysfunction after cardiac surgery with cardiopulmonary bypass is associated with plasmatic IL6 increase. Cytokine. 2009 ; 45: 92-98
37. Xing Q, Wang B, Su H, et al. Elevated Th17 cells are accompanied by FoxP3+ Treg cells decrease in patients with lupus nephritis. Rheumatol Int. 2012 ; 32: 949-958
38. Shah K, Lee WW, Lee SH, et al. Dysregulated balance of Th17 and Th1 cells in systemic lupus erythematosus. Arthritis Res Ther. 2010 ; 12: R53 - R53
39. Zhang Z, Kyttaris VC, Tsokos GC. The role of IL-23/IL-17 axis in lupus nephritis. J Immunol. 2009 ; 183: 3160-3169
40. Korn T, Oukka M, Kuchroo VK, et al. Th17 cells: effector cells with inflammatory properties. Semin Immunol. 2007 ; 19: 362-371
41. Liang SC, Long AJ, Bennett F, et al. An IL-17F/A heterodimer protein is produced by mouse Th17 cells and induces airway neutrophil recruitment. J Immunol. 2007 ; 179: 7791-7799
42. Roark CL, Simonian PL, Fontenot AP, et al. Gammadelta T cells: an important source of IL-17. Curr Opin Immunol. 2008 ; 20: 353-357
43. Hueber AJ, Asquith DL, Miller AM, et al. Mast cells express IL-17A in rheumatoid arthritis synovium. J Immunol. 2010 ; 184: 3336-3340
44. Wan S, Xia C, Morel L. IL-6 produced by dendritic cells from lupus-prone mice inhibits CD4+CD25+ T cell regulatory functions. J Immunol. 2007 ; 178: 271-279
45. Dong G, Ye R, Shi W, et al. IL-17 induces autoantibody overproduction and peripheral blood mononuclear cell overexpression of IL-6 in lupus nephritis patients. Chin Med J. 2003 ; 116: 543-548
46. Illei GG, Shirota Y, Yarboro CH, et al. Tocilizumab in systemic lupus erythematosus: data on safety, preliminary efficacy, and impact on circulating plasma cells from an open-label phase I dosage-escalation study. Arthritis Rheum. 2010 ; 62: 542-552
47. Aggarwal S, Ghilardi N, Xie MH, et al. Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of IL-17. J Biol Chem. 2003 ; 278: 1910-1914
48. Espinosa A, Dardalhon V, Brauner S, et al. Loss of the lupus autoantigen Ro52/Trim21 induces tissue inflammation and systemic autoimmunity by disregulating the IL-23-Th17 pathway. J Exp Med. 2009 ; 206: 1661-1671
49. Huang X, Hua J, Shen N, et al. Dysregulated expression of interleukin-23 and interleukin-12 subunits in systemic lupus erythematosus patients. Mod Rheumatol. 2007 ; 17: 220-223
50. Kang HK, Liu M, Datta SK. Low-dose peptide tolerance therapy of lupus generates plasmacytoid dendritic cells that cause expansion of autoantigen-specific regulatory T cells and contraction of inflammatory Th17 cells. J Immunol. 2007 ; 178: 7849-7858
51. Kwan BCH, Tam LS, Lai KB, et al. The gene expression of type 17 T-helper cell-related cytokines in the urinary sediment of patients with systemic lupus erythematosus. Rheumatology. 2009 ; 48: 1491-1497
52. Summers SA, Steinmetz OM, Li M, et al. Th1 and Th17 cells induce proliferative glomerulonephritis. J Am Soc Nephrol. 2009 ; 20: 2518-2524
53. Turner JE, Paust HJ, Steinmetz OM, et al. The Th17 immune responses in renal inflammation. Kidney Int. 2010 ; 77: 1070-1075
54. Apostolidis SA, Crispín JC, Tsokos GC. IL-17-producing T cells in lupus nephritis. Lupus. 2011 ; 20: 120-124
55. Kikly K, Liu L, Na S, et al. The IL-23/Th17 axis: therapeutic targets for autoimmune inflammation. Curr Opin Immunol. 2006 ; 18: 670-675
56. Leng RX, Pan HF, Chen GM, et al. IL-23: a promising therapeutic target for systemic lupus erythematosus. Arch Med Res. 2010 ; 41: 221-225
57. Floege J, Rees A Immunologic renal diseases. Neilson EG Couser WG, ed. Philadelphia, PA: Lippincott-Raven ; 1997: 417-454.