Profiling of CD4+ T cells with epigenetic immune lineage analysis

Journal of Immunology

Volumn 186, Issue 1, 2011, Pages 92-102

  Janson, Peter C J ^a   Linton, Ludvig Bernt ^a   Bergman, Emma Ahlén ^a   Marits, Per ^a   Eberhardson, Michael ^b   Piehl, Fredrik ^a   Malmström, Vivianne ^a   Winqvist, Ola ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b STOCKHOLM SÖDER HOSPITAL   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; DNA; INTERLEUKIN 17; TRANSCRIPTION FACTOR;

ADULT; ARTICLE; CD4+ T LYMPHOCYTE; CELL ISOLATION; CELLULAR IMMUNITY; CONTROLLED STUDY; CPG ISLAND; DNA METHYLATION; EPIGENETIC IMMUNE LINEAGE ANALYSIS; EPIGENETICS; GENE EXPRESSION PROFILING; GENE LOCUS; GENETIC LINE; GENETIC REGULATION; HUMAN; HUMAN CELL; LYMPHOCYTE DIFFERENTIATION; LYMPHOCYTIC INFILTRATION; MULTIPLE SCLEROSIS; PHENOTYPE; PRIORITY JOURNAL; PROMOTER REGION; REGULATORY T LYMPHOCYTE; RHEUMATOID ARTHRITIS; SYNOVIAL FLUID; T LYMPHOCYTE SUBPOPULATION; TH1 CELL; TH17 CELL; TH2 CELL;

ARTHRITIS, RHEUMATOID; CD4-POSITIVE T-LYMPHOCYTES; CELL LINEAGE; CELLS, CULTURED; CYTOKINES; DNA METHYLATION; EPIGENESIS, GENETIC; GENE EXPRESSION PROFILING; HUMANS; INTERLEUKIN-17; MULTIPLE SCLEROSIS; TH1 CELLS; TH2 CELLS; TRANSCRIPTION FACTORS;

EID: 79251589323     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1000960     Document Type: Article

References (38)

1. Murphy, K. M., and S. L. Reiner. 2002. The lineage decisions of helper T cells. Nat. Rev. Immunol. 2: 933-944.
2. Ouyang, W., J. K. Kolls, and Y. Zheng. 2008. The biological functions of T helper 17 cell effector cytokines in inflammation. Immunity 28: 454-467.
3. Hori, S., T. Nomura, and S. Sakaguchi. 2003. Control of regulatory T cell development by the transcription factor Foxp3. Science 299: 1057-1061. (Pubitemid 36222930)
4. Janson, P. C., M. E. Winerdal, and O. Winqvist. 2009. At the crossroads of T helper lineage commitment: epigenetics points the way. Biochim. Biophys. Acta 1790: 906-919.
5. Wilson, C. B., E. Rowell, and M. Sekimata. 2009. Epigenetic control of T-helper-cell differentiation. Nat. Rev. Immunol. 9: 91-105.
6. Ansel, K. M., I. Djuretic, B. Tanasa, and A. Rao. 2006. Regulation of Th2 differentiation and Il4 locus accessibility. Annu. Rev. Immunol. 24: 607-656.
7. Lee, G. R., S. T. Kim, C. G. Spilianakis, P. E. Fields, and R. A. Flavell. 2006. T helper cell differentiation: regulation by cis elements and epigenetics. Immunity 24: 369-379.
8. Schoenborn, J. R., M. O. Dorschner, M. Sekimata, D. M. Santer, M. Shnyreva, D. R. Fitzpatrick, J. A. Stamatoyannopoulos, J. A. Stamatoyannopoulos, and C. B. Wilson. 2007. Comprehensive epigenetic profiling identifies multiple distal regulatory elements directing transcription of the gene encoding interferon-γ. [Published erratum appears in 2008 Nat. Immunol. 9: 105.] Nat. Immunol. 8: 732-742.
9. Floess, S., J. Freyer, C. Siewert, U. Baron, S. Olek, J. Polansky, K. Schlawe, H. D. Chang, T. Bopp, E. Schmitt, et al. 2007. Epigenetic control of the foxp3 locus in regulatory T cells. PLoS Biol. 5: e38.
10. Janson, P. C., M. E. Winerdal, P. Marits, M. Thorn, R. Ohlsson, and O. Winqvist. 2008. FOXP3 promoter demethylation reveals the committed Treg population in humans. PLoS One 3: e1612.
11. Zheng, Y., S. Josefowicz, A. Chaudhry, X. P. Peng, K. Forbush, and A. Y. Rudensky. 2010. Role of conserved non-coding DNA elements in the Foxp3 gene in regulatory T-cell fate. Nature 463: 808-812.
12. Akimzhanov, A. M., X. O. Yang, and C. Dong. 2007. Chromatin remodeling of interleukin-17 (IL-17)-IL-17F cytokine gene locus during inflammatory helper T cell differentiation. J. Biol. Chem. 282: 5969-5972.
13. Janson, P. C., P. Marits, M. Thörn, R. Ohlsson, and O. Winqvist. 2008. CpG methylation of the IFNG gene as a mechanism to induce immunosuppression [correction of immunosupression] in tumor-infiltrating lymphocytes. J. Immunol. 181: 2878-2886.
14. Kumaki, Y., M. Oda, and M. Okano. 2008. QUMA: quantification tool for methylation analysis. Nucleic Acids Res. 36(Web Server issue): W170-W175.
15. + T cell differentiation. J. Immunol. 169: 1893-1903.
16. + lymphocytes in physically active adults. Eur. J. Immunol. 23: 2704-2706.
17. Lee, Y. K., R. Mukasa, R. D. Hatton, and C. T. Weaver. 2009. Developmental plasticity of Th17 and Treg cells. Curr. Opin. Immunol. 21: 274-280.
18. Strickland, F. M., and B. C. Richardson. 2008. Epigenetics in human autoimmunity: Epigenetics in autoimmunity - DNA methylation in systemic lupus erythematosus and beyond. Autoimmunity 41: 278-286.
19. von Andrian, U. H., and B. Engelhardt. 2003. Alpha4 integrins as therapeutic targets in autoimmune disease. N. Engl. J. Med. 348: 68-72.
20. Yang, Y., J. Weiner, Y. Liu, A. J. Smith, D. J. Huss, R. Winger, H. Peng, P. D. Cravens, M. K. Racke, and A. E. Lovett-Racke. 2009. T-bet is essential for encephalitogenicity of both Th1 and Th17 cells. J. Exp. Med. 206: 1549-1564.
21. Nistala, K., S. Adams, H. Cambrook, S. Ursu, B. Olivito, W. de Jager, J. G. Evans, R. Cimaz, M. Bajaj-Elliott, and L. R.Wedderburn. Th17 plasticity in human autoimmune arthritis is driven by the inflammatory environment. Proc. Natl. Acad. Sci. USA 107: 14751-14756.
22. Lee, Y. K., H. Turner, C. L. Maynard, J. R. Oliver, D. Chen, C. O. Elson, and C. T. Weaver. 2009. Late developmental plasticity in the T helper 17 lineage. Immunity 30: 92-107.
23. - T cells or are self-induced to become Th17 cells in the absence of exogenous TGF-β. J. Immunol. 178: 6725-6729.
24. Yang, X. O., R. Nurieva, G. J. Martinez, H. S. Kang, Y. Chung, B. P. Pappu, B. Shah, S. H. Chang, K. S. Schluns, S. S. Watowich, et al. 2008. Molecular antagonism and plasticity of regulatory and inflammatory T cell programs. Immunity 29: 44-56.
25. + T cells. Immunity 30: 155-167.
26. Murphy, C. A., C. L. Langrish, Y. Chen, W. Blumenschein, T. McClanahan, R. A. Kastelein, J. D. Sedgwick, and D. J. Cua. 2003. Divergent pro- and antiinflammatory roles for IL-23 and IL-12 in joint autoimmune inflammation. J. Exp. Med. 198: 1951-1957.
27. Cua, D. J., J. Sherlock, Y. Chen, C. A. Murphy, B. Joyce, B. Seymour, L. Lucian, W. To, S. Kwan, T. Churakova, et al. 2003. Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain. Nature 421: 744-748.
28. Nakae, S., A. Nambu, K. Sudo, and Y. Iwakura. 2003. Suppression of immune induction of collagen-induced arthritis in IL-17-deficient mice. J. Immunol. 171: 6173-6177.
29. Doodes, P. D., Y. Cao, K. M. Hamel, Y. Wang, B. Farkas, Y. Iwakura, and A. Finnegan. 2008. Development of proteoglycan-induced arthritis is independent of IL-17. J. Immunol. 181: 329-337.
30. Yamada, H., Y. Nakashima, K. Okazaki, T. Mawatari, J. I. Fukushi, N. Kaibara, A. Hori, Y. Iwamoto, and Y. Yoshikai. 2008. Th1 but not Th17 cells predominate in the joints of patients with rheumatoid arthritis. Ann. Rheum. Dis. 67: 1299-1304.
31. van Hamburg, J. P., A. M. Mus, M. J. de Bruijn, L. de Vogel, L. Boon, F. Cornelissen, P. Asmawidjaja, R. W. Hendriks, and E. Lubberts. 2009. GATA-3 protects against severe joint inflammation and bone erosion and reduces differentiation of Th17 cells during experimental arthritis. Arthritis Rheum. 60: 750-759.
32. Joosten, L. A., E. Lubberts, M. M. Helsen, T. Saxne, C. J. Coenen-de Roo, D. Heinegård, and W. B. van den Berg. 1999. Protection against cartilage and bone destruction by systemic interleukin-4 treatment in established murine type II collagen-induced arthritis. Arthritis Res. 1: 81-91. (Pubitemid 32223676)
33. Hwang, E. S., S. J. Szabo, P. L. Schwartzberg, and L. H. Glimcher. 2005. T helper cell fate specified by kinase-mediated interaction of T-bet with GATA-3. Science 307: 430-433.
34. Mantel, P. Y., H. Kuipers, O. Boyman, C. Rhyner, N. Ouaked, B. Rückert, C. Karagiannidis, B. N. Lambrecht, R. W. Hendriks, R. Crameri, et al. 2007. GATA3-driven Th2 responses inhibit TGF-β1-induced FOXP3 expression and the formation of regulatory T cells. PLoS Biol. 5: e329.
35. Usui, T., R. Nishikomori, A. Kitani, and W. Strober. 2003. GATA-3 suppresses Th1 development by downregulation of Stat4 and not through effects on IL-12Rβ2 chain or T-bet. Immunity 18: 415-428. (Pubitemid 36351520)
36. Usui, T., J. C. Preiss, Y. Kanno, Z. J. Yao, J. H. Bream, J. J. O'Shea, and W. Strober. 2006. T-bet regulates Th1 responses through essential effects on GATA-3 function rather than on IFNG gene acetylation and transcription. J. Exp. Med. 203: 755-766.
37. El-behi, M., A. Rostami, and B. Ciric. 2010. Current views on the roles of Th1 and Th17 cells in experimental autoimmune encephalomyelitis. J. Neuroimmune Pharmacol. 5: 189-197.
38. Matusevicius, D., P. Kivisäkk, B. He, N. Kostulas, V. Ozenci, S. Fredrikson, and H. Link. 1999. Interleukin-17 mRNA expression in blood and CSF mononuclear cells is augmented in multiple sclerosis. Mult. Scler. 5: 101-104.