A murine autoimmune model of rheumatoid arthritis and systemic lupus erythematosus associated with deregulated production of IL-17 and IL-21

Methods in Molecular Biology

Volumn 900, Issue , 2012, Pages 233-251

  Biswas, Partha S ^a   Kang, Kyuho ^b   Gupta, Sanjay ^a   Bhagat, Govind ^c   Pernis, Alessandra B ^a,b  

^a HOSPITAL FOR SPECIAL SURGERY   (United States)

^b Weill Cornell Graduate School of Biomedical Sciences   (United States)

^c NewYork Presbyterian Hospital   (United States)

Author keywords

Animal models; Arthritis; Autoimmunity; Interleukin 17; Interleukin 21; Systemic lupus erythematosus

Indexed keywords

EID: 84868593854     PISSN: 10643745     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-60761-720-4_11     Document Type: Article

References (22)

1. McInnes IB, Schett G (2007) Cytokines in the pathogenesis of rheumatoid arthritis. Nat Rev Immunol 7:429-4422
2. Toh ML, Miossec P (2007) The role of T cells in rheumatoid arthritis: New subsets and new targets. Curr Opin Rheumatol 19:284-2888
3. Sarkar S, Cooney LA, Fox DA (2010) The role of T helper type 17 cells in in fl ammatory arthritis. Clin Exp Immunol 159:225-2377
4. Tesmer LA, Lundy SK, Sarkar S, Fox DA (2008) Th17 cells in human disease. Immunol Rev 223:87-1133
5. Koenders MI, Joosten LA, van den Berg WB (2006) Potential new targets in arthritis therapy: Interleukin (IL)-17 and its relation to tumour necrosis factor and IL-1 in experimental arthritis. Ann Rheum Dis 65(Suppl 3):iii29-iii333
6. Stamp LK, James MJ, Cleland LG (2004) Interleukin-17: The missing link between T-cell accumulation and effector cell actions in rheumatoid arthritis? Immunol Cell Biol 82:1-99
7. Korn T, Bettelli E, Gao W, Awasthi A, Jager A, Strom TB, Oukka M, Kuchroo VK (2007) IL-21 initiates an alternative pathway to induce proin fl ammatory T(H)17 cells. Nature 448: 484-4877
8. Nurieva R, Yang XO, Martinez G, Zhang Y, Panopoulos AD, Ma L, Schluns K, Tian Q, Watowich SS, Jetten AM, Dong C (2007) Essential autocrine regulation by IL-21 in the generation of in fl ammatory T cells. Nature 448:480-4833
9. Zhou L, Ivanov II, Spolski R, Min R, Shenderov K, Egawa T, Levy DE, Leonard WJ, Littman L. McInnes IB, Schett G (2007) Cytokines in the pathogenesis of rheumatoid arthritis. Nat Rev Immunol 7:429-4422
10. Toh ML, Miossec P (2007) The role of T cells in rheumatoid arthritis: New subsets and new targets. Curr Opin Rheumatol 19:284-2888
11. Sarkar S, Cooney LA, Fox DA (2010) The role of T helper type 17 cells in in fl ammatory arthritis. Clin Exp Immunol 159:225-2377
12. Tesmer LA, Lundy SK, Sarkar S, Fox DA (2008) Th17 cells in human disease. Immunol Rev 223:87-1133
13. Koenders MI, Joosten LA, van den Berg WB (2006) Potential new targets in arthritis therapy: Interleukin (IL)-17 and its relation to tumour necrosis factor and IL-1 in experimental arthritis. Ann Rheum Dis 65(Suppl 3):iii29-iii333
14. Stamp LK, James MJ, Cleland LG (2004) Interleukin-17: The missing link between T-cell accumulation and effector cell actions in rheumatoid arthritis? Immunol Cell Biol 82:1-99
15. Korn T, Bettelli E, Gao W, Awasthi A, Jager A, Strom TB, Oukka M, Kuchroo VK (2007) IL-21 initiates an alternative pathway to induce proin fl ammatory T(H)17 cells. Nature 448: 484-4877
16. Nurieva R, Yang XO, Martinez G, Zhang Y, Panopoulos AD, Ma L, Schluns K, Tian Q, Watowich SS, Jetten AM, Dong C (2007) Essential autocrine regulation by IL-21 in the generation of in fl ammatory T cells. Nature 448:480-4833
17. Zhou L, Ivanov II, Spolski R, Min R, Shenderov K, Egawa T, Levy DE, Leonard WJ, Littman differentially expressed in the hematopoietic system. Br J Haematol 106:335-3444
18. Tanaka Y, Bi K, Kitamura R, Hong S, Altman Y, Matsumoto A, Tabata H, Lebedeva S, Bushway PJ, Altman A (2003) SWAP-70-like adapter of T cells, an adapter protein that regulates early TCR-initiated signaling in Th2 lineage cells. Immunity 18:403-4144
19. Fanzo JC, Yang W, Jang SY, Gupta S, Chen Q, Siddiq A, Greenberg S, Pernis AB (2006) Loss of IRF-4-binding protein leads to the spontaneous development of systemic autoimmunity. J Clin Invest 116:703-7144
20. Murphy KM, Heimberger AB, Loh DY (1990) Induction by antigen of intrathymic apoptosis of CD4 + CD8 + TCRlo thymocytes in vivo. Science 250:1720-17233
21. Biswas PS, Gupta S, Chang E, Song L, Stirzaker RA, Liao JK, Bhagat G, Pernis AB (2010) Phosphorylation of IRF4 by ROCK2 regulates IL-17 and IL-21 production and the development of autoimmunity in mice. J Clin Invest 120:3280-32955
22. Brand DD, Kang AH, Rosloniec EF (2004) The mouse model of collagen-induced arthritis. Methods Mol Med 102:295-3122