GSK3-mediated raptor phosphorylation supports amino-acid-dependent mTORC1-directed signalling

Biochemical Journal

Volumn 470, Issue 2, 2015, Pages 207-221

  Stretton, Clare ^a   Hoffmann, Thorsten M ^a   Munson, Michael J ^a   Prescott, Alan ^a   Taylor, Peter M ^a   Ganley, Ian G ^a   Hundal, Harinder S ^a  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

Author keywords

Amino acid; Autophagy; Growth; Insulin; L type (leucine) amino acid transporter 1 (LAT1); Leucine; p70S6K1; Proliferation; Sodium coupled neutral amino acid transporter 2 (SNAT2); Transcription factor EB (TFEB); Uncoordinated 51 like kinase (ULK1)

Indexed keywords

2 (2,4 DICHLOROPHENYL) 3 (1 METHYL 3 INDOLYL)MALEIMIDE; 2 (3 CHLORO 4 HYDROXYANILINO) 3 (2 NITROPHENYL)MALEIMIDE; GLYCOGEN SYNTHASE KINASE 3; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; RAPAMYCIN; ROSCOVITINE; SCAFFOLD PROTEIN; SHORT HAIRPIN RNA; AMINO ACID; MECHANISTIC TARGET OF RAPAMYCIN COMPLEX 1; MULTIPROTEIN COMPLEX; RPTOR PROTEIN, HUMAN; SERINE; SIGNAL TRANSDUCING ADAPTOR PROTEIN; SMALL INTERFERING RNA; TARGET OF RAPAMYCIN KINASE;

ANIMAL CELL; ARTICLE; AUTOLYSOSOME; AUTOPHAGOSOME; AUTOPHAGY; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME PHOSPHORYLATION; GENE SILENCING; HELA CELL LINE; IMMUNOFLUORESCENCE; IMMUNOPRECIPITATION; LYSOSOME MEMBRANE; MALE; MOUSE; MYOTUBE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN SYNTHESIS; RAT; SIGNAL TRANSDUCTION; UPREGULATION; AMINO ACID SEQUENCE; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL LINE; GENETICS; HUMAN; LYSOSOME; METABOLISM; MOLECULAR GENETICS; MUTATION; PHOSPHORYLATION;

MAMMALIA; RAPTORES;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; AMINO ACID SEQUENCE; AMINO ACIDS; ANIMALS; AUTOPHAGY; CELL LINE; CELL PROLIFERATION; GENE SILENCING; GLYCOGEN SYNTHASE KINASE 3; HUMANS; LYSOSOMES; MICE; MOLECULAR SEQUENCE DATA; MULTIPROTEIN COMPLEXES; MUTATION; PHOSPHORYLATION; RATS; RNA, SMALL INTERFERING; SERINE; SIGNAL TRANSDUCTION; TOR SERINE-THREONINE KINASES;

EID: 84940416372     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20150404     Document Type: Article

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