-
1
-
-
77951231349
-
mTOR and cancer: Many loops in one pathway
-
Efeyan A, Sabatini DM (2010) mTOR and cancer: Many loops in one pathway. Curr Opin Cell Biol 22:169-176.
-
(2010)
Curr Opin Cell Biol
, vol.22
, pp. 169-176
-
-
Efeyan, A.1
Sabatini, D.M.2
-
2
-
-
34249679614
-
mTOR Complex1-S6K1 signaling: at the crossroads of obesity, diabetes and cancer
-
DOI 10.1016/j.molmed.2007.04.002, PII S1471491407000664
-
Dann SG, Selvaraj A, Thomas G (2007) mTOR Complex1-S6K1 signaling: At the crossroads of obesity, diabetes and cancer. Trends Mol Med 13:252-259. (Pubitemid 46836871)
-
(2007)
Trends in Molecular Medicine
, vol.13
, Issue.6
, pp. 252-259
-
-
Dann, S.G.1
Selvaraj, A.2
Thomas, G.3
-
3
-
-
37549028779
-
Coordinate regulation of ribosome biogenesis and function by the ribosomal protein S6 kinase, a key mediator of mTOR function
-
Jastrzebski K, Hannan KM, Tchoubrieva EB, Hannan RD, Pearson RB (2007) Coordinate regulation of ribosome biogenesis and function by the ribosomal protein S6 kinase, a key mediator of mTOR function. Growth Factors 25:209-226.
-
(2007)
Growth Factors
, vol.25
, pp. 209-226
-
-
Jastrzebski, K.1
Hannan, K.M.2
Tchoubrieva, E.B.3
Hannan, R.D.4
Pearson, R.B.5
-
4
-
-
77952893054
-
S6K1 plays a critical role in early adipocyte differentiation
-
Carnevalli LS, et al. (2010) S6K1 plays a critical role in early adipocyte differentiation. Dev Cell 18:763-774.
-
(2010)
Dev Cell
, vol.18
, pp. 763-774
-
-
Carnevalli, L.S.1
-
5
-
-
77955483125
-
Activation of a metabolic gene regulatory network downstream of mTOR complex 1
-
Düvel K, et al. (2010) Activation of a metabolic gene regulatory network downstream of mTOR complex 1. Mol Cell 39:171-183.
-
(2010)
Mol Cell
, vol.39
, pp. 171-183
-
-
Düvel, K.1
-
6
-
-
67650944993
-
Rapamycin fed late in life extends lifespan in genetically heterogeneous mice
-
Harrison DE, et al. (2009) Rapamycin fed late in life extends lifespan in genetically heterogeneous mice. Nature 460:392-395.
-
(2009)
Nature
, vol.460
, pp. 392-395
-
-
Harrison, D.E.1
-
7
-
-
70349669095
-
Ribosomal protein S6 kinase 1 signaling regulates mammalian life span
-
Selman C, et al. (2009) Ribosomal protein S6 kinase 1 signaling regulates mammalian life span. Science 326:140-144.
-
(2009)
Science
, vol.326
, pp. 140-144
-
-
Selman, C.1
-
10
-
-
47949104258
-
Essential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation and signalling
-
Ikenoue T, Inoki K, Yang Q, Zhou X, Guan KL (2008) Essential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation and signalling. EMBO J 27:1919-1931.
-
(2008)
EMBO J
, vol.27
, pp. 1919-1931
-
-
Ikenoue, T.1
Inoki, K.2
Yang, Q.3
Zhou, X.4
Guan, K.L.5
-
11
-
-
47949125486
-
The mammalian target of rapamycin complex 2 controls folding and stability of Akt and protein kinase C
-
Facchinetti V, et al. (2008) The mammalian target of rapamycin complex 2 controls folding and stability of Akt and protein kinase C. EMBO J 27:1932-1943.
-
(2008)
EMBO J
, vol.27
, pp. 1932-1943
-
-
Facchinetti, V.1
-
12
-
-
78649712949
-
mTORC2 can associate with ribosomes to promote cotranslational phosphorylation and stability of nascent Akt polypeptide
-
Oh WJ, et al. (2010) mTORC2 can associate with ribosomes to promote cotranslational phosphorylation and stability of nascent Akt polypeptide. EMBO J 29:3939-3951.
-
(2010)
EMBO J
, vol.29
, pp. 3939-3951
-
-
Oh, W.J.1
-
13
-
-
67349217986
-
Molecular mechanisms of mTOR-mediated translational control
-
Ma XM, Blenis J (2009) Molecular mechanisms of mTOR-mediated translational control. Nat Rev Mol Cell Biol 10:307-318.
-
(2009)
Nat Rev Mol Cell Biol
, vol.10
, pp. 307-318
-
-
Ma, X.M.1
Blenis, J.2
-
14
-
-
2342545519
-
Target of rapamycin (TOR): An integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression
-
DOI 10.1038/sj.onc.1207542
-
Fingar DC, Blenis J (2004) Target of rapamycin (TOR): An integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression. Oncogene 23:3151-3171. (Pubitemid 38638827)
-
(2004)
Oncogene
, vol.23
, Issue.18
, pp. 3151-3171
-
-
Fingar, D.C.1
Blenis, J.2
-
15
-
-
0037205409
-
Regulation of an activated S6 kinase 1 variant reveals a novel mammalian target of rapamycin phosphorylation site
-
DOI 10.1074/jbc.M201745200
-
Saitoh M, et al. (2002) Regulation of an activated S6 kinase 1 variant reveals a novel mammalian target of rapamycin phosphorylation site. J Biol Chem 277:20104-20112. (Pubitemid 34967534)
-
(2002)
Journal of Biological Chemistry
, vol.277
, Issue.22
, pp. 20104-20112
-
-
Saitoh, M.1
Pullen, N.2
Brennan, P.3
Cantrell, D.4
Dennis, P.B.5
Thomas, G.6
-
16
-
-
0037117409
-
Identification of a conserved motif required for mTOR signaling
-
DOI 10.1016/S0960-9822(02)00762-5, PII S0960982202007625
-
Schalm SS, Blenis J (2002) Identification of a conserved motif required for mTOR signaling. Curr Biol 12:632-639. (Pubitemid 34315846)
-
(2002)
Current Biology
, vol.12
, Issue.8
, pp. 632-639
-
-
Schalm, S.S.1
Blenis, J.2
-
17
-
-
15744396300
-
Characterization of a conserved C-terminal motif (RSPRR) in ribosomal protein S6 kinase 1 required for its mammalian target of rapamycin-dependent regulation
-
DOI 10.1074/jbc.M413995200
-
Schalm SS, Tee AR, Blenis J (2005) Characterization of a conserved C-terminal motif (RSPRR) in ribosomal protein S6 kinase 1 required for its mammalian target of rapamycin-dependent regulation. J Biol Chem 280:11101-11106. (Pubitemid 40418414)
-
(2005)
Journal of Biological Chemistry
, vol.280
, Issue.12
, pp. 11101-11106
-
-
Schalm, S.S.1
Tee, A.R.2
Blenis, J.3
-
18
-
-
6344256753
-
mTOR: A protein kinase switching between life and death
-
DOI 10.1016/j.phrs.2004.03.007, PII S1043661804000672
-
Asnaghi L, Bruno P, Priulla M, Nicolin A (2004) mTOR: A protein kinase switching between life and death. Pharmacol Res 50:545-549. (Pubitemid 39388965)
-
(2004)
Pharmacological Research
, vol.50
, Issue.6
, pp. 545-549
-
-
Asnaghi, L.1
Bruno, P.2
Priulla, M.3
Nicolin, A.4
-
19
-
-
0033551234
-
Protein phosphatase 2A interacts with the 70-kDa S6 kinase and is activated by inhibition of FKBP12-rapamycinassociated protein
-
DOI 10.1073/pnas.96.8.4438
-
Peterson RT, Desai BN, Hardwick JS, Schreiber SL (1999) Protein phosphatase 2A interacts with the 70-kDa S6 kinase and is activated by inhibition of FKBP12-rapamycinassociated protein. Proc Natl Acad Sci USA 96:4438-4442. (Pubitemid 29190354)
-
(1999)
Proceedings of the National Academy of Sciences of the United States of America
, vol.96
, Issue.8
, pp. 4438-4442
-
-
Peterson, R.T.1
Desai, B.N.2
Hardwick, J.S.3
Schreiber, S.L.4
-
20
-
-
0025241896
-
Ordered multisite protein phosphorylation. Analysis of glycogen synthase kinase 3 action using model peptide substrates
-
Fiol CJ, Wang A, Roeske RW, Roach PJ (1990) Ordered multisite protein phosphorylation. Analysis of glycogen synthase kinase 3 action using model peptide substrates. J Biol Chem 265:6061-6065.
-
(1990)
J Biol Chem
, vol.265
, pp. 6061-6065
-
-
Fiol, C.J.1
Wang, A.2
Roeske, R.W.3
Roach, P.J.4
-
21
-
-
0037205315
-
Glycogen synthase kinase-3beta a novel regulator of cardiac hypertrophy and development
-
DOI 10.1161/01.RES.0000018952.70505.F1
-
Hardt SE, Sadoshima J (2002) Glycogen synthase kinase-3beta: A novel regulator of cardiac hypertrophy and development. Circ Res 90:1055-1063. (Pubitemid 34627903)
-
(2002)
Circulation Research
, vol.90
, Issue.10
, pp. 1055-1063
-
-
Hardt, S.E.1
Sadoshima, J.2
-
22
-
-
0036090823
-
Glycogen synthase kinase 3: An emerging therapeutic target
-
Eldar-Finkelman H (2002) Glycogen synthase kinase 3: An emerging therapeutic target. Trends Mol Med 8:126-132.
-
(2002)
Trends Mol Med
, vol.8
, pp. 126-132
-
-
Eldar-Finkelman, H.1
-
23
-
-
0037383322
-
GSK-3: Tricks of the trade for a multi-tasking kinase
-
DOI 10.1242/jcs.00384
-
Doble BW, Woodgett JR (2003) GSK-3: Tricks of the trade for a multi-tasking kinase. J Cell Sci 116:1175-1186. (Pubitemid 36410657)
-
(2003)
Journal of Cell Science
, vol.116
, Issue.7
, pp. 1175-1186
-
-
Doble, B.W.1
Woodgett, J.R.2
-
24
-
-
67650569513
-
Glycogen synthase kinase 3: More than a namesake
-
Rayasam GV, Tulasi VK, Sodhi R, Davis JA, Ray A (2009) Glycogen synthase kinase 3: More than a namesake. Br J Pharmacol 156:885-898.
-
(2009)
Br J Pharmacol
, vol.156
, pp. 885-898
-
-
Rayasam, G.V.1
Tulasi, V.K.2
Sodhi, R.3
Davis, J.A.4
Ray, A.5
-
25
-
-
54549120290
-
Glycogen synthase kinase-3 and cancer: Good cop, bad cop?
-
Patel S, Woodgett J (2008) Glycogen synthase kinase-3 and cancer: Good cop, bad cop? Cancer Cell 14:351-353.
-
(2008)
Cancer Cell
, vol.14
, pp. 351-353
-
-
Patel, S.1
Woodgett, J.2
-
26
-
-
34547691071
-
The role of GSK3 in glucose homeostasis and the development of insulin resistance
-
DOI 10.1016/j.diabres.2007.01.033, PII S0168822707001635
-
Lee J, Kim MS (2007) The role of GSK3 in glucose homeostasis and the development of insulin resistance. Diabetes Res Clin Pract 77(suppl 1):S49-S57. (Pubitemid 47212553)
-
(2007)
Diabetes Research and Clinical Practice
, vol.77
, Issue.3 SUPPL.
-
-
Lee, J.1
Kim, M.-S.2
-
27
-
-
58049192725
-
Long-term all-cause mortality in cancer patients with preexisting diabetes mellitus: A systematic review and meta-analysis
-
Barone BB, et al. (2008) Long-term all-cause mortality in cancer patients with preexisting diabetes mellitus: A systematic review and meta-analysis. JAMA 300:2754-2764.
-
(2008)
JAMA
, vol.300
, pp. 2754-2764
-
-
Barone, B.B.1
-
28
-
-
13344270279
-
Diabetes mellitus and breast cancer
-
DOI 10.1016/S1470-2045(05)01736-5, PII S1470204505017365
-
Wolf I, Sadetzki S, Catane R, Karasik A, Kaufman B (2005) Diabetes mellitus and breast cancer. Lancet Oncol 6:103-111. (Pubitemid 40197704)
-
(2005)
Lancet Oncology
, vol.6
, Issue.2
, pp. 103-111
-
-
Wolf, I.1
Sadetzki, S.2
Catane, R.3
Karasik, A.4
Kaufman, B.5
-
29
-
-
0036190970
-
Role of glycogen synthase kinase-3 in cancer: Regulation by Wnts and other signaling pathways
-
DOI 10.1016/S0065-230X(02)84007-6
-
Manoukian AS, Woodgett JR (2002) Role of glycogen synthase kinase-3 in cancer: Regulation by Wnts and other signaling pathways. Adv Cancer Res 84:203-229. (Pubitemid 34188198)
-
(2002)
Advances in Cancer Research
, vol.84
, pp. 203-229
-
-
Manoukian, A.S.1
Woodgett, J.R.2
-
30
-
-
73349140832
-
An emerging strategy for cancer treatment targeting aberrant glycogen synthase kinase 3 beta
-
Miyashita K, et al. (2009) An emerging strategy for cancer treatment targeting aberrant glycogen synthase kinase 3 beta. Anticancer Agents Med Chem 9:1114-1122.
-
(2009)
Anticancer Agents Med Chem
, vol.9
, pp. 1114-1122
-
-
Miyashita, K.1
-
31
-
-
57349143530
-
Glycogen synthase kinase 3beta (GSK3beta) in tumorigenesis and cancer chemotherapy
-
Luo J (2009) Glycogen synthase kinase 3beta (GSK3beta) in tumorigenesis and cancer chemotherapy. Cancer Lett 273:194-200.
-
(2009)
Cancer Lett
, vol.273
, pp. 194-200
-
-
Luo, J.1
-
32
-
-
33646795341
-
Targeting GSK-3: A promising approach for cancer therapy?
-
Ougolkov AV, Billadeau DD (2006) Targeting GSK-3: A promising approach for cancer therapy? Future Oncol 2:91-100.
-
(2006)
Future Oncol
, vol.2
, pp. 91-100
-
-
Ougolkov, A.V.1
Billadeau, D.D.2
-
33
-
-
0034612636
-
Requirement for glycogen synthase kinase-3beta in cell survival and NF-kappaB activation
-
DOI 10.1038/35017574
-
Hoeflich KP, et al. (2000) Requirement for glycogen synthase kinase-3beta in cell survival and NF-kappaB activation. Nature 406:86-90. (Pubitemid 30460216)
-
(2000)
Nature
, vol.406
, Issue.6791
, pp. 86-90
-
-
Hoeflich, K.P.1
Luo, J.2
Rubie, E.A.3
Tsao, M.-S.4
Jin, O.5
Woodgett, J.R.6
-
34
-
-
0037172661
-
Glycogen synthase kinase-3beta modulates notch signaling and stability
-
DOI 10.1016/S0960-9822(02)00888-6, PII S0960982202008886
-
Foltz DR, Santiago MC, Berechid BE, Nye JS (2002) Glycogen synthase kinase-3beta modulates notch signaling and stability. Curr Biol 12:1006-1011. (Pubitemid 34703331)
-
(2002)
Current Biology
, vol.12
, Issue.12
, pp. 1006-1011
-
-
Foltz, D.R.1
Santiago, M.C.2
Berechid, B.E.3
Nye, J.S.4
-
35
-
-
10744232627
-
Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta
-
DOI 10.1101/gad.1165804
-
Qu L, et al. (2004) Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta. Genes Dev 18:261-277. (Pubitemid 38199252)
-
(2004)
Genes and Development
, vol.18
, Issue.3
, pp. 261-277
-
-
Qu, L.1
Huang, S.2
Baltzis, D.3
Rivas-Estilla, A.-M.4
Pluquet, O.5
Hatzoglou, M.6
Koumenis, C.7
Taya, Y.8
Yoshimura, A.9
Koromilas, A.E.10
-
36
-
-
36249022250
-
GSK-3-Mediated Phosphorylation Enhances Maf-Transforming Activity
-
DOI 10.1016/j.molcel.2007.11.009, PII S1097276507007423
-
Rocques N, et al. (2007) GSK-3-mediated phosphorylation enhances Maf-transforming activity. Mol Cell 28:584-597. (Pubitemid 350137803)
-
(2007)
Molecular Cell
, vol.28
, Issue.4
, pp. 584-597
-
-
Rocques, N.1
Abou, Z.N.2
Sii-Felice, K.3
Lecoin, L.4
Felder-Schmittbuhl, M.-P.5
Eychene, A.6
Pouponnot, C.7
-
37
-
-
77953233857
-
GSK-3 promotes conditional association of CREB and its coactivators with MEIS1 to facilitate HOX-mediated transcription and oncogenesis
-
Wang Z, et al. (2010) GSK-3 promotes conditional association of CREB and its coactivators with MEIS1 to facilitate HOX-mediated transcription and oncogenesis. Cancer Cell 17:597-608.
-
(2010)
Cancer Cell
, vol.17
, pp. 597-608
-
-
Wang, Z.1
-
38
-
-
53049084191
-
S6K1 plays a key role in glial transformation
-
Nakamura JL, Garcia E, Pieper RO (2008) S6K1 plays a key role in glial transformation. Cancer Res 68:6516-6523.
-
(2008)
Cancer Res
, vol.68
, pp. 6516-6523
-
-
Nakamura, J.L.1
Garcia, E.2
Pieper, R.O.3
-
39
-
-
77952161462
-
Targeting p70S6K prevented lung metastasis in a breast cancer xenograft model
-
Akar U, et al. (2010) Targeting p70S6K prevented lung metastasis in a breast cancer xenograft model. Mol Cancer Ther 9:1180-1187.
-
(2010)
Mol Cancer Ther
, vol.9
, pp. 1180-1187
-
-
Akar, U.1
-
40
-
-
0034596364
-
Detecting activation of ribosomal protein S6 kinase by complementary DNA and tissue microarray analysis
-
Bärlund M, et al. (2000) Detecting activation of ribosomal protein S6 kinase by complementary DNA and tissue microarray analysis. J Natl Cancer Inst 92:1252-1259. (Pubitemid 30627733)
-
(2000)
Journal of the National Cancer Institute
, vol.92
, Issue.15
, pp. 1252-1259
-
-
Barlund, M.1
Forozan, F.2
Kononen, J.3
Bubendorf, L.4
Chen, Y.5
Bittner, M.L.6
Torhorst, J.7
Haas, P.8
Bucher, C.9
Sauter, G.10
Kallioniemi, O.-P.11
Kallioniemi, A.12
-
41
-
-
33644529055
-
ErbB2 increases vascular endothelial growth factor protein synthesis via activation of mammalian target of rapamycin/p70S6K leading to increased angiogenesis and spontaneous metastasis of human breast cancer cells
-
Klos KS, et al. (2006) ErbB2 increases vascular endothelial growth factor protein synthesis via activation of mammalian target of rapamycin/p70S6K leading to increased angiogenesis and spontaneous metastasis of human breast cancer cells. Cancer Res 66:2028-2037.
-
(2006)
Cancer Res
, vol.66
, pp. 2028-2037
-
-
Klos, K.S.1
-
42
-
-
33748153690
-
TSC2 Integrates Wnt and Energy Signals via a Coordinated Phosphorylation by AMPK and GSK3 to Regulate Cell Growth
-
DOI 10.1016/j.cell.2006.06.055, PII S0092867406010166
-
Inoki K, et al. (2006) TSC2 integrates Wnt and energy signals via a coordinated phosphorylation by AMPK and GSK3 to regulate cell growth. Cell 126:955-968. (Pubitemid 44310775)
-
(2006)
Cell
, vol.126
, Issue.5
, pp. 955-968
-
-
Inoki, K.1
Ouyang, H.2
Zhu, T.3
Lindvall, C.4
Wang, Y.5
Zhang, X.6
Yang, Q.7
Bennett, C.8
Harada, Y.9
Stankunas, K.10
Wang, C.-y.11
He, X.12
MacDougald, O.A.13
You, M.14
Williams, B.O.15
Guan, K.-L.16
-
43
-
-
84856772150
-
GSK-3â inhibition in pancreatic cancer
-
ed Pollock RE (Springer, Boston)
-
Kim GP, Billadeau DD (2008) GSK-3â inhibition in pancreatic cancer. Pancreatic Cancer, ed Pollock RE (Springer, Boston), pp 635-646.
-
(2008)
Pancreatic Cancer
, pp. 635-646
-
-
Kim, G.P.1
Billadeau, D.D.2
-
44
-
-
16844374033
-
Glycogen synthase kinase-3beta participates in nuclear factor kappaB-mediated gene transcription and cell survival in pancreatic cancer cells
-
DOI 10.1158/0008-5472.CAN-04-3642
-
Ougolkov AV, Fernandez-Zapico ME, Savoy DN, Urrutia RA, Billadeau DD (2005) Glycogen synthase kinase-3beta participates in nuclear factor kappaB-mediated gene transcription and cell survival in pancreatic cancer cells. Cancer Res 65:2076-2081. (Pubitemid 40490111)
-
(2005)
Cancer Research
, vol.65
, Issue.6
, pp. 2076-2081
-
-
Ougolkov, A.V.1
Fernandez-Zapico, M.E.2
Savoy, D.N.3
Urrutia, R.A.4
Billadeau, D.D.5
-
45
-
-
23044444841
-
Deregulated GSK3beta activity in colorectal cancer: Its association with tumor cell survival and proliferation
-
DOI 10.1016/j.bbrc.2005.07.041, PII S0006291X05014920
-
Shakoori A, et al. (2005) Deregulated GSK3beta activity in colorectal cancer: Its association with tumor cell survival and proliferation. Biochem Biophys Res Commun 334:1365-1373. (Pubitemid 41074725)
-
(2005)
Biochemical and Biophysical Research Communications
, vol.334
, Issue.4
, pp. 1365-1373
-
-
Shakoori, A.1
Ougolkov, A.2
Zhi, W.Y.3
Zhang, B.4
Modarressi, M.H.5
Billadeau, D.D.6
Mai, M.7
Takahashi, Y.8
Minamoto, T.9
-
46
-
-
0035896525
-
Ribosomal S6 Kinase 2 Inhibition by a Potent C-terminal Repressor Domain Is Relieved by Mitogen-activated Protein-Extracellular Signal-regulated Kinase Kinase-regulated Phosphorylation
-
DOI 10.1074/jbc.M009972200
-
Martin KA, Schalm SS, Romanelli A, Keon KL, Blenis J (2001) Ribosomal S6 kinase 2 inhibition by a potent C-terminal repressor domain is relieved by mitogen-activated protein-extracellular signal-regulated kinase kinase-regulated phosphorylation. J Biol Chem 276:7892-7898. (Pubitemid 37385584)
-
(2001)
Journal of Biological Chemistry
, vol.276
, Issue.11
, pp. 7892-7898
-
-
Martin, K.A.1
Schalm, S.S.2
Romanelli, A.3
Keon, K.L.4
Blenis, J.5
-
47
-
-
77956548321
-
Rictor forms a complex with Cullin-1 to promote SGK1 ubiquitination and destruction
-
Gao D, et al. (2010) Rictor forms a complex with Cullin-1 to promote SGK1 ubiquitination and destruction. Mol Cell 39:797-808.
-
(2010)
Mol Cell
, vol.39
, pp. 797-808
-
-
Gao, D.1
|