Osmotic stress regulates mammalian target of rapamycin (mTOR) complex 1 via c-Jun N-terminal kinase (JNK)-mediated raptor protein phosphorylation

Journal of Biological Chemistry

Volumn 287, Issue 22, 2012, Pages 18398-18407

  Kwak, Dongoh ^a   Choi, Sunkyu ^a   Jeong, Heeyoon ^a   Jang, Jin Hyeok ^a   Lee, Youngmi ^a   Jeon, Hyeona ^a   Lee, Mi Nam ^a   Noh, Jungeun ^a   Cho, Kun ^b   Yoo, Jong Shin ^b   Hwang, Daehee ^a   Suh, Pann Ghill ^c   Ryu, Sung Ho ^a  

^a Pohang University of Science and Technology (POSTECH)   (South Korea)

^b Korea Basic Science Institute (KBSI)   (South Korea)

^c Ulsan National Institute of Science and Technology   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

C-JUN N-TERMINAL KINASE; COMPLEX 1; CONTROL-CELL; ESSENTIAL COMPONENT; GROWTH FACTOR; IN-VITRO; KINASE ACTIVITY; LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY; MAMMALIAN TARGET OF RAPAMYCIN (MTOR); MOLECULAR LINKS; MULTI-PROTEIN COMPLEX; OSMOTIC STRESS; POTENTIAL MECHANISM; PROTEIN PHOSPHORYLATION; SIGNALING PATHWAYS;

ANTIBIOTICS; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; OSMOSIS;

PHOSPHORYLATION;

MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; RAPTOR PROTEIN; SCAFFOLD PROTEIN; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; IN VITRO STUDY; OSMOTIC STRESS; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; REGULATORY MECHANISM;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; BASE SEQUENCE; CELL LINE; CHROMATIN IMMUNOPRECIPITATION; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; OSMOTIC PRESSURE; PHOSPHORYLATION; RNA, SMALL INTERFERING; TANDEM MASS SPECTROMETRY; TOR SERINE-THREONINE KINASES;

MAMMALIA; RAPTORES;

EID: 84861553116     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.326538     Document Type: Article

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