Glycogen synthase kinase-3 (GSK3) inhibition induces prosurvival autophagic signals in human pancreatic cancer cells

Journal of Biological Chemistry

Volumn 290, Issue 9, 2015, Pages 5592-5605

  Marchand, Benoît ^a   Arsenault, Dominique ^a   Raymond Fleury, Alexandre ^a   Boisvert, François Michel ^a   Boucher, Marie José ^b,c  

^a Division of Gastroenterology   (Canada)

^b UNIVERSITY OF SHERBROOKE   (Canada)

^c UNIVERSITÉ DE SHERBROOKE   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; ANTIBIOTICS; CELL DEATH; MAMMALS; MASS SPECTROMETRY; PHOSPHATASES; PHOSPHORYLATION; TRANSCRIPTION;

GLYCOGEN SYNTHASE KINASE-3; LYSOSOMAL BIOGENESIS; MAMMALIAN TARGET OF RAPAMYCIN (MTOR); NUCLEAR LOCALIZATION; QUANTITATIVE MASS SPECTROMETRIES; TRANSCRIPTIONAL FUNCTIONS; TRANSCRIPTIONAL REGULATION; TRANSCRIPTIONAL REGULATOR;

DISEASES;

2 (2,4 DICHLOROPHENYL) 3 (1 METHYL 3 INDOLYL)MALEIMIDE; 6 [[2 [[4 (2,4 DICHLOROPHENYL) 5 (4 METHYL 1H IMIDAZOL 2 YL) 2 PYRIMIDINYL]AMINO]ETHYL]AMINO]NICOTINONITRILE; BAFILOMYCIN A1; MAMMALIAN TARGET OF RAPAMYCIN; MAMMALIAN TARGET OF RAPAMYCIN INHIBITOR; NUCLEAR PROTEIN; PROTEIN 14 3 3; TORIN 1; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR EB; UNCLASSIFIED DRUG; 1-(4-(4-PROPIONYLPIPERAZIN-1-YL)-3-(TRIFLUOROMETHYL)PHENYL)-9-(QUINOLIN-3-YL)BENZO(H)(1,6)NAPHTHYRIDIN-2(1H)-ONE; BASIC HELIX LOOP HELIX LEUCINE ZIPPER TRANSCRIPTION FACTOR; GLYCOGEN SYNTHASE KINASE 3; GREEN FLUORESCENT PROTEIN; NAPHTHYRIDINE DERIVATIVE; PYRIDINE DERIVATIVE; PYRIMIDINE DERIVATIVE; TARGET OF RAPAMYCIN KINASE; TFEB PROTEIN, HUMAN;

ANCHORAGE INDEPENDENT GROWTH; ANIMAL CELL; APOPTOSIS; ARTICLE; AUTOPHAGY; BIOGENESIS; CELL NUCLEUS; CELL SURVIVAL; CONTROLLED STUDY; DISSOCIATION; DRUG MECHANISM; EMBRYO; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME REGULATION; GENETIC TRANSFECTION; GROWTH INHIBITION; HUMAN; HUMAN CELL; LYSOSOME; MASS SPECTROMETRY; MOUSE; NONHUMAN; PANCREAS CANCER; PRIORITY JOURNAL; PROTEIN DEPHOSPHORYLATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION; ACTIVE TRANSPORT; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL CULTURE; CELL LINE; CONFOCAL MICROSCOPY; DRUG EFFECTS; GENETICS; HEK293 CELL LINE; IMMUNOBLOTTING; KNOCKOUT MOUSE; METABOLISM; PANCREAS TUMOR; PATHOLOGY; RNA INTERFERENCE; TUMOR CELL LINE;

MAMMALIA;

ACTIVE TRANSPORT, CELL NUCLEUS; ANIMALS; APOPTOSIS; AUTOPHAGY; BASIC HELIX-LOOP-HELIX LEUCINE ZIPPER TRANSCRIPTION FACTORS; CELL LINE; CELL LINE, TUMOR; CELL NUCLEUS; CELL SURVIVAL; CELLS, CULTURED; GLYCOGEN SYNTHASE KINASE 3; GREEN FLUORESCENT PROTEINS; HEK293 CELLS; HUMANS; IMMUNOBLOTTING; MASS SPECTROMETRY; MICE, KNOCKOUT; MICROSCOPY, CONFOCAL; NAPHTHYRIDINES; PANCREATIC NEOPLASMS; PYRIDINES; PYRIMIDINES; RNA INTERFERENCE; TOR SERINE-THREONINE KINASES;

EID: 84923762495     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.616714     Document Type: Article

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