AlphaSpace: Fragment-Centric Topographical Mapping to Target Protein-Protein Interaction Interfaces

Journal of Chemical Information and Modeling

Volumn 55, Issue 8, 2015, Pages 1585-1599

  Rooklin, David ^a   Wang, Cheng ^a   Katigbak, Joseph ^a   Arora, Paramjit S ^a   Zhang, Yingkai ^a,b  

^a NEW YORK UNIVERSITY   (United States)

^b NEW YORK UNIVERSITY SHANGHAI   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BIOMIMETICS; DRUG INTERACTIONS; MAPPING; MOLECULES;

COMPUTATIONAL ANALYSIS; DETECTION METHODS; GEOMETRIC FEATURE; INTERACTION REGION; MAPPING STRATEGY; PROTEIN-PROTEIN INTERACTIONS; STRUCTURAL CHARACTERIZATION; THERAPEUTIC STRATEGY;

PROTEINS;

LIGAND; PROTEIN; PROTEIN BINDING; PROTEIN MDM2; PROTEIN P53;

BINDING SITE; CHEMISTRY; DRUG DEVELOPMENT; DRUG EFFECTS; HUMAN; METABOLISM; MOLECULAR MODEL; MOLECULARLY TARGETED THERAPY; PROCEDURES; PROTEIN ANALYSIS; PROTEIN DATABASE; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION;

BINDING SITES; DATABASES, PROTEIN; DRUG DISCOVERY; HUMANS; LIGANDS; MODELS, MOLECULAR; MOLECULAR TARGETED THERAPY; PROTEIN BINDING; PROTEIN INTERACTION DOMAINS AND MOTIFS; PROTEIN INTERACTION MAPPING; PROTEIN INTERACTION MAPS; PROTEINS; PROTO-ONCOGENE PROTEINS C-MDM2; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84940200063     PISSN: 15499596     EISSN: 1549960X     Source Type: Journal    
DOI: 10.1021/acs.jcim.5b00103     Document Type: Article

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