Optimization and determination of the absolute configuration of a series of potent inhibitors of human papillomavirus type-11 E1-E2 protein-protein interaction: A combined medicinal chemistry, NMR and computational chemistry approach

Bioorganic and Medicinal Chemistry

Volumn 15, Issue 7, 2007, Pages 2690-2700

  Goudreau, Nathalie ^a   Cameron, Dale R ^a   Déziel, Robert ^a   Haché, Bruno ^a   Jakalian, Araz ^a   Malenfant, Eric ^a   Naud, Julie ^a   Ogilvie, William W ^a   O'Meara, Jeff ^a   White, Peter W ^a   Yoakim, Christiane ^a  

^a BOEHRINGER INGELHEIM CANADA LTD   (Canada)

Author keywords

Human papillomavirus; Indandione, NMR; Protein protein interaction

Indexed keywords

ANTIVIRUS AGENT; GLYCOPROTEIN E1; GLYCOPROTEIN E2; INDAN DERIVATIVE; NANOPARTICLE; TETRAHYDROFURAN;

ARTICLE; CONTROLLED STUDY; DRUG DETERMINATION; DRUG POTENCY; HUMAN PAPILLOMAVIRUS TYPE 11; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PROTEIN PROTEIN INTERACTION; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION;

ANTIVIRAL AGENTS; CHEMISTRY, PHARMACEUTICAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; COMPUTATIONAL BIOLOGY; COMPUTER SIMULATION; DNA-BINDING PROTEINS; EPOXY COMPOUNDS; HUMAN PAPILLOMAVIRUS 11; HUMANS; INDICATORS AND REAGENTS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; MOLECULAR CONFORMATION; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; VIRAL PROTEINS;

HUMAN PAPILLOMAVIRUS; HUMAN PAPILLOMAVIRUS TYPE 11;

EID: 33847619355     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2007.01.036     Document Type: Article

References (11)

1. Shah K.V., and Howley P.M. Fields Virology. 3rd ed. (1996), Lippincott-Raven Publishers, Philadadelphia 2077-2109
2. Hanna E., and Bachmann G. Expert Opin. Biol. Ther. 6 (2006) 1223-1227
3. Beutner K.R., and Ferenczy A. Am. J. Med. 102 (1997) 28-37
4. Beutner K.R., Tyring S.K., Trofatter Jr. K.F., Douglas Jr. J.M., Spruance S., Owens M.L., Fox T.L., Hougham A.J., and Schmitt K.A. Antimicrob. Agents Chemother. 42 (1998) 789-794
5. Howley P.M. Fields Virology. 3rd ed. (1996), Lippincott-Raven Publishers, Philadadelphia 2045-2076
6. Abbate E.A., Berger J.M., and Botchan M.R. Gene and Development 18 (2004) 1981-1996
7. Yoakim C., Ogilvie W.W., Goudreau N., Naud J., Haché B., O'Meara J.A., Cordingley M.G., Archambault J., and White P.W. Bioorg. Med. Chem. Lett. 13 (2003) 2539-2541
8. White P.W., Titolo S., Brault K., Thauvette L., Pelletier A., Welchner E., Bourgon L., Doyon L., Ogilvie W.W., Yoakim C., Cordingley M.G., and Archambault J. J. Biol. Chem. 278 (2003) 26765-26772
9. White P.W., Pelletier A., Brault K., Titolo S., Welchner E., Thauvette L., Fazekas M., Cordingley M.G., and Archambault J. J. Biol. Chem. 25 (2001) 22426-22438
10. Yoakim C., Goudreau N., McGibbon G.A., O'Meara J.A., White P.W., and Ogilvie W.W. Helvetica Chim. Acta 86 (2003) 3427-3444
11. Wang Y., Coulombe R., Cameron D.R., Thauvette L., Massariol M.-J., Amon L.M., Fink D., Titolo S., Welchner E., Yoakim C., Archambault J., and White P.W. J. Biol. Chem. 8 (2004) 6976-6985