Discovery of AMG 232, a potent, selective, and orally bioavailable MDM2-p53 inhibitor in clinical development

Journal of Medicinal Chemistry

Volumn 57, Issue 4, 2014, Pages 1454-1472

  Sun, Daqing ^a   Li, Zhihong ^a   Rew, Yosup ^a   Gribble, Michael ^a   Bartberger, Michael D ^a   Beck, Hilary P ^a   Canon, Jude ^a   Chen, Ada ^a   Chen, Xiaoqi ^a   Chow, David ^a   Deignan, Jeffrey ^a   Duquette, Jason ^a   Eksterowicz, John ^a   Fisher, Benjamin ^a   Fox, Brian M ^a   Fu, Jiasheng ^a   Gonzalez, Ana Z ^a   Gonzalez Lopez De Turiso, Felix ^a   Houze, Jonathan B ^a   Huang, Xin ^a   Jiang, Min ^a   Jin, Lixia ^a   Kayser, Frank ^a   Liu, Jiwen ^a   Lo, Mei Chu ^a   Long, Alexander M ^a   Lucas, Brian ^a   McGee, Lawrence R ^a   McIntosh, Joel ^a   Mihalic, Jeff ^a   Oliner, Jonathan D ^a   Osgood, Tao ^a   Peterson, Matthew L ^a   Roveto, Philip ^a   Saiki, Anne Y ^a   Shaffer, Paul ^a   Toteva, Maria ^a   Wang, Yingcai ^a   Wang, Yu Chung ^a   Wortman, Sarah ^a   Yakowec, Peter ^a   Yan, Xuelei ^a   Ye, Qiuping ^a   Yu, Dongyin ^a   Yu, Ming ^a   Zhao, Xiaoning ^a   Zhou, Jing ^a   Zhu, Jiang ^a   Olson, Steven H ^a   Medina, Julio C ^a   more..

^a AMGEN INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMG 232; PIPERIDONE DERIVATIVE; PROTEIN INHIBITOR; RG 7112; RG 7388; SAR 299155; SULFONAMIDE; UNCLASSIFIED DRUG;

ARTICLE; BIOCHEMISTRY; CELL ACTIVITY; DRUG STRUCTURE; SURFACE PLASMON RESONANCE;

ACETATES; ADMINISTRATION, ORAL; ANTINEOPLASTIC AGENTS; BIOLOGICAL AVAILABILITY; CRYSTALLOGRAPHY, X-RAY; DRUG DISCOVERY; HUMANS; PIPERIDONES; PROTEIN CONFORMATION; PROTO-ONCOGENE PROTEINS C-MDM2; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84896837973     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm401753e     Document Type: Article

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