Computational method to identify druggable binding sites that target protein-protein interactions

Journal of Chemical Information and Modeling

Volumn 54, Issue 5, 2014, Pages 1391-1400

  Li, Hubert ^a   Kasam, Vinod ^a   Tautermann, Christofer S ^b   Seeliger, Daniel ^b   Vaidehi, Nagarajan ^a  

^a CITY OF HOPE NATIONAL MEDICAL CENTER   (United States)

^b BOEHRINGER INGELHEIM PHARMA GMBH AND CO KG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING SITES; DRUG INTERACTIONS; LIGANDS; MOLECULES;

INTERFACE SURFACES; LIMITED SENSITIVITY; PROTEIN STRUCTURES; PROTEIN-PROTEIN COMPLEXES; PROTEIN-PROTEIN INTERACTIONS; PROTEIN-PROTEIN INTERFACE; RATIONAL DRUG DESIGNS; SMALL-MOLECULE LIBRARY;

PROTEINS;

LIGAND; PROTEIN; PROTEIN BINDING;

BINDING SITE; CHEMISTRY; DRUG DATABASE; DRUG DESIGN; DRUG EFFECTS; METABOLISM; MOLECULAR DOCKING; PROCEDURES; PROTEIN CONFORMATION; SURFACE PROPERTY;

BINDING SITES; DATABASES, PHARMACEUTICAL; DRUG DESIGN; LIGANDS; MOLECULAR DOCKING SIMULATION; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEINS; SURFACE PROPERTIES;

EID: 84901596602     PISSN: 15499596     EISSN: 1549960X     Source Type: Journal    
DOI: 10.1021/ci400750x     Document Type: Article

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