In vivo modulation of hypoxia-inducible signaling by topographical helix mimetics

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 21, 2014, Pages 7531-7536

  Lao, Brooke Bullock ^a   Grishagin, Ivan ^b   Mesallati, Hanah ^b   Brewer, Thomas F ^a   Olenyuk, Bogdan Z ^b   Arora, Paramjit S ^a  

^a NEW YORK UNIVERSITY   (United States)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

Helix mimics; Hypoxia signaling; Synthetic inhibitors of transcription

Indexed keywords

E1A ASSOCIATED P300 PROTEIN; HYPOXIA INDUCIBLE FACTOR 1ALPHA; TRYPTOPHAN;

ALPHA HELIX; ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BINDING AFFINITY; BIOMIMETICS; CELL PROLIFERATION; CONTROLLED STUDY; DOWN REGULATION; ENERGY METABOLISM; FLUORESCENCE SPECTROSCOPY; GENE EXPRESSION; GENE EXPRESSION PROFILING; HISTOPATHOLOGY; HUMAN; HUMAN CELL; METASTASIS; MODULATION; MOUSE; NEOPLASM; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN PROTEIN INTERACTION; PROTEIN SECONDARY STRUCTURE; PROTEIN SYNTHESIS; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION; UPREGULATION;

HELIX MIMICS; HYPOXIA SIGNALING; SYNTHETIC INHIBITORS OF TRANSCRIPTION;

AMINO ACID SEQUENCE; ANAEROBIOSIS; ANIMALS; BIOMIMETICS; BLOTTING, WESTERN; CLONING, MOLECULAR; DRUG DISCOVERY; GENE EXPRESSION PROFILING; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; LUCIFERASES; MICE; MOLECULAR SEQUENCE DATA; MOLECULAR STRUCTURE; MUTAGENESIS; P300-CBP TRANSCRIPTION FACTORS; PIPERAZINES; PROTEIN INTERACTION DOMAINS AND MOTIFS; SMALL MOLECULE LIBRARIES;

EID: 84901649551     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1402393111     Document Type: Article

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