Discovery of novel inhibitors of the ZipA/FtsZ complex by NMR fragment screening coupled with structure-based design

Bioorganic and Medicinal Chemistry

Volumn 14, Issue 23, 2006, Pages 7953-7961

  Tsao, Désirée H H ^a   Sutherland, Alan G ^b   Jennings, Lee D ^b   Li, Yuanhong ^a   Rush III, Thomas S ^a   Alvarez, Juan C ^a   Ding, Weidong ^b   Dushin, Elizabeth G ^b   Dushin, Russell G ^b   Haney, Steve A ^a   Kenny, Cynthia H ^b   Karl Malakian, A ^a   Nilakantan, Ramaswamy ^a   Mosyak, Lidia ^a  

^a PFIZER INC   (United States)

^b WYETH RESEARCH   (United States)

Author keywords

Fragment based drug discovery; NMR screening; X ray structures; ZipA FtsZ inhibitor

Indexed keywords

ANTIINFECTIVE AGENT; FTSZ PROTEIN; PROTEIN; UNCLASSIFIED DRUG; ZIPA PROTEIN;

ARTICLE; CARBOXY TERMINAL SEQUENCE; CRYSTAL STRUCTURE; DRUG SCREENING; DRUG STRUCTURE; HYDROPHOBICITY; NUCLEAR MAGNETIC RESONANCE; PROTEIN BINDING; PROTEIN PROTEIN INTERACTION; X RAY CRYSTALLOGRAPHY;

ANTI-BACTERIAL AGENTS; CARRIER PROTEINS; CELL CYCLE PROTEINS; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; ESCHERICHIA COLI PROTEINS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; HYDROPHOBICITY; LIGANDS; MAGNETIC RESONANCE SPECTROSCOPY; MULTIPROTEIN COMPLEXES; PEPTIDE FRAGMENTS; PROTEIN BINDING; STRUCTURE-ACTIVITY RELATIONSHIP;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; EUKARYOTA;

EID: 33750067690     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2006.07.050     Document Type: Article

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