메뉴 건너뛰기




Volumn 5, Issue 1, 2015, Pages 21-26

Evaluation of biological properties and clinical effectiveness of Aloe vera: A systematic review

Author keywords

Aloe vera; biological properties; clinical effectiveness; phytocomponents; review

Indexed keywords


EID: 84940166146     PISSN: None     EISSN: 22254110     Source Type: Journal    
DOI: 10.1016/j.jtcme.2014.10.006     Document Type: Review
Times cited : (345)

References (86)
  • 1
    • 0032744713 scopus 로고    scopus 로고
    • Aloe vera gel leaf: A review update
    • Reynolds T, Dweck AC. Aloe vera gel leaf: a review update. J Ethnopharmacol. 1999; 68: 3-37
    • (1999) J Ethnopharmacol , vol.68 , pp. 3-37
    • Reynolds, T.1    Dweck, A.C.2
  • 2
    • 2142845959 scopus 로고    scopus 로고
    • Aloe vera: A valuable ingredient for the food, pharmaceutical and cosmetic industriesda review
    • Eshun K, Qian H. Aloe vera: a valuable ingredient for the food, pharmaceutical and cosmetic industriesda review. Crit Rev Food Sci Nutr. 2004; 44: 91-96
    • (2004) Crit Rev Food Sci Nutr , vol.44 , pp. 91-96
    • Eshun, K.1    Qian, H.2
  • 3
    • 84974798146 scopus 로고    scopus 로고
    • Evaluation of the nutritional and metabolic effects of aloe vera
    • Benzie IFF, Wachtel-Galor S, eds. 2nd ed. Boca Raton: CRC
    • Foster M, Hunter D, Samman S. Evaluation of the nutritional and metabolic effects of Aloe vera. In: Benzie IFF, Wachtel-Galor S, eds. Herbal Medicine: Biomolecular and Clinical Aspects. 2nd ed. Boca Raton: CRC; 2011
    • (2011) Herbal Medicine: Biomolecular and Clinical Aspects
    • Foster, M.1    Hunter, D.2    Samman, S.3
  • 4
    • 50949107303 scopus 로고    scopus 로고
    • Composition and applications of aloe vera leaf gel
    • Hamman JH. Composition and applications of Aloe vera leaf gel. Molecules. 2008; 13: 1599-1616
    • (2008) Molecules , vol.13 , pp. 1599-1616
    • Hamman, J.H.1
  • 5
    • 0345504760 scopus 로고    scopus 로고
    • Compositional features of polysaccharides from aloe vera (aloe barbadensis miller) plant tissues
    • Femenia A, Sanchez ES, Simal S, Rossello C. Compositional features of polysaccharides from Aloe vera (Aloe barbadensis Miller) plant tissues. Carbohydr Polym. 1999; 39: 109-117
    • (1999) Carbohydr Polym , vol.39 , pp. 109-117
    • Femenia, A.1    Sanchez, E.S.2    Simal, S.3    Rossello, C.4
  • 6
    • 8644259968 scopus 로고    scopus 로고
    • Isolation and characterization of structural components of aloe vera l leaf pulp
    • Ni Y, Turner D, Yates KM, Tizard I. Isolation and characterization of structural components of Aloe vera L leaf pulp. Int Immunopharmacol. 2004; 4: 1745-1755
    • (2004) Int Immunopharmacol , vol.4 , pp. 1745-1755
    • Ni, Y.1    Turner, D.2    Yates, K.M.3    Tizard, I.4
  • 7
    • 0029973175 scopus 로고    scopus 로고
    • Antiinflammatory c-glucosyl chromone from aloe barbadensis
    • Hutter JA, Salman M, Stavinoha WB, et al. Antiinflammatory C-glucosyl chromone from Aloe barbadensis. J Nat Prod. 1996; 59: 541-543
    • (1996) J Nat Prod , vol.59 , pp. 541-543
    • Hutter, J.A.1    Salman, M.2    Stavinoha, W.B.3
  • 8
    • 15944396899 scopus 로고    scopus 로고
    • Chemical characterization of the immunomodulating polysaccharide of aloe vera l
    • Chow JT-N, Williamson DA, Yates KM, Goux WJ. Chemical characterization of the immunomodulating polysaccharide of Aloe vera L Carbohydr Res. 2005; 340: 1131-1142
    • (2005) Carbohydr Res , vol.340 , pp. 1131-1142
    • Chow, J.T.-N.1    Williamson, D.A.2    Yates, K.M.3    Goux, W.J.4
  • 9
    • 0033973050 scopus 로고    scopus 로고
    • Isolation and identification of a phenolic antioxidant from aloe barbadensis
    • Lee KY, Weintraub ST, Yu BP. Isolation and identification of a phenolic antioxidant from Aloe barbadensis. Free Radic Biol Med. 2000; 28: 261-265
    • (2000) Free Radic Biol Med , vol.28 , pp. 261-265
    • Lee, K.Y.1    Weintraub, S.T.2    Yu, B.P.3
  • 10
    • 34249798714 scopus 로고    scopus 로고
    • Screening methods used to determine the anti-microbial properties of aloe vera inner gel
    • Habeeb F, Shakir E, Bradbury F, et al. Screening methods used to determine the anti-microbial properties of Aloe vera inner gel. Methods. 2007; 42: 315-320
    • (2007) Methods , vol.42 , pp. 315-320
    • Habeeb, F.1    Shakir, E.2    Bradbury, F.3
  • 11
    • 84902551780 scopus 로고    scopus 로고
    • Synergistic activity between echinophora platyloba dc ethanolic extract and azole drugs against clinical isolates of candida albicans from women suffering chronic recurrent vaginitis
    • Avijgan M, Mahboubi M, Moheb Nasab M, Ahmadi Nia E, Yousefi H. Synergistic activity between Echinophora platyloba DC ethanolic extract and azole drugs against clinical isolates of Candida albicans from women suffering chronic recurrent vaginitis. J Mycol Med. 2014; 24: 112-116
    • (2014) J Mycol Med , vol.24 , pp. 112-116
    • Avijgan, M.1    Mahboubi, M.2    Moheb Nasab, M.3    Ahmadi Nia, E.4    Yousefi, H.5
  • 12
    • 81255134441 scopus 로고    scopus 로고
    • Physical and chemical characteristics of aloe ferox leaf gel
    • O'Brien C, van Wyk BE, van Heerden FR. Physical and chemical characteristics of Aloe ferox leaf gel. S Afr J Botany. 2011; 77: 988-995
    • (2011) S Afr J Botany , vol.77 , pp. 988-995
    • O'Brien, C.1    Van Wyk, B.E.2    Van Heerden, F.R.3
  • 14
    • 77952830184 scopus 로고    scopus 로고
    • In vitro antioxidant activities of aloe vera leaf skin extracts
    • Miladi S, Damak M. In vitro antioxidant activities of Aloe vera leaf skin extracts. J Soc Chim Tunisie. 2008; 10: 101-109
    • (2008) J Soc Chim Tunisie , vol.10 , pp. 101-109
    • Miladi, S.1    Damak, M.2
  • 16
    • 58149397782 scopus 로고    scopus 로고
    • Perspective of industrial application of aloe vera
    • In: Park YI, Lee SK, eds. New York: Springer Verlag
    • Park YI, Jo TH. Perspective of industrial application of Aloe vera. In: Park YI, Lee SK, eds. New Perspective on Aloe. New York: Springer Verlag; 2006: 199-200. ISBN 0387317996
    • (2006) New Perspective on Aloe , pp. 199-200
    • Park, Y.I.1    Jo, T.H.2
  • 17
    • 33646806070 scopus 로고    scopus 로고
    • An evaluation of the biological and toxicological properties of aloe barbadensis (miller), aloe vera
    • Boudreau M, Beland F. An evaluation of the biological and toxicological properties of Aloe barbadensis (Miller), Aloe vera. J Environ Sci Heal. 2006; C 24: 103-154
    • (2006) J Environ Sci Heal , vol.C24 , pp. 103-154
    • Boudreau, M.1    Beland, F.2
  • 18
    • 79958806505 scopus 로고    scopus 로고
    • Separation and purification of aloe anthraquinones using peg/salt aqueous two-phase system
    • Tan Z, Li F, Xing J. Separation and purification of Aloe anthraquinones using PEG/salt aqueous two-phase system. Sep Sci Technol. 2011; 46: 1503-1510
    • (2011) Sep Sci Technol , vol.46 , pp. 1503-1510
    • Tan, Z.1    Li, F.2    Xing, J.3
  • 19
    • 63049114865 scopus 로고    scopus 로고
    • Novel type iii polyketide synthases from aloe arborescens
    • Mizuuchi Y, Shi SP, Wanibuchi K, et al. Novel type III polyketide synthases from Aloe arborescens. FEBS J. 2009; 276: 2391-2401
    • (2009) FEBS J. , vol.276 , pp. 2391-2401
    • Mizuuchi, Y.1    Shi, S.P.2    Wanibuchi, K.3
  • 20
    • 84892693774 scopus 로고    scopus 로고
    • Enhancement of anti-inflammatory activity of aloe vera adventitious root extracts through the alteration of primary and secondary metabolites via salicylic acid elicitation
    • Lee YS, Ju HK, Kim YJ, et al. Enhancement of anti-inflammatory activity of Aloe vera adventitious root extracts through the alteration of primary and secondary metabolites via salicylic acid elicitation. PLoS One. 2013; 8: e82479
    • (2013) PLoS One , vol.8 , pp. e82479
    • Lee, Y.S.1    Ju, H.K.2    Kim, Y.J.3
  • 21
    • 33645054804 scopus 로고    scopus 로고
    • Beneficial effects of aloe vera leaf gel extract on lipid profile status in rats with streptozotocin diabetes
    • Rajasekaran S, Ravi K, Sivagnanam K, Subramanian S. Beneficial effects of Aloe vera leaf gel extract on lipid profile status in rats with streptozotocin diabetes. Clin Exp Pharmacol Physiol. 2006; 33: 232-237
    • (2006) Clin Exp Pharmacol Physiol , vol.33 , pp. 232-237
    • Rajasekaran, S.1    Ravi, K.2    Sivagnanam, K.3    Subramanian, S.4
  • 22
    • 53449100910 scopus 로고    scopus 로고
    • Therapeutic uses of aloe l (asphodelaceae) in southern africa
    • Grace OM, Simmonds MS, Smith GF, Wyk AE. Therapeutic uses of Aloe L (Asphodelaceae) in southern Africa. J Ethnopharmacol. 2008; 119: 604-614
    • (2008) J Ethnopharmacol , vol.119 , pp. 604-614
    • Grace, O.M.1    Simmonds, M.S.2    Smith, G.F.3    Wyk, A.E.4
  • 24
    • 33748432397 scopus 로고    scopus 로고
    • Macrophage activation by polysaccharide biological response modifier isolated from Aloe vera L var. Chinensis (Haw) Berg
    • Liu C, Leung MYK, Koon JCM, et al. Macrophage activation by polysaccharide biological response modifier isolated from Aloe vera L var. chinensis (Haw) Berg. Int Immunopharmacol. 2006; 18: 1634-1641
    • (2006) Int Immunopharmacol , vol.18 , pp. 1634-1641
    • Liu, C.1    Leung, M.Y.K.2    Koon, J.C.M.3
  • 25
    • 77952403719 scopus 로고    scopus 로고
    • Wound healing potential of aloe vera leaf gel studied in experimental rats
    • Subramanian S, Kumar DS, Arulselvan P. Wound healing potential of Aloe vera leaf gel studied in experimental rats. Asian J Biochem. 2006; 1: 178-185
    • (2006) Asian J Biochem , vol.1 , pp. 178-185
    • Subramanian, S.1    Kumar, D.S.2    Arulselvan, P.3
  • 26
    • 77949599683 scopus 로고    scopus 로고
    • Influence of aloe polysaccharide on proliferation and hyaluronic acid and hydroxyproline secretion of human fibroblasts in vitro
    • in Chinese]
    • Liu LY, Chen XD, Wu BY, Jiang Q. Influence of Aloe polysaccharide on proliferation and hyaluronic acid and hydroxyproline secretion of human fibroblasts in vitro. Zhong Xi Yi Jie He Xue Bao. 2010; 8: 256-262 [in Chinese]
    • (2010) Zhong Xi Yi Jie He Xue Bao , vol.8 , pp. 256-262
    • Liu, L.Y.1    Chen, X.D.2    Wu, B.Y.3    Jiang, Q.4
  • 27
    • 84897627068 scopus 로고    scopus 로고
    • Acemannan sponges stimulate alveolar bone, cementum and periodontal ligament regeneration in a canine class ii furcation defect model
    • Chantarawaratit P, Sangvanich P, Banlunara W, Soontornvipart K, Thunyakitpisal P. Acemannan sponges stimulate alveolar bone, cementum and periodontal ligament regeneration in a canine class II furcation defect model. J Periodontal Res. 2013; 49: 164-178
    • (2013) J Periodontal Res , vol.49 , pp. 164-178
    • Chantarawaratit, P.1    Sangvanich, P.2    Banlunara, W.3    Soontornvipart, K.4    Thunyakitpisal, P.5
  • 28
    • 84873828027 scopus 로고    scopus 로고
    • Effectiveness of aloe vera gel compared with 1% silver sulphadiazine cream as burn wound dressing in second degree burns
    • Shahzad MN, Ahmed N. Effectiveness of Aloe vera gel compared with 1% silver sulphadiazine cream as burn wound dressing in second degree burns. J Pak Med Assoc. 2013; 63: 225-230
    • (2013) J Pak Med Assoc , vol.63 , pp. 225-230
    • Shahzad, M.N.1    Ahmed, N.2
  • 29
    • 84896719895 scopus 로고    scopus 로고
    • Polysaccharides of aloe vera induce mmp-3 and timp-2 gene expression during the skin wound repair of rat
    • Tabandeh MR, Oryan A, Mohammadalipour A. Polysaccharides of Aloe vera induce MMP-3 and TIMP-2 gene expression during the skin wound repair of rat. Int J Biol Macromol. 2014; 65: 424-430
    • (2014) Int J Biol Macromol , vol.65 , pp. 424-430
    • Tabandeh, M.R.1    Oryan, A.2    Mohammadalipour, A.3
  • 30
    • 84881111515 scopus 로고    scopus 로고
    • Aloe vera downregulates lpsinduced inflammatory cytokine production and expression of nlrp3 inflammasome in human macrophages
    • Budai MM, Varga A, Milesz S, Tozsér J, Benko S. Aloe vera downregulates LPSinduced inflammatory cytokine production and expression of NLRP3 inflammasome in human macrophages. Mol Immunol. 2013; 56: 471-479
    • (2013) Mol Immunol , vol.56 , pp. 471-479
    • Budai, M.M.1    Varga, A.2    Milesz, S.3    Tozsér, J.4    Benko, S.5
  • 31
    • 1642521726 scopus 로고    scopus 로고
    • Effect of aloe vera on leukocyte adhesion and tnf-A and il-6 levels in burn wounded rats
    • Duansak D, Somboonwong J, Patumraj S. Effect of Aloe vera on leukocyte adhesion and TNF-A and IL-6 levels in burn wounded rats. Med Biochem Biophys. 2009; 29: 239-246
    • (2009) Med Biochem Biophys , vol.29 , pp. 239-246
    • Duansak, D.1    Somboonwong, J.2    Patumraj, S.3
  • 32
    • 79961169837 scopus 로고    scopus 로고
    • Effects of chitosan molecular weight and degree of deacetylation on the properties of gelatine-based films
    • Liu Z, Ge X, Lu Y, Dong S, Zhao Y, Zeng M. Effects of chitosan molecular weight and degree of deacetylation on the properties of gelatine-based films. Food Hydrocolloids. 2012; 26: 311-317
    • (2012) Food Hydrocolloids , vol.26 , pp. 311-317
    • Liu, Z.1    Ge, X.2    Lu, Y.3    Dong, S.4    Zhao, Y.5    Zeng, M.6
  • 33
    • 12344267009 scopus 로고    scopus 로고
    • Identification of optimal molecular size of modified aloe polysaccharides with maximum immunomodulatory activity
    • Im SA, Oh ST, Song S, et al. Identification of optimal molecular size of modified Aloe polysaccharides with maximum immunomodulatory activity. Int Immunopharmacol. 2005; 5: 271-279
    • (2005) Int Immunopharmacol , vol.5 , pp. 271-279
    • Im, S.A.1    Oh, S.T.2    Song, S.3
  • 34
    • 84875809042 scopus 로고    scopus 로고
    • Immune modulatory effects of aloe arborescens extract on the piscine saf-1 cell line
    • Picchietti S, Bernini C, Belardinelli MC, et al. Immune modulatory effects of Aloe arborescens extract on the piscine SAF-1 cell line. Fish Shellfish Immunol. 2012; 34: 1335-1344
    • (2012) Fish Shellfish Immunol , vol.34 , pp. 1335-1344
    • Picchietti, S.1    Bernini, C.2    Belardinelli, M.C.3
  • 35
    • 67149097678 scopus 로고    scopus 로고
    • Evaluation of aloin and aloe-emodin as antiinflammatory agents in aloe by using murine macrophages
    • Park MY, Kwon HJ, Sung MK. Evaluation of aloin and aloe-emodin as antiinflammatory agents in aloe by using murine macrophages. Biosci Biotechnol Biochem. 2009; 73: 828-832
    • (2009) Biosci Biotechnol Biochem , vol.73 , pp. 828-832
    • Park, M.Y.1    Kwon, H.J.2    Sung, M.K.3
  • 36
    • 1642332211 scopus 로고    scopus 로고
    • Anti-inflammatory effects of aloe vera gel in human colorectal mucosa in vitro
    • Langmead L, Makins RJ, Rampton DS. Anti-inflammatory effects of Aloe vera gel in human colorectal mucosa in vitro. Aliment Pharmacol Ther. 2004; 19: 521-527
    • (2004) Aliment Pharmacol Ther , vol.19 , pp. 521-527
    • Langmead, L.1    Makins, R.J.2    Rampton, D.S.3
  • 37
    • 84896483729 scopus 로고    scopus 로고
    • Evaluation of the therapeutic effects of aloe vera gel on minor recurrent aphthous stomatitis
    • Babaee N, Zabihi E, Mohseni S, Moghadamnia AA. Evaluation of the therapeutic effects of Aloe vera gel on minor recurrent aphthous stomatitis. Dent Res J (Isfahan). 2012; 9: 381-385
    • (2012) Dent Res J (Isfahan , vol.9 , pp. 381-385
    • Babaee, N.1    Zabihi, E.2    Mohseni, S.3    Moghadamnia, A.A.4
  • 38
    • 84902513894 scopus 로고    scopus 로고
    • Modulation of drug efflux by aloe materials: An in vitro investigation across rat intestinal tissue
    • Carien B, Alvaro V, Josias H. Modulation of drug efflux by aloe materials: an in vitro investigation across rat intestinal tissue. Pharmacogn Mag. 2013; 9: 44-48
    • (2013) Pharmacogn Mag , vol.9 , pp. 44-48
    • Carien, B.1    Alvaro, V.2    Josias, H.3
  • 39
    • 84884170259 scopus 로고    scopus 로고
    • In vitro and in vivo antioxidant activities of polysaccharide purified from aloe vera (aloe barbadensis) gel
    • Kang MC, Kim SY, Kim YT, et al. In vitro and in vivo antioxidant activities of polysaccharide purified from Aloe vera (Aloe barbadensis) gel. Carbohydr Polym. 2014; 99: 365-371
    • (2014) Carbohydr Polym , vol.99 , pp. 365-371
    • Kang, M.C.1    Kim, S.Y.2    Kim, Y.T.3
  • 40
    • 84857918973 scopus 로고    scopus 로고
    • Aloe emodin inhibits colon cancer cell migration/angiogenesis by downregulating mmp-2/9, rhob and vegf via reduced dna binding activity of nf-kb
    • Suboj P, Babykutty S, Valiyaparambil Gopi DR, Nair RS, Srinivas P, Gopala S. Aloe emodin inhibits colon cancer cell migration/angiogenesis by downregulating MMP-2/9, RhoB and VEGF via reduced DNA binding activity of NF-kB. Eur J Pharm Sci. 2012; 45: 581-591
    • (2012) Eur J Pharm Sci , vol.45 , pp. 581-591
    • Suboj, P.1    Babykutty, S.2    Valiyaparambil Gopi, D.R.3    Nair, R.S.4    Srinivas, P.5    Gopala, S.6
  • 41
    • 68949112556 scopus 로고    scopus 로고
    • Intestinal drug transport enhancement by aloe vera
    • Chen W, Lu Z, Viljoen A, Hamman J. Intestinal drug transport enhancement by Aloe vera. Planta Med. 2009; 75: 587-595
    • (2009) Planta Med , vol.75 , pp. 587-595
    • Chen, W.1    Lu, Z.2    Viljoen, A.3    Hamman, J.4
  • 42
    • 84858151895 scopus 로고    scopus 로고
    • Anti-hyperglycemic and anti-hypercholesterolemic effects of aloe vera leaf gel in hyperlipidemic type 2 diabetic patients: A randomized double-blind placebo-controlled clinical trial
    • Huseini HF, Kianbakht S, Hajiaghaee R, Dabaghian FH. Anti-hyperglycemic and anti-hypercholesterolemic effects of Aloe vera leaf gel in hyperlipidemic type 2 diabetic patients: a randomized double-blind placebo-controlled clinical trial. Planta Med. 2012; 78: 311-316
    • (2012) Planta Med , vol.78 , pp. 311-316
    • Huseini, H.F.1    Kianbakht, S.2    Hajiaghaee, R.3    Dabaghian, F.H.4
  • 43
    • 80052454400 scopus 로고    scopus 로고
    • In vivo evaluation of hypoglycemic activity of aloe spp and identification of its mode of action on glut-4 gene expression in vitro
    • Kumar R, Sharma B, Tomar NR, Roy P, Gupta AK, Kumar A. In vivo evaluation of hypoglycemic activity of Aloe spp. and identification of its mode of action on GLUT-4 gene expression in vitro. Appl Biochem Biotechnol. 2011; 164: 1246-1256
    • (2011) Appl Biochem Biotechnol , vol.164 , pp. 1246-1256
    • Kumar, R.1    Sharma, B.2    Tomar, N.R.3    Roy, P.4    Gupta, A.K.5    Kumar, A.6
  • 44
    • 84881367993 scopus 로고    scopus 로고
    • Metabolic effects of aloe vera gel complex in obese prediabetes and early non-Treated diabetic patients: Randomized controlled trial
    • Choi HC, Kim SJ, Son KY, Oh BJ, Cho BL. Metabolic effects of Aloe vera gel complex in obese prediabetes and early non-Treated diabetic patients: randomized controlled trial. Nutrition. 2013; 29: 1110-1114
    • (2013) Nutrition , vol.29 , pp. 1110-1114
    • Choi, H.C.1    Kim, S.J.2    Son, K.Y.3    Oh, B.J.4    Cho, B.L.5
  • 45
    • 71949127868 scopus 로고    scopus 로고
    • A pilot randomized placebo controlled trial of 2 aloe vera supplements in patients with pre-diabetes/metabolic syndrome
    • Devaraj S, Jialal R, Jialal I, Rockwood R. A pilot randomized placebo controlled trial of 2 Aloe vera supplements in patients with pre-diabetes/metabolic syndrome. Planta Med. 2008; 74: SL77
    • (2008) Planta Med , vol.74 , pp. SL77
    • Devaraj, S.1    Jialal, R.2    Jialal, I.3    Rockwood, R.4
  • 46
    • 77954176088 scopus 로고    scopus 로고
    • Aloe emodin glycosides stimulates glucose transport and glycogen storage through pi3k dependent mechanism in l6 myotubes and inhibits adipocyte differentiation in 3t3l1 adipocytes
    • Anand S, Muthusamy VS, Sujatha S, et al. Aloe emodin glycosides stimulates glucose transport and glycogen storage through PI3K dependent mechanism in L6 myotubes and inhibits adipocyte differentiation in 3T3L1 adipocytes. FEBS Lett. 2010; 584: 3170-3178
    • (2010) FEBS Lett , vol.584 , pp. 3170-3178
    • Anand, S.1    Muthusamy, V.S.2    Sujatha, S.3
  • 47
    • 33745714081 scopus 로고    scopus 로고
    • Identification of five phytosterols from aloe vera gel as anti-diabetic compounds
    • Tanaka M, Misawa E, Ito Y, et al. Identification of five phytosterols from Aloe vera gel as anti-diabetic compounds. Biol Pharm Bull. 2006; 29: 1418-1422
    • (2006) Biol Pharm Bull , vol.29 , pp. 1418-1422
    • Tanaka, M.1    Misawa, E.2    Ito, Y.3
  • 48
    • 77949497635 scopus 로고    scopus 로고
    • Aloe vera gel alleviates cardiotoxicity in streptozocin-induced diabetes in rats
    • Jain N, Vijayaraghavan R, Pant SC, Lomash V, Ali M. Aloe vera gel alleviates cardiotoxicity in streptozocin-induced diabetes in rats. J Pharm Pharmacol. 2010; 62: 115-123
    • (2010) J Pharm Pharmacol , vol.62 , pp. 115-123
    • Jain, N.1    Vijayaraghavan, R.2    Pant, S.C.3    Lomash, V.4    Ali, M.5
  • 49
    • 84869223441 scopus 로고    scopus 로고
    • Dietary aloe improves insulin sensitivity via the suppression of obesity-induced inflammation in obese mice
    • Shin E, Shim KS, Kong H, et al. Dietary Aloe improves insulin Sensitivity via the suppression of obesity-induced inflammation in obese mice. Immune Netw. 2011; 11: 59-67
    • (2011) Immune Netw , vol.11 , pp. 59-67
    • Shin, E.1    Shim, K.S.2    Kong, H.3
  • 50
    • 84903542057 scopus 로고    scopus 로고
    • Improvement in the function of isolated rat pancreatic islets through reduction of oxidative stress using traditional iranian medicine
    • Rahimifard M, Navaei-Nigjeh M, Mahroui N, et al. Improvement in the function of isolated rat pancreatic islets through reduction of oxidative stress using traditional Iranian medicine. Cell J. 2013; 16: 147-163
    • (2013) Cell J. , vol.16 , pp. 147-163
    • Rahimifard, M.1    Navaei-Nigjeh, M.2    Mahroui, N.3
  • 51
    • 84897459638 scopus 로고    scopus 로고
    • Anti-inflammatory and antioxidant effects of aloe saponaria haw in a model of uvb-induced paw sunburn in rats
    • Silva MA, Trevisan G, Hoffmeister C, et al. Anti-inflammatory and antioxidant effects of Aloe saponaria Haw in a model of UVB-induced paw sunburn in rats. J Photochem Photobiol B. 2014; 133: 47-54
    • (2014) J Photochem Photobiol B. , vol.133 , pp. 47-54
    • Silva, M.A.1    Trevisan, G.2    Hoffmeister, C.3
  • 52
    • 79954800353 scopus 로고    scopus 로고
    • Evaluation of radioprotective efficacy and possible mechanism of action of aloe gel
    • Saini DK, Saini MR. Evaluation of radioprotective efficacy and possible mechanism of action of Aloe gel. Environ Toxicol Pharmacol. 2011; 31: 427-435
    • (2011) Environ Toxicol Pharmacol , vol.31 , pp. 427-435
    • Saini, D.K.1    Saini, M.R.2
  • 53
    • 12344264705 scopus 로고    scopus 로고
    • Modulatory effects of aloe vera leaf gel extract on oxidative stress in rats treated with streptozotocin
    • Rajasekaran S, Sivagnanam K, Subramanian S. Modulatory effects of Aloe vera leaf gel extract on oxidative stress in rats treated with streptozotocin. J Pharm Pharmacol. 2005; 57: 241-246
    • (2005) J Pharm Pharmacol , vol.57 , pp. 241-246
    • Rajasekaran, S.1    Sivagnanam, K.2    Subramanian, S.3
  • 54
    • 79751537250 scopus 로고    scopus 로고
    • In vitro study of the pla2 inhibition and antioxidants activities of aloe vera leaf skin extracts
    • Kammoun M, Miladi S, Ben Ali Y, Damak M, Gargouri Y, Bezzine S. In vitro study of the PLA2 inhibition and antioxidants activities of Aloe vera leaf skin extracts. Lipids Health Dis. 2011; 10: 30
    • (2011) Lipids Health Dis , vol.10 , pp. 30
    • Kammoun, M.1    Miladi, S.2    Ben Ali, Y.3    Damak, M.4    Gargouri, Y.5    Bezzine, S.6
  • 55
    • 84878323806 scopus 로고    scopus 로고
    • Phenolic constituents antioxidant and preliminary antimycoplasmic activities of leaf skin and flowers of aloe vera (l) burm f (syn a barbadensis mill) from the canary islands (spain
    • Lopez A, de Tangil MS, Vega-Orellana O, Ramirez AS, Rico M. Phenolic constituents, antioxidant and preliminary antimycoplasmic activities of leaf skin and flowers of Aloe vera (L) Burm. f. (syn. A. barbadensis Mill) from the Canary Islands (Spain). Molecules. 2013; 18: 4942-4954
    • (2013) Molecules , vol.18 , pp. 4942-4954
    • Lopez, A.1    De Tangil, M.S.2    Vega-Orellana, O.3    Ramirez, A.S.4    Rico, M.5
  • 56
    • 84863346623 scopus 로고    scopus 로고
    • Oral ingestion of aloe vera phytosterols alters hepatic gene expression profiles and ameliorates obesityassociated metabolic disorders in zucker diabetic fatty rats
    • Misawa E, Tanaka M, Nomaguchi K, et al. Oral ingestion of Aloe vera phytosterols alters hepatic gene expression profiles and ameliorates obesityassociated metabolic disorders in Zucker diabetic fatty rats. J Agric Food Chem. 2012; 60: 2799-2806
    • (2012) J Agric Food Chem , vol.60 , pp. 2799-2806
    • Misawa, E.1    Tanaka, M.2    Nomaguchi, K.3
  • 57
    • 84873571586 scopus 로고    scopus 로고
    • Probiotic lactobacillus rhamnosus gg and aloe vera gel improve lipid profiles in hypercholesterolemic rats
    • Kumar M, Rakesh S, Nagpal R, et al. Probiotic Lactobacillus rhamnosus GG and Aloe vera gel improve lipid profiles in hypercholesterolemic rats. Nutrition. 2013; 29: 574-579
    • (2013) Nutrition , vol.29 , pp. 574-579
    • Kumar, M.1    Rakesh, S.2    Nagpal, R.3
  • 58
    • 84890808212 scopus 로고    scopus 로고
    • Chemopreventive effects of aloin against 1, 2-dimethylhydrazine-induced preneoplastic lesions in the colon of wistar rats
    • Hamiza OO, Rehman MU, Khan R, et al. Chemopreventive effects of aloin against 1, 2-dimethylhydrazine-induced preneoplastic lesions in the colon of Wistar rats. Hum Exp Toxicol. 2014; 33: 148-163
    • (2014) Hum Exp Toxicol , vol.33 , pp. 148-163
    • Hamiza, O.O.1    Rehman, M.U.2    Khan, R.3
  • 59
    • 84880027971 scopus 로고    scopus 로고
    • Inhibition of the angiogenesis and growth of aloin in human colorectal cancer in vitro and in vivo
    • Pan Q, Pan H, Lou H, Xu Y, Tian L Inhibition of the angiogenesis and growth of aloin in human colorectal cancer in vitro and in vivo. Cancer Cell Int. 2013; 13: 69
    • (2013) Cancer Cell Int , vol.13 , pp. 69
    • Pan, Q.1    Pan, H.2    Lou, H.3    Xu, Y.4    Tian, L.5
  • 60
    • 61449096777 scopus 로고    scopus 로고
    • Emodin induces apoptosis of human tongue squamous cancer scc-4 cells through reactive oxygen species and mitochondria-dependent pathways
    • Lin SY, Lai WW, Ho CC, et al. Emodin induces apoptosis of human tongue squamous cancer SCC-4 cells through reactive oxygen species and mitochondria-dependent pathways. Anticancer Res. 2009; 29: 327-335
    • (2009) Anticancer Res , vol.29 , pp. 327-335
    • Lin, S.Y.1    Lai, W.W.2    Ho, C.C.3
  • 61
    • 34147152865 scopus 로고    scopus 로고
    • Emodin has a cytotoxic activity against human multiple myeloma as a janus-Activated kinase 2 inhibitor
    • Muto A, Hori M, Sasaki Y, et al. Emodin has a cytotoxic activity against human multiple myeloma as a Janus-Activated kinase 2 inhibitor. Mol Cancer Ther. 2007; 6: 987-994
    • (2007) Mol Cancer Ther , vol.6 , pp. 987-994
    • Muto, A.1    Hori, M.2    Sasaki, Y.3
  • 62
    • 79952572370 scopus 로고    scopus 로고
    • Destabilization of carp mrnas by aloeemodin contributes to caspase-8-mediated p53-independent apoptosis of human carcinoma cells
    • Lin ML, Lu YC, Su HL, et al. Destabilization of CARP mRNAs by aloeemodin contributes to caspase-8-mediated p53-independent apoptosis of human carcinoma cells. J Cell Biochem. 2011; 112: 1176-1191
    • (2011) J Cell Biochem , vol.112 , pp. 1176-1191
    • Lin, M.L.1    Lu, Y.C.2    Su, H.L.3
  • 63
    • 84886773472 scopus 로고    scopus 로고
    • Exploration of effects of emodin in selected cancer cell lines: Enhanced growth inhibition by ascorbic acid and regulation of lrp1 and ar under hypoxia-like conditions
    • Masaldan S, Iyer VV. Exploration of effects of emodin in selected cancer cell lines: enhanced growth inhibition by ascorbic acid and regulation of LRP1 and AR under hypoxia-like conditions. J Appl Toxicol. 2014; 34: 95-104
    • (2014) J Appl Toxicol , vol.34 , pp. 95-104
    • Masaldan, S.1    Iyer, V.V.2
  • 64
    • 27944469465 scopus 로고    scopus 로고
    • Berberine decreased n-Acetylation of 2-Aminofluorene through inhibition of n-Acetyltransferase gene expression in human leukemia hl-60 cells
    • Lin CC, Kao ST, Chen GW, Chung JG. Berberine decreased N-Acetylation of 2-Aminofluorene through inhibition of N-Acetyltransferase gene expression in human leukemia HL-60 cells. Anticancer Res. 2005; 25: 4149-4155
    • (2005) Anticancer Res , vol.25 , pp. 4149-4155
    • Lin, C.C.1    Kao, S.T.2    Chen, G.W.3    Chung, J.G.4
  • 65
    • 29144467980 scopus 로고    scopus 로고
    • Aloe-emodin induces apoptosis in t24 human bladder cancer cells through the p53 dependent apoptotic pathway
    • Lin JG, Chen GW, Li TM, Chouh ST, Tan TW, Chung JG. Aloe-emodin induces apoptosis in T24 human bladder cancer cells through the p53 dependent apoptotic pathway. J Urol. 2006; 175: 343-347
    • (2006) J Urol , vol.175 , pp. 343-347
    • Lin, J.G.1    Chen, G.W.2    Li, T.M.3    Chouh, S.T.4    Tan, T.W.5    Chung, J.G.6
  • 66
    • 84872189366 scopus 로고    scopus 로고
    • Anthraquinone-2-sulfonic acid (aq2s) is a novel neurotherapeutic agent
    • Jackson TC, Verrier JD, Kochanek PM. Anthraquinone-2-sulfonic acid (AQ2S) is a novel neurotherapeutic agent. Cell Death Dis. 2013; 4: e451
    • (2013) Cell Death Dis , vol.4 , pp. e451
    • Jackson, T.C.1    Verrier, J.D.2    Kochanek, P.M.3
  • 67
    • 78650241588 scopus 로고    scopus 로고
    • Isolation and characterization of novel protein with anti-fungal and anti-inflammatory properties from aloe vera leaf gel
    • Das S, Mishra B, Gill K, et al. Isolation and characterization of novel protein with anti-fungal and anti-inflammatory properties from Aloe vera leaf gel. Int J Biol Macromol. 2011; 48: 38-43
    • (2011) Int J Biol Macromol , vol.48 , pp. 38-43
    • Das, S.1    Mishra, B.2    Gill, K.3
  • 68
    • 77949290312 scopus 로고    scopus 로고
    • Antibacterial activities of crude extract of aloe barbadensis to clinically isolated bacterial pathogens
    • Pandey R, Mishra A. Antibacterial activities of crude extract of Aloe barbadensis to clinically isolated bacterial pathogens. Appl Biochem Biotechnol. 2010; 160: 1356-1361
    • (2010) Appl Biochem Biotechnol , vol.160 , pp. 1356-1361
    • Pandey, R.1    Mishra, A.2
  • 69
    • 0037417053 scopus 로고    scopus 로고
    • In vitro susceptibilities of shigella flexneri and streptococcus pyogenes to inner gel of aloe barbadensis miller
    • Ferro VA, Bradbury F, Cameron P, Shakir E, Rahman SR, Stimson WH. In vitro susceptibilities of Shigella flexneri and Streptococcus pyogenes to inner gel of Aloe barbadensis Miller. Agents Chemother. 2003; 47: 1137-1139
    • (2003) Agents Chemother , vol.47 , pp. 1137-1139
    • Ferro, V.A.1    Bradbury, F.2    Cameron, P.3    Shakir, E.4    Rahman, S.R.5    Stimson, W.H.6
  • 70
    • 0013400664 scopus 로고    scopus 로고
    • In: Aloe vera: Natural Wonder Cure London Thorsons Publishing Ltd
    • Lawless J, Allan J. The clinical composition of Aloe vera. In: Aloe vera: Natural Wonder Cure. London: Thorsons Publishing Ltd; 2000: 161-171
    • (2000) The Clinical Composition of Aloe Vera , pp. 161-171
    • Lawless, J.1    Allan, J.2
  • 71
    • 0035117509 scopus 로고    scopus 로고
    • Characterization of aloeride, a new high molecular weight polysaccharide from aloe vera with potent immunostimulatory activity
    • Pugh N, Ross SA, ElSohly MA, Pasco DS. Characterization of Aloeride, a new high molecular weight polysaccharide from Aloe vera with potent immunostimulatory activity. J Agric Food Chem. 2001; 49: 1030-1034
    • (2001) J Agric Food Chem , vol.49 , pp. 1030-1034
    • Pugh, N.1    Ross, S.A.2    Elsohly, M.A.3    Pasco, D.S.4
  • 72
    • 34347406197 scopus 로고    scopus 로고
    • Chemical constituents of cape aloe and their synergistic growth inhibiting effect on ehrlich ascites tumor cells
    • Kametani S, Yuasa AK, Kikuzaki H, Kennedy DO, HonzawaM, Yuasa M. Chemical constituents of Cape Aloe and their synergistic growth inhibiting effect on Ehrlich ascites tumor cells. Biosci Biotechnol Biochem. 2007; 71: 1220-1229
    • (2007) Biosci Biotechnol Biochem , vol.71 , pp. 1220-1229
    • Kametani, S.1    Yuasa, A.K.2    Kikuzaki, H.3    Kennedy, D.O.4    Honzawam Yuasa, M.5
  • 73
    • 0032861743 scopus 로고    scopus 로고
    • Plant products as antimicrobial agents
    • Cowan MM. Plant products as antimicrobial agents. Clin Microbiol Rev. 1999; 12: 564-582
    • (1999) Clin Microbiol Rev , vol.12 , pp. 564-582
    • Cowan, M.M.1
  • 75
    • 84902061776 scopus 로고    scopus 로고
    • Antiviral activity of aloe-emodin against influenza a virus via galectin-3 up-regulation
    • Li SW, Yang TC, Lai CC, et al. Antiviral activity of Aloe-emodin against influenza A virus via galectin-3 up-regulation. Eur J Pharmacol. 2014; 27: 125-132
    • (2014) Eur J Pharmacol , vol.27 , pp. 125-132
    • Li, S.W.1    Yang, T.C.2    Lai, C.C.3
  • 77
    • 84870385839 scopus 로고    scopus 로고
    • Expression of biologically active human interferon alpha 2 in aloe vera
    • Lowther W, Lorick K, Lawrence SD, Yeow WS. Expression of biologically active human interferon alpha 2 in Aloe vera. Transgenic Res. 2012; 21: 1349-1357
    • (2012) Transgenic Res , vol.21 , pp. 1349-1357
    • Lowther, W.1    Lorick, K.2    Lawrence, S.D.3    Yeow, W.S.4
  • 78
    • 84880178686 scopus 로고    scopus 로고
    • Emodin and aloe-emodin suppress breast cancer cell proliferation through era inhibition
    • Huang PH, Huang CY, Chen MC, et al. Emodin and Aloe-emodin suppress breast cancer cell proliferation through ERa inhibition. Evid Based Complement Alternat Med. 2013; 2013: 376123
    • (2013) Evid Based Complement Alternat Med , vol.2013 , pp. 376123
    • Huang, P.H.1    Huang, C.Y.2    Chen, M.C.3
  • 79
    • 79952914509 scopus 로고    scopus 로고
    • Effect of Aloe barbadensis Mill. Formulation on Letrozole induced polycystic ovarian syndrome rat model
    • Maharjan R, Nagar PS, Nampoothiri L Effect of Aloe barbadensis Mill. formulation on Letrozole induced polycystic ovarian syndrome rat model. J Ayurveda Integr Med. 2010; 1: 273-279
    • (2010) J Ayurveda Integr Med , vol.1 , pp. 273-279
    • Maharjan, R.1    Nagar, P.S.2    Nampoothiri, L.3
  • 80
    • 84862652746 scopus 로고    scopus 로고
    • The effect of aloe vera leaf gel on fatty streak formation in hypercholesterolemic rabbits
    • Dana N, Javanmard SH, Asgary S, Asnaashari H, Abdian N. The effect of Aloe vera leaf gel on fatty streak formation in hypercholesterolemic rabbits. J Res Med Sci. 2012; 17: 439-442
    • (2012) J Res Med Sci , vol.17 , pp. 439-442
    • Dana, N.1    Javanmard, S.H.2    Asgary, S.3    Asnaashari, H.4    Abdian, N.5
  • 81
    • 84908891722 scopus 로고    scopus 로고
    • Antihyperlipidemic activity of aloe succotrina in rats: Possibly mediated by inhibition of hmg-coa reductase
    • Dhingra D, Lamba D, Kumar R, Nath P, Gauttam S. Antihyperlipidemic activity of Aloe succotrina in rats: possibly mediated by inhibition of HMG-CoA reductase. ISRN Pharmacol. 2014; 2014: 243575
    • (2014) ISRN Pharmacol , vol.2014 , pp. 243575
    • Dhingra, D.1    Lamba, D.2    Kumar, R.3    Nath, P.4    Gauttam, S.5
  • 82
    • 84859795933 scopus 로고    scopus 로고
    • Aloe barbadensis Mill. Formulation restores lipid profile to normal in a letrozole-induced polycystic ovarian syndrome rat model
    • Desai BN, Maharjan RH, Nampoothiri LP. Aloe barbadensis Mill. formulation restores lipid profile to normal in a letrozole-induced polycystic ovarian syndrome rat model. Pharmacognosy Res. 2012; 4: 109-115
    • (2012) Pharmacognosy Res , vol.4 , pp. 109-115
    • Desai, B.N.1    Maharjan, R.H.2    Nampoothiri, L.P.3
  • 83
    • 84903793974 scopus 로고    scopus 로고
    • Clinical efficacy of new aloe veraand myrrh-based oral mucoadhesive gels in the management of minor recurrent aphthous stomatitis: A randomized, double-blind, vehicle-controlled study
    • Mansour G, Ouda S, Shaker A, Abdallah HM. Clinical efficacy of new Aloe veraand myrrh-based oral mucoadhesive gels in the management of minor recurrent aphthous stomatitis: a randomized, double-blind, vehicle-controlled study. J Oral Pathol Med. 2014; 43: 405-409
    • (2014) J Oral Pathol Med , vol.43 , pp. 405-409
    • Mansour, G.1    Ouda, S.2    Shaker, A.3    Abdallah, H.M.4
  • 84
    • 75749104331 scopus 로고    scopus 로고
    • Estimation of tolerable upper intake level (ul) of active aloe
    • Kwack SJ, Kim KB, Lee BM. Estimation of tolerable upper intake level (UL) of active Aloe. J Toxicol Environ Health A. 2009; 72: 1455-1462
    • (2009) J Toxicol Environ Health A. , vol.72 , pp. 1455-1462
    • Kwack, S.J.1    Kim, K.B.2    Lee, B.M.3
  • 85
    • 0024506449 scopus 로고
    • Toxicity studies on six plants used in the traditional arab system of medicine
    • Shah AH, Quereshi S, Tariq M, Ageel AM. Toxicity studies on six plants used in the traditional Arab system of medicine. Phytother Res. 1989; 3: 25-29
    • (1989) Phytother Res , vol.3 , pp. 25-29
    • Shah, A.H.1    Quereshi, S.2    Tariq, M.3    Ageel, A.M.4
  • 86
    • 84905990057 scopus 로고    scopus 로고
    • Toxicology and carcinogenesis studies of a noncolorized whole leaf extract of aloe barbadensis miller (aloe vera) in f344/n rats and b6c3f1 mice (drinking water study
    • Boudreau MD, Beland FA, Nichols JA, Pogribna M. Toxicology and carcinogenesis studies of a noncolorized whole leaf extract of Aloe barbadensis Miller (Aloe vera) in F344/N rats and B6C3F1 mice (drinking water study). Natl Toxicol Program Tech Rep Ser. 2013: 1-266
    • (2013) Natl Toxicol Program Tech Rep ser , pp. 1-266
    • Boudreau, M.D.1    Beland, F.A.2    Nichols, J.A.3    Pogribna, M.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.