Effect of Aloe barbadensis Mill. Formulation on Letrozole induced polycystic ovarian syndrome rat model

Journal of Ayurveda and Integrative Medicine

Volumn 1, Issue 4, 2010, Pages 273-279

  Maharjan, Radha ^a   Nagar, Padamnabhi ^a   Nampoothiri, Laxmipriya ^a  

^a M S UNIVERSITY OF BARODA   (India)

Author keywords

Aloe vera; anovulation; infertility; insulin resistance; letrozole; polycystic ovary syndrome.

Indexed keywords

3(OR 17)BETA HYDROXYSTEROID DEHYDROGENASE; ALOE BARBADENSIS EXTRACT; GLUCOSE; LETROZOLE; METFORMIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG EFFICACY; DRUG FORMULATION; ENZYME ACTIVITY; ESTRUS CYCLE; FEMALE; GEL; HISTOPATHOLOGY; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; OVARY POLYCYSTIC DISEASE; PHENOTYPE; PHYTOCHEMISTRY; PLANT LEAF; PRIORITY JOURNAL; RAT; STEROIDOGENESIS;

EID: 79952914509     PISSN: 09759476     EISSN: 09762809     Source Type: Journal    
DOI: 10.4103/0975-9476.74090     Document Type: Article

References (41)

1. Teede H, Deeks A, Moran L. Polycystic ovary syndrome: a complex conditions with psychological, reproductive and metabolic manifestations those impacts on health across the lifespan. BMC Med 2010;8-41.
2. Strowitzki T, Capp E, von Eye Corleta H. The degree of cycle irregularity correlates with the grade of endocrine and metabolic disorders in PCOS patients. Eur J Obstet Gynecol Reprod Biol 2010;149:178-81.
3. Soares GM, Vieira CS, de Paula Martins W, Dos Reis RM, de Sá, MF, Ferriani RA. Metabolic and cardiovascular impact of oral contraceptives in polycystic ovary syndrome. Int J Clin Pract 2009;63:160-9.
4. Kahn JA, Gordon CM. Polycystic ovary syndrome. Adolesc Med 1999; 10:321-6.
5. Carmina E, Lobo RA. Polycystic ovary syndrome (PCOS): arguably the most common endocrinopathy is associated with significant morbidity in women. J Clin Endocrinol Metab 1999;84:1897-9. (Pubitemid 30647006)
6. Wachs DS, Coffler MS, Malcom PJ, Shimasaki S, Chang RJ. Increased androgen response to follicle-stimulating hormone administration in women with polycystic ovary syndrome. J Clin Endocrinol Metab 2008;93:1827-33. (Pubitemid 351656525)
7. Dunaif A. Insulin resistance and polycystic ovarian syndrome: mechanism and implications for pathogenesis. Endocr Rev 1997;18:774-800. (Pubitemid 28009567)
8. Boudreaux MY, Talbott EO, Kip KE, Brooks MM, Witchel SF. Risk of T2DM and impaired fasting glucose among PCOS subjects: results of an 8-year follow-up. Curr Diab Rep 2006;6:77-83.
9. Tang T, Lord JM, Norman RJ, Yasmin E, Balen AH. WITHDRAWN: Insulin-sensitising drugs for polycystic ovary syndrome. Cochrane Database Syst Rev 2009;3:CD003053.
10. Costello MF, Shrestha B, Eden J, Johnson NP, Sjoblom P. Metformin versus oral contraceptive pill in polycystic ovary syndrome: a Cochrane review. Hum Reprod 2007;22: 1200-9. (Pubitemid 47062785)
11. Dunaif, A. Drug insight: insulin-sensitizing drugs in the treatment of polycystic ovary syndrome-a reappraisal. Nat Clin Pract Endocrinol Metab 2008;5:272-83. (Pubitemid 351571139)
12. Salpeter SR, Greyber E, Pasternak GA, Salpeter EE. Risk of fatal and nonfatal lactic acidosis with metformin use in type 2 diabetes mellitus: systematic review and meta-analysis. Arch Intern Med 2003;163:2594-602. (Pubitemid 37464417)
13. Diamanti-Kandarakis E, Zapanti E. Insulin sensitizers and antiandrogens in the treatment of polycystic ovary syndrome. Ann N Y Acad Sci 2000;900:203-12. (Pubitemid 30251470)
14. Jain A, Katewa SS, Chaudhary BL, Galav P. Folk herbal medicines used in birth control and sexual diseases by tribals of southern Rajasthan, India. J Ethnopharmacol 2004;1: 171-7. (Pubitemid 38091704)
15. Kamath JV, Rana AC. Preliminary study on antifertility activity of Calotropis procera roots in female rats. Fitoterapia 2002;73:111-5. (Pubitemid 34308921)
16. Song JJ, Yan ME, Wu, XK, Hou LH. Progress of integrative Chinese and Western medicine in treating polycystic ovarian syndrome caused infertility. Chin J Integr Med 2006;12: 312-6.
17. Musabayane CT, Bwititi PT, Ojewole JA. Effects of oral administration of some herbal extracts on food consumption and blood glucose levels in normal and streptozotocin-treated diabetic rats. Methods Find Exp Clin Pharmacol 2006;28: 223-8. (Pubitemid 44013392)
18. Beppu H, Negamura Y, Fujita K. Hypoglycemic and antidiabetic effect in mice in Aloe arborescens Millar var. natalensis Berger. Phytother Res 1993;7:37-42.
19. Tanaka M, Misawa E, Ito Y, Habara N, Nomaguchi K, Yamada M, et al. Identification of five phytosterols from Aloe vera gel as anti-diabetic compounds. Biol Pharm Bull 2006;29: 1418-22.
20. Rajasekaran S, Sivagnanam K, Subramanian S. Modulatory effects of Aloe vera leaf gel extract on oxidative stress in rats treated with streptozotocin. J Pharm Pharmacol 2005;57: 241-6. (Pubitemid 40129093)
21. Kim K, Kim H, Kwon J, Lee S, Kong H, Im S, et al. Hypoglycemic and hypolipidemic effects of processed Aloe vera gel in a mouse model of non-insulin-dependent diabetes mellitus. Phytomedicine 2009;16:856-63.
22. Rajasekaran S, Ravi K, Sivagnanam K, Subramanian S. Beneficial effects of Aloe vera leaf gel extract on lipid profile status in rats with streptozotocin diabetes. Clin Exp Pharmacol Physiol 2006;33:232-7.
23. PerezYY, Jimenez-Ferrer E, Zamilpa A, Hernandez-Velencia M, Alarcon-Aguilar FJ, Tortoriello J, et al. Effect of Polyphenol-rich extract from Aloe vera gel on experimentally induced insulin resistance in mice. Am J Chin Med 2007;35: 1037-46.
24. Botes L, van der Westhuizen FH, Loots du T. Phytochemical contents and antioxidant capacities of two Aloe greatheadii var. davyana extracts. Molecules 2008;3:2169-80.
25. Singleton VL, Orthofer R, Lamuela-Raventos RM. Analysis of total phenols and other oxidation substrates and antioxidants by means of Folin-Ciocalteu reagent. Meth Enzymol 1999;299:152-78. (Pubitemid 28483890)
26. Sabir SM, Hayat I, Gardezi SD. Estimation of sterols in edible fats and oils. Pak. J Nutr 2003;2:178-81.
27. Chang CC, Yang MH, Wen HM, Chern JC. Estimation of total Flavonoid content in propolis by two complementary colorimetric methods. J Food Drug Anal 2002;10:3-8.
28. Kafali H, Iradam M, Ozardali I, Demir M, Letrozole induced polycystic ovaries in the Rat: A new model for Cystic Ovarian Disease. Arch Med Res 2004;35:103-8. (Pubitemid 38316828)
29. Buchanan TA, Sipos GF, Gadalah S, Yip KP, Marsh DJ, Hsueh W et al. Glucose tolerance and insulin action in rats with renovascular hypertension. Hypertension 1991;8: 341-7.
30. Shivanandappa P, Venkatesh S. A colorimetric method assay method for 3β- Hydroxy- 5- steroid Dehydrogenase Anal biochem 1997;45:57-61.
31. Lillie RD. Histopathologic Technic and Practical Histochemistry 3rd ed, McGraw-Hill Book Co, 1965.
32. Tosca L, Chabrolle C, Uzbekova S, Dupont J. Effects of metformin on bovine granulosa cells steroidogenesis: possible involvement of adenosine 5' monophosphate-activated protein kinase (AMPK). Biol Reprod 2007;76:368-78.
33. Reitman S, Frankel S. A colorimetric method for the determination of serum glutamic oxalacetic and glutamic pyruvic transaminases. Am J Clin Pathol 1957;28:56-63.
34. Bonanes RW, Taussky HA. The colorimatric determination of creatinine by the Jaffe reaction. J Biol Chem 1945;158-9.
35. Dickerson EH, Cho LW, Maguiness SD, Killick SL, Robinson J, Atkin SL. Insulin resistance and free androgen index correlate with the outcome of controlled ovarian hyperstimulation in non-PCOS women undergoing IVF. Hum Reprod 2010;25:504-9.
36. Diamanti M, Lamb H J, van de Ree M A, Endert EL, Groeneveld Y, Bots ML, et al. The association between abdominal visceral fat and carotid stiffness is mediated by circulating inflammatory markers in uncomplicated type 2 diabetes. J Clin Endocrinol Metab 2005;90:1495-01. (Pubitemid 40464010)
37. Barber TM, Bennett AJ, Groves CJ, Sovio U, Ruokonen A, Martikainen H, et al. Association of variants in the fat mass and obesity associated (FTO) gene with polycystic ovary syndrome. Diabetologia 2008;51:1153-8.
38. Honnma H, Endo T, Henmi H, Nagasawa K, Baba T, Yamazaki, K, et al. Altered expression of Fas/Fas ligand/caspase 8 and membrane type 1-matrix metalloproteinase in atretic follicles within dehydroepiandrosterone po-induced lycystic ovaries in rats. Apoptosis 2006;11:1525-33. (Pubitemid 44253670)
39. Garruti G, Depalo R, Vita MG, Lorusso F, Giampetruzzi F, Damato AB, et al. Adipose tissue, metabolic syndrome and polycystic ovary syndrome: from pathophysiology to treatment. Reprod Biomed Online 2009;4:552-63.
40. Qu J, Wang Y Wu X, Gao L, Hou L, Erkkola R. Insulin resistance directly contributes to androgenic potential within ovarian theca cells. Fertil Steril 2008;5:1990-7.
41. Doi SA, Al-Zaid M, Towers P A, Scott C J, Al-Shoumer KA. Steroidogenic alterations and adrenal androgen excess in PCOS. Steroids 2006;71:751-9. (Pubitemid 44081934)