The effect of Aloe vera leaf gel on fatty streak formation in hypercholesterolemic rabbits

Journal of Research in Medical Sciences

Volumn 17, Issue 5, 2012, Pages 439-442

  Dana, Nasim ^a   Javanmard, Shaghayegh Haghjooy ^a   Asgary, Sedigheh ^b   Asnaashari, Hossein ^c   Abdian, Narges ^a  

^a ISFAHAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b ISFAHAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c ISFAHAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Aloe vera; Atherosclerosis; C reactive protein; Fatty streak; Inflammation

Indexed keywords

ALOE VERA LEAF GEL; ANTILIPEMIC AGENT; C REACTIVE PROTEIN; CHOLESTEROL; GLUCOSE; HERBACEOUS AGENT; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

ALOE VERA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATHEROSCLEROSIS; CHOLESTEROL DIET; COLORIMETRY; CONTROLLED STUDY; DIETARY INTAKE; DISEASE SEVERITY; ENZYME LINKED IMMUNOSORBENT ASSAY; HYPERCHOLESTEROLEMIA; MALE; NONHUMAN; PLANT LEAF; RABBIT; RISK FACTOR;

EID: 84862652746     PISSN: 17351995     EISSN: 17357136     Source Type: Journal    
DOI: None     Document Type: Article

References (38)

1. Libby P, Ridker PM. Inflammation and atherosclerosis: role of C-reactive protein in risk assessment. Am J Med 2004; 116(Suppl 6A): 9S-16S.
2. Hansson GK, Libby P. The immune response in atherosclerosis: a double-edged sword. Nat Rev Immunol 2006; 6(7): 508-19.
3. Asgary S, Naderi G, Dashti G, Paknahad Z. Effect of Amirkabiria odorastissima mozaffarian on the development and progression of fatty streaks in hypercholesterolemic rabbits. Phytother Res 2004; 18(5): 370-2.
4. Setorki M, Asgary S, Eidi A, Rohani AH, Khazaei M. Acute effects of vinegar intake on some biochemical risk factors of atherosclerosis in hypercholesterolemic rabbits. Lipids Health Dis 2010; 9: 10.
5. Kritchevsky D. Dietary protein, cholesterol and atherosclerosis: a review of the early history. J Nutr 1995; 125(3 Suppl): 589S-93S.
6. Paulsen E, Korsholm L, Brandrup F. A double-blind, placebocontrolled study of a commercial Aloe vera gel in the treatment of slight to moderate psoriasis vulgaris. J Eur Acad Dermatol Venereol 2005; 19(3): 326-31.
7. Reynolds T, Dweck AC. Aloe vera leaf gel: a review update. J Ethnopharmacol 1999; 68(1-3): 3-37.
8. Heggers JP, Kucukcelebi A, Listengarten D, Broemel KF. Wound healing effects of Aloe gel and other topical antibacterial agents in rat skin. Phytotherapy Res 1995; 9(6): 455-7.
9. Chithra P, Sajithlal GB, Chandrakasan G. Influence of Aloe vera on the healing of dermal wounds in diabetic rats. J Ethnopharmacol 1998; 59(3): 195-201.
10. Davis RH, Leitner MG, Russo JM, Byrne ME. Wound healing. Oral and topical activity of Aloe vera. J Am Podiatr Med Assoc 1989; 79(11): 559-62.
11. Javanmard Sh, Nematbakhsh M, Mahmoodi F, Mohajeri MR. l-Arginine supplementation enhances eNOS expression in experimental model of hypercholesterolemic rabbits aorta. Pathophysiology 2009; 16(1): 9-13.
12. Ross R. Atherosclerosis--an inflammatory disease. N Engl J Med 1999; 340(2): 115-26.
13. Engstrom G, Hedblad B, Janzon L, Lindgarde F. Long-term change in cholesterol in relation to inflammation-sensitive plasma proteins: a longitudinal study. Ann Epidemiol 2007; 17(1): 57-63.
14. Skretting G, Gjernes E, Prydz H. Regulation of lecithin:cholesterol acyltransferase by TGF-beta and interleukin-6. Biochim Biophys Acta 1995; 1255(3): 267-72.
15. Feister HA, Auerbach BJ, Cole LA, Krause BR, Karathanasis SK. Identification of an IL-6 response element in the human LCAT promoter. J Lipid Res 2002; 43(6): 960-70.
16. Greenberg AS, Nordan RP, McIntosh J, Calvo JC, Scow RO, Jablons D. Interleukin 6 reduces lipoprotein lipase activity in adipose tissue of mice in vivo and in 3T3-L1 adipocytes: a possible role for interleukin 6 in cancer cachexia. Cancer Res 1992; 52(15): 4113-6.
17. Hardardottir I, Moser AH, Fuller J, Fielding C, Feingold K, Grunfeld C. Endotoxin and cytokines decrease serum levels and extra hepatic protein and mRNA levels of cholesteryl ester transfer protein in syrian hamsters. J Clin Invest 1996; 97(11): 2585-92.
18. Feingold KR, Hardardottir I, Grunfeld C. Beneficial effects of cytokine induced hyperlipidemia. Z Ernahrungswiss 1998; 37(Suppl 1): 66-74.
19. Broedl UC, Jin W, Rader DJ. Endothelial lipase: a modulator of lipoprotein metabolism upregulated by inflammation. Trends Cardiovasc Med 2004; 14(5): 202-6.
20. Zhang L, Peppel K, Sivashanmugam P, Orman ES, Brian L, Exum ST, et al. Expression of tumor necrosis factor receptor-1 in arterial wall cells promotes atherosclerosis. Arterioscler Thromb Vasc Biol 2007; 27(5): 1087-94.
21. Elhage R, Maret A, Pieraggi MT, Thiers JC, Arnal JF, Bayard F. Differential effects of interleukin-1 receptor antagonist and tumor necrosis factor binding protein on fatty-streak formation in apolipoprotein E-deficient mice. Circulation 1998; 97(3): 242-4.
22. Buono C, Come CE, Stavrakis G, Maguire GF, Connelly PW, Lichtman AH. Influence of interferon-gamma on the extent and phenotype of diet-induced atherosclerosis in the LDLRdeficient mouse. Arterioscler Thromb Vasc Biol 2003; 23(3): 454-60.
23. Ohta H, Wada H, Niwa T, Kirii H, Iwamoto N, Fujii H, et al. Disruption of tumor necrosis factor-alpha gene diminishes the development of atherosclerosis in ApoE-deficient mice. Atherosclerosis 2005; 180(1): 11-7.
24. Branen L, Hovgaard L, Nitulescu M, Bengtsson E, Nilsson J, Jovinge S. Inhibition of tumor necrosis factor-alpha reduces atherosclerosis in apolipoprotein E knockout mice. Arterioscler Thromb Vasc Biol 2004; 24(11): 2137-42.
25. Bisoendial RJ, Kastelein JJ, Stroes ES. C-reactive protein and atherogenesis: from fatty streak to clinical event. Atherosclerosis 2007; 195(2): e10-e18.
26. Pepys MB, Hirschfield GM, Tennent GA, Gallimore JR, Kahan MC, Bellotti V, et al. Targeting C-reactive protein for the treatment of cardiovascular disease. Nature 2006; 440(7088): 1217-21.
27. Verma S, Devaraj S, Jialal I. Is C-reactive protein an innocent bystander or proatherogenic culprit? C-reactive protein promotes atherothrombosis. Circulation 2006; 113(17): 2135-50.
28. Arroyo-Espliguero R, Avanzas P, Cosin-Sales J, Aldama G, Pizzi C, Kaski JC. C-reactive protein elevation and disease activity in patients with coronary artery disease. Eur Heart J 2004; 25(5): 401-8.
29. Blake GJ, Ridker PM. Novel clinical markers of vascular wall inflammation. Circ Res 2001; 89(9): 763-71.
30. Burke AP, Tracy RP, Kolodgie F, Malcom GT, Zieske A, Kutys R, et al. Elevated C-reactive protein values and atherosclerosis in sudden coronary death: association with different pathologies. Circulation 2002; 105(17): 2019-23.
31. Ridker PM. C-reactive protein and the prediction of cardiovascular events among those at intermediate risk: moving an inflammatory hypothesis toward consensus. J Am Coll Cardiol 2007; 49(21): 2129-38.
32. Lim BO, Seong NS, Choue RW, Kim JD, Lee HY, Kim SY, et al. Efficacy of dietary Aloe vera supplementation on hepatic cholesterol and oxidative status in aged rats. J Nutr Sci Vitaminol (Tokyo) 2003; 49(4): 292-6.
33. Eamlamnam K, Patumraj S, Visedopas N, Thong-Ngam D. Effects of Aloe vera and sucralfate on gastric microcirculatory changes, cytokine levels and gastric ulcer healing in rats. World J Gastroenterol 2006; 12(13): 2034-9.
34. Hutter JA, Salman M, Stavinoha WB, Satsangi N, Williams RF, Streeper RT, et al. Antiinflammatory C-glucosyl chromone from Aloe barbadensis. J Nat Prod 1996; 59(5): 541-3.
35. Langmead L, Makins RJ, Rampton DS. Anti-inflammatory effects of Aloe vera gel in human colorectal mucosa in vitro. Aliment Pharmacol Ther 2004; 19(5): 521-7.
36. Atherton P. Aloe vera revisited. Br J Phytotherapy 1998; 4(4): 176-83.
37. Hamman JH. Composition and applications of Aloe vera leaf gel. Molecules 2008; 13(8): 1599-616.
38. Surjushe A, Vasani R, Saple DG. Aloe vera: a short review. Indian J Dermatol 2008; 53(4): 163-6.