메뉴 건너뛰기




Volumn 13, Issue 8, 2008, Pages 1599-1616

Composition and applications of Aloe vera leaf gel

Author keywords

Absorption enhancement; Aloe vera; Biological activities; Excipient; Skin permeation

Indexed keywords

DRUG CARRIER; EMOLLIENT AGENT; POLYSACCHARIDE;

EID: 50949107303     PISSN: None     EISSN: 14203049     Source Type: Journal    
DOI: 10.3390/molecules13081599     Document Type: Review
Times cited : (772)

References (52)
  • 1
    • 0035859973 scopus 로고    scopus 로고
    • Polysaccharides in colon-specific drug delivery
    • Sinha, V.R.; Kumria, R. Polysaccharides in colon-specific drug delivery. Int. J. Pharm. 2001, 224, 19-38.
    • (2001) Int. J. Pharm , vol.224 , pp. 19-38
    • Sinha, V.R.1    Kumria, R.2
  • 3
    • 50949101632 scopus 로고    scopus 로고
    • Aloe polysaccharides
    • Reynolds, T, Ed, CRC Press: Boca Raton
    • Ni, Y.; Yates, K.M.; Tizard, I.R. Aloe polysaccharides. In Aloes The Genus Aloe; Reynolds, T., Ed.; CRC Press: Boca Raton, 2004; pp. 75-87.
    • (2004) Aloes The Genus Aloe , pp. 75-87
    • Ni, Y.1    Yates, K.M.2    Tizard, I.R.3
  • 5
    • 47749109206 scopus 로고    scopus 로고
    • Aloes in habitat
    • Reynolds, T, Ed, CRC Press: Boca Raton
    • Newton, L.E. Aloes in habitat. In Aloes The Genus Aloe; Reynolds, T., Ed.; CRC Press: Boca Raton, 2004; pp. 3-36.
    • (2004) Aloes The Genus Aloe , pp. 3-36
    • Newton, L.E.1
  • 7
    • 50949084975 scopus 로고    scopus 로고
    • Analytical methodology: The gel-analysis of aloe pulp and its derivatives
    • Reynolds, T, Ed, CRC Press: Boca Raton
    • Ni, Y.; Tizard, I.R. Analytical methodology: the gel-analysis of aloe pulp and its derivatives. In Aloes The Genus Aloe; Reynolds, T., Ed.; CRC Press: Boca Raton, 2004; pp. 111-126.
    • (2004) Aloes The Genus Aloe , pp. 111-126
    • Ni, Y.1    Tizard, I.R.2
  • 8
    • 8644259968 scopus 로고    scopus 로고
    • Isolation and characterisation of structural components of Aloe vera L. leaf pulp
    • Ni, Y.; Turner, D.; Yates, K.M.; Tizard, I. Isolation and characterisation of structural components of Aloe vera L. leaf pulp. Int. Immunopharmacol. 2004, 4, 1745-1755.
    • (2004) Int. Immunopharmacol , vol.4 , pp. 1745-1755
    • Ni, Y.1    Turner, D.2    Yates, K.M.3    Tizard, I.4
  • 10
    • 2142845959 scopus 로고    scopus 로고
    • Eshun, K.; He, Q. Aloe vera: A valuable ingredient for the food, pharmaceutical and cosmetic industries - A review. Crit. Rev. Food Sci. Nutr. 2004, 44, 91-96.
    • Eshun, K.; He, Q. Aloe vera: A valuable ingredient for the food, pharmaceutical and cosmetic industries - A review. Crit. Rev. Food Sci. Nutr. 2004, 44, 91-96.
  • 11
    • 4444317344 scopus 로고    scopus 로고
    • Quality and safety assurance in the processing of Aloe vera gel juice
    • He, Q.; Changhong, L.; Kojo, E.; Tian, Z. Quality and safety assurance in the processing of Aloe vera gel juice. Food Control. 2005, 16, 95-104.
    • (2005) Food Control , vol.16 , pp. 95-104
    • He, Q.1    Changhong, L.2    Kojo, E.3    Tian, Z.4
  • 12
    • 27144478301 scopus 로고    scopus 로고
    • Effect of Aloe vera preparations on the human bioavailability of vitamins C and E
    • Vinson, J.A.; Al Kharrat, H.; Andreoli, L. Effect of Aloe vera preparations on the human bioavailability of vitamins C and E. Phytomedicine 2005, 12, 760-765.
    • (2005) Phytomedicine , vol.12 , pp. 760-765
    • Vinson, J.A.1    Al Kharrat, H.2    Andreoli, L.3
  • 13
    • 50949099766 scopus 로고    scopus 로고
    • Evaluating mucilage from Aloe Barbadensis Miller as a pharmaceutical excipient for sustained-release matrix tablets
    • Jani, G.K.; Shah, D.P.; Jain, V.C.; Patel, M.J.; Vithalan, D.A. Evaluating mucilage from Aloe Barbadensis Miller as a pharmaceutical excipient for sustained-release matrix tablets. Pharm. Technol. 2007, 31, 90-98.
    • (2007) Pharm. Technol , vol.31 , pp. 90-98
    • Jani, G.K.1    Shah, D.P.2    Jain, V.C.3    Patel, M.J.4    Vithalan, D.A.5
  • 14
    • 33646806070 scopus 로고    scopus 로고
    • An evaluation of the biological and toxicological properties of Aloe Barbadensis (Miller), Aloe vera
    • Boudreau, M.D.; Beland, F.A. An evaluation of the biological and toxicological properties of Aloe Barbadensis (Miller), Aloe vera. J. Environ. Sci. Health C. 2006, 24, 103-154.
    • (2006) J. Environ. Sci. Health C , vol.24 , pp. 103-154
    • Boudreau, M.D.1    Beland, F.A.2
  • 15
    • 0030476431 scopus 로고    scopus 로고
    • Antiinflammatory activity of extracts from Aloe vera gel
    • Vazquez, B.; Avila, G.; Segura, D.; Escalante, B. Antiinflammatory activity of extracts from Aloe vera gel. J. Ethnopharmacol. 1996, 55, 69-75.
    • (1996) J. Ethnopharmacol , vol.55 , pp. 69-75
    • Vazquez, B.1    Avila, G.2    Segura, D.3    Escalante, B.4
  • 16
    • 36549056813 scopus 로고    scopus 로고
    • Aloe chemistry
    • Reynolds, T, Ed, CRC Press: Boca Raton
    • Reynolds, T. Aloe chemistry. In Aloes The Genus Aloe; Reynolds, T., Ed.; CRC Press: Boca Raton, 2004; pp. 39-74.
    • (2004) Aloes The Genus Aloe , pp. 39-74
    • Reynolds, T.1
  • 17
    • 34447134163 scopus 로고    scopus 로고
    • Cosmetic Ingredient Review Expert Panel. Final report on the safety assessment of Aloe andongensis extract, Aloe andongensis leaf juice, Aloe arborescens leaf extract, Aloe arborescens leaf juice, Aloe arborescens leaf protoplasts, Aloe barbadensis flower extract, Aloe barbadensis leaf, Aloe barbadensis leaf extract, Aloe barbadensis leaf juice, Aloe barbadensis leaf polysaccharides, Aloe barbadensis leaf water, Aloe ferox leaf extract, Aloe ferox leaf juice and Aloe ferox leaf juice extract. Int. J. Toxicol. 2007, 26, 1-50.
    • Cosmetic Ingredient Review Expert Panel. Final report on the safety assessment of Aloe andongensis extract, Aloe andongensis leaf juice, Aloe arborescens leaf extract, Aloe arborescens leaf juice, Aloe arborescens leaf protoplasts, Aloe barbadensis flower extract, Aloe barbadensis leaf, Aloe barbadensis leaf extract, Aloe barbadensis leaf juice, Aloe barbadensis leaf polysaccharides, Aloe barbadensis leaf water, Aloe ferox leaf extract, Aloe ferox leaf juice and Aloe ferox leaf juice extract. Int. J. Toxicol. 2007, 26, 1-50.
  • 18
    • 0345504760 scopus 로고    scopus 로고
    • Compositional features of polysaccharides from Aloe vera (Aloe barbadensis Miller) plant tissues
    • Femenia, A.; Sanchez, E.S.; Simal, S.; Rosello, C. Compositional features of polysaccharides from Aloe vera (Aloe barbadensis Miller) plant tissues. Carbohydr. Polym. 1999, 39, 109-117.
    • (1999) Carbohydr. Polym , vol.39 , pp. 109-117
    • Femenia, A.1    Sanchez, E.S.2    Simal, S.3    Rosello, C.4
  • 19
    • 5144224411 scopus 로고    scopus 로고
    • A review on the relationship between Aloe vera components and their biologic effects
    • Choi, S.; Chung, M-H. A review on the relationship between Aloe vera components and their biologic effects. Semin. Integr. Med. 2003, 1, 53-62.
    • (2003) Semin. Integr. Med , vol.1 , pp. 53-62
    • Choi, S.1    Chung, M.-H.2
  • 20
    • 0037343651 scopus 로고    scopus 로고
    • Effects of heat treatment and dehydration on bioactive polysaccharide acemannan and cell wall polymers from Aloe barbadensis Miller
    • Femenia, A.; Garcia-Pascual, P.; Simal, S.; Rosello, C. Effects of heat treatment and dehydration on bioactive polysaccharide acemannan and cell wall polymers from Aloe barbadensis Miller. Carbohydr. Polym. 2003, 51, 397-405.
    • (2003) Carbohydr. Polym , vol.51 , pp. 397-405
    • Femenia, A.1    Garcia-Pascual, P.2    Simal, S.3    Rosello, C.4
  • 21
    • 42649129680 scopus 로고    scopus 로고
    • An overview of mannan structure and mannan-degrading enzyme systems
    • Moreira, L.R.S.; Filho, E.X.F. An overview of mannan structure and mannan-degrading enzyme systems. Appl. Microbiol. Biotechnol. 2008, 79, 165-178.
    • (2008) Appl. Microbiol. Biotechnol , vol.79 , pp. 165-178
    • Moreira, L.R.S.1    Filho, E.X.F.2
  • 22
    • 34250304994 scopus 로고    scopus 로고
    • Medicinal applications and toxicological activities of Aloe products
    • Steenkamp, V.; Stewart, M.J. Medicinal applications and toxicological activities of Aloe products. Pharm. Biol. 2007, 45, 411-420.
    • (2007) Pharm. Biol , vol.45 , pp. 411-420
    • Steenkamp, V.1    Stewart, M.J.2
  • 23
    • 30744474730 scopus 로고    scopus 로고
    • Novel bioactive maloyl glucans from Aloe vera gel: Isolation, structure elucidation and in vitro bioassays
    • Esua, M.F.; Rauwald, J-W. Novel bioactive maloyl glucans from Aloe vera gel: isolation, structure elucidation and in vitro bioassays. Carbohydr. Res. 2006, 341, 355-364.
    • (2006) Carbohydr. Res , vol.341 , pp. 355-364
    • Esua, M.F.1    Rauwald, J.-W.2
  • 24
    • 0035117509 scopus 로고    scopus 로고
    • Characterisation of aloeride, a new high-molecular-weight polysaccharide from Aloe vera with potent immunostimulatory activity
    • Pugh, N.; Ross, S.A.; ElSohly, M.A.; Pasco, D.S. Characterisation of aloeride, a new high-molecular-weight polysaccharide from Aloe vera with potent immunostimulatory activity. J. Agric. Food Chem. 2001, 49, 1030-1034.
    • (2001) J. Agric. Food Chem , vol.49 , pp. 1030-1034
    • Pugh, N.1    Ross, S.A.2    ElSohly, M.A.3    Pasco, D.S.4
  • 25
    • 0031574261 scopus 로고    scopus 로고
    • Kotzé, A.F.; De Leeuw, B.J.; Lueβen, H.L.; De Boer, (A)Bert.G.; Verhoef, J.C.; Junginger, H.E. Chitosans for enhanced delivery of therapeutic peptides across intestinal epithelia: in vitro evaluation in Caco-2 cell monolayers. Int. J. Pharm. 1997, 159, 243-253.
    • Kotzé, A.F.; De Leeuw, B.J.; Lueβen, H.L.; De Boer, (A)Bert.G.; Verhoef, J.C.; Junginger, H.E. Chitosans for enhanced delivery of therapeutic peptides across intestinal epithelia: in vitro evaluation in Caco-2 cell monolayers. Int. J. Pharm. 1997, 159, 243-253.
  • 26
    • 0345267307 scopus 로고    scopus 로고
    • Macromolecules as safe penetration enhancers for hydrophilic drugs: A fiction?
    • Junginger, H.E.; Verhoef, J.C. Macromolecules as safe penetration enhancers for hydrophilic drugs: a fiction? Pharm. Sci. Technol. Today. 1998, 1, 370-376.
    • (1998) Pharm. Sci. Technol. Today , vol.1 , pp. 370-376
    • Junginger, H.E.1    Verhoef, J.C.2
  • 27
    • 50949123045 scopus 로고    scopus 로고
    • Hamman, J.H.; Viljoen, A.M. Use of Aloe vera for increasing the bioavailability of poorly absorbable drugs. 2008. SA patent application 2008/01542.
    • Hamman, J.H.; Viljoen, A.M. Use of Aloe vera for increasing the bioavailability of poorly absorbable drugs. 2008. SA patent application 2008/01542.
  • 29
    • 27744605985 scopus 로고    scopus 로고
    • In situ and in vivo efficacy of peroral absorption enhancers in rats and correlation to in vitro mechanistic studies
    • Sharma, P.; Varma, M.V.S.; Chawla, H.P.S.; Panchagnula R. In situ and in vivo efficacy of peroral absorption enhancers in rats and correlation to in vitro mechanistic studies. Il Farmaco 2005, 60, 874-883.
    • (2005) Il Farmaco , vol.60 , pp. 874-883
    • Sharma, P.1    Varma, M.V.S.2    Chawla, H.P.S.3    Panchagnula, R.4
  • 31
    • 0031671475 scopus 로고    scopus 로고
    • Novel oral drug delivery gateways for biotechnology products: Polypeptides and vaccines
    • Brayden, D.J.; O'Mahony, D.J. Novel oral drug delivery gateways for biotechnology products: polypeptides and vaccines. Pharm. Sci. Technol. Today. 1998, 1, 291-299.
    • (1998) Pharm. Sci. Technol. Today , vol.1 , pp. 291-299
    • Brayden, D.J.1    O'Mahony, D.J.2
  • 32
    • 0033037654 scopus 로고    scopus 로고
    • Passive enhancement strategies in topical and transdermal drug delivery
    • Hadgraft, J. Passive enhancement strategies in topical and transdermal drug delivery. Int. J. Pharm. 1999, 184, 1-6.
    • (1999) Int. J. Pharm , vol.184 , pp. 1-6
    • Hadgraft, J.1
  • 33
    • 0034880643 scopus 로고    scopus 로고
    • Passive skin penetration enhancement and its quantification in vitro
    • Moser, K; Kriwet, K.; Naik, A.; Kalia, Y.N.; Guy, R.H. Passive skin penetration enhancement and its quantification in vitro. Eur. J. Pharm. Biopharm. 2001, 52, 103-112.
    • (2001) Eur. J. Pharm. Biopharm , vol.52 , pp. 103-112
    • Moser, K.1    Kriwet, K.2    Naik, A.3    Kalia, Y.N.4    Guy, R.H.5
  • 34
    • 17844389701 scopus 로고    scopus 로고
    • Physical enhancement of transdermal drug application: Is delivery technology keeping up with pharmaceutical development?
    • Cross, S.E.; Roberts, M.S. Physical enhancement of transdermal drug application: Is delivery technology keeping up with pharmaceutical development? Curr. Drug Deliv. 2004, 1, 81-92.
    • (2004) Curr. Drug Deliv , vol.1 , pp. 81-92
    • Cross, S.E.1    Roberts, M.S.2
  • 36
    • 33847159862 scopus 로고    scopus 로고
    • Skin permeation enhancement potential of Aloe vera and a proposed mechanism of action based upon size exclusion and pull effect
    • Cole, L.; Heard, C. Skin permeation enhancement potential of Aloe vera and a proposed mechanism of action based upon size exclusion and pull effect. Int. J. Pharm. 2007, 333, 10-16.
    • (2007) Int. J. Pharm , vol.333 , pp. 10-16
    • Cole, L.1    Heard, C.2
  • 37
    • 22144467364 scopus 로고    scopus 로고
    • Development of controlled release spheroids using natural polysaccharide as release modifier
    • Kulkarni, G.T.; Gowthamarajan, K.; Dhobe, R.R.; Yohanan, F.; Suresh, B. Development of controlled release spheroids using natural polysaccharide as release modifier. Drug Deliv. 2005, 12, 201-206.
    • (2005) Drug Deliv , vol.12 , pp. 201-206
    • Kulkarni, G.T.1    Gowthamarajan, K.2    Dhobe, R.R.3    Yohanan, F.4    Suresh, B.5
  • 38
    • 0032744713 scopus 로고    scopus 로고
    • Aloe vera leaf gel: A review update
    • Reynolds, T.; Dweck, A.C. Aloe vera leaf gel: a review update. J. Ethnopharmacol. 1999, 68, 3-37.
    • (1999) J. Ethnopharmacol , vol.68 , pp. 3-37
    • Reynolds, T.1    Dweck, A.C.2
  • 39
    • 8644291501 scopus 로고    scopus 로고
    • Evaluation and comparison of commercially available Aloe vera L. products using size exclusion chromatography with refractive index and multi-angle laser light scattering detection
    • Turner, C.E.; Williamson, D.A.; Stroud, P.A.; Talley, D.J. Evaluation and comparison of commercially available Aloe vera L. products using size exclusion chromatography with refractive index and multi-angle laser light scattering detection. Int. Immunopharmacol. 2004, 4, 1727-1737.
    • (2004) Int. Immunopharmacol , vol.4 , pp. 1727-1737
    • Turner, C.E.1    Williamson, D.A.2    Stroud, P.A.3    Talley, D.J.4
  • 40
    • 33645054804 scopus 로고    scopus 로고
    • Beneficial effects of Aloe vera leaf gel extract on lipid profile status in rats with streptozotocin diabetes
    • Rajasekaran, S.; Ravi, K.; Sivagnanam, K.; Subramanian, S. Beneficial effects of Aloe vera leaf gel extract on lipid profile status in rats with streptozotocin diabetes. Clin. Exp. Pharmacol. Physiol. 2006, 33, 232-237.
    • (2006) Clin. Exp. Pharmacol. Physiol , vol.33 , pp. 232-237
    • Rajasekaran, S.1    Ravi, K.2    Sivagnanam, K.3    Subramanian, S.4
  • 41
    • 0030297997 scopus 로고    scopus 로고
    • Activation of a mouse macrophage cell line by acemannan: The major carbohydrate fraction from Aloe vera
    • Zhang, L.; Tizard, I.R. Activation of a mouse macrophage cell line by acemannan: The major carbohydrate fraction from Aloe vera. Immunopharmacology 1996, 35, 119-128.
    • (1996) Immunopharmacology , vol.35 , pp. 119-128
    • Zhang, L.1    Tizard, I.R.2
  • 42
    • 15944396899 scopus 로고    scopus 로고
    • Chemical characterisation of the immunomodulating polysaccharide of Aloe vera L
    • Chow, J.T-N.; Williamson, D.A.; Yates, K.M.; Goux, W.J. Chemical characterisation of the immunomodulating polysaccharide of Aloe vera L. Carbohydr. Res. 2005, 340, 1131-1142.
    • (2005) Carbohydr. Res , vol.340 , pp. 1131-1142
    • Chow, J.T.-N.1    Williamson, D.A.2    Yates, K.M.3    Goux, W.J.4
  • 43
  • 44
    • 0035472217 scopus 로고    scopus 로고
    • Immune regulation by polysaccharides: Implications for skin cancer
    • Strickland, F.M. Immune regulation by polysaccharides: implications for skin cancer. J. Photochem. Photobiol. B. 2001, 63, 132-140.
    • (2001) J. Photochem. Photobiol. B , vol.63 , pp. 132-140
    • Strickland, F.M.1
  • 45
    • 33747099223 scopus 로고    scopus 로고
    • Anti-inflammatory effects of Aloe vera on leukocyte-endothelium interaction in the gastric microcirculation of Helicobacter pylori-infected rats
    • Prabjone, R.; Thong-Ngam, D.; Wisedopas, N.; Chatsuwan, T.; Patumraj, S. Anti-inflammatory effects of Aloe vera on leukocyte-endothelium interaction in the gastric microcirculation of Helicobacter pylori-infected rats. Clin. Hemorheol. Microcirc. 2006, 35, 359-366.
    • (2006) Clin. Hemorheol. Microcirc , vol.35 , pp. 359-366
    • Prabjone, R.1    Thong-Ngam, D.2    Wisedopas, N.3    Chatsuwan, T.4    Patumraj, S.5
  • 46
    • 1642332211 scopus 로고    scopus 로고
    • Anti-inflammatory effects of aloe vera gel in human colorectal mucosa in vitro
    • Langmead, L.; Makins, R.J.; Rampton, D.S. Anti-inflammatory effects of aloe vera gel in human colorectal mucosa in vitro. Aliment. Pharmacol. Ther. 2004, 19, 521-527.
    • (2004) Aliment. Pharmacol. Ther , vol.19 , pp. 521-527
    • Langmead, L.1    Makins, R.J.2    Rampton, D.S.3
  • 49
    • 2942596314 scopus 로고    scopus 로고
    • The effect of Aloe vera A. berger (Liliaceae) on gastric acid secretion and acute gastric mucosal injury in rats
    • Yusuf, S.; Agunu, A.; Diana, M. The effect of Aloe vera A. berger (Liliaceae) on gastric acid secretion and acute gastric mucosal injury in rats. J. Ethnopharmacol. 2004, 93, 33-37.
    • (2004) J. Ethnopharmacol , vol.93 , pp. 33-37
    • Yusuf, S.1    Agunu, A.2    Diana, M.3
  • 50
    • 33749507653 scopus 로고    scopus 로고
    • Dal'Belo, S.E.; Gaspar, L.R.; Berardo Goncalves Maia Campos, P.M. Moisturising effect of cosmetic formulations containing Aloe vera extract in different concentrations assessed by skin bioengineering techniques. Skin Res. Technol. 2006, 12, 241-246.
    • Dal'Belo, S.E.; Gaspar, L.R.; Berardo Goncalves Maia Campos, P.M. Moisturising effect of cosmetic formulations containing Aloe vera extract in different concentrations assessed by skin bioengineering techniques. Skin Res. Technol. 2006, 12, 241-246.
  • 52
    • 3042824901 scopus 로고    scopus 로고
    • Membrane-related effects underlying the biological activity of the anthraquinones emodin and barbaloin
    • Alves, D.S.; Pérez-Fons, L.; Estepa, A.; Micol, V. Membrane-related effects underlying the biological activity of the anthraquinones emodin and barbaloin. Biochem. Pharmacol. 2004, 68, 549-561.
    • (2004) Biochem. Pharmacol , vol.68 , pp. 549-561
    • Alves, D.S.1    Pérez-Fons, L.2    Estepa, A.3    Micol, V.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.