Probiotic Lactobacillus rhamnosus GG and Aloe vera gel improve lipid profiles in hypercholesterolemic rats

Nutrition

Volumn 29, Issue 3, 2013, Pages 574-579

  Kumar, Manoj ^a   Rakesh, Shruti ^b   Nagpal, Ravinder ^c   Hemalatha, R ^a   Ramakrishna, A ^a   Sudarshan, V ^a   Ramagoni, Ramesh ^a   Shujauddin, Mohd ^a   Verma, Vinod ^d   Kumar, Ashok ^e   Tiwari, Akhilesh ^b   Singh, Birbal ^f   Kumar, Rajesh ^a  

^a NATIONAL INSTITUTE OF NUTRITION   (India)

^b ITS Paramedical College   (India)

^c Shaheed Udham Singh College of Research and Technology   (India)

^d DEPARTMENT OF CARDIOLOGY   (Singapore)

^e Department of Zoology   (India)

^f INDIAN VETERINARY RESEARCH INSTITUTE   (India)

Author keywords

Aloe vera; Cardiovascular diseases; Cholesterol; Lipid profile; Probiotics

Indexed keywords

ALOE VERA EXTRACT; CHOLESTEROL; CHOLESTEROL 7ALPHA MONOOXYGENASE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; LOW DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN RECEPTOR; MESSENGER RNA; PROBIOTIC AGENT; TRIACYLGLYCEROL; VERY LOW DENSITY LIPOPROTEIN;

ALOE VERA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTERIAL COUNT; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL SYNTHESIS; CONTROLLED STUDY; DRUG EFFECT; DRUG RESPONSE; FERMENTED PRODUCT; GEL; GENE EXPRESSION; HYPERCHOLESTEROLEMIA; LACTOBACILLUS RHAMNOSUS; MALE; MILK; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; TRIACYLGLYCEROL BLOOD LEVEL;

ALOE; ANIMALS; CARDIOVASCULAR DISEASES; CHOLESTEROL; CHOLESTEROL, DIETARY; CHOLESTEROL, HDL; CHOLESTEROL, LDL; GELS; HYPERCHOLESTEROLEMIA; LACTOBACILLUS RHAMNOSUS; LIPIDS; MALE; PLANT EXTRACTS; PROBIOTICS; RATS; RATS, WISTAR; RISK FACTORS; TRIGLYCERIDES;

ALOE VERA; LACTOBACILLUS; LACTOBACILLUS RHAMNOSUS; RATTUS;

EID: 84873571586     PISSN: 08999007     EISSN: 18731244     Source Type: Journal    
DOI: 10.1016/j.nut.2012.09.006     Document Type: Article

References (42)

1. Cardiovascular disease; fact sheet no 317 2009, World Health Organization, World Health Organization, Geneva, Available at:, Accessed May 19, 2010. http://www.who.int/mediacentre/factsheets/fs317/en/print.html.
2. Dunn-Emke S., Weidner G., Ornish D. Benefits of a low-fat plant-based diet. Obes Res 2001, 9:731.
3. Bliznakov E.G. Lipid-lowering drugs (statins), cholesterol, and coenzyme Q10. The Baycol case-a modern Pandora's box. Biomed Pharmacother 2002, 56:56-59.
4. Fabian E., Elmadfa I. Influence of daily consumption of probiotic and conventional yoghurt on the plasma lipid profile in young healthy women. Ann Nutr Metab 2006, 50:387-393.
5. Nagpal R., Kumar A., Arora S. In-vitro probiotic potential of lactobacilli from indigenous milk products. Int J Probiotics Prebiotics 2010, 5:103-110.
6. Nagpal R., Behare P.V., Kumar M., Mohania D., Yadav M., Jain S., et al. Milk, milk products and disease free health: an updated overview. Crit Rev Food Sci Nutr 2012, 52:321-333.
7. Kumar M., Verma V., Nagpal R., Kumar A., Gautam S.K., Behare P.V., et al. Effect of Probiotic fermented milk and chlorophyllin on gene expressions and genotoxicity during afb1-induced hepatocellular carcinoma. Gene 2011, 490:54-59.
8. Kumar M., Mohania D., Poddar D., Behare P.V., Nagpal R., Kumar A., Aggarwal P.K. A probiotic fermented milk prepared by mixed culture combination reduces pathogen shedding and alleviates disease signs in rats challenged with pathogens. Int J Probiotics Prebiotics 2009, 4:211-218.
9. Kumar M., Kumar A., Nagpal R., Mohania D., Behare P., Verma V., et al. Cancer-preventing attributes of probiotics: an update. Int J Food Sci Nutr 2010, 61:473-496.
10. 1-induced liver carcinogenesis in rats. Br J Nutr 2012, 107:1006-1016.
11. Ooi L.G., Liong M.T. Cholesterol-lowering effects of probiotics and prebiotics: a review of in vivo and in vitro findings. Int J Mol Sci 2010, 11:2499-2522.
12. Begley M., Hill C., Gahan C.G. Bile salt hydrolase activity in probiotics. Appl Environ Microbiol 2006, 72:1729-1738.
13. Liong M.T. Probiotics: a critical review of their potential role as antihypertensives, immune modulators, hypocholesterolemics, and perimenopausal treatments. Nutr Rev 2007, 65:316-328.
14. Liong M.T., Shah N.P. Production of organic acids from fermentation of mannitol, fructooligosaccharide and inulin by a cholesterol removing Lactobacillus acidophilus strain. J Appl Microbiol 2005, 99:783-793.
15. Lye H.S., Rusul G., Liong M.T. Removal of cholesterol by lactobacilli via incorporation and conversion to coprostanol. J Dairy Sci 2010, 93:1383-1392.
16. Maenthaisong R., Chaiyakunapruk N., Niruntraporn S., Kongkaew C. The efficacy of aloe vera used for burn wound healing: a systematic review. Burns 2007, 33:713-718.
17. Bunyapraphatsara N., Yongchaiyudha S., Rungpitarangsi V., Chokechaijaroenporn O. Antidiabetic activity of Aloe vera L juice. II. Clinical trial in diabetes mellitus patients in combination with glibenclamide. Phytomedicine 1996, 3:245-248.
18. Rajasekaran S., Ravi K., Sivagnanam K., Subramanian S. Beneficial effects of aloe vera leaf gel extract on lipid profile status in rats with streptozotocin diabetes. Clin Exp Pharmacol Physiol 2006, 33:232-237.
19. Bottenberg M.M., Wall G.C., Harvey R.L., Habib S. Oral Aloe vera-induced hepatitis. Ann Pharmacother 2007, 41:1740-1743.
20. Langmead L., Feakins R.M., Goldthorpe S., Holt H., Tsironi E., De Silva A., et al. Randomized, double-blind, placebo-controlled trial of oral aloe vera gel for active ulcerative colitis. Aliment Pharmacol Ther 2004, 19:739-747.
21. Sumbul S., Ahmed S.W., Iqbal A. Antifungal activity of Allium, Aloe, and Solanum species. Pharm Biol 2004, 42:491-498.
22. Lim B.O., Seong N.S., Choue R.W., Kim J.D., Lee H.Y., Kim S.Y., et al. Efficacy of dietary aloe vera supplementation on hepatic cholesterol and oxidative status in aged rats. J Nutr Sci Vitaminol (Tokyo) 2003, 49:292-296.
23. Huseini H.F., Kianbakht S., Hajiaghaee R., Dabaghian F.H. Anti-hyperglycemic and anti-hypercholesterolemic effects of aloe vera leaf gel in hyperlipidemic type 2 diabetic patients: a randomized double-blind placebo-controlled clinical trial. Planta Med 2012, 78:311-316.
24. Friedewald W.T., Levy R.I., Fredrickson D.S. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem 1972, 18:499-502.
25. Massimi M., Lear S.R., Huling S.L., Jones A.L., Erickson S.K. Cholesterol 7α-hydroxylase (CYP7A): patterns of messenger RNA expression during rat liver development. Hepatology 1998, 28:1064-1072.
26. Akalin A.S., Gonc S., Duzel S. Influence of yoghurt and acidophilus yoghurt on serum cholesterol levels in mice. J Dairy Sci 1997, 80:2721-2725.
27. Xiao J.Z., Kondo S., Takahashi N., Miyaji K., Oshida K., Hiramatsu A., et al. Effect of milk products fermented by Bifidobacterium longum on blood lipids in rats and healthy adult male volunteers. J Dairy Sci 2003, 86:2452-2461.
28. Brown M.S., Goldstein J.L. A receptor-mediated pathway for cholesterol homeostasis. Review. Science 1986, 232:34-47.
29. Goldstein J.L., Brown M.S. Regulation of the mevalonate pathway. Review. Nature 1990, 343:425-430.
30. Mayes P.A., Botham K.M. Cholesterol synthesis, transport, and excretion. Harper's illustrated biochemistry 2003, 219-230. McGraw-Hill Companies, New York. 26th ed. P.K. Murray, D.K. Granner, P.A. Mayes, V.W. Rodwell (Eds.).
31. Smit M.J., Kuipers F., Vonk R.J., Temmerman A.M., Jäckle S., Windler E.E. Effects of dietary cholesterol on bile formation and hepatic processing of chylomicron remnant cholesterol in the rat. Hepatology 1993, 17:445-454.
32. Reynier M.O., Montet J.C., Gerolami A., Marteau C., Crotte C., Montet A.M., Mathieu S. Comparative effects of cholic, chenodeoxycholic, and ursodeoxycholic acids on micellar solubilization and intestinal absorption of cholesterol. J Lipid Res 1981, 22:467-473.
33. Wolever T.M.S., Fernandes J., Rao A.V. Serum acetate:propionate ratio is related to serum cholesterol in men but not women. J Nutr 1996, 126:2790-2797.
34. Wong J.M., de Souza R., Kendall C.W., Emam A., Jenkins D.J. Colonic health: fermentation and short chain fatty acids. J Clin Gastroenterol 2006, 40:235-243.
35. Venter C.S., Hester V.H., Cummings J.H. Effects of dietary propionate on carbohydrate and lipid metabolism in healthy volunteers. Am J Gastroenterol 1990, 85:549-553.
36. Cummings J.H., Macfarlane G.T. Role of intestinal bacteria in nutrient metabolism. J Parenter Enteral Nutr 1997, 21:357-365.
37. Wolever T.M.S., Spadafora P., Eshuis H. Interaction between colonic acetate and propionate in humans. Am J Clin Nutr 1991, 53:681-687.
38. Yadav H., Jain S., Sinha P.R. Antidiabetic effect of probiotic dahi containing Lactobacillus acidophilus and Lactobacillus casei in high fructose fed rats. Nutrition 2007, 23:62-68.
39. Singh B., Bhat T.K., Singh B. Potential therapeutic applications of some antinutritional plant secondary metabolites. J Agric Food Chem 2003, 51:5579-5597.
40. Nassiff H.A., Fajardo F., Velez F. Effecto del aloe sobre la hiperlipidemia en pacientes refractarios a la dieta. Rev Cuba Med Gen Integr 1993, 9:43-51.
41. Kim K., Kim H., Kwon J., Lee S., Kong H., Im S.A., et al. Hypoglycemic and hypolipidemic effects of processed Aloe vera gel in a mouse model of non-insulin-dependent diabetes mellitus. Phytomedicine 2009, 16:856-863.
42. Rodríguez Rodríguez E., Darias Martín J., Díaz Romero C. Aloe vera as a functional ingredient in foods. Crit Rev Food Sci Nutr 2010, 50:305-326.