Aloe emodin glycosides stimulates glucose transport and glycogen storage through PI3K dependent mechanism in L6 myotubes and inhibits adipocyte differentiation in 3T3L1 adipocytes

FEBS Letters

Volumn 584, Issue 14, 2010, Pages 3170-3178

  Anand, S ^a   Muthusamy, V S ^a   Sujatha, S ^a   Sangeetha, K N ^a   Bharathi Raja, R ^a   Sudhagar, S ^a   Poornima Devi, N ^a   Lakshmi, B S ^a  

^a ANNA UNIVERSITY   (India)

Author keywords

Aloe emodin glycosides; Glucose transporter 4; Glycogen synthesis; Insulin resistance; Insulin signaling; Phosphatidyl inositol 3 kinase

Indexed keywords

ALOE EMODIN 8 O GLYCOSIDE; GLUCOSE; GLUCOSE TRANSPORTER 4; GLYCOGEN; GLYCOGEN SYNTHASE KINASE 3BETA; INSULIN RECEPTOR; INSULIN RECEPTOR BETA; INSULIN RECEPTOR SUBSTRATE 1; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PLANT GLYCOSIDE; PROTEIN KINASE B; PROTEIN TYROSINE KINASE INHIBITOR; UNCLASSIFIED DRUG; GLYCOGEN SYNTHASE KINASE; GLYCOSIDE; INSULIN;

ADIPOCYTE; ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CELL STRAIN 3T3; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFICACY; DRUG MECHANISM; DRUG STRUCTURE; GLUCOSE TRANSPORT; GLYCOGEN METABOLISM; GLYCOGEN SYNTHESIS; IMMUNOBLOTTING; INSULIN RESISTANCE; MITOSIS INHIBITION; MOUSE; MYOTUBE; NONHUMAN; PRIORITY JOURNAL; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION; ANIMAL; CARBOHYDRATE METABOLISM; DRUG EFFECT; METABOLISM; SKELETAL MUSCLE; TRANSPORT AT THE CELLULAR LEVEL;

ALOE;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ADIPOCYTES; ANIMALS; BIOLOGICAL TRANSPORT; CARBOHYDRATE METABOLISM; CELL DIFFERENTIATION; GLUCOSE; GLYCOGEN; GLYCOGEN SYNTHASE KINASES; GLYCOSIDES; INSULIN; INSULIN RESISTANCE; MICE; MUSCLE FIBERS, SKELETAL; RECEPTOR, INSULIN;

EID: 77954176088     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.febslet.2010.06.004     Document Type: Article

References (46)

1. Sumana G., Suryawanshi S.A. Effect of Vinca rosea extracts in treatment of alloxan diabetes in male albino rats. Indian J. Exp. Biol. 2001, 39:748-758.
2. Melander A. Non-insulin dependent diabetes mellitus treatment with Sulphonylureas. Clinical Endocrinology and Metabolism 1988, 443-453. Balliere-Tindall, London. M. Natrass, P. Hale (Eds.).
3. Kahn C.R. Banting lecture. Insulin action, diabetogenes, and the cause of type 2 diabetes. Diabetes 1994, 43:1066-1084.
4. Hamman J.H. Composition and applications of Aloe vera leaf gel. Molecules 2008, 13:1599-1616.
5. Tsai T.H., Chen C.F. Ultra violet spectrum identification of emodin in rabbit plasma by HPLC and its pharmacokinetics application. Asia-Pac. J. Pharmacol. 1992, 7:53-56.
6. Liang J.W., Hsiu S.L., Huang H.C., Lee-Chao P.D. HPLC analysis of emodin in serum, herbs and Chinese herbal prescriptions. J. Food Drug Anal. 1993, 1:251-257.
7. Wasserman L., Avigad S., Beery E., Nordenberg J., Fenig E. The effect of aloe emodin on the proliferation of a new Merkel carcinoma cell line. Am. J. Dermatopathol. 2002, 24:17-22.
8. Fenig E., Nordenberg J., Beery E., Sulkes J., Wasserman L. Combined effect of aloe-emodin and chemotherapeutic agents on the proliferation of an adherent variant cell line of Merkel cell carcinoma. Oncol. Rep. 2004, 11:213-217.
9. Chen H.C., Hsieh W.T., Chang W.C., Chung J.G. Aloe-emodin induced in vitro G2/M arrest of cell cycle in human promyelocytic leukemia HL-60 cells. Food Chem. Toxicol. 2004, 42:1251-1257.
10. Pecere T., Gazzola M., Mucignat V., et al. Aloe-emodin is a new type of anticancer agent with selective activity against neuroectodermal tumors. Cancer Res. 2000, 60:2800-2804.
11. Saleem R., Faizi S., Siddiqui B.S., et al. Hypotensive effect of chemical constituents from Aloe barbadensis. Planta Med. 2001, 67:757-760.
12. Yonemitsu S., Nishimura H., Shintani M., et al. Troglitazone induces GLUT4 translocation in L6 myotubes. Diabetes 2001, 50:1093-1101.
13. Gayathri B., Manjula N., Vinay kumar K.S., Lakshmi B.S., Balakrishnan A. Pure compound from Boswellia serrata extract exhibits anti-inflammatory properties in human PBMC's and mouse macrophages through inhibition of TNF alpha, IL-1 beta, NO and MAP kinases. Int. Immunopharmacol. 2007, 7(4):473-482.
14. Ambati S., Kim H.K., Yang J.Y., Lin J., Della-Fera M.A., Baile C.A. Effects of leptin on apoptosis and adipogenesis in 3T3-L1 adipocytes. Biochem. Pharmacol. 2007, 73:378-384.
15. Merlijn B., Peter J.A., Maassen J.A. Genistein directly inhibits GLUT4 mediated glucose uptake in 3T3-L1 adipocytes. Biochem. Biophys. Res. Commun. 2005, 326:511-514.
16. Zhe C., Pang Tao., Min Gu., et al. Berberine stimulated glucose uptake in L6 myotubes involves both AMPK and p38 MAPK. Biochim. Biophys. Acta 2006, 1760:1682-1689.
17. Muthusamy V.S., Anand S., Sangeetha K.N., Sujatha S., Arun B., Lakshmi B.S. Tannins present in Cichorium intybus enhance glucose uptake and inhibit adipogenesis in 3T3-L1 adipocytes through PTP1B inhibition. Chem.-Biol. Interact. 2008, 174:69-78.
18. Tzeng Y.-M., Chen K., Rao Y.K., Lee M.-J. Kaempferitrin activates the insulin signaling pathway and stimulates secretion of adiponectin in 3T3-L1 adipocytes. Mol. Cell. Pharmacol. 2009, 10.1016/j.ejphar.2009.01.023.
19. Sangeetha K.N., Sujatha S., Muthusamy V.S., Anand S., Nithya N., Velmurugan D., Balakrishnan Arun., Lakshmi B.S. 3β-taraxerol of Mangifera indica, a PI3K dependent dual activator of glucose transport and glycogen synthesis in 3T3-L1 adipocytes. Biochim. Biophys. Acta 2010, 1800:359-366.
20. Gould G.W., Derechin V., James D.E., Tordjman K., Ahern S., Gibbs E.M., Lienhard G.E., Mueckler M. Insulin stimulated translocation of the HepG2/erythrocyte type glucose transporter expressed in 3T3 L1 adipocytes. J. Biol. Chem. 1989, 264:2180-2184.
21. Shepherd P.R., Withers D.J., Siddle K. Phosphoinositide 3 kinase. The key switch mechanism in insulin signaling. Biochem. J. 1998, 333:471-490.
22. Zierath J.R., Krook A., Wallberg-Henriksson H. Insulin action and insulin resistance in human skeletal muscle. Diabetologia 2000, 43(7):821-835.
23. Whitehead J.P., Clark Sharon F., Urs B., James David E. Signaling through the insulin receptor. Curr. Opin. Cell Biol. 2000, 12:222-228.
24. Laville M., Auboeuf D., Khalfallah Y., Vega N., Riou J.P., Vidal H. Acute regulation by insulin of phosphotidylinositol-3-kinase, Rad, GLUT4 and lipoprotein lipase mRNA Levels in human muscle. J. Clin. Invest. 1996, 98:43-49.
25. Leng Y., Karlsson H.R., Zierath J.R. Insulin signaling defects in type 2 diabetes. Rev. Endocr. Metab. Disord. 2004, 5:111-117.
26. Ueki K., Yamamoto-Honda R., Kaburagi Y., Yamauchi T., et al. Potential role of protein kinase B in insulin-induced glucose transport, glycogen synthesis, and protein synthesis. J. Biol. Chem. 1998, 273(9):5315-5322.
27. Cross D.A., Alessi D.R., Cohen P., Andjelkovich M., Hemmings B.A. Inhibition of glycogen synthase kinase- 3 by insulin mediated by protein kinase B. Nature 1995, 378:785-789.
28. Tanti J.F., Grillo S., Gremeaux T., Coffer P.J., Van Obberghen E., Le Marchand-Brustel Y. Potential role of protein kinase B in glucose transporter 4 translocation in adipocytes. Endocrinology 1997, 138:2005-2010.
29. Ueki K., Yamamoto-Honda R., Kaburagi Y., Yamauchi T., Tobe K., Burgering B.M.T., Coffer P.J., Komuro I., Akanuma Y., Yazaki Y., Kadowaki T. Potential role of protein kinase B in insulin-induced glucose transport, glycogen synthesis, and protein synthesis. J. Biol. Chem. 1998, 273:5315-5322.
30. Gino M.S., Pelaez F., Zhang Bei B. Discovery of a small molecule insulin receptor activator. J. Endocrinol. 2001, 107-127.
31. Jung K.H., Choi H.S., Kim D.H., Han M.Y., Chang U.J., Yim S.V., Song B.C., Kim C.H., Kang S.A. Epigallocatechin gallate stimulates glucose uptake through the phosphatidylinositol 3-kinase-mediated pathway in L6 rat skeletal muscle cells. J. Med. Food. 2008, 11(3):429-434.
32. Sujatha S., Anand S., Sangeetha K.N., Shilpa K., Lakshmi J., Balakrishnan A., Lakshmi B.S. Biological evaluation of (3β)-STIGMAST-5-EN-3-OL as potent anti-diabetic agent in regulating glucose transport using in vitro model. Int. J. Diabetes Mellitus 2010, 10.1016/j.ijdm.2009.12.013.
33. Goodyear L.J., Giorgino F., Sherman L.A., Carey J., Smith R.J., Dohm G.L. Insulin receptor phosphorylation, insulin receptor substrate-1 phosphorylation, and phosphatidylinositol 3-kinase activity are decreased in intact skeletal muscle strips from obese subjects. J. Clin. Invest. 1995, 95(5):2195-2204.
34. Pessin J., Thurmond D., Elmendorf J., Coker K., Andokada S. 'Molecular basis of insulin-stimulated GLUT4 vesicle trafficking'. J. Biol. Chem. 1999, 274:2593-2596.
35. Klip A., Leiter L.A. Cellular mechanism of action of metformin. Diabetes Care 1990, 13:696-704.
36. Jiang Z.Y., Zhou Q.L., Coleman K.A., et al. Insulin signaling through Akt/protein kinase B analyzed by small interfering RNA-mediated gene silencing. Proc. Natl. Acad. Sci. USA 2003, 100:7569-7574.
37. Orena S.J., Torchia A.J., Garofalo R.S. Inhibition of glycogen synthase kinase 3 stimulates glycogen synthase and glucose transport by distinct mechanism in 3T3L1 adipocytes. J. Biol. Chem. 2000, 275:15765-15772.
38. Cross D.A., Alessi D.R., Cohen P., Andjelkovich M., Hemmings B.A. Inhibition of glycogen synthase 3 by insulin mediated by protein kinase B. Nature 1995, 378:785-789.
39. MacDougald O.A., Mandrup S. Adipogenesis: forces that tip the scales. Trends Endocrinol. Metab. 2002, 13:5-11.
40. Sheng X., Zhang Y., Gong Z., Huang C., Zang Y.Q. improved insulin resistance and lipid metabolism by cinnamon extract through activation of peroxisome proliferator-activated receptors. PPAR Res. 2008, 581348.
41. Pastromas S., Koulouris S. Thiazolidinediones: antidiabetic drugs with cardiovascular effects. Hellenic J. Cardiol. 2006, 47:352-360.
42. Zhang S., Zhang Z.-Y. PTP 1B as a drug target; recent developments in PTP 1B inhibitor discovery. Drug Discovery Today 2007, 12(9-10).
43. Bertrand L., Ginion A., Beauloye C., Hebert Alexandre D., Guigas B., Hue L., Vanoverschelde J.-L. AMPK activation restores the stimulation of glucose uptake in an in vitro model of insulin-resistant cardiomyocytes via the activation of protein kinase B. Am. J. Physiol. Heart Circ. Physiol. 2006, 291:H239-H250.
44. Bjornholm M., Kawano Y., Lehtihet M., Zierath J.R. Insulin receptor substrate-1 phosphorylation and phosphatidylonositol 3-kinase activity are decreased in skeletal muscle from NIDDM subjects following in vivo insulin stimulation. Diabetes 1997, 46:524-527.
45. Goodyear W.T., Giorgino F., Sherman L.A., Carvey J., Smith R.J., Dohm G.L. Insulin receptor phosphorylation, insulin receptor substrate-1 phosphorylation and phosphatidylinositol 3- kinase activity are decreased in intact skeletal muscle strips from obese subjects. J. Clin. Invest. 1995, 95:2195-2204.
46. Rondinone C.M., Trevillyan J.M., Clampit J., et al. Protein tyrosine phosphatase 1B reduction regulates adiposity and expression of genes involved in lipogenesis. Diabetes 2002, 51:2405-2411.