Aloe vera downregulates LPS-induced inflammatory cytokine production and expression of NLRP3 inflammasome in human macrophages

Molecular Immunology

Volumn 56, Issue 4, 2013, Pages 471-479

  Budai, Marietta M ^a   Varga, Aliz ^a   Milesz, Sándor ^b   Tozsér, József ^a   Benko, Szilvia ^a  

^a UNIVERSITY OF DEBRECEN   (Hungary)

^b FLP Hungary   (Hungary)

Author keywords

Aloe vera; Cytokine; Macrophage; Nlrp3 inflammasome; P2X7R; Signal transduction

Indexed keywords

ADENOSINE TRIPHOSPHATE; CASPASE; CRYOPYRIN; CYTOKINE; I KAPPA B; INFLAMMASOME; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE; PURINERGIC P2X7 RECEPTOR; TUMOR NECROSIS FACTOR ALPHA; CARRIER PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA CONVERTING ENZYME; NLRP3 PROTEIN, HUMAN; PLANT MEDICINAL PRODUCT;

ALOE VERA; ARTICLE; BIOSENSOR; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DOWN REGULATION; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IMMUNOMODULATION; MACROPHAGE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; ALOE; CELL CULTURE; CELL DIFFERENTIATION; CELL SURVIVAL; CHEMISTRY; CYTOLOGY; DOSE RESPONSE; DRUG EFFECTS; GENE EXPRESSION; GENETICS; METABOLISM; MONOCYTE; PHOSPHORYLATION; TUMOR CELL LINE; WESTERN BLOTTING;

ALOE; BLOTTING, WESTERN; CARRIER PROTEINS; CASPASE 1; CELL DIFFERENTIATION; CELL LINE, TUMOR; CELL SURVIVAL; CELLS, CULTURED; CYTOKINES; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; GENE EXPRESSION; HUMANS; INFLAMMASOMES; INTERLEUKIN-1BETA; LIPOPOLYSACCHARIDES; MACROPHAGES; MITOGEN-ACTIVATED PROTEIN KINASES; MONOCYTES; NF-KAPPA B; PHOSPHORYLATION; PLANT PREPARATIONS; RECEPTORS, PURINERGIC P2X7;

EID: 84881111515     PISSN: 01615890     EISSN: 18729142     Source Type: Journal    
DOI: 10.1016/j.molimm.2013.05.005     Document Type: Article

References (46)

1. Akira S., Takeda K. Toll-like receptor signalling. Nat. Rev. Immunol. 2004, 4:499-511.
2. Barrantes E., Guinea M. Inhibition of collagenase and metalloproteinases by aloins and aloe gel. Life Sci. 2003, 72(7):843-850.
3. Bauernfeind F.G., Horvath G., Stutz A., Alnemri E.S., MacDonald K., Speert D., et al. Cutting edge: NF-kappaB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression. J. Immunol. 2009, 183:787-791.
4. Cassel S.L., Joly S., Sutterwala F.S. The NLRP3 inflammasome: a sensor of immune danger signals. Seminar Immunol. 2009, 4:194-198.
5. Ciraci C., Janczy J.R., Sutterwala F.S., Cassel S.L. Control of innate and adaptive immunity by the inflammasome. Microbes Infect. 2012, 14:1263-1270.
6. Dat A.D., Poon F., Pham K.B., Doust J. Aloe vera for treating acute and chronic wounds. Cochrane Database Syst. Rev. 2012, 2. CD008762.
7. Davis R.H., Leitner M.G., Russo J.M., Byrne M.E. Anti-inflammatory activity of Aloe vera against a spectrum of irritants. J. Am. Pediatr. Med. Assoc. 1989, 79:263-276.
8. De Nardo D., Latz E. NLRP3 inflammasomes link inflammation and metabolic disease. Trends Immunol. 2011, 32:373-379.
9. Dinarello C.A. Interleukin-1. Cytokine Growth Factor Rev. 1997, 8:253-265.
10. Dinarello C.A. Immunological and inflammatory functions of the interleukin-1 family. Annu. Rev. Immunol. 2009, 27:519-550.
11. Dinarello C.A. Blocking interleukin-1beta in acute and chronic autoinflammatory diseases. J. Intern. Med. 2011, 269:16-28.
12. Dinarello C.A. A clinical perspective of IL-1beta as the gatekeeper of inflammation. Eur. J. Immunol. 2011, 41:1203-1217.
13. Duansak D., Somboonwong J., Patumraj S. Effects of Aloe vera on leukocyte adhesion and TNF-alpha and IL-6 levels in burn wounded rats. Clin. Hemorheol. Microcirc. 2003, 29:239-246.
14. Eamlamnam K., Patumraj S., Visedopas N., Thong-Ngam D. Effects of Aloe vera and sucralfate on gastric microcirculatory changes, cytokine levels and gastric ulcer healing in rats. World J. Gastroenterol. 2006, 12:2034-2039.
15. Franchi L., Munoz-Planillo R., Nunez G. Sensing and reacting to microbes through the inflammasomes. Nat. Immunol. 2012, 13:325-332.
16. Gabay C., Lamacchia C., Palmer G. IL-1 pathways in inflammation and human diseases. Nat. Rev. Rheumatol. 2010, 6:232-241.
17. Grahames C.B.A., Michel A.D., Chessell I.P., Humphrey P.A. Pharmacological characterization of ATP- and LPS-induced IL-1β release in human monocyte. Br. J. Pharmacol. 1999, 127:1915-1921.
18. Gross O., Thomas C.J., Guarda G., Tschopp J. The inflammasome: an integrated view. Immunol. Rev. 2011, 243:136-151.
19. Habeeb F., Stables G., Bradbury F., Nong S., Cameron P., Plevin R., et al. The inner gel component of Aloe vera suppresses bacterial-induced pro-inflammatory cytokines from human immune cells. Methods 2007, 42:388-393.
20. Hamman J.H. Composition and applications of Aloe vera leaf gel. Molecules 2008, 13:1599-1616.
21. Hamman J.H. Composition and applications of Aloe vera leaf gel. Molecules 2008, 13(8):1599-1616.
22. Hsu H.Y., Wen M.H. Lipopolysaccharide-mediated reactive oxygen species and signal transduction in the regulation of interleukin-1 gene expression. J. Biol. Chem. 2002, 277:22131-22139.
23. Im S.A., Lee Y.R., Lee Y.H., Lee M.K., Park Y.I., Lee S., et al. In vivo evidence of the immunomodulatory activity of orally administered Aloe vera gel. Arch. Pharm. Res. 2010, 33:451-456.
24. Juliana C., Fernandes-Alnemri T., Kang S., Farias A., Qin F., Alnemri E.S. Non-transcriptional priming and deubiquitination regulate NLRP3 inflammasome activation. J. Biol. Chem. 2012, 43:36617-36622.
25. Karaca K., Sharma J.M., Nordgren R. Nitric oxide production by chicken macrophages activated by Acemannan, a complex carbohydrate extracted from Aloe vera. Int. J. Immunopharmacol. 1995, 17(3):183-188.
26. Langmead L., Makins R.J., Rampton D.S. Anti-inflammatory effects of aloe vera gel in human colorectal mucosa in vitro. Aliment. Pharmacol. Ther. 2004, 19:521-527.
27. Liao P.C., Chao L.K., Chou J.C., Dong W.C., Lin C.N., Lin C.Y., et al. Lipopolysaccharide/adenosine triphosphate-mediated signal transduction in the regulation of NLRP3 protein expression and caspase-1-mediated interleukin-1beta secretion. Inflamm. Res. 2012, 62:89-96.
28. Lopez-Castejon G., Brough D. Understanding the mechanism of IL-1beta secretion. Cytokine Growth Factor Rev. 2011, 22:189-195.
29. Menu P., Vince J.E. The NLRP3 inflammasome in health and disease: the good, the bad and the ugly. Clin. Exp. Immunol. 2011, 166:1-15.
30. Netea M.G., Nold-Petry C.A., Nold M.F., Joosten L.A.B., Opitz B., van der Meer J.H.M., et al. Differential requirement for the activation of the inflammasome for processing and release of IL-1beta in monocytes and macrophages. Blood 2009, 113:2324-2335.
31. Park M.Y., Kwon H.J., Sung M.K. Dietary aloin, aloesin, or aloe-gel exerts anti-inflammatory activity in a rat colitis model. Life Sci. 2011, 88:486-492.
32. Prabjone R., Thong-Ngam D., Wisedopas N., Chatsuwan T., Patumraj S. Anti-inflammatory effects of Aloe vera on leukocyte-endothelium interaction in the gastric microcirculation of Helicobacter pylori-infected rats. Clin. Hemorheol. Microcirc. 2006, 35:359-366.
33. Qiao Y., Wang P., Qi J., Zhang L., Gao C. TLR-induced NF-kappaB activation regulates NLRP3 expression in murine macrophages. FEBS Lett. 2012, 586:1022-1026.
34. Rathinam V.A., Vanaja S.K., Fitzgerald K.A. Regulation of inflammasome signaling. Nat. Immunol. 2012, 13:333-432.
35. Reuter J., Jocher A., Stump J., Grossjohann B., Franke G., Schempp C.M. Investigation of the anti-inflammatory potential of Aloe vera gel (97.5%) in the ultraviolet erythema test. Skin Pharmacol. Physiol. 2008, 21:106-110.
36. Rey-Giraud F., Hafner M., Ries C.H. In vitro generation of monocyte-derived macrophages under serum-free conditions improves their tumor promoting functions. Plos ONE 2012, 8:e42656.
37. Schroder K., Sagulenko V., Zamoshnikova A., Richards A.A., Cridland J.A., Irvine K.M. Acute lipopolysaccharide priming boosts inflammasome activation independently of inflammasome sensor induction. Immunobiology 2012, 217:1325-1329.
38. Surjushe A., Vasani R., Saple D.G. Aloe vera: a short review. Indian J. Dermatol. 2008, 53:163-166.
39. 't Hart L.A., Nibbering P.H., Van Den Barselaar M.T., van Dijk H., Van Den Berg A.J., Labadie R.P. Effects of low molecular constituents from Aloe vera gel on oxidative metabolism and cytotoxic and bactericidal activities of human neutrophils. Int. J. Immunopharmacol. 1990, 12(4):427-434.
40. Tracey K.J., Fong Y., Hesse D.G., Manogue K.R., Lee A.T., Kuo G.C., et al. Anti-cachectin/TNF monoclonal antibodies prevent septic shock during lethal bacteraemia. Nature 1987, 330:662-664.
41. Van't Wout E.F., van Schadewijk A., Savage N.D., Stolk J., Hiemstra P.B. α1-Antitrypsin production by proinflammatory and antiinflammatory macrophages and dendritic cells. Am. J. Resp. Cell Mol. Biol. 2012, 5:607-613.
42. Vazquez B., Avila G., Segura D., Escalante B. Antiinflammatory activity of extracts from Aloe vera gel. J. Ethnopharmacol. 1996, 55:69-75.
43. Vijayalakshmi D., Dhandapani R., Jayaveni S., Jithendra P.S., Rose C., Mandal A.B. In vitro anti-inflammatory activity of Aloe vera by down regulation of MMP-9 in peripheral blood mononuclear cells. J. Ethnopharmacol. 2012, 141:542-546.
44. Vogler B.K., Ernst E. Aloe vera: a systematic review of its clinical effectiveness. Br. J. Gen. Pract. 1999, 49:823-828.
45. Yu C.S., Yu F.S., Chan J.K., Li T.M., Lin S.S., Chen S.C., Hsia T.C., Chang Y.H., Chung J.G. Aloe-emodin affects the levels of cytokines and functions of leukocytes from Sprague-Dawley rats. In Vivo 2006, 20(4):505-509.
46. Yun N., Lee C.H., Lee S.M. Protective effect of Aloe vera on polymicrobial sepsis in mice. Food Chem. Toxicol. 2009, 47:1341-1348.