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Volumn 5, Issue JUL, 2015, Pages

Overview of methods for overcoming hindrance to drug delivery to tumors, with special attention to tumor interstitial fluid

Author keywords

Adjuvant; Chemotherapy; Drug delivery systems; Tumor interstitial fluid; Tumor interstitial fluid pressure; Vascular normalization

Indexed keywords

ANGIOPOIETIN; BEVACIZUMAB; HYDRALAZINE; NOTCH4 RECEPTOR; NUTRACEUTICAL; PLATELET DERIVED GROWTH FACTOR; VASCULOTROPIN;

EID: 84940106291     PISSN: None     EISSN: 2234943X     Source Type: Journal    
DOI: 10.3389/fonc.2015.00165     Document Type: Review
Times cited : (64)

References (212)
  • 1
    • 8744280019 scopus 로고    scopus 로고
    • The contribution of cytotoxic chemotherapy to 5-year survival in adult malignancies
    • Morgan G, Ward R, Barton M. The contribution of cytotoxic chemotherapy to 5-year survival in adult malignancies. Clin Oncol (R Coll Radiol) (2004) 16(8):549-60. doi: 10.1016/j.clon.2004.06.007.
    • (2004) Clin Oncol (R Coll Radiol) , vol.16 , Issue.8 , pp. 549-560
    • Morgan, G.1    Ward, R.2    Barton, M.3
  • 2
    • 0018778710 scopus 로고
    • Pharmacokinetics of methotrexate in solid tumors
    • Jain RK, Wei J, Gullino PM. Pharmacokinetics of methotrexate in solid tumors. J Pharmacokinet Biopharm (1979) 7(2):181-94. doi:10.1007/BF01059737.
    • (1979) J Pharmacokinet Biopharm , vol.7 , Issue.2 , pp. 181-194
    • Jain, R.K.1    Wei, J.2    Gullino, P.M.3
  • 4
    • 0015874380 scopus 로고
    • Primary mammary tumors connected to the host by a single artery and vein
    • Grantham FH, Hill DM, Gullino PM. Primary mammary tumors connected to the host by a single artery and vein. J Natl Cancer Inst (1973) 50(5):1381-3.
    • (1973) J Natl Cancer Inst , vol.50 , Issue.5 , pp. 1381-1383
    • Grantham, F.H.1    Hill, D.M.2    Gullino, P.M.3
  • 6
    • 0027944129 scopus 로고
    • Characterisation of tumour blood flow using a 'tissue-isolated' preparation
    • Tozer GM, Shaffi KM, Prise VE, Cunningham VJ. Characterisation of tumour blood flow using a 'tissue-isolated' preparation. Br J Cancer (1994) 70(6):1040-6. doi:10.1038/bjc.1994.445.
    • (1994) Br J Cancer , vol.70 , Issue.6 , pp. 1040-1046
    • Tozer, G.M.1    Shaffi, K.M.2    Prise, V.E.3    Cunningham, V.J.4
  • 7
    • 0028470454 scopus 로고
    • Barriers to drug delivery in solid tumors
    • Jain RK. Barriers to drug delivery in solid tumors. Sci Am (1994) 271(1):58-65. doi:10.1038/scientificamerican0794-58.
    • (1994) Sci Am , vol.271 , Issue.1 , pp. 58-65
    • Jain, R.K.1
  • 8
    • 84870240636 scopus 로고    scopus 로고
    • Delivery of molecular and cellular medicine to solid tumors
    • Jain RK. Delivery of molecular and cellular medicine to solid tumors. Adv Drug Deliv Rev (2012) 64(Suppl):353-65. doi:10.1016/j.addr.2012.09.011.
    • (2012) Adv Drug Deliv Rev , vol.64 , pp. 353-365
    • Jain, R.K.1
  • 9
    • 0029900738 scopus 로고    scopus 로고
    • Quantitation and physiological characterization of angiogenic vessels in mice: effect of basic fibroblast growth factor, vascular endothelial growth factor/vascular permeability factor, and host microenvironment
    • Dellian M, Witwer BP, Salehi HA, Yuan F, Jain RK. Quantitation and physiological characterization of angiogenic vessels in mice: effect of basic fibroblast growth factor, vascular endothelial growth factor/vascular permeability factor, and host microenvironment. Am J Pathol (1996) 149(1):59-71.
    • (1996) Am J Pathol , vol.149 , Issue.1 , pp. 59-71
    • Dellian, M.1    Witwer, B.P.2    Salehi, H.A.3    Yuan, F.4    Jain, R.K.5
  • 10
    • 0029804151 scopus 로고    scopus 로고
    • Fluorescence ratio imaging of interstitial pH in solid tumours: effect of glucose on spatial and temporal gradients
    • Dellian M, Helmlinger G, Yuan F, Jain RK. Fluorescence ratio imaging of interstitial pH in solid tumours: effect of glucose on spatial and temporal gradients. Br J Cancer (1996) 74(8):1206-15. doi:10.1038/bjc.1996.518.
    • (1996) Br J Cancer , vol.74 , Issue.8 , pp. 1206-1215
    • Dellian, M.1    Helmlinger, G.2    Yuan, F.3    Jain, R.K.4
  • 11
    • 0023219734 scopus 로고
    • Transport of molecules in the tumor interstitium: a review
    • Jain RK. Transport of molecules in the tumor interstitium: a review. Cancer Res (1987) 47(12):3039-51.
    • (1987) Cancer Res , vol.47 , Issue.12 , pp. 3039-3051
    • Jain, R.K.1
  • 12
    • 84940102290 scopus 로고    scopus 로고
    • Circumventing anatomic and physiologic barriers to the intratumoral delivery of therapeutics
    • Monsky WL. Circumventing anatomic and physiologic barriers to the intratumoral delivery of therapeutics. Anat Physiol (2012) 2:2-4. doi:10.4172/2161-0940.1000e114.
    • (2012) Anat Physiol , vol.2 , pp. 2-4
    • Monsky, W.L.1
  • 14
    • 79960025389 scopus 로고    scopus 로고
    • Role of tumor vascular architecture in drug delivery
    • Narang AS, Varia S. Role of tumor vascular architecture in drug delivery. Adv Drug Deliv Rev (2011) 63(8):640-58. doi:10.1016/j.addr.2011.04.002.
    • (2011) Adv Drug Deliv Rev , vol.63 , Issue.8 , pp. 640-658
    • Narang, A.S.1    Varia, S.2
  • 15
    • 84898542253 scopus 로고    scopus 로고
    • Hypoxia in tumors: pathogenesis-related classification, characterization of hypoxia subtypes, and associated biological and clinicalimplications
    • Vaupel P, Mayer A. Hypoxia in tumors: pathogenesis-related classification, characterization of hypoxia subtypes, and associated biological and clinicalimplications. Adv Exp Med Biol (2014) 812:19-24. doi:10.1007/978-1-4939-0620-8_3.
    • (2014) Adv Exp Med Biol , vol.812 , pp. 19-24
    • Vaupel, P.1    Mayer, A.2
  • 16
    • 84896543112 scopus 로고    scopus 로고
    • Vascular endothelial growth factor signaling in hypoxia and inflammation
    • Ramakrishnan S, Anand V, Roy S. Vascular endothelial growth factor signaling in hypoxia and inflammation. J Neuroimmune Pharmacol (2014) 9(2):142-60. doi:10.1007/s11481-014-9531-7.
    • (2014) J Neuroimmune Pharmacol , vol.9 , Issue.2 , pp. 142-160
    • Ramakrishnan, S.1    Anand, V.2    Roy, S.3
  • 17
    • 33745138232 scopus 로고    scopus 로고
    • Regulation of angiogenesis by hypoxia-inducible factor 1
    • Hirota K, Semenza GL. Regulation of angiogenesis by hypoxia-inducible factor 1. Crit Rev Oncol Hematol (2006) 59(1):15-26. doi:10.1016/j.critrevonc.2005.12.003.
    • (2006) Crit Rev Oncol Hematol , vol.59 , Issue.1 , pp. 15-26
    • Hirota, K.1    Semenza, G.L.2
  • 18
    • 84861494122 scopus 로고    scopus 로고
    • Antiangiogenic therapies targeting the vascular endothelia growth factor signaling system
    • Tie J, Desai J. Antiangiogenic therapies targeting the vascular endothelia growth factor signaling system. Crit Rev Oncog (2012) 17(1):51-67. doi:10.1615/CritRevOncog.v17.i1.50.
    • (2012) Crit Rev Oncog , vol.17 , Issue.1 , pp. 51-67
    • Tie, J.1    Desai, J.2
  • 19
    • 84871633270 scopus 로고    scopus 로고
    • Vascular endothelial growth factor and its receptor system: physiological functions in angiogenesis and pathological roles in various diseases
    • Shibuya M. Vascular endothelial growth factor and its receptor system: physiological functions in angiogenesis and pathological roles in various diseases. J Biochem (2013) 153(1):13-9. doi:10.1093/jb/mvs136.
    • (2013) J Biochem , vol.153 , Issue.1 , pp. 13-19
    • Shibuya, M.1
  • 20
    • 84872553104 scopus 로고    scopus 로고
    • VEGFA and tumour angiogenesis
    • Claesson-Welsh L, Welsh M. VEGFA and tumour angiogenesis. J Intern Med (2013) 273(2):114-27. doi:10.1111/joim.12019.
    • (2013) J Intern Med , vol.273 , Issue.2 , pp. 114-127
    • Claesson-Welsh, L.1    Welsh, M.2
  • 21
    • 14644440555 scopus 로고    scopus 로고
    • Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis
    • Hicklin DJ, Ellis LM. Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis. J Clin Oncol (2005) 23(5):1011-27. doi:10.1200/JCO.2005.06.081.
    • (2005) J Clin Oncol , vol.23 , Issue.5 , pp. 1011-1027
    • Hicklin, D.J.1    Ellis, L.M.2
  • 22
    • 0028355888 scopus 로고
    • PDGF-BB modulates endothelial proliferation and angiogenesis in vitro via PDGF beta-receptors
    • Battegay EJ, Rupp J, Iruela-Arispe L, Sage EH, Pech M. PDGF-BB modulates endothelial proliferation and angiogenesis in vitro via PDGF beta-receptors. J Cell Biol (1994) 125(4):917-28. doi:10.1083/jcb.125.4.917.
    • (1994) J Cell Biol , vol.125 , Issue.4 , pp. 917-928
    • Battegay, E.J.1    Rupp, J.2    Iruela-Arispe, L.3    Sage, E.H.4    Pech, M.5
  • 23
    • 84927132915 scopus 로고    scopus 로고
    • Vascular endothelial growth factor and angiogenesis in the regulation of cutaneous wound repair
    • Johnson KE, Wilgus TA. Vascular endothelial growth factor and angiogenesis in the regulation of cutaneous wound repair. Adv Wound Care (New Rochelle) (2014) 3(10):647-61. doi:10.1089/wound.2013.0517.
    • (2014) Adv Wound Care (New Rochelle) , vol.3 , Issue.10 , pp. 647-661
    • Johnson, K.E.1    Wilgus, T.A.2
  • 24
    • 80054012347 scopus 로고    scopus 로고
    • Developmental and pathological angiogenesis
    • Chung AS, Ferrara N. Developmental and pathological angiogenesis. Annu Rev Cell Dev Biol (2011) 27:563-84. doi:10.1146/annurev-cellbio-092910-154002.
    • (2011) Annu Rev Cell Dev Biol , vol.27 , pp. 563-584
    • Chung, A.S.1    Ferrara, N.2
  • 25
    • 84897937667 scopus 로고    scopus 로고
    • Role of tumor associated macrophages in tumor angiogenesis and lymphangiogenesis
    • Riabov V, Gudima A, Wang N, Mickley A, Orekhov A, Kzhyshkowska J. Role of tumor associated macrophages in tumor angiogenesis and lymphangiogenesis. Front Physiol (2014) 5:75. doi:10.3389/fphys.2014.00075.
    • (2014) Front Physiol , vol.5 , pp. 75
    • Riabov, V.1    Gudima, A.2    Wang, N.3    Mickley, A.4    Orekhov, A.5    Kzhyshkowska, J.6
  • 26
    • 68449085753 scopus 로고    scopus 로고
    • Angiogenesis: complexity of tumor vasculature and microenvironment
    • Furuya M, Yonemitsu Y, Aoki IIII. Angiogenesis: complexity of tumor vasculature and microenvironment. Curr Pharm Des (2009) 15(16):1854-67. doi:10.2174/138161209788453275.
    • (2009) Curr Pharm Des , vol.15 , Issue.16 , pp. 1854-1867
    • Furuya, M.1    Yonemitsu, Y.2    Aoki, I.3
  • 27
    • 0037404072 scopus 로고    scopus 로고
    • Aberrant vascular architecture in tumors and its importance in drug-based therapies
    • Munn LL. Aberrant vascular architecture in tumors and its importance in drug-based therapies. Drug Discov Today (2003) 8(9):396-403. doi:10.1016/S1359-6446(03)02686-2.
    • (2003) Drug Discov Today , vol.8 , Issue.9 , pp. 396-403
    • Munn, L.L.1
  • 28
    • 84894257687 scopus 로고    scopus 로고
    • Computational approach to characterize causative factors and molecular indicators of chronic wound inflammation
    • Nagaraja S, Wallqvist A, Reifman J, Mitrophanov AY. Computational approach to characterize causative factors and molecular indicators of chronic wound inflammation. J Immunol (2014) 192(4):1824-34. doi:10.4049/jimmunol.1302481.
    • (2014) J Immunol , vol.192 , Issue.4 , pp. 1824-1834
    • Nagaraja, S.1    Wallqvist, A.2    Reifman, J.3    Mitrophanov, A.Y.4
  • 29
    • 0035906856 scopus 로고    scopus 로고
    • 3D microvascular architecture of pre-cancerous lesions and invasive carcinomas of the colon
    • Konerding MA, Fait E, Gaumann A. 3D microvascular architecture of pre-cancerous lesions and invasive carcinomas of the colon. Br J Cancer (2001) 84(10):1354-62. doi:10.1054/bjoc.2001.1809.
    • (2001) Br J Cancer , vol.84 , Issue.10 , pp. 1354-1362
    • Konerding, M.A.1    Fait, E.2    Gaumann, A.3
  • 30
    • 84955388268 scopus 로고    scopus 로고
    • Vascular casting for the study of vascular morphogenesis
    • Ackermann M, Konerding MA. Vascular casting for the study of vascular morphogenesis. Methods Mol Biol (2015) 1214:49-66. doi:10.1007/978-1-4939-1462-3_5.
    • (2015) Methods Mol Biol , vol.1214 , pp. 49-66
    • Ackermann, M.1    Konerding, M.A.2
  • 31
    • 84900327941 scopus 로고    scopus 로고
    • Blood vessels in cancer: can't stop whispering
    • Azzi S, Gavard J. [Blood vessels in cancer: can't stop whispering]. Med Sci (Paris) (2014) 30(4):408-14. doi:10.1051/medsci/20143004015.
    • (2014) Med Sci (Paris) , vol.30 , Issue.4 , pp. 408-414
    • Azzi, S.1    Gavard, J.2
  • 32
    • 84878962706 scopus 로고    scopus 로고
    • Vascular hyperpermeability, angiogenesis, and stroma generation
    • Nagy JA, Dvorak AM, Dvorak HF. Vascular hyperpermeability, angiogenesis, and stroma generation. Cold Spring Harb Perspect Med (2012) 2(2):a006544. doi:10.1101/cshperspect.a006544.
    • (2012) Cold Spring Harb Perspect Med , vol.2 , Issue.2
    • Nagy, J.A.1    Dvorak, A.M.2    Dvorak, H.F.3
  • 33
    • 0029010434 scopus 로고
    • Increased microvascular permeability and endothelial fenestration induced by vascular endothelial growth factor
    • Roberts WG, Palade GE. Increased microvascular permeability and endothelial fenestration induced by vascular endothelial growth factor. J Cell Sci (1995) 108(Pt 6):2369-79.
    • (1995) J Cell Sci , vol.108 , pp. 2369-2379
    • Roberts, W.G.1    Palade, G.E.2
  • 34
    • 25644449640 scopus 로고    scopus 로고
    • Pathophysiological consequences of VEGF-induced vascular permeability
    • Weis SM, Cheresh DA. Pathophysiological consequences of VEGF-induced vascular permeability. Nature (2005) 437(7058):497-504. doi:10.1038/nature03987.
    • (2005) Nature , vol.437 , Issue.7058 , pp. 497-504
    • Weis, S.M.1    Cheresh, D.A.2
  • 35
    • 77954333963 scopus 로고    scopus 로고
    • Vascular endothelial growth factors and vascular permeability
    • Bates DO. Vascular endothelial growth factors and vascular permeability. Cardiovasc Res (2010) 87(2):262-71. doi:10.1093/cvr/cvq105.
    • (2010) Cardiovasc Res , vol.87 , Issue.2 , pp. 262-271
    • Bates, D.O.1
  • 36
    • 0037036136 scopus 로고    scopus 로고
    • Lymphatic metastasis in the absence of functional intratumor lymphatics
    • Padera TP, Kadambi A, di Tomaso E, Carreira CM, Brown EB, Boucher Y, et al. Lymphatic metastasis in the absence of functional intratumor lymphatics. Science (2002) 296(5574):1883-6. doi:10.1126/science.1071420.
    • (2002) Science , vol.296 , Issue.5574 , pp. 1883-1886
    • Padera, T.P.1    Kadambi, A.2    di Tomaso, E.3    Carreira, C.M.4    Brown, E.B.5    Boucher, Y.6
  • 37
    • 0037139527 scopus 로고    scopus 로고
    • Intratumoral lymphatic vessels: a case of mistaken identity or malfunction?
    • Jain RK, Fenton BT. Intratumoral lymphatic vessels: a case of mistaken identity or malfunction? J Natl Cancer Inst (2002) 94(6):417-21. doi:10.1093/jnci/94.6.417.
    • (2002) J Natl Cancer Inst , vol.94 , Issue.6 , pp. 417-421
    • Jain, R.K.1    Fenton, B.T.2
  • 38
    • 84864075113 scopus 로고    scopus 로고
    • Interstitial fluid and lymph formation and transport: physiological regulation and roles in inflammation and cancer
    • Wiig H, Swartz MA. Interstitial fluid and lymph formation and transport: physiological regulation and roles in inflammation and cancer. Physiol Rev (2012) 92(3):1005-60. doi:10.1152/physrev.00037.2011.
    • (2012) Physiol Rev , vol.92 , Issue.3 , pp. 1005-1060
    • Wiig, H.1    Swartz, M.A.2
  • 39
    • 84934271859 scopus 로고    scopus 로고
    • Tumor interstitial fluid formation, characterization, and clinical implications
    • Wagner M, Wiig H. Tumor interstitial fluid formation, characterization, and clinical implications. Front Oncol (2015) 5:115. doi:10.3389/fonc.2015.00115.
    • (2015) Front Oncol , vol.5 , pp. 115
    • Wagner, M.1    Wiig, H.2
  • 40
    • 34249825478 scopus 로고    scopus 로고
    • Vascular endothelial growth factor and its relationship to inflammatory mediators
    • Angelo LS, Kurzrock R. Vascular endothelial growth factor and its relationship to inflammatory mediators. Clin Cancer Res (2007) 13(10):2825-30. doi:10.1158/1078-0432.CCR-06-2416.
    • (2007) Clin Cancer Res , vol.13 , Issue.10 , pp. 2825-2830
    • Angelo, L.S.1    Kurzrock, R.2
  • 42
    • 49749124618 scopus 로고    scopus 로고
    • Molecular links between tumor angiogenesis and inflammation: inflammatory stimuli of macrophages and cancer cells as targets for therapeutic strategy
    • Ono M. Molecular links between tumor angiogenesis and inflammation: inflammatory stimuli of macrophages and cancer cells as targets for therapeutic strategy. Cancer Sci (2008) 99(8):1501-6. doi:10.1111/j.1349-7006.2008.00853.x.
    • (2008) Cancer Sci , vol.99 , Issue.8 , pp. 1501-1506
    • Ono, M.1
  • 44
    • 0013870212 scopus 로고
    • The internal milieu of tumors
    • Gullino PM. The internal milieu of tumors. Prog Exp Tumor Res (1966) 8:1-25. doi:10.1159/000386002.
    • (1966) Prog Exp Tumor Res , vol.8 , pp. 1-25
    • Gullino, P.M.1
  • 45
    • 0001496579 scopus 로고
    • Extracellular compartments of solid tumors
    • Becker FF, editor. New York, NY: Plenum Press
    • Gullino PM. Extracellular compartments of solid tumors. In: Becker FF, editor. Cancer a Comprehensive Treatise. New York, NY: Plenum Press (1975). p. 327-54.
    • (1975) Cancer a Comprehensive Treatise , pp. 327-354
    • Gullino, P.M.1
  • 46
    • 77954321271 scopus 로고    scopus 로고
    • Microvascular fluid exchange and the revised Starling principle
    • Levick JR, Michel CC. Microvascular fluid exchange and the revised Starling principle. Cardiovasc Res (2010) 87(2):198-210. doi:10.1093/cvr/cvq062.
    • (2010) Cardiovasc Res , vol.87 , Issue.2 , pp. 198-210
    • Levick, J.R.1    Michel, C.C.2
  • 47
    • 84856814073 scopus 로고    scopus 로고
    • Tumor interstitial fluid as modulator of cancer inflammation,thrombosis, immunity and angiogenesis
    • Baronzio G, Schwartz L, Kiselevsky M, Guais A, Sanders E, Milanesi G, et al. Tumor interstitial fluid as modulator of cancer inflammation,thrombosis, immunity and angiogenesis. Anticancer Res (2012) 32(2):405-14.
    • (2012) Anticancer Res , vol.32 , Issue.2 , pp. 405-414
    • Baronzio, G.1    Schwartz, L.2    Kiselevsky, M.3    Guais, A.4    Sanders, E.5    Milanesi, G.6
  • 48
    • 0027475568 scopus 로고
    • Interstitial-lymphatic mechanisms in the control of extracellular fluid volume
    • Aukland K, Reed RK. Interstitial-lymphatic mechanisms in the control of extracellular fluid volume. Physiol Rev (1993) 73(1):1-78.
    • (1993) Physiol Rev , vol.73 , Issue.1 , pp. 1-78
    • Aukland, K.1    Reed, R.K.2
  • 49
    • 0032580493 scopus 로고    scopus 로고
    • Delivery of molecular and cellular medicine to solid tumors
    • Jain RK. Delivery of molecular and cellular medicine to solid tumors. J Control Release (1998) 53(1-3):49-67. doi:10.1016/S0168-3659(97)00237-X.
    • (1998) J Control Release , vol.53 , Issue.1-3 , pp. 49-67
    • Jain, R.K.1
  • 50
    • 0023909330 scopus 로고
    • Determinants of tumor blood flow: a review
    • Jain RK. Determinants of tumor blood flow: a review. Cancer Res (1988) 48(10):2641-58.
    • (1988) Cancer Res , vol.48 , Issue.10 , pp. 2641-2658
    • Jain, R.K.1
  • 51
    • 0000895492 scopus 로고
    • Protein content and enzymatic assays of interstitial fluid from some normal tissues and transplanted mouse tumors
    • Sylven B, Bois I. Protein content and enzymatic assays of interstitial fluid from some normal tissues and transplanted mouse tumors. Cancer Res (1960) 20:831-6.
    • (1960) Cancer Res , vol.20 , pp. 831-836
    • Sylven, B.1    Bois, I.2
  • 52
    • 73849161133 scopus 로고
    • The collagen content of transplanted tumors
    • Gullino PM, Grantham FH, Clark SH. The collagen content of transplanted tumors. Cancer Res (1962) 22:1031-7.
    • (1962) Cancer Res , vol.22 , pp. 1031-1037
    • Gullino, P.M.1    Grantham, F.H.2    Clark, S.H.3
  • 54
    • 84884672315 scopus 로고    scopus 로고
    • Interstitial fluid-a reflection of the tumor cell microenvironment and secretome
    • Haslene-Hox H, Tenstad O, Wiig H. Interstitial fluid-a reflection of the tumor cell microenvironment and secretome. Biochim Biophys Acta (2013) 1834(11):2336-46. doi:10.1016/j.bbapap.2013.01.028.
    • (2013) Biochim Biophys Acta , vol.1834 , Issue.11 , pp. 2336-2346
    • Haslene-Hox, H.1    Tenstad, O.2    Wiig, H.3
  • 55
    • 0013826242 scopus 로고
    • Pressure-volume relationships in the interstitial spaces
    • Guyton AC. Pressure-volume relationships in the interstitial spaces. Invest Ophthalmol (1965) 4(6):1075-84.
    • (1965) Invest Ophthalmol , vol.4 , Issue.6 , pp. 1075-1084
    • Guyton, A.C.1
  • 57
    • 84901290212 scopus 로고    scopus 로고
    • Releasing pressure in tumors: what do we know so far and where do we go from here? A review
    • Ariffin AB, Forde PF, Jahangeer S, Soden DM, Hinchion J. Releasing pressure in tumors: what do we know so far and where do we go from here? A review. Cancer Res (2014) 74(10):2655-62. doi:10.1158/0008-5472.CAN-13-3696.
    • (2014) Cancer Res , vol.74 , Issue.10 , pp. 2655-2662
    • Ariffin, A.B.1    Forde, P.F.2    Jahangeer, S.3    Soden, D.M.4    Hinchion, J.5
  • 58
    • 84929663729 scopus 로고    scopus 로고
    • Pressure gradients in solid tumors
    • Bae YH, Mrsny RJ, Park K, editors. Springer
    • Stapleton S, Milosevic MF. Pressure gradients in solid tumors. In: Bae YH, Mrsny RJ, Park K, editors. Cancer Target Drug Delivery. Springer (2013). p. 241-72.
    • (2013) Cancer Target Drug Delivery , pp. 241-272
    • Stapleton, S.1    Milosevic, M.F.2
  • 59
    • 0001217379 scopus 로고
    • The significance of the tissue pressure of normal testicular and of neoplastic (Brown-Pearce carcinoma) tissue in the rabbit
    • Young JS, Lumsden CE, Stalker AL. The significance of the tissue pressure of normal testicular and of neoplastic (Brown-Pearce carcinoma) tissue in the rabbit. J Pathol Bacteriol (1950) 62(3):313-33. doi:10.1002/path.1700620303.
    • (1950) J Pathol Bacteriol , vol.62 , Issue.3 , pp. 313-333
    • Young, J.S.1    Lumsden, C.E.2    Stalker, A.L.3
  • 60
    • 0001850880 scopus 로고
    • Physiological resistance to the treatment of solid tumors
    • Teicher BA, editor. Marcel Dekker
    • Jain RK. Physiological resistance to the treatment of solid tumors. In: Teicher BA, editor. Drug Resistance in Oncology. Marcel Dekker (1993). p. 87-105.
    • (1993) Drug Resistance in Oncology , pp. 87-105
    • Jain, R.K.1
  • 61
    • 61449558421 scopus 로고    scopus 로고
    • Interstitial fluid pressure in tumors:therapeutic barrier and biomarker of angiogenesis
    • Lunt SJ, Fyles A, Hill RP, Milosevic M. Interstitial fluid pressure in tumors:therapeutic barrier and biomarker of angiogenesis. Future Oncol (2008) 4(6):793-802. doi:10.2217/14796694.4.6.793.
    • (2008) Future Oncol , vol.4 , Issue.6 , pp. 793-802
    • Lunt, S.J.1    Fyles, A.2    Hill, R.P.3    Milosevic, M.4
  • 62
    • 3142631966 scopus 로고    scopus 로고
    • The human tumor microenvironment:invasive (needle) measurement of oxygen and interstitial fluid pressure
    • Milosevic M, Fyles A, Hedley D, Hill R. The human tumor microenvironment:invasive (needle) measurement of oxygen and interstitial fluid pressure. Semin Radiat Oncol (2004) 14(3):249-58. doi:10.1016/j.semradonc.2004.04.006.
    • (2004) Semin Radiat Oncol , vol.14 , Issue.3 , pp. 249-258
    • Milosevic, M.1    Fyles, A.2    Hedley, D.3    Hill, R.4
  • 64
    • 0016824929 scopus 로고
    • Bulk transfer of fluid in the interstitial compartment of mammary tumors
    • Butler TP, Grantham FH, Gullino PM. Bulk transfer of fluid in the interstitial compartment of mammary tumors. Cancer Res (1975) 35(11 Pt 1):3084-8.
    • (1975) Cancer Res , vol.35 , Issue.11 , pp. 3084-3088
    • Butler, T.P.1    Grantham, F.H.2    Gullino, P.M.3
  • 65
    • 84925258395 scopus 로고    scopus 로고
    • Interstitial fluid flow in cancer: implications for disease progression and treatment
    • Munson JM, Shieh AC. Interstitial fluid flow in cancer: implications for disease progression and treatment. Cancer Manag Res (2014) 6:317-28. doi:10.2147/CMAR.S65444.
    • (2014) Cancer Manag Res , vol.6 , pp. 317-328
    • Munson, J.M.1    Shieh, A.C.2
  • 66
    • 84867126737 scopus 로고    scopus 로고
    • Interstitial fluid pressure and associated lymph node metastasis revealed in tumors by dynamic contrast-enhanced MRI
    • Hompland T, Ellingsen C, Øvrebø KM, Rofstad EK. Interstitial fluid pressure and associated lymph node metastasis revealed in tumors by dynamic contrast-enhanced MRI. Cancer Res (2012) 72(19):4899-908. doi:10.1158/0008-5472.CAN-12-0903.
    • (2012) Cancer Res , vol.72 , Issue.19 , pp. 4899-4908
    • Hompland, T.1    Ellingsen, C.2    Øvrebø, K.M.3    Rofstad, E.K.4
  • 67
    • 0024373052 scopus 로고
    • Direct measurement of interstitial convection and diffusion of albumin in normal and neoplastic tissues by fluorescence photobleaching
    • Chary SR, Jain RK. Direct measurement of interstitial convection and diffusion of albumin in normal and neoplastic tissues by fluorescence photobleaching. Proc Natl Acad Sci U S A (1989) 86(14):5385-9. doi:10.1073/pnas.86.14.5385.
    • (1989) Proc Natl Acad Sci U S A , vol.86 , Issue.14 , pp. 5385-5389
    • Chary, S.R.1    Jain, R.K.2
  • 68
    • 13944273372 scopus 로고    scopus 로고
    • Characterizing extravascular fluid transport of macromolecules in the tumor interstitium by magnetic resonance imaging
    • Pathak AP, Artemov D, Ward BD, Jackson DG, Neeman M, Bhujwalla ZM. Characterizing extravascular fluid transport of macromolecules in the tumor interstitium by magnetic resonance imaging. Cancer Res (2005) 65(4):1425-32. doi:10.1158/0008-5472.CAN-04-3682.
    • (2005) Cancer Res , vol.65 , Issue.4 , pp. 1425-1432
    • Pathak, A.P.1    Artemov, D.2    Ward, B.D.3    Jackson, D.G.4    Neeman, M.5    Bhujwalla, Z.M.6
  • 69
    • 84904230947 scopus 로고    scopus 로고
    • Simulation of interstitial fluid flow in ligaments: comparison among Stokes, Brinkman and Darcy models
    • Yao W, Shen Z, Ding G. Simulation of interstitial fluid flow in ligaments: comparison among Stokes, Brinkman and Darcy models. Int J Biol Sci (2013) 9(10):1050-6. doi:10.7150/ijbs.7242.
    • (2013) Int J Biol Sci , vol.9 , Issue.10 , pp. 1050-1056
    • Yao, W.1    Shen, Z.2    Ding, G.3
  • 70
    • 84925444489 scopus 로고    scopus 로고
    • Tumor interstitial fluid pressure-a link between tumor hypoxia, microvascular density, and lymph node metastasis
    • Rofstad EK, Galappathi K, Mathiesen BS. Tumor interstitial fluid pressure-a link between tumor hypoxia, microvascular density, and lymph node metastasis. Neoplasia (2014) 16(7):586-94. doi:10.1016/j.neo.2014.07.003.
    • (2014) Neoplasia , vol.16 , Issue.7 , pp. 586-594
    • Rofstad, E.K.1    Galappathi, K.2    Mathiesen, B.S.3
  • 71
    • 84920756802 scopus 로고    scopus 로고
    • Immunomodulatory roles of lymphatic vessels in cancer progression
    • Swartz MA. Immunomodulatory roles of lymphatic vessels in cancer progression. Cancer Immunol Res (2014) 2(8):701-7. doi:10.1158/2326-6066.CIR-14-0115.
    • (2014) Cancer Immunol Res , vol.2 , Issue.8 , pp. 701-707
    • Swartz, M.A.1
  • 72
    • 33845883279 scopus 로고    scopus 로고
    • A driving force for change: interstitial flow as a morphoregulator
    • Rutkowski JM, Swartz MA. A driving force for change: interstitial flow as a morphoregulator. Trends Cell Biol (2007) 17(1):44-50. doi:10.1016/j.tcb.2006.11.007.
    • (2007) Trends Cell Biol , vol.17 , Issue.1 , pp. 44-50
    • Rutkowski, J.M.1    Swartz, M.A.2
  • 73
    • 27844457560 scopus 로고    scopus 로고
    • Interstitial fluid flow induces myofibroblast differentiation and collagen alignment in vitro
    • Ng CP, Hinz B, Swartz MA. Interstitial fluid flow induces myofibroblast differentiation and collagen alignment in vitro. J Cell Sci (2005) 118(Pt20):4731-9. doi:10.1242/jcs.02605.
    • (2005) J Cell Sci , vol.118 , pp. 4731-4739
    • Ng, C.P.1    Hinz, B.2    Swartz, M.A.3
  • 74
    • 34249774277 scopus 로고    scopus 로고
    • Autologous chemotaxis as a mechanism of tumor cell homing to lymphatics via interstitial flow and autocrine CCR7 signaling
    • Shields JD, Fleury ME, Yong C, Tomei AA, Randolph GJ, Swartz MA. Autologous chemotaxis as a mechanism of tumor cell homing to lymphatics via interstitial flow and autocrine CCR7 signaling. Cancer Cell (2007) 11(6):526-38. doi:10.1016/j.ccr.2007.04.020.
    • (2007) Cancer Cell , vol.11 , Issue.6 , pp. 526-538
    • Shields, J.D.1    Fleury, M.E.2    Yong, C.3    Tomei, A.A.4    Randolph, G.J.5    Swartz, M.A.6
  • 75
    • 84898828017 scopus 로고    scopus 로고
    • Radiation-induced changes in microcirculation and interstitial fluid pressure affecting the delivery of macromolecules and nanotherapeutics to tumors
    • Multhoff G, Vaupel P. Radiation-induced changes in microcirculation and interstitial fluid pressure affecting the delivery of macromolecules and nanotherapeutics to tumors. Front Oncol (2012) 2:165. doi:10.3389/fonc.2012.00165.
    • (2012) Front Oncol , vol.2 , pp. 165
    • Multhoff, G.1    Vaupel, P.2
  • 76
    • 0031903379 scopus 로고    scopus 로고
    • Transvascular drug delivery in solid tumors
    • Yuan F. Transvascular drug delivery in solid tumors. Semin Radiat Oncol (1998) 8(3):164-75. doi:10.1016/S1053-4296(98)80042-8.
    • (1998) Semin Radiat Oncol , vol.8 , Issue.3 , pp. 164-175
    • Yuan, F.1
  • 77
    • 77956162919 scopus 로고    scopus 로고
    • Physiologic upper limits of pore size of different blood capillary types and another perspective on the dual pore theory of microvascular permeability
    • Sarin H. Physiologic upper limits of pore size of different blood capillary types and another perspective on the dual pore theory of microvascular permeability. J Angiogenes Res (2010) 2:14. doi:10.1186/2040-2384-2-14.
    • (2010) J Angiogenes Res , vol.2 , pp. 14
    • Sarin, H.1
  • 78
    • 0033567094 scopus 로고    scopus 로고
    • Augmentation of transvascular transport of macromolecules and nanoparticles in tumors using vascular endothelial growth factor
    • Monsky WL, Fukumura D, Gohongi T, Ancukiewcz M, Weich HA, Torchilin VP, et al. Augmentation of transvascular transport of macromolecules and nanoparticles in tumors using vascular endothelial growth factor. Cancer Res (1999) 59(16):4129-35.
    • (1999) Cancer Res , vol.59 , Issue.16 , pp. 4129-4135
    • Monsky, W.L.1    Fukumura, D.2    Gohongi, T.3    Ancukiewcz, M.4    Weich, H.A.5    Torchilin, V.P.6
  • 79
    • 0030731563 scopus 로고    scopus 로고
    • Interstitial fluid pressue as an obstacle in treatment of solid tumors
    • Pusenjak J, Miklavcic D. Interstitial fluid pressue as an obstacle in treatment of solid tumors. Radiol Oncol (1997) 31:291-7.
    • (1997) Radiol Oncol , vol.31 , pp. 291-297
    • Pusenjak, J.1    Miklavcic, D.2
  • 80
    • 0016277217 scopus 로고
    • Diffusion and convection in normal and neoplastic tissues
    • Swabb EA, Wei J, Gullino PM. Diffusion and convection in normal and neoplastic tissues. Cancer Res (1974) 34(10):2814-22.
    • (1974) Cancer Res , vol.34 , Issue.10 , pp. 2814-2822
    • Swabb, E.A.1    Wei, J.2    Gullino, P.M.3
  • 82
    • 84881110925 scopus 로고    scopus 로고
    • Interstitial fluid flow and drug delivery in vascularized tumors: a computational model
    • Welter M, Rieger H. Interstitial fluid flow and drug delivery in vascularized tumors: a computational model. PLoS One (2013) 8(8):e70395. doi:10.1371/journal.pone.0070395.
    • (2013) PLoS One , vol.8 , Issue.8
    • Welter, M.1    Rieger, H.2
  • 83
    • 79958078447 scopus 로고    scopus 로고
    • Numerical modeling of fluid flow in solid tumors
    • Soltani M, Chen P. Numerical modeling of fluid flow in solid tumors. PLoS One (2011) 6(6):e20344. doi:10.1371/journal.pone.0020344.
    • (2011) PLoS One , vol.6 , Issue.6
    • Soltani, M.1    Chen, P.2
  • 84
    • 84879465492 scopus 로고    scopus 로고
    • Numerical modeling of interstitial fluid flow coupled with blood flow through a remodeled solid tumor microvascular network
    • Soltani M, Chen P. Numerical modeling of interstitial fluid flow coupled with blood flow through a remodeled solid tumor microvascular network. PLoS One (2013) 8(6):e67025. doi:10.1371/journal.pone.0067025.
    • (2013) PLoS One , vol.8 , Issue.6
    • Soltani, M.1    Chen, P.2
  • 85
    • 84891444301 scopus 로고    scopus 로고
    • A mathematical model of the enhanced permeability and retention effect for liposome transport in solid tumors
    • Stapleton S, Milosevic M, Allen C, Zheng J, Dunne M, Yeung I, et al. A mathematical model of the enhanced permeability and retention effect for liposome transport in solid tumors. PLoS One (2013) 8(12):e81157. doi:10.1371/journal.pone.0081157.
    • (2013) PLoS One , vol.8 , Issue.12
    • Stapleton, S.1    Milosevic, M.2    Allen, C.3    Zheng, J.4    Dunne, M.5    Yeung, I.6
  • 86
    • 0022646873 scopus 로고
    • Measurement of interstitial fluid pressure: comparison of methods
    • Wiig H, Reed RK, Aukland K. Measurement of interstitial fluid pressure: comparison of methods. Ann Biomed Eng (1986) 14(2):139-51. doi:10.1007/BF02584264.
    • (1986) Ann Biomed Eng , vol.14 , Issue.2 , pp. 139-151
    • Wiig, H.1    Reed, R.K.2    Aukland, K.3
  • 87
    • 0024991704 scopus 로고
    • Evaluation of methodologies for measurement of interstitial fluid pressure (Pi): physiological implications of recent Pi data
    • Wiig H. Evaluation of methodologies for measurement of interstitial fluid pressure (Pi): physiological implications of recent Pi data. Crit Rev Biomed Eng (1990) 18(1):27-54.
    • (1990) Crit Rev Biomed Eng , vol.18 , Issue.1 , pp. 27-54
    • Wiig, H.1
  • 88
    • 0019446352 scopus 로고
    • Normal transcapillary pressures in human skeletal muscle and subcutaneous tissues
    • Hargens AR, Cologne JB, Menninger FJ, Hogan JS, Tucker BJ, Peters RM. Normal transcapillary pressures in human skeletal muscle and subcutaneous tissues. Microvasc Res (1981) 22(2):177-89. doi:10.1016/0026-2862(81)90087-X.
    • (1981) Microvasc Res , vol.22 , Issue.2 , pp. 177-189
    • Hargens, A.R.1    Cologne, J.B.2    Menninger, F.J.3    Hogan, J.S.4    Tucker, B.J.5    Peters, R.M.6
  • 89
    • 0014430971 scopus 로고
    • Negative pressure in the interstitial fluid of animals. Fluid tensions are spectacular in plants; in animals they are elusively small, but just as vital
    • Scholander PF, Hargens AR, Miller SL. Negative pressure in the interstitial fluid of animals. Fluid tensions are spectacular in plants; in animals they are elusively small, but just as vital. Science (1968) 161(3839):321-8. doi:10.1126/science.161.3839.321.
    • (1968) Science , vol.161 , Issue.3839 , pp. 321-328
    • Scholander, P.F.1    Hargens, A.R.2    Miller, S.L.3
  • 90
    • 0017373031 scopus 로고
    • Interstitial fluid pressure in rats measured with a modified wick technique
    • Fadnes HO, Reed RK, Aukland K. Interstitial fluid pressure in rats measured with a modified wick technique. Microvasc Res (1977) 14(1):27-36. doi:10.1016/0026-2862(77)90138-8.
    • (1977) Microvasc Res , vol.14 , Issue.1 , pp. 27-36
    • Fadnes, H.O.1    Reed, R.K.2    Aukland, K.3
  • 91
    • 0015793736 scopus 로고
    • Microvascular, lymphatic, and tissue pressures in the unanesthetized mammal
    • Wiederhielm CA, Weston BV. Microvascular, lymphatic, and tissue pressures in the unanesthetized mammal. Am J Physiol (1973) 225(4):992-6.
    • (1973) Am J Physiol , vol.225 , Issue.4 , pp. 992-996
    • Wiederhielm, C.A.1    Weston, B.V.2
  • 92
    • 0019503565 scopus 로고
    • Micropuncture measurement of interstitial fluid pressure in rat subcutis and skeletal muscle: comparison to wick-in-needle technique
    • Wiig H, Reed RK, Aukland K. Micropuncture measurement of interstitial fluid pressure in rat subcutis and skeletal muscle: comparison to wick-in-needle technique. Microvasc Res (1981) 21(3):308-19. doi:10.1016/0026-2862(81)90014-5.
    • (1981) Microvasc Res , vol.21 , Issue.3 , pp. 308-319
    • Wiig, H.1    Reed, R.K.2    Aukland, K.3
  • 93
    • 0022148261 scopus 로고
    • Comparison of methods for measurement of interstitial fluid pressure in cat skin/subcutis and muscle
    • Wiig H. Comparison of methods for measurement of interstitial fluid pressure in cat skin/subcutis and muscle. Am J Physiol (1985) 249(5 Pt 2):H929-44.
    • (1985) Am J Physiol , vol.249 , Issue.5 , pp. H929-H944
    • Wiig, H.1
  • 94
    • 84940116425 scopus 로고    scopus 로고
    • Biomedical Transducers and Instruments. CRC press
    • Tatsuo T, Toshiyo T, Oberg P. Pressure measurement. Biomedical Transducers and Instruments. CRC press (1997). p. 13-70.
    • (1997) Pressure measurement , pp. 13-70
    • Tatsuo, T.1    Toshiyo, T.2    Oberg, P.3
  • 95
    • 0027174138 scopus 로고
    • Interstitial pressure of subcutaneous nodules in melanoma and lymphoma patients:changes during treatment
    • Curti BD, Urba WJ, Alvord WG, Janik JE, Smith JW II, Madara K, et al. Interstitial pressure of subcutaneous nodules in melanoma and lymphoma patients:changes during treatment. Cancer Res (1993) 53(10 Suppl):2204-7.
    • (1993) Cancer Res , vol.53 , Issue.10 , pp. 2204-2207
    • Curti, B.D.1    Urba, W.J.2    Alvord, W.G.3    Janik, J.E.4    Smith, J.W.5    Madara, K.6
  • 96
    • 0031022501 scopus 로고    scopus 로고
    • Proton relaxation times and interstitial fluid pressure in human melanoma xenografts
    • Lyng H, Tufto I, Skretting A, Rofstad EK. Proton relaxation times and interstitial fluid pressure in human melanoma xenografts. Br J Cancer (1997) 75(2):180-3. doi:10.1038/bjc.1997.30.
    • (1997) Br J Cancer , vol.75 , Issue.2 , pp. 180-183
    • Lyng, H.1    Tufto, I.2    Skretting, A.3    Rofstad, E.K.4
  • 97
    • 33646229539 scopus 로고    scopus 로고
    • Noninvasive magnetic resonance imaging of transport and interstitial fluid pressure in ectopic human lung tumors
    • Hassid Y, Furman-Haran E, Margalit R, Eilam R, Degani H. Noninvasive magnetic resonance imaging of transport and interstitial fluid pressure in ectopic human lung tumors. Cancer Res (2006) 66(8):4159-66. doi:10.1158/0008-5472.CAN-05-3289.
    • (2006) Cancer Res , vol.66 , Issue.8 , pp. 4159-4166
    • Hassid, Y.1    Furman-Haran, E.2    Margalit, R.3    Eilam, R.4    Degani, H.5
  • 98
    • 49749123449 scopus 로고    scopus 로고
    • Non-invasive imaging of barriers to drug delivery in tumors
    • Hassid Y, Eyal E, Margalit R, Furman-Haran E, Degani H. Non-invasive imaging of barriers to drug delivery in tumors. Microvasc Res (2008) 76(2):94-103. doi:10.1016/j.mvr.2008.06.002.
    • (2008) Microvasc Res , vol.76 , Issue.2 , pp. 94-103
    • Hassid, Y.1    Eyal, E.2    Margalit, R.3    Furman-Haran, E.4    Degani, H.5
  • 99
    • 58849097668 scopus 로고    scopus 로고
    • Imaging intratumoral convection: pressure-dependent enhancement in chemotherapeutic delivery to solid tumors
    • Gade TP, Buchanan IM, Motley MW, Mazaheri Y, Spees WM, Koutcher JA. Imaging intratumoral convection: pressure-dependent enhancement in chemotherapeutic delivery to solid tumors. Clin Cancer Res (2009) 15(1):247-55. doi:10.1158/1078-0432.CCR-08-0611.
    • (2009) Clin Cancer Res , vol.15 , Issue.1 , pp. 247-255
    • Gade, T.P.1    Buchanan, I.M.2    Motley, M.W.3    Mazaheri, Y.4    Spees, W.M.5    Koutcher, J.A.6
  • 100
    • 84891139124 scopus 로고    scopus 로고
    • Positron emission tomography as a method for measuring drug delivery to tumors in vivo: the example of [(11)C]docetaxel
    • van der Veldt AA, Smit EF, Lammertsma AA. Positron emission tomography as a method for measuring drug delivery to tumors in vivo: the example of [(11)C]docetaxel. Front Oncol (2013) 3:208. doi:10.3389/fonc.2013.00208.
    • (2013) Front Oncol , vol.3 , pp. 208
    • van der Veldt, A.A.1    Smit, E.F.2    Lammertsma, A.A.3
  • 101
    • 4944266313 scopus 로고    scopus 로고
    • High interstitial fluid pressure-an obstacle in cancer therapy
    • Heldin CH, Rubin K, Pietras K, Ostman A. High interstitial fluid pressure-an obstacle in cancer therapy. Nat Rev Cancer (2004) 4(10):806-13. doi:10.1038/nrc1456.
    • (2004) Nat Rev Cancer , vol.4 , Issue.10 , pp. 806-813
    • Heldin, C.H.1    Rubin, K.2    Pietras, K.3    Ostman, A.4
  • 102
    • 0025014962 scopus 로고
    • Physiological barriers to delivery of monoclonal antibodies and other macromolecules in tumors
    • Jain RK. Physiological barriers to delivery of monoclonal antibodies and other macromolecules in tumors. Cancer Res (1990) 50(3 Suppl):814s-9s.
    • (1990) Cancer Res , vol.50 , Issue.3 , pp. 814s-819s
    • Jain, R.K.1
  • 103
    • 9444260479 scopus 로고    scopus 로고
    • Biological impediments to monoclonal antibody-based cancer immunotherapy
    • Christiansen J, Rajasekaran AK. Biological impediments to monoclonal antibody-based cancer immunotherapy. Mol Cancer Ther (2004) 3(11):1493-501.
    • (2004) Mol Cancer Ther , vol.3 , Issue.11 , pp. 1493-1501
    • Christiansen, J.1    Rajasekaran, A.K.2
  • 104
    • 79959393938 scopus 로고    scopus 로고
    • Delivery of molecular and nanoscale medicine to tumors: transport barriers and strategies
    • Chauhan VP, Stylianopoulos T, Boucher Y, Jain RK. Delivery of molecular and nanoscale medicine to tumors: transport barriers and strategies. Annu Rev Chem Biomol Eng (2011) 2:281-98. doi:10.1146/annurev-chembioeng-061010-114300.
    • (2011) Annu Rev Chem Biomol Eng , vol.2 , pp. 281-298
    • Chauhan, V.P.1    Stylianopoulos, T.2    Boucher, Y.3    Jain, R.K.4
  • 105
    • 33750806589 scopus 로고    scopus 로고
    • Tumor physiology and delivery of nanopharmaceuticals
    • Campbell RB. Tumor physiology and delivery of nanopharmaceuticals. Anticancer Agents Med Chem (2006) 6(6):503-12. doi:10.2174/187152006778699077.
    • (2006) Anticancer Agents Med Chem , vol.6 , Issue.6 , pp. 503-512
    • Campbell, R.B.1
  • 106
    • 33947385483 scopus 로고    scopus 로고
    • Optimization of radioimmunotherapy of solid tumors: biological impediments and their modulation
    • Jain M, Venkatraman G, Batra SK. Optimization of radioimmunotherapy of solid tumors: biological impediments and their modulation. Clin Cancer Res (2007) 13(5):1374-82. doi:10.1158/1078-0432.CCR-06-2436.
    • (2007) Clin Cancer Res , vol.13 , Issue.5 , pp. 1374-1382
    • Jain, M.1    Venkatraman, G.2    Batra, S.K.3
  • 107
    • 84880079914 scopus 로고    scopus 로고
    • Coevolution of solid stress and interstitial fluid pressure in tumors during progression: implications for vascular collapse
    • Stylianopoulos T, Martin JD, Snuderl M, Mpekris F, Jain SR, Jain RK. Coevolution of solid stress and interstitial fluid pressure in tumors during progression: implications for vascular collapse. Cancer Res (2013) 73(13):3833-41. doi:10.1158/0008-5472.
    • (2013) Cancer Res , vol.73 , Issue.13 , pp. 3833-3841
    • Stylianopoulos, T.1    Martin, J.D.2    Snuderl, M.3    Mpekris, F.4    Jain, S.R.5    Jain, R.K.6
  • 108
    • 0141706804 scopus 로고    scopus 로고
    • Lowering of tumor interstitial fluid pressure specifically augments efficacy of chemotherapy
    • Salnikov AV, Iversen VV, Koisti M, Sundberg C, Johansson L, Stuhr LB, et al. Lowering of tumor interstitial fluid pressure specifically augments efficacy of chemotherapy. FASEB J (2003) 17(12):1756-8.
    • (2003) FASEB J , vol.17 , Issue.12 , pp. 1756-1758
    • Salnikov, A.V.1    Iversen, V.V.2    Koisti, M.3    Sundberg, C.4    Johansson, L.5    Stuhr, L.B.6
  • 109
    • 0028054780 scopus 로고
    • Photodynamic therapy-induced alterations in interstitial fluid pressure, volume and water content of an amelanotic melanoma in the hamster
    • Leunig M, Goetz AE, Gamarra F, Zetterer G, Messmer K, Jain RK. Photodynamic therapy-induced alterations in interstitial fluid pressure, volume and water content of an amelanotic melanoma in the hamster. Br J Cancer (1994) 69(1):101-3. doi:10.1038/bjc.1994.15.
    • (1994) Br J Cancer , vol.69 , Issue.1 , pp. 101-103
    • Leunig, M.1    Goetz, A.E.2    Gamarra, F.3    Zetterer, G.4    Messmer, K.5    Jain, R.K.6
  • 110
    • 84885129359 scopus 로고    scopus 로고
    • Angiotensin inhibition enhances drug delivery and potentiates chemotherapy by decompressing tumour blood vessels
    • Chauhan VP, Martin JD, Liu H, Lacorre DA, Jain SR, Kozin SV, et al. Angiotensin inhibition enhances drug delivery and potentiates chemotherapy by decompressing tumour blood vessels. Nat Commun (2013) 4:2516. doi:10.1038/ncomms3516.
    • (2013) Nat Commun , vol.4 , pp. 2516
    • Chauhan, V.P.1    Martin, J.D.2    Liu, H.3    Lacorre, D.A.4    Jain, S.R.5    Kozin, S.V.6
  • 111
    • 11844254414 scopus 로고    scopus 로고
    • Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy
    • Jain RK. Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy. Science (2005) 307(5706):58-62. doi:10.1126/science.1104819.
    • (2005) Science , vol.307 , Issue.5706 , pp. 58-62
    • Jain, R.K.1
  • 112
    • 84863655863 scopus 로고    scopus 로고
    • Normalization of tumour blood vessels improves the delivery of nanomedicines in a size-dependent manner
    • Chauhan VP, Stylianopoulos T, Martin JD, Popovic Z, Chen O, Kamoun WS, et al. Normalization of tumour blood vessels improves the delivery of nanomedicines in a size-dependent manner. Nat Nanotechnol (2012) 7(6):383-8. doi:10.1038/nnano.2012.45.
    • (2012) Nat Nanotechnol , vol.7 , Issue.6 , pp. 383-388
    • Chauhan, V.P.1    Stylianopoulos, T.2    Martin, J.D.3    Popovic, Z.4    Chen, O.5    Kamoun, W.S.6
  • 113
    • 84890282284 scopus 로고    scopus 로고
    • Benefits of vascular normalization are dose and time dependent-letter
    • Huang Y, Stylianopoulos T, Duda DG, Fukumura D, Jain RK. Benefits of vascular normalization are dose and time dependent-letter. Cancer Res (2013) 73(23):7144-6. doi:10.1158/0008-5472.
    • (2013) Cancer Res , vol.73 , Issue.23 , pp. 7144-7146
    • Huang, Y.1    Stylianopoulos, T.2    Duda, D.G.3    Fukumura, D.4    Jain, R.K.5
  • 115
    • 84877870613 scopus 로고    scopus 로고
    • Vascular normalization as an emerging strategy to enhance cancer immunotherapy
    • Huang Y, Goel S, Duda DG, Fukumura D, Jain RK. Vascular normalization as an emerging strategy to enhance cancer immunotherapy. Cancer Res (2013) 73(10):2943-8. doi:10.1158/0008-5472.CAN-12-4354.
    • (2013) Cancer Res , vol.73 , Issue.10 , pp. 2943-2948
    • Huang, Y.1    Goel, S.2    Duda, D.G.3    Fukumura, D.4    Jain, R.K.5
  • 116
    • 84955657303 scopus 로고    scopus 로고
    • HIF-1 at the crossroads of hypoxia, inflammation, and cancer
    • Balamurugan K. HIF-1 at the crossroads of hypoxia, inflammation, and cancer. Int J Cancer (2015). doi:10.1002/ijc.29519.
    • (2015) Int J Cancer
    • Balamurugan, K.1
  • 117
    • 77955406159 scopus 로고    scopus 로고
    • Antiangiogenic agents can increase lymphocyte infiltration into tumor and enhance the effectiveness of adoptive immunotherapy of cancer
    • Shrimali RK, Yu Z, Theoret MR, Chinnasamy D, Restifo NP, Rosenberg SA. Antiangiogenic agents can increase lymphocyte infiltration into tumor and enhance the effectiveness of adoptive immunotherapy of cancer. Cancer Res (2010) 70(15):6171-80. doi:10.1158/0008-5472.CAN-10-0153.
    • (2010) Cancer Res , vol.70 , Issue.15 , pp. 6171-6180
    • Shrimali, R.K.1    Yu, Z.2    Theoret, M.R.3    Chinnasamy, D.4    Restifo, N.P.5    Rosenberg, S.A.6
  • 118
    • 84922569615 scopus 로고    scopus 로고
    • Improved tumor vascularization after anti-VEGF therapy with carboplatin and nab-paclitaxel associates with survival in lung cancer
    • Heist RS, Duda DG, Sahani DV, Ancukiewicz M, Fidias P, Sequist LV, et al. Improved tumor vascularization after anti-VEGF therapy with carboplatin and nab-paclitaxel associates with survival in lung cancer. Proc Natl Acad Sci U S A (2015) 112(5):1547-52. doi:10.1073/pnas.1424024112.
    • (2015) Proc Natl Acad Sci U S A , vol.112 , Issue.5 , pp. 1547-1552
    • Heist, R.S.1    Duda, D.G.2    Sahani, D.V.3    Ancukiewicz, M.4    Fidias, P.5    Sequist, L.V.6
  • 119
    • 19344378137 scopus 로고    scopus 로고
    • Vascular disrupting agents: a new class of drug in cancer therapy
    • Gaya AM, Rustin GJ. Vascular disrupting agents: a new class of drug in cancer therapy. Clin Oncol (R Coll Radiol) (2005) 17(4):277-90. doi:10.1016/j.clon.2004.11.011.
    • (2005) Clin Oncol (R Coll Radiol) , vol.17 , Issue.4 , pp. 277-290
    • Gaya, A.M.1    Rustin, G.J.2
  • 120
    • 33644536374 scopus 로고    scopus 로고
    • Effects of the vascular disrupting agent ZD6126 on interstitial fluid pressure and cell survival in tumors
    • Skliarenko JV, Lunt SJ, Gordon ML, Vitkin A, Milosevic M, Hill RP. Effects of the vascular disrupting agent ZD6126 on interstitial fluid pressure and cell survival in tumors. Cancer Res (2006) 66(4):2074-80. doi:10.1158/0008-5472.CAN-05-2046.
    • (2006) Cancer Res , vol.66 , Issue.4 , pp. 2074-2080
    • Skliarenko, J.V.1    Lunt, S.J.2    Gordon, M.L.3    Vitkin, A.4    Milosevic, M.5    Hill, R.P.6
  • 121
    • 33847322988 scopus 로고    scopus 로고
    • Early effects of combretastatin-A4 disodium phosphate on tumor perfusion and interstitial fluid pressure
    • Ley CD, Horsman MR, Kristjansen PE. Early effects of combretastatin-A4 disodium phosphate on tumor perfusion and interstitial fluid pressure. Neoplasia (2007) 9(2):108-12.
    • (2007) Neoplasia , vol.9 , Issue.2 , pp. 108-112
    • Ley, C.D.1    Horsman, M.R.2    Kristjansen, P.E.3
  • 122
    • 0028818116 scopus 로고
    • Pharmacologic modification of tumor blood flow and interstitial fluid pressure in a human tumor xenograft:network analysis and mechanistic interpretation
    • Zlotecki RA, Baxter LT, Boucher Y, Jain RK. Pharmacologic modification of tumor blood flow and interstitial fluid pressure in a human tumor xenograft:network analysis and mechanistic interpretation. Microvasc Res (1995) 50(3):429-43. doi:10.1006/mvre.1995.1069.
    • (1995) Microvasc Res , vol.50 , Issue.3 , pp. 429-443
    • Zlotecki, R.A.1    Baxter, L.T.2    Boucher, Y.3    Jain, R.K.4
  • 123
    • 0002972851 scopus 로고
    • Oxygenation of solid tumors
    • Teicher BA, editor. New York, NY: Marcel Dekker Inc
    • Vaupel P. Oxygenation of solid tumors. In: Teicher BA, editor. Drug Resistance in Oncology. New York, NY: Marcel Dekker Inc (1993). p. 53-85.
    • (1993) Drug Resistance in Oncology , pp. 53-85
    • Vaupel, P.1
  • 124
    • 0034761159 scopus 로고    scopus 로고
    • Effect of hydralazine on interstitial fluid pressure in experimental tumours and in normal tissue
    • Podobnik B, Sersa G, Miklavcic D. Effect of hydralazine on interstitial fluid pressure in experimental tumours and in normal tissue. In Vivo (2001) 15(5):417-24.
    • (2001) In Vivo , vol.15 , Issue.5 , pp. 417-424
    • Podobnik, B.1    Sersa, G.2    Miklavcic, D.3
  • 125
    • 0037225794 scopus 로고    scopus 로고
    • Effect of hydralazine on blood flow, oxygenation, and interstitial fluid pressure in subcutaneous tumors
    • Jarm T, Podobnik B, Sersa G, Miklavcic D. Effect of hydralazine on blood flow, oxygenation, and interstitial fluid pressure in subcutaneous tumors. Adv Exp Med Biol (2003) 10:25-9. doi:10.1007/978-1-4615-0205-0_5.
    • (2003) Adv Exp Med Biol , vol.10 , pp. 25-29
    • Jarm, T.1    Podobnik, B.2    Sersa, G.3    Miklavcic, D.4
  • 126
    • 3242699617 scopus 로고    scopus 로고
    • Effects of the taxanes paclitaxel and docetaxel on edema formation and interstitial fluid pressure
    • Brønstad A, Berg A, Reed RK. Effects of the taxanes paclitaxel and docetaxel on edema formation and interstitial fluid pressure. Am J Physiol Heart Circ Physiol (2004) 287(2):H963-8. doi:10.1152/ajpheart.01052.2003.
    • (2004) Am J Physiol Heart Circ Physiol , vol.287 , Issue.2 , pp. H963-H968
    • Brønstad, A.1    Berg, A.2    Reed, R.K.3
  • 127
    • 0033178578 scopus 로고    scopus 로고
    • Taxane-induced apoptosis decompresses blood vessels and lowers interstitial fluid pressure in solid tumors: clinical implications
    • Griffon-Etienne G, Boucher Y, Brekken C, Suit HD, Jain RK. Taxane-induced apoptosis decompresses blood vessels and lowers interstitial fluid pressure in solid tumors: clinical implications. Cancer Res (1999) 59(15):3776-82.
    • (1999) Cancer Res , vol.59 , Issue.15 , pp. 3776-3782
    • Griffon-Etienne, G.1    Boucher, Y.2    Brekken, C.3    Suit, H.D.4    Jain, R.K.5
  • 128
    • 20144373280 scopus 로고    scopus 로고
    • Paclitaxel decreases the interstitial fluid pressure and improves oxygenation in breast cancers in patients treated with neoadjuvant chemotherapy: clinical implications
    • Taghian AG, Abi-Raad R, Assaad SI, Casty A, Ancukiewicz M, Yeh E, et al. Paclitaxel decreases the interstitial fluid pressure and improves oxygenation in breast cancers in patients treated with neoadjuvant chemotherapy: clinical implications. J Clin Oncol (2005) 23(9):1951-61. doi:10.1200/JCO.2005.08.119.
    • (2005) J Clin Oncol , vol.23 , Issue.9 , pp. 1951-1961
    • Taghian, A.G.1    Abi-Raad, R.2    Assaad, S.I.3    Casty, A.4    Ancukiewicz, M.5    Yeh, E.6
  • 129
    • 0019865893 scopus 로고
    • High-dose dexamethasone for prevention of cis-platin-induced vomiting
    • Aapro MS, Alberts DS. High-dose dexamethasone for prevention of cis-platin-induced vomiting. Cancer Chemother Pharmacol (1981) 7(1):11-4. doi:10.1007/BF00258206.
    • (1981) Cancer Chemother Pharmacol , vol.7 , Issue.1 , pp. 11-14
    • Aapro, M.S.1    Alberts, D.S.2
  • 130
    • 1842428890 scopus 로고    scopus 로고
    • Pretreatment with dexamethasone increases antitumor activity of carboplatin and gemcitabine in mice bearing human cancer xenografts: in vivo activity, pharmacokinetics, and clinical implications for cancer chemotherapy
    • Wang H, Li M, Rinehart JJ, Zhang R. Pretreatment with dexamethasone increases antitumor activity of carboplatin and gemcitabine in mice bearing human cancer xenografts: in vivo activity, pharmacokinetics, and clinical implications for cancer chemotherapy. Clin Cancer Res (2004) 10(5):1633-44. doi:10.1158/1078-0432.CCR-0829-3.
    • (2004) Clin Cancer Res , vol.10 , Issue.5 , pp. 1633-1644
    • Wang, H.1    Li, M.2    Rinehart, J.J.3    Zhang, R.4
  • 131
    • 0027429968 scopus 로고
    • Dexamethasone reduces the interstitial fluid pressure in a human colon adenocarcinoma xenograft
    • Kristjansen PE, Boucher Y, Jain RK. Dexamethasone reduces the interstitial fluid pressure in a human colon adenocarcinoma xenograft. Cancer Res (1993) 53(20):4764-6.
    • (1993) Cancer Res , vol.53 , Issue.20 , pp. 4764-4766
    • Kristjansen, P.E.1    Boucher, Y.2    Jain, R.K.3
  • 132
    • 0021285982 scopus 로고
    • Hyperthermia for the engineer: a short biological primer
    • Hahn GM. Hyperthermia for the engineer: a short biological primer. IEEE Trans Biomed Eng (1984) 31(1):3-8. doi:10.1109/TBME.1984.325363.
    • (1984) IEEE Trans Biomed Eng , vol.31 , Issue.1 , pp. 3-8
    • Hahn, G.M.1
  • 133
    • 0026527259 scopus 로고
    • Interstitial fluid pressure in solid tumors following hyperthermia: possible correlation with therapeutic response
    • Leunig M, Goetz AE, Dellian M, Zetterer G, Gamarra F, Jain RK, et al. Interstitial fluid pressure in solid tumors following hyperthermia: possible correlation with therapeutic response. Cancer Res (1992) 52(2):487-90.
    • (1992) Cancer Res , vol.52 , Issue.2 , pp. 487-490
    • Leunig, M.1    Goetz, A.E.2    Dellian, M.3    Zetterer, G.4    Gamarra, F.5    Jain, R.K.6
  • 134
    • 79957928543 scopus 로고    scopus 로고
    • Mild elevation of body temperature reduces tumor interstitial fluid pressure and hypoxia and enhances efficacy of radiotherapy in murine tumor models
    • Sen A, Capitano ML, Spernyak JA, Schueckler JT, Thomas S, Singh AK, et al. Mild elevation of body temperature reduces tumor interstitial fluid pressure and hypoxia and enhances efficacy of radiotherapy in murine tumor models. Cancer Res (2011) 71(11):3872-80. doi:10.1158/0008-5472.CAN-10-4482.
    • (2011) Cancer Res , vol.71 , Issue.11 , pp. 3872-3880
    • Sen, A.1    Capitano, M.L.2    Spernyak, J.A.3    Schueckler, J.T.4    Thomas, S.5    Singh, A.K.6
  • 135
    • 70350704691 scopus 로고    scopus 로고
    • Radiocurability is associated with interstitial fluid pressure in human tumor xenografts
    • Rofstad EK, Gaustad JV, Brurberg KG, Mathiesen B, Galappathi K, Simonsen TG. Radiocurability is associated with interstitial fluid pressure in human tumor xenografts. Neoplasia (2009) 11(11):1243-51. doi:10.1593/neo.91152.
    • (2009) Neoplasia , vol.11 , Issue.11 , pp. 1243-1251
    • Rofstad, E.K.1    Gaustad, J.V.2    Brurberg, K.G.3    Mathiesen, B.4    Galappathi, K.5    Simonsen, T.G.6
  • 136
    • 0030022119 scopus 로고    scopus 로고
    • Effect of radiation on interstitial fluid pressure and oxygenation in a human tumorxenograft
    • Znati CA, Rosenstein M, Boucher Y, Epperly MW, Bloomer WD, Jain RK. Effect of radiation on interstitial fluid pressure and oxygenation in a human tumorxenograft. Cancer Res (1996) 56(5):964-8.
    • (1996) Cancer Res , vol.56 , Issue.5 , pp. 964-968
    • Znati, C.A.1    Rosenstein, M.2    Boucher, Y.3    Epperly, M.W.4    Bloomer, W.D.5    Jain, R.K.6
  • 138
    • 33745537921 scopus 로고    scopus 로고
    • Photodynamic therapy and anti-tumour immunity
    • Castano AP, Mroz P, Hamblin MR. Photodynamic therapy and anti-tumour immunity. Nat Rev Cancer (2006) 6(7):535-45. doi:10.1038/nrc1894.
    • (2006) Nat Rev Cancer , vol.6 , Issue.7 , pp. 535-545
    • Castano, A.P.1    Mroz, P.2    Hamblin, M.R.3
  • 139
    • 84924795897 scopus 로고    scopus 로고
    • Low-dose vascular photodynamic therapy decreases tumor interstitial fluid pressure, which promotes liposomal doxorubicin distribution in a murine sarcoma metastasis model
    • Perentes JY, Wang Y, Wang X, Abdelnour E, Gonzalez M, Decosterd L, et al. Low-dose vascular photodynamic therapy decreases tumor interstitial fluid pressure, which promotes liposomal doxorubicin distribution in a murine sarcoma metastasis model. Transl Oncol (2014) 7(3):393-9. doi:10.1016/j.tranon.2014.04.010.
    • (2014) Transl Oncol , vol.7 , Issue.3 , pp. 393-399
    • Perentes, J.Y.1    Wang, Y.2    Wang, X.3    Abdelnour, E.4    Gonzalez, M.5    Decosterd, L.6
  • 140
    • 84881246125 scopus 로고    scopus 로고
    • Ultrasound-mediated drug/gene delivery in solid tumor treatment
    • Zhou Y. Ultrasound-mediated drug/gene delivery in solid tumor treatment. J Healthc Eng (2013) 4(2):223-54. doi:10.1260/2040-2295.4.2.223.
    • (2013) J Healthc Eng , vol.4 , Issue.2 , pp. 223-254
    • Zhou, Y.1
  • 141
    • 84863229509 scopus 로고    scopus 로고
    • Ultrasound increases nanoparticle delivery by reducing intratumoral pressure and increasing transport in epithelial and epithelial-mesenchymal transition tumors
    • Watson KD, Lai CY, Qin S, Kruse DE, Lin YC, Seo JW, et al. Ultrasound increases nanoparticle delivery by reducing intratumoral pressure and increasing transport in epithelial and epithelial-mesenchymal transition tumors. Cancer Res (2012) 72(6):1485-93. doi:10.1158/0008-5472.CAN-11-3232.
    • (2012) Cancer Res , vol.72 , Issue.6 , pp. 1485-1493
    • Watson, K.D.1    Lai, C.Y.2    Qin, S.3    Kruse, D.E.4    Lin, Y.C.5    Seo, J.W.6
  • 142
    • 84873835896 scopus 로고    scopus 로고
    • Epithelial mesenchymal transition in drug resistance and metastasis of lung cancer
    • Nurwidya F, Takahashi F, Murakami A, Takahashi K. Epithelial mesenchymal transition in drug resistance and metastasis of lung cancer. Cancer Res Treat (2012) 44(3):151-6. doi:10.4143/crt.2012.44.3.151.
    • (2012) Cancer Res Treat , vol.44 , Issue.3 , pp. 151-156
    • Nurwidya, F.1    Takahashi, F.2    Murakami, A.3    Takahashi, K.4
  • 143
    • 67650999875 scopus 로고    scopus 로고
    • The basics of epithelial-mesenchymal transition
    • Kalluri R, Weinberg RA. The basics of epithelial-mesenchymal transition. J Clin Invest (2009) 119(6):1420-8. doi:10.1172/JCI39104.
    • (2009) J Clin Invest , vol.119 , Issue.6 , pp. 1420-1428
    • Kalluri, R.1    Weinberg, R.A.2
  • 144
    • 79952594233 scopus 로고    scopus 로고
    • Losartan inhibits collagen I synthesis and improves the distribution and efficacy of nanotherapeutics in tumors
    • Diop-Frimpong B, Chauhan VP, Krane S, Boucher Y, Jain RK. Losartan inhibits collagen I synthesis and improves the distribution and efficacy of nanotherapeutics in tumors. Proc Natl Acad Sci U S A (2011) 108(7):2909-14. doi:10.1073/pnas.1018892108.
    • (2011) Proc Natl Acad Sci U S A , vol.108 , Issue.7 , pp. 2909-2914
    • Diop-Frimpong, B.1    Chauhan, V.P.2    Krane, S.3    Boucher, Y.4    Jain, R.K.5
  • 145
    • 0034193258 scopus 로고    scopus 로고
    • Role of extracellular matrix assembly in interstitial transport in solid tumors
    • Netti PA, Berk DA, Swartz MA, Grodzinsky AJ, Jain RK. Role of extracellular matrix assembly in interstitial transport in solid tumors. Cancer Res (2000) 60(9):2497-503.
    • (2000) Cancer Res , vol.60 , Issue.9 , pp. 2497-2503
    • Netti, P.A.1    Berk, D.A.2    Swartz, M.A.3    Grodzinsky, A.J.4    Jain, R.K.5
  • 146
    • 84859949610 scopus 로고    scopus 로고
    • The extracellular matrix: a dynamic niche in cancer progression
    • Lu P, Weaver VM, Werb Z. The extracellular matrix: a dynamic niche in cancer progression. J Cell Biol (2012) 196(4):395-406. doi:10.1083/jcb.201102147.
    • (2012) J Cell Biol , vol.196 , Issue.4 , pp. 395-406
    • Lu, P.1    Weaver, V.M.2    Werb, Z.3
  • 147
    • 84905103883 scopus 로고    scopus 로고
    • Fibroblast heterogeneity in the cancer wound
    • Öhlund D, Elyada E, Tuveson D. Fibroblast heterogeneity in the cancer wound. J Exp Med (2014) 211(8):1503-23. doi:10.1084/jem.20140692.
    • (2014) J Exp Med , vol.211 , Issue.8 , pp. 1503-1523
    • Öhlund, D.1    Elyada, E.2    Tuveson, D.3
  • 148
    • 52049122865 scopus 로고    scopus 로고
    • Biological functions of the small leucine-rich proteoglycans: from genetics to signal transduction
    • Schaefer L, Iozzo RV. Biological functions of the small leucine-rich proteoglycans: from genetics to signal transduction. J Biol Chem (2008) 283(31):21305-9. doi:10.1074/jbc.R800020200.
    • (2008) J Biol Chem , vol.283 , Issue.31 , pp. 21305-21309
    • Schaefer, L.1    Iozzo, R.V.2
  • 149
    • 84922333220 scopus 로고    scopus 로고
    • Remodelling the extracellular matrix in development and disease
    • Bonnans C, Chou J, Werb Z. Remodelling the extracellular matrix in development and disease. Nat Rev Mol Cell Biol (2014) 15(12):786-801. doi:10.1038/nrm3904.
    • (2014) Nat Rev Mol Cell Biol , vol.15 , Issue.12 , pp. 786-801
    • Bonnans, C.1    Chou, J.2    Werb, Z.3
  • 150
    • 79955528442 scopus 로고    scopus 로고
    • Extracellular matrix and cell signalling: the dynamic cooperation of integrin, proteoglycan and growth factor receptor
    • Kim SH, Turnbull J, Guimond S. Extracellular matrix and cell signalling: the dynamic cooperation of integrin, proteoglycan and growth factor receptor. J Endocrinol (2011) 209(2):139-51. doi:10.1530/JOE-10-0377.
    • (2011) J Endocrinol , vol.209 , Issue.2 , pp. 139-151
    • Kim, S.H.1    Turnbull, J.2    Guimond, S.3
  • 151
    • 3142660422 scopus 로고    scopus 로고
    • Collagenase increases the transcapillary pressure gradient and improves the uptake and distribution of monoclonal antibodies in human osteosarcoma xenografts
    • Eikenes L, Bruland ØS, Brekken C, Davies Cde L. Collagenase increases the transcapillary pressure gradient and improves the uptake and distribution of monoclonal antibodies in human osteosarcoma xenografts. Cancer Res (2004) 64(14):4768-73. doi:10.1158/0008-5472.CAN-03-1472.
    • (2004) Cancer Res , vol.64 , Issue.14 , pp. 4768-4773
    • Eikenes, L.1    Bruland, ØS.2    Brekken, C.3    Davies Cde, L.4
  • 152
    • 23144448579 scopus 로고    scopus 로고
    • Hyaluronidase induces a transcapillary pressure gradient and improves the distribution and uptake of liposomal doxorubicin (Caelyx) in human osteosarcoma xenografts
    • Eikenes L, Tari M, Tufto I, Bruland OS, de Lange Davies C. Hyaluronidase induces a transcapillary pressure gradient and improves the distribution and uptake of liposomal doxorubicin (Caelyx) in human osteosarcoma xenografts. Br J Cancer (2005) 93(1):81-8. doi:10.1038/sj.bjc.6602626.
    • (2005) Br J Cancer , vol.93 , Issue.1 , pp. 81-88
    • Eikenes, L.1    Tari, M.2    Tufto, I.3    Bruland, O.S.4    de Lange Davies, C.5
  • 153
    • 84921916417 scopus 로고    scopus 로고
    • Role of TGFβ in regulation of the tumor microenvironment and drug delivery (review)
    • Papageorgis P, Stylianopoulos T. Role of TGFβ in regulation of the tumor microenvironment and drug delivery (review). Int J Oncol (2015) 46(3):933-43. doi:10.3892/ijo.2015.2816.
    • (2015) Int J Oncol , vol.46 , Issue.3 , pp. 933-943
    • Papageorgis, P.1    Stylianopoulos, T.2
  • 154
    • 0036790060 scopus 로고    scopus 로고
    • Inhibition of PDGF receptor signaling in tumor stroma enhances antitumor effect of chemotherapy
    • Pietras K, Rubin K, Sjöblom T, Buchdunger E, Sjöquist M, Heldin CH, et al. Inhibition of PDGF receptor signaling in tumor stroma enhances antitumor effect of chemotherapy. Cancer Res (2002) 62(19):5476-84.
    • (2002) Cancer Res , vol.62 , Issue.19 , pp. 5476-5484
    • Pietras, K.1    Rubin, K.2    Sjöblom, T.3    Buchdunger, E.4    Sjöquist, M.5    Heldin, C.H.6
  • 155
    • 24744462115 scopus 로고    scopus 로고
    • Effect of platelet-derived growth factor receptor-beta inhibition with STI571 on radioimmunotherapy
    • Baranowska-Kortylewicz J, Abe M, Pietras K, Kortylewicz ZP, Kurizaki T, Nearman J, et al. Effect of platelet-derived growth factor receptor-beta inhibition with STI571 on radioimmunotherapy. Cancer Res (2005) 65(17):7824-31. doi:10.1158/0008-5472.CAN-04-3991.
    • (2005) Cancer Res , vol.65 , Issue.17 , pp. 7824-7831
    • Baranowska-Kortylewicz, J.1    Abe, M.2    Pietras, K.3    Kortylewicz, Z.P.4    Kurizaki, T.5    Nearman, J.6
  • 156
    • 0033635039 scopus 로고    scopus 로고
    • Interstitial fluid pressure in human osteosarcoma xenografts: significance of implantation site and the response to intratumoral injection of hyaluronidase
    • Brekken C, Bruland ØS, de Lange Davies C. Interstitial fluid pressure in human osteosarcoma xenografts: significance of implantation site and the response to intratumoral injection of hyaluronidase. Anticancer Res (2000) 20(5B):3503-12.
    • (2000) Anticancer Res , vol.20 , Issue.5 , pp. 3503-3512
    • Brekken, C.1    Bruland, ØS.2    de Lange Davies, C.3
  • 157
    • 0033613119 scopus 로고    scopus 로고
    • Platelet-derived growth factor beta receptor regulates interstitial fluid homeostasis through phosphatidylinositol-3' kinase signaling
    • Heuchel R, Berg A, Tallquist M, Ahlén K, Reed RK, Rubin K, et al. Platelet-derived growth factor beta receptor regulates interstitial fluid homeostasis through phosphatidylinositol-3' kinase signaling. Proc Natl Acad Sci U S A (1999) 96(20):11410-5. doi:10.1073/pnas.96.20.11410.
    • (1999) Proc Natl Acad Sci U S A , vol.96 , Issue.20 , pp. 11410-11415
    • Heuchel, R.1    Berg, A.2    Tallquist, M.3    Ahlén, K.4    Reed, R.K.5    Rubin, K.6
  • 158
    • 77957221459 scopus 로고    scopus 로고
    • Dynamic interplay between the collagen scaffold and tumor evolution
    • Egeblad M, Rasch MG, Weaver VM. Dynamic interplay between the collagen scaffold and tumor evolution. Curr Opin Cell Biol (2010) 22(5):697-706. doi:10.1016/j.ceb.2010.08.015.
    • (2010) Curr Opin Cell Biol , vol.22 , Issue.5 , pp. 697-706
    • Egeblad, M.1    Rasch, M.G.2    Weaver, V.M.3
  • 159
    • 76749102053 scopus 로고    scopus 로고
    • Anti-transforming growth factor beta receptor II antibody has therapeutic efficacy against primary tumor growth and metastasis through multieffects on cancer, stroma, and immune cells
    • Zhong Z, Carroll KD, Policarpio D, Osborn C, Gregory M, Bassi R, et al. Anti-transforming growth factor beta receptor II antibody has therapeutic efficacy against primary tumor growth and metastasis through multieffects on cancer, stroma, and immune cells. Clin Cancer Res (2010) 16(4):1191-205. doi:10.1158/1078-0432.CCR-09-1634.
    • (2010) Clin Cancer Res , vol.16 , Issue.4 , pp. 1191-1205
    • Zhong, Z.1    Carroll, K.D.2    Policarpio, D.3    Osborn, C.4    Gregory, M.5    Bassi, R.6
  • 160
    • 33745837774 scopus 로고    scopus 로고
    • Targeting tumor-associated fibroblasts improves cancer chemotherapy by increasing intratumoral drug uptake
    • Loeffler M, Krüger JA, Niethammer AG, Reisfeld RA. Targeting tumor-associated fibroblasts improves cancer chemotherapy by increasing intratumoral drug uptake. J Clin Invest (2006) 116(7):1955-62. doi:10.1172/JCI26532.
    • (2006) J Clin Invest , vol.116 , Issue.7 , pp. 1955-1962
    • Loeffler, M.1    Krüger, J.A.2    Niethammer, A.G.3    Reisfeld, R.A.4
  • 161
    • 34447103275 scopus 로고    scopus 로고
    • Targeting tumor stroma and exploiting mature tumor vasculature to improve anti-cancer drug delivery
    • Bouzin C, Feron O. Targeting tumor stroma and exploiting mature tumor vasculature to improve anti-cancer drug delivery. Drug Resist Updat (2007) 10(3):109-20. doi:10.1016/j.drup.2007.03.001.
    • (2007) Drug Resist Updat , vol.10 , Issue.3 , pp. 109-120
    • Bouzin, C.1    Feron, O.2
  • 162
    • 84878460362 scopus 로고    scopus 로고
    • Treatment with EGCG in NSCLC leads to decreasing interstitial fluid pressure and hypoxia to improve chemotherapy efficacy through rebalance of Ang-1 and Ang-2
    • Deng PB, Hu CP, Xiong Z, Yang HP, Li YY. Treatment with EGCG in NSCLC leads to decreasing interstitial fluid pressure and hypoxia to improve chemotherapy efficacy through rebalance of Ang-1 and Ang-2. Chin J Nat Med (2013) 11(3):245-53. doi:10.1016/S1875-5364(13)60023-0.
    • (2013) Chin J Nat Med , vol.11 , Issue.3 , pp. 245-253
    • Deng, P.B.1    Hu, C.P.2    Xiong, Z.3    Yang, H.P.4    Li, Y.Y.5
  • 163
    • 84856577045 scopus 로고    scopus 로고
    • Reducing endothelial NOS activation and interstitial fluid pressure with n-3 PUFA offset tumor chemoresistance
    • Kornfeld S, Goupille C, Vibet S, Chevalier S, Pinet A, Lebeau J, et al. Reducing endothelial NOS activation and interstitial fluid pressure with n-3 PUFA offset tumor chemoresistance. Carcinogenesis (2012) 33(2):260-7. doi:10.1093/carcin/bgr274.
    • (2012) Carcinogenesis , vol.33 , Issue.2 , pp. 260-267
    • Kornfeld, S.1    Goupille, C.2    Vibet, S.3    Chevalier, S.4    Pinet, A.5    Lebeau, J.6
  • 164
    • 34547103275 scopus 로고    scopus 로고
    • Angiopoietin: a TIE(d) balance in tumor angiogenesis
    • Shim WS, Ho IA, Wong PE. Angiopoietin: a TIE(d) balance in tumor angiogenesis. Mol Cancer Res (2007) 5(7):655-65. doi:10.1158/1541-7786.MCR-07-0072.
    • (2007) Mol Cancer Res , vol.5 , Issue.7 , pp. 655-665
    • Shim, W.S.1    Ho, I.A.2    Wong, P.E.3
  • 165
    • 84878720719 scopus 로고    scopus 로고
    • Dietary ω-3 polyunsaturated fatty acid DHA: a potential adjuvant in the treatment of cancer
    • Merendino N, Costantini L, Manzi L, Molinari R, D'Eliseo D, Velotti F. Dietary ω-3 polyunsaturated fatty acid DHA: a potential adjuvant in the treatment of cancer. Biomed Res Int (2013) 2013:310186. doi:10.1155/2013/310186.
    • (2013) Biomed Res Int , vol.2013
    • Merendino, N.1    Costantini, L.2    Manzi, L.3    Molinari, R.4    D'Eliseo, D.5    Velotti, F.6
  • 166
    • 0037122744 scopus 로고    scopus 로고
    • Clinical aspects of drug delivery to tumors
    • Au JL, Jang SH, Wientjes MG. Clinical aspects of drug delivery to tumors. J Control Release (2002) 78(1-3):81-95. doi:10.1016/S0168-3659(01)00488-6.
    • (2002) J Control Release , vol.78 , Issue.1-3 , pp. 81-95
    • Au, J.L.1    Jang, S.H.2    Wientjes, M.G.3
  • 167
    • 0035816178 scopus 로고    scopus 로고
    • Determinants of drug delivery and transport to solid tumors
    • Au JL, Jang SH, Zheng J, Chen CT, Song S, Hu L, et al. Determinants of drug delivery and transport to solid tumors. J Control Release (2001) 74(1-3):31-46. doi:10.1016/S0168-3659(01)00308-X.
    • (2001) J Control Release , vol.74 , Issue.1-3 , pp. 31-46
    • Au, J.L.1    Jang, S.H.2    Zheng, J.3    Chen, C.T.4    Song, S.5    Hu, L.6
  • 168
    • 35148881028 scopus 로고    scopus 로고
    • Drug resistance and the solid tumor microenvironment
    • Trédan O, Galmarini CM, Patel K, Tannock IF. Drug resistance and the solid tumor microenvironment. J Natl Cancer Inst (2007) 99(19):1441-54. doi:10.1093/jnci/djm135.
    • (2007) J Natl Cancer Inst , vol.99 , Issue.19 , pp. 1441-1454
    • Trédan, O.1    Galmarini, C.M.2    Patel, K.3    Tannock, I.F.4
  • 169
    • 77957734063 scopus 로고    scopus 로고
    • Multifactorial nature of tumor drug resistance
    • Solyanik GI. Multifactorial nature of tumor drug resistance. Exp Oncol (2010) 32(3):181-5.
    • (2010) Exp Oncol , vol.32 , Issue.3 , pp. 181-185
    • Solyanik, G.I.1
  • 170
    • 84891053440 scopus 로고    scopus 로고
    • The tumor microenvironment and strategies to improve drug distribution
    • Saggar JK, Yu M, Tan Q, Tannock IF. The tumor microenvironment and strategies to improve drug distribution. Front Oncol (2013) 3:154. doi:10.3389/fonc.2013.00154.
    • (2013) Front Oncol , vol.3 , pp. 154
    • Saggar, J.K.1    Yu, M.2    Tan, Q.3    Tannock, I.F.4
  • 171
    • 33746491709 scopus 로고    scopus 로고
    • Drug penetration in solid tumours
    • Minchinton AI, Tannock IF. Drug penetration in solid tumours. Nat Rev Cancer (2006) 6(8):583-92. doi:10.1038/nrc1893.
    • (2006) Nat Rev Cancer , vol.6 , Issue.8 , pp. 583-592
    • Minchinton, A.I.1    Tannock, I.F.2
  • 172
    • 84861804406 scopus 로고    scopus 로고
    • Penetration of anticancer drugs through tumour tissue as a function of cellular packing density and interstitial fluid pressure and its modification by bortezomib
    • Grantab RH, Tannock IF. Penetration of anticancer drugs through tumour tissue as a function of cellular packing density and interstitial fluid pressure and its modification by bortezomib. BMC Cancer (2012) 12:214. doi:10.1186/1471-2407-12-214.
    • (2012) BMC Cancer , vol.12 , pp. 214
    • Grantab, R.H.1    Tannock, I.F.2
  • 173
    • 0029783842 scopus 로고    scopus 로고
    • Reversal by hyaluronidase of adhesion-dependent multicellular drug resistance in mammary carcinoma cells
    • Croix BS, Rak JW, Kapitain S, Sheehan C, Graham CH, Kerbel RS. Reversal by hyaluronidase of adhesion-dependent multicellular drug resistance in mammary carcinoma cells. J Natl Cancer Inst (1996) 88(18):1285-96. doi:10.1093/jnci/88.18.1285.
    • (1996) J Natl Cancer Inst , vol.88 , Issue.18 , pp. 1285-1296
    • Croix, B.S.1    Rak, J.W.2    Kapitain, S.3    Sheehan, C.4    Graham, C.H.5    Kerbel, R.S.6
  • 176
    • 70350151690 scopus 로고    scopus 로고
    • Convection-enhanced delivery for the treatment of brain tumors
    • Debinski W, Tatter SB. Convection-enhanced delivery for the treatment of brain tumors. Expert Rev Neurother (2009) 9(10):1519-27. doi:10.1586/ern.09.99.
    • (2009) Expert Rev Neurother , vol.9 , Issue.10 , pp. 1519-1527
    • Debinski, W.1    Tatter, S.B.2
  • 177
    • 11144355073 scopus 로고    scopus 로고
    • Distribution of liposomes into brain and rat brain tumor models by convection-enhanced delivery monitored with magnetic resonance imaging
    • Saito R, Bringas JR, McKnight TR, Wendland MF, Mamot C, Drummond DC, et al. Distribution of liposomes into brain and rat brain tumor models by convection-enhanced delivery monitored with magnetic resonance imaging. Cancer Res (2004) 64(7):2572-9. doi:10.1158/0008-5472.CAN-03-3631.
    • (2004) Cancer Res , vol.64 , Issue.7 , pp. 2572-2579
    • Saito, R.1    Bringas, J.R.2    McKnight, T.R.3    Wendland, M.F.4    Mamot, C.5    Drummond, D.C.6
  • 178
    • 33747174300 scopus 로고    scopus 로고
    • Convection-enhanced delivery of immunotoxins and radioisotopes for treatment of malignant gliomas
    • Vandergrift WA, Patel SJ, Nicholas JS, Varma AK. Convection-enhanced delivery of immunotoxins and radioisotopes for treatment of malignant gliomas. Neurosurg Focus (2006) 20(4):E13. doi:10.3171/foc.2006.20.4.8.
    • (2006) Neurosurg Focus , vol.20 , Issue.4 , pp. E13
    • Vandergrift, W.A.1    Patel, S.J.2    Nicholas, J.S.3    Varma, A.K.4
  • 179
    • 84918823804 scopus 로고    scopus 로고
    • Convection-enhanced delivery for targeted delivery of antiglioma agents: the translational experience
    • Yun J, Rothrock RJ, Canoll P, Bruce JN. Convection-enhanced delivery for targeted delivery of antiglioma agents: the translational experience. J Drug Deliv (2013) 2013:107573. doi:10.1155/2013/107573.
    • (2013) J Drug Deliv , vol.2013
    • Yun, J.1    Rothrock, R.J.2    Canoll, P.3    Bruce, J.N.4
  • 180
    • 0034662609 scopus 로고    scopus 로고
    • Hyperthermia enables tumor-specific nanoparticle delivery: effect of particle size
    • Kong G, Braun RD, Dewhirst MW. Hyperthermia enables tumor-specific nanoparticle delivery: effect of particle size. Cancer Res (2000) 60(16):4440-5.
    • (2000) Cancer Res , vol.60 , Issue.16 , pp. 4440-4445
    • Kong, G.1    Braun, R.D.2    Dewhirst, M.W.3
  • 181
    • 44249123015 scopus 로고    scopus 로고
    • Ultrasound mediated delivery of drugs and genes to solid tumors
    • Frenkel V. Ultrasound mediated delivery of drugs and genes to solid tumors. Adv Drug Deliv Rev (2008) 60(10):1193-208. doi:10.1016/j.addr.2008.03.007.
    • (2008) Adv Drug Deliv Rev , vol.60 , Issue.10 , pp. 1193-1208
    • Frenkel, V.1
  • 182
    • 84867748641 scopus 로고    scopus 로고
    • Interaction of tumor cells and lymphatic vessels in cancer progression
    • Alitalo A, Detmar M. Interaction of tumor cells and lymphatic vessels in cancer progression. Oncogene (2012) 31(42):4499-508. doi:10.1038/onc.2011.602.
    • (2012) Oncogene , vol.31 , Issue.42 , pp. 4499-4508
    • Alitalo, A.1    Detmar, M.2
  • 183
    • 48349129069 scopus 로고    scopus 로고
    • Blocking VEGFR-3 suppresses angiogenic sprouting and vascular network formation
    • Tammela T, Zarkada G, Wallgard E, Murtomäki A, Suchting S, Wirzenius M, et al. Blocking VEGFR-3 suppresses angiogenic sprouting and vascular network formation. Nature (2008) 454(7204):656-60. doi:10.1038/nature07083.
    • (2008) Nature , vol.454 , Issue.7204 , pp. 656-660
    • Tammela, T.1    Zarkada, G.2    Wallgard, E.3    Murtomäki, A.4    Suchting, S.5    Wirzenius, M.6
  • 184
    • 84891112609 scopus 로고    scopus 로고
    • Vascular permeability and drug delivery in cancers
    • Azzi S, Hebda JK, Gavard J. Vascular permeability and drug delivery in cancers. Front Oncol (2013) 3:211. doi:10.3389/fonc.2013.00211.
    • (2013) Front Oncol , vol.3 , pp. 211
    • Azzi, S.1    Hebda, J.K.2    Gavard, J.3
  • 185
    • 84878217732 scopus 로고    scopus 로고
    • Vascular permeability changes involved in tumor metastasis
    • García-Román J, Zentella-Dehesa A. Vascular permeability changes involved in tumor metastasis. Cancer Lett (2013) 335(2):259-69. doi:10.1016/j.canlet.2013.03.005.
    • (2013) Cancer Lett , vol.335 , Issue.2 , pp. 259-269
    • García-Román, J.1    Zentella-Dehesa, A.2
  • 186
    • 37848998838 scopus 로고    scopus 로고
    • Angiopoietin-1 prevents VEGF-induced endothelial permeability by sequestering Src through mDia
    • Gavard J, Patel V, Gutkind JS. Angiopoietin-1 prevents VEGF-induced endothelial permeability by sequestering Src through mDia. Dev Cell (2008) 14(1):25-36. doi:10.1016/j.devcel.2007.10.019.
    • (2008) Dev Cell , vol.14 , Issue.1 , pp. 25-36
    • Gavard, J.1    Patel, V.2    Gutkind, J.S.3
  • 187
    • 84876993950 scopus 로고    scopus 로고
    • Normalizing tumor microenvironment to treat cancer: bench to bedside to biomarkers
    • Jain RK. Normalizing tumor microenvironment to treat cancer: bench to bedside to biomarkers. J Clin Oncol (2013) 31(17):2205-18. doi:10.1200/JCO.2012.46.3653.
    • (2013) J Clin Oncol , vol.31 , Issue.17 , pp. 2205-2218
    • Jain, R.K.1
  • 188
    • 84862907876 scopus 로고    scopus 로고
    • Increased survival of glioblastoma patients who respond to antiangiogenic therapy with elevated blood perfusion
    • Erratum in: Cancer Res (2012) 72(5):1316. Cancer Res (2012) 72(2)
    • Sorensen AG, Emblem KE, Polaskova P, Jennings D, Kim H, Ancukiewicz M, et al. Increased survival of glioblastoma patients who respond to antiangiogenic therapy with elevated blood perfusion. Cancer Res (2012) 72(2):402-7; Erratum in: Cancer Res (2012) 72(5):1316. Cancer Res (2012) 72(2). doi:10.1158/0008-5472.CAN-11-2464.
    • (2012) Cancer Res , vol.72 , Issue.2 , pp. 402-407
    • Sorensen, A.G.1    Emblem, K.E.2    Polaskova, P.3    Jennings, D.4    Kim, H.5    Ancukiewicz, M.6
  • 189
    • 84856720055 scopus 로고    scopus 로고
    • Antiangiogenic therapy for glioblastoma
    • Gerstner ER, Batchelor TT. Antiangiogenic therapy for glioblastoma. Cancer J (2012) 18(1):45-50. doi:10.1097/PPO.0b013e3182431c6f.
    • (2012) Cancer J , vol.18 , Issue.1 , pp. 45-50
    • Gerstner, E.R.1    Batchelor, T.T.2
  • 190
    • 84929320945 scopus 로고    scopus 로고
    • Vascular endothelial growth factor blockade alters magnetic resonance imaging biomarkers of vascular function and decreases barrier permeability in a rat model of lung cancer brain metastasis
    • Pishko GL, Muldoon LL, Pagel MA, Schwartz DL, Neuwelt EA. Vascular endothelial growth factor blockade alters magnetic resonance imaging biomarkers of vascular function and decreases barrier permeability in a rat model of lung cancer brain metastasis. Fluids Barriers CNS (2015) 12:5. doi:10.1186/2045-8118-12-5.
    • (2015) Fluids Barriers CNS , vol.12 , pp. 5
    • Pishko, G.L.1    Muldoon, L.L.2    Pagel, M.A.3    Schwartz, D.L.4    Neuwelt, E.A.5
  • 191
    • 37049012486 scopus 로고    scopus 로고
    • Delta-like 4 Notch ligand regulates tumor angiogenesis, improves tumor vascular function, and promotes tumor growth in vivo
    • Li JL, Sainson RC, Shi W, Leek R, Harrington LS, Preusser M, et al. Delta-like 4 Notch ligand regulates tumor angiogenesis, improves tumor vascular function, and promotes tumor growth in vivo. Cancer Res (2007) 67(23):11244-53. doi:10.1158/0008-5472.CAN-07-0969.
    • (2007) Cancer Res , vol.67 , Issue.23 , pp. 11244-11253
    • Li, J.L.1    Sainson, R.C.2    Shi, W.3    Leek, R.4    Harrington, L.S.5    Preusser, M.6
  • 192
  • 193
    • 79952281910 scopus 로고    scopus 로고
    • Modulation of tumor immunity by therapeutic monoclonal antibodies
    • Abès R, Teillaud JL. Modulation of tumor immunity by therapeutic monoclonal antibodies. Cancer Metastasis Rev (2011) 30(1):111-24. doi:10.1007/s10555-011-9282-3.
    • (2011) Cancer Metastasis Rev , vol.30 , Issue.1 , pp. 111-124
    • Abès, R.1    Teillaud, J.L.2
  • 194
    • 80755142757 scopus 로고    scopus 로고
    • The tumor microenvironment: part 1
    • Leibovici J, Itzhaki O, Huszar M, Sinai J. The tumor microenvironment: part 1. Immunotherapy (2011) 3(11):1367-84. doi:10.2217/imt.11.111.
    • (2011) Immunotherapy , vol.3 , Issue.11 , pp. 1367-1384
    • Leibovici, J.1    Itzhaki, O.2    Huszar, M.3    Sinai, J.4
  • 195
    • 0036793223 scopus 로고    scopus 로고
    • MRI of the tumor microenvironment
    • Erratum in: J Magn Reson Imaging (2002) 16(6):751
    • Gillies RJ, Raghunand N, Karczmar GS, Bhujwalla ZM. MRI of the tumor microenvironment. J Magn Reson Imaging (2002) 16(4):430-50; Erratum in: J Magn Reson Imaging (2002) 16(6):751. doi:10.1002/jmri.10181.
    • (2002) J Magn Reson Imaging , vol.16 , Issue.4 , pp. 430-450
    • Gillies, R.J.1    Raghunand, N.2    Karczmar, G.S.3    Bhujwalla, Z.M.4
  • 196
    • 84907854838 scopus 로고    scopus 로고
    • Molecular imaging of the tumor microenvironment for precision medicine and theranostics
    • Penet MF, Krishnamachary B, Chen Z, Jin J, Bhujwalla ZM. Molecular imaging of the tumor microenvironment for precision medicine and theranostics. Adv Cancer Res (2014) 124:235-56. doi:10.1016/B978-0-12-411638-2.00007-0.
    • (2014) Adv Cancer Res , vol.124 , pp. 235-256
    • Penet, M.F.1    Krishnamachary, B.2    Chen, Z.3    Jin, J.4    Bhujwalla, Z.M.5
  • 197
    • 84921711123 scopus 로고    scopus 로고
    • Improving drug delivery to solid tumors: priming the tumor microenvironment
    • Khawar IA, Kim JH, Kuh HJ. Improving drug delivery to solid tumors: priming the tumor microenvironment. J Control Release (2015) 201:78-89. doi:10.1016/j.jconrel.2014.12.018.
    • (2015) J Control Release , vol.201 , pp. 78-89
    • Khawar, I.A.1    Kim, J.H.2    Kuh, H.J.3
  • 198
    • 84891887947 scopus 로고    scopus 로고
    • Imaging aspects of the tumor stroma with therapeutic implications
    • Narunsky L, Oren R, Bochner F, Neeman M. Imaging aspects of the tumor stroma with therapeutic implications. Pharmacol Ther (2014) 141(2):192-208. doi:10.1016/j.pharmthera.2013.10.003.
    • (2014) Pharmacol Ther , vol.141 , Issue.2 , pp. 192-208
    • Narunsky, L.1    Oren, R.2    Bochner, F.3    Neeman, M.4
  • 200
    • 84891067126 scopus 로고    scopus 로고
    • Current advances in mathematical modeling of anti-cancer drug penetration into tumor tissues
    • Kim M, Gillies RJ, Rejniak KA. Current advances in mathematical modeling of anti-cancer drug penetration into tumor tissues. Front Oncol (2013) 3:278. doi:10.3389/fonc.2013.00278.
    • (2013) Front Oncol , vol.3 , pp. 278
    • Kim, M.1    Gillies, R.J.2    Rejniak, K.A.3
  • 201
    • 74049097142 scopus 로고    scopus 로고
    • Cardiotoxicity of anticancer drugs: the need for cardio-oncology and cardio-oncological prevention
    • Albini A, Pennesi G, Donatelli F, Cammarota R, De Flora S, Noonan DM. Cardiotoxicity of anticancer drugs: the need for cardio-oncology and cardio-oncological prevention. J Natl Cancer Inst (2010) 102(1):14-25. doi:10.1093/jnci/djp440.
    • (2010) J Natl Cancer Inst , vol.102 , Issue.1 , pp. 14-25
    • Albini, A.1    Pennesi, G.2    Donatelli, F.3    Cammarota, R.4    De Flora, S.5    Noonan, D.M.6
  • 202
    • 84877057639 scopus 로고    scopus 로고
    • Cardiac fibrosis and vascular remodeling are attenuated by metformin in obese rats
    • Burlá AK, Lobato NS, Fortes ZB, Oigman W, Neves MF. Cardiac fibrosis and vascular remodeling are attenuated by metformin in obese rats. Int J Cardiol (2013) 165(3):483-7. doi:10.1016/j.ijcard.2011.09.012.
    • (2013) Int J Cardiol , vol.165 , Issue.3 , pp. 483-487
    • Burlá, A.K.1    Lobato, N.S.2    Fortes, Z.B.3    Oigman, W.4    Neves, M.F.5
  • 203
    • 84922220567 scopus 로고    scopus 로고
    • The biguanides metformin and phenformin inhibit angiogenesis, local and metastatic growth of breast cancer by targeting both neoplastic and microenvironment cells
    • Orecchioni S, Reggiani F, Talarico G, Mancuso P, Calleri A, Gregato G, et al. The biguanides metformin and phenformin inhibit angiogenesis, local and metastatic growth of breast cancer by targeting both neoplastic and microenvironment cells. Int J Cancer (2015) 136(6):E534-44. doi:10.1002/ijc.29193.
    • (2015) Int J Cancer , vol.136 , Issue.6 , pp. E534-E544
    • Orecchioni, S.1    Reggiani, F.2    Talarico, G.3    Mancuso, P.4    Calleri, A.5    Gregato, G.6
  • 204
    • 0242298635 scopus 로고    scopus 로고
    • Tumor microenvironment and hemorheological abnormalities
    • Baronzio G, Freitas I, Kwaan HC. Tumor microenvironment and hemorheological abnormalities. Semin Thromb Hemost (2003) 29(5):489-97. doi:10.1055/s-2003-44557.
    • (2003) Semin Thromb Hemost , vol.29 , Issue.5 , pp. 489-497
    • Baronzio, G.1    Freitas, I.2    Kwaan, H.C.3
  • 205
    • 84856548639 scopus 로고    scopus 로고
    • Combining functional imaging and interstitial pressure measurements to evaluate two anti-angiogenic treatments
    • Leguerney I, Lassau N, Koscielny S, Rodrigues M, Massard C, Rouffiac V, et al. Combining functional imaging and interstitial pressure measurements to evaluate two anti-angiogenic treatments. Invest New Drugs (2012) 30(1):144-56. doi:10.1007/s10637-010-9543-y.
    • (2012) Invest New Drugs , vol.30 , Issue.1 , pp. 144-156
    • Leguerney, I.1    Lassau, N.2    Koscielny, S.3    Rodrigues, M.4    Massard, C.5    Rouffiac, V.6
  • 206
    • 84940956193 scopus 로고    scopus 로고
    • Toward a full understanding of the EPR effect in primary and metastatic tumors as well as issues related to its heterogeneity
    • Maeda H. Toward a full understanding of the EPR effect in primary and metastatic tumors as well as issues related to its heterogeneity. Adv Drug Deliv Rev (2015). doi:10.1016/j.addr.2015.01.002.
    • (2015) Adv Drug Deliv Rev
    • Maeda, H.1
  • 207
    • 0141790758 scopus 로고    scopus 로고
    • Drug delivery and transport to solid tumors
    • Jang SH, Wientjes MG, Lu D, Au JL. Drug delivery and transport to solid tumors. Pharm Res (2003) 20(9):1337-50. doi:10.1023/A:1025785505977.
    • (2003) Pharm Res , vol.20 , Issue.9 , pp. 1337-1350
    • Jang, S.H.1    Wientjes, M.G.2    Lu, D.3    Au, J.L.4
  • 208
    • 79960924361 scopus 로고    scopus 로고
    • Vascular normalization: a real benefit?
    • Ribatti D. Vascular normalization: a real benefit? Cancer Chemother Pharmacol (2011) 68(2):275-8. doi:10.1007/s00280-011-1683-z.
    • (2011) Cancer Chemother Pharmacol , vol.68 , Issue.2 , pp. 275-278
    • Ribatti, D.1
  • 209
    • 84945460646 scopus 로고    scopus 로고
    • Local hyperthermia combined with radiotherapy and-/or chemotherapy: Recent advances and promises for the future
    • Datta NR, Ordóñez SG, Gaipl US, Paulides MM, Crezee H, Gellermann J, et al. Local hyperthermia combined with radiotherapy and-/or chemotherapy: Recent advances and promises for the future. Cancer Treat Rev (2015). doi:10.1016/j.ctrv.2015.05.009.
    • (2015) Cancer Treat Rev
    • Datta, N.R.1    Ordóñez, S.G.2    Gaipl, U.S.3    Paulides, M.M.4    Crezee, H.5    Gellermann, J.6
  • 210
    • 84920649897 scopus 로고    scopus 로고
    • Hyperthermia, radiation and chemotherapy: the role of heat in multidisciplinary cancer care
    • Hurwitz M, Stauffer P. Hyperthermia, radiation and chemotherapy: the role of heat in multidisciplinary cancer care. Semin Oncol (2014) 41(6):714-29. doi:10.1053/j.seminoncol.2014.09.014.
    • (2014) Semin Oncol , vol.41 , Issue.6 , pp. 714-729
    • Hurwitz, M.1    Stauffer, P.2
  • 211
    • 78649450413 scopus 로고    scopus 로고
    • Interaction between the extracellular matrix and lymphatics: consequences for lymphangiogenesis and lymphatic function
    • Wiig H, Keskin D, Kalluri R. Interaction between the extracellular matrix and lymphatics: consequences for lymphangiogenesis and lymphatic function. Matrix Biol (2010) 29(8):645-56. doi:10.1016/j.matbio.2010.08.001.
    • (2010) Matrix Biol , vol.29 , Issue.8 , pp. 645-656
    • Wiig, H.1    Keskin, D.2    Kalluri, R.3
  • 212
    • 84891096576 scopus 로고    scopus 로고
    • The role of tumor tissue architecture in treatment penetration and efficacy: an integrative study
    • Rejniak KA, Estrella V, Chen T, Cohen AS, Lloyd MC, Morse DL. The role of tumor tissue architecture in treatment penetration and efficacy: an integrative study. Front Oncol (2013) 3:111. doi:10.3389/fonc.2013.00111.
    • (2013) Front Oncol , vol.3 , pp. 111
    • Rejniak, K.A.1    Estrella, V.2    Chen, T.3    Cohen, A.S.4    Lloyd, M.C.5    Morse, D.L.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.