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Volumn 17, Issue 4, 2005, Pages 277-290

Vascular disrupting agents: A new class of drug in cancer therapy

Author keywords

Angiogenesis; Combretastatin; DCE MRI; DMXAA; Vascular targeting; ZD6126

Indexed keywords

5,6 DIMETHYLXANTHENONE 4 ACETIC ACID; ANGIOGENESIS INHIBITOR; ANTINEOPLASTIC AGENT; AURISTATIN PE; AVE 8062A; CISPLATIN; COLCHICINE; COMBRETASTATIN; COMBRETASTATIN A1 PHOSPHATE; COMBRETASTATIN A4; COMBRETASTATIN A4 PHOSPHATE; CYTOKINE; DOCETAXEL; DOLASTATIN; DOLASTATIN 10; DOXORUBICIN; DURAMYCIN IMMUNOGLOBULIN G CONJUGATE; FLAVONOID; FLUOROURACIL; HYDRALAZINE; IRINOTECAN; MITOFLAXONE; MN 029; MONOCLONAL ANTIBODY 3G4; N ACETYLCOLCHINOL PHOSPHATE; NPI 2358; PACLITAXEL; SERINE 2 METHOXY 5 [2 (3,4,5 TRIMETHOXYPHENYL)VINYL]ANILIDE; UNCLASSIFIED DRUG; VASCULAR TARGETING AGENT; VASCULOTROPIN GELONIN CONJUGATE; VINBLASTINE;

EID: 19344378137     PISSN: 09366555     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.clon.2004.11.011     Document Type: Article
Times cited : (129)

References (135)
  • 1
    • 19344363471 scopus 로고    scopus 로고
    • Abnormal microvasculature and defective microcirculatory function in solid tumours
    • [abstract 1]
    • Vaupel P. Abnormal microvasculature and defective microcirculatory function in solid tumours [abstract 1]. Proc 2nd international conference on vascular targeting 2004.
    • (2004) Proc 2nd International Conference on Vascular Targeting
    • Vaupel, P.1
  • 2
    • 0030576517 scopus 로고    scopus 로고
    • Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis
    • D. Hanahan J. Folkman Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis Cell 86 1996 353-364
    • (1996) Cell , vol.86 , pp. 353-364
    • Hanahan, D.1    Folkman, J.2
  • 3
    • 0030952289 scopus 로고    scopus 로고
    • Mechanisms of angiogenesis
    • W. Risau Mechanisms of angiogenesis Nature 386 1997 671-674
    • (1997) Nature , vol.386 , pp. 671-674
    • Risau, W.1
  • 5
    • 0033839080 scopus 로고    scopus 로고
    • Openings between defective endothelial cells explain tumor vessel leakiness
    • H. Hashizume P. Baluk S. Morikawa et al. Openings between defective endothelial cells explain tumor vessel leakiness Am J Pathol 156 2000 1363-1380
    • (2000) Am. J. Pathol. , vol.156 , pp. 1363-1380
    • Hashizume, H.1    Baluk, P.2    Morikawa, S.3
  • 6
    • 0037105721 scopus 로고    scopus 로고
    • Significance of blood vessel leakiness in cancer
    • D.M. McDonald P. Baluk Significance of blood vessel leakiness in cancer Cancer Res 62 2002 5381-5385
    • (2002) Cancer Res. , vol.62 , pp. 5381-5385
    • McDonald, D.M.1    Baluk, P.2
  • 7
    • 0034647922 scopus 로고    scopus 로고
    • Distinct antitumor properties of a type IV collagen domain derived from basement membrane
    • Y. Maeshima P.C. Colorado A. Torre et al. Distinct antitumor properties of a type IV collagen domain derived from basement membrane J Biol Chem 275 2000 21340-21348
    • (2000) J. Biol. Chem. , vol.275 , pp. 21340-21348
    • Maeshima, Y.1    Colorado, P.C.2    Torre, A.3
  • 8
    • 0037341637 scopus 로고    scopus 로고
    • Antivascular therapy of cancer: DMXAA
    • B.C. Baguley Antivascular therapy of cancer: DMXAA Lancet Oncol 4 2003 141-188
    • (2003) Lancet Oncol. , vol.4 , pp. 141-188
    • Baguley, B.C.1
  • 9
    • 0026602628 scopus 로고
    • Coley's toxins in perspective
    • C.O. Starnes Coley's toxins in perspective Nature 357 1992 11-12
    • (1992) Nature , vol.357 , pp. 11-12
    • Starnes, C.O.1
  • 10
    • 0036453656 scopus 로고    scopus 로고
    • Decreased tumor blood flow as measured by positron emission tomography in cancer patients treated with interleukin-1 and carboplatin on a phase I trial
    • T.F. Logan F. Jadali M.J. Egorin et al. Decreased tumor blood flow as measured by positron emission tomography in cancer patients treated with interleukin-1 and carboplatin on a phase I trial Cancer Chemother Pharmacol 50 2002 433-444
    • (2002) Cancer Chemother. Pharmacol. , vol.50 , pp. 433-444
    • Logan, T.F.1    Jadali, F.2    Egorin, M.J.3
  • 11
    • 0028232019 scopus 로고
    • Early endothelium activation and polymorphonuclear cell invasion precede specific necrosis of human melanoma and sarcoma treated by intravascular high-dose tumour necrosis factor alpha (rTNF alpha)
    • N. Renard D. Lienard L. Lespagnard A. Eggermont R. Heimann F. Lejeune Early endothelium activation and polymorphonuclear cell invasion precede specific necrosis of human melanoma and sarcoma treated by intravascular high-dose tumour necrosis factor alpha (rTNF alpha) Int J Cancer 57 1994 656-663
    • (1994) Int. J. Cancer , vol.57 , pp. 656-663
    • Renard, N.1    Lienard, D.2    Lespagnard, L.3    Eggermont, A.4    Heimann, R.5    Lejeune, F.6
  • 12
    • 0028863627 scopus 로고
    • Molecular mechanisms and therapeutic strategies related to nitric oxide
    • S. Moncada E.A. Higgs Molecular mechanisms and therapeutic strategies related to nitric oxide FASEB J 9 1995 1319-1330
    • (1995) FASEB J. , vol.9 , pp. 1319-1330
    • Moncada, S.1    Higgs, E.A.2
  • 13
    • 0027563591 scopus 로고
    • Angiogenesis, neovascular proliferation and vascular pathophysiology as targets for cancer therapy
    • [review]
    • J. Denekamp Angiogenesis, neovascular proliferation and vascular pathophysiology as targets for cancer therapy [review] Br J Radiol 66 1993 181-196
    • (1993) Br. J. Radiol. , vol.66 , pp. 181-196
    • Denekamp, J.1
  • 14
    • 0027368441 scopus 로고
    • Eradication of large solid tumors in mice with an immunotoxin directed against tumor vasculature
    • F.J. Burrows P.E. Thorpe Eradication of large solid tumors in mice with an immunotoxin directed against tumor vasculature Proc Natl Acad Sci U S A 90 1993 8996-9000
    • (1993) Proc. Natl. Acad. Sci. U S A , vol.90 , pp. 8996-9000
    • Burrows, F.J.1    Thorpe, P.E.2
  • 16
  • 17
    • 0031026481 scopus 로고    scopus 로고
    • Tumor infarction in mice by antibody-directed targeting of tissue factor to tumor vasculature
    • X. Huang G. Molema S. King L. Watkins T.S. Edgington P.E. Thorpe Tumor infarction in mice by antibody-directed targeting of tissue factor to tumor vasculature Science 275 1997 547-550
    • (1997) Science , vol.275 , pp. 547-550
    • Huang, X.1    Molema, G.2    King, S.3    Watkins, L.4    Edgington, T.S.5    Thorpe, P.E.6
  • 18
    • 0036278972 scopus 로고    scopus 로고
    • Antitumor activity of the novel vascular targeting agent ZD6126 in a panel of tumor models
    • D.C. Blakey F.R. Westwood M. Walker et al. Antitumor activity of the novel vascular targeting agent ZD6126 in a panel of tumor models Clin Cancer Res 8 2002 1974-1983
    • (2002) Clin. Cancer Res. , vol.8 , pp. 1974-1983
    • Blakey, D.C.1    Westwood, F.R.2    Walker, M.3
  • 19
    • 0033565644 scopus 로고    scopus 로고
    • Induction of intratumoral tumor necrosis factor (TNF) synthesis and hemorrhagic necrosis by 5,6-dimethylxanthenone-4-acetic acid (DMXAA) in TNF knockout mice
    • L.M. Ching D. Goldsmith W.R. Joseph H. Korner J.D. Sedgwick B.C. Baguley Induction of intratumoral tumor necrosis factor (TNF) synthesis and hemorrhagic necrosis by 5,6-dimethylxanthenone-4-acetic acid (DMXAA) in TNF knockout mice Cancer Res 59 1999 3304-3307
    • (1999) Cancer Res. , vol.59 , pp. 3304-3307
    • Ching, L.M.1    Goldsmith, D.2    Joseph, W.R.3    Korner, H.4    Sedgwick, J.D.5    Baguley, B.C.6
  • 20
    • 0037373826 scopus 로고    scopus 로고
    • The first international conference on vascular targeting: Meeting overview
    • P.E. Thorpe D.J. Chaplin D.C. Blakey The first international conference on vascular targeting: Meeting overview Cancer Res 63 2003 1144-1147
    • (2003) Cancer Res. , vol.63 , pp. 1144-1147
    • Thorpe, P.E.1    Chaplin, D.J.2    Blakey, D.C.3
  • 21
    • 0031469819 scopus 로고    scopus 로고
    • Antiangiogenic therapy of experimental cancer does not induce acquired drug resistance
    • T. Boehm J. Folkman T. Browder M.S. O'Reilly Antiangiogenic therapy of experimental cancer does not induce acquired drug resistance Nature 390 1997 404-407
    • (1997) Nature , vol.390 , pp. 404-407
    • Boehm, T.1    Folkman, J.2    Browder, T.3    O'Reilly, M.S.4
  • 22
    • 0035262598 scopus 로고    scopus 로고
    • Targeting tumour vasculature: The development of combretastatin A4
    • J. Griggs J.C. Metcalfe R. Hesketh Targeting tumour vasculature: The development of combretastatin A4 Lancet Oncol 2 2001 82-87
    • (2001) Lancet Oncol. , vol.2 , pp. 82-87
    • Griggs, J.1    Metcalfe, J.C.2    Hesketh, R.3
  • 23
    • 0033873782 scopus 로고    scopus 로고
    • Vasculogenic mimicry: How convincing, how novel, and how significant?
    • D.M. McDonald L. Munn R.K. Jain Vasculogenic mimicry: How convincing, how novel, and how significant? Am J Pathol 156 2000 383-388
    • (2000) Am. J. Pathol. , vol.156 , pp. 383-388
    • McDonald, D.M.1    Munn, L.2    Jain, R.K.3
  • 24
    • 0032887340 scopus 로고    scopus 로고
    • Vascular channel formation by human melanoma cells in vivo and in vitro: Vasculogenic mimicry
    • A.J. Maniotis R. Folberg A. Hess et al. Vascular channel formation by human melanoma cells in vivo and in vitro: Vasculogenic mimicry Am J Pathol 155 1999 739-752
    • (1999) Am. J. Pathol. , vol.155 , pp. 739-752
    • Maniotis, A.J.1    Folberg, R.2    Hess, A.3
  • 26
    • 0027979227 scopus 로고
    • The influence of tumour temperature on ischemia-induced cell death: Potential implications for the evaluation of vascular mediated therapies
    • D.J. Chaplin M.R. Horsman The influence of tumour temperature on ischemia-induced cell death: Potential implications for the evaluation of vascular mediated therapies Radiother Oncol 30 1994 59-65
    • (1994) Radiother. Oncol. , vol.30 , pp. 59-65
    • Chaplin, D.J.1    Horsman, M.R.2
  • 27
    • 0842311621 scopus 로고    scopus 로고
    • Vascular targeting agents as cancer therapeutics
    • P.E. Thorpe Vascular targeting agents as cancer therapeutics Clin Cancer Res 10 2004 415-427
    • (2004) Clin. Cancer Res. , vol.10 , pp. 415-427
    • Thorpe, P.E.1
  • 28
    • 0036990079 scopus 로고    scopus 로고
    • Translation of vascular diversity into targeted therapeutics
    • R. Pasqualini W. Arap Translation of vascular diversity into targeted therapeutics Ann Hematol 81 suppl 2 2002 S66-S67
    • (2002) Ann. Hematol. , vol.81 , Issue.SUPPL. 2
    • Pasqualini, R.1    Arap, W.2
  • 29
    • 0034496639 scopus 로고    scopus 로고
    • Exploring vascular heterogeneity for gene therapy targeting
    • M. Trepel W. Arap R. Pasqualini Exploring vascular heterogeneity for gene therapy targeting Gene Ther 7 2000 2059-2060
    • (2000) Gene. Ther. , vol.7 , pp. 2059-2060
    • Trepel, M.1    Arap, W.2    Pasqualini, R.3
  • 30
    • 0035863566 scopus 로고    scopus 로고
    • Targeted delivery of tissue factor to the ED-B domain of fibronectin, a marker of angiogenesis, mediates the infarction of solid tumors in mice
    • F. Nilsson H. Kosmehl L. Zardi D. Neri Targeted delivery of tissue factor to the ED-B domain of fibronectin, a marker of angiogenesis, mediates the infarction of solid tumors in mice Cancer Res 61 2001 711-716
    • (2001) Cancer Res. , vol.61 , pp. 711-716
    • Nilsson, F.1    Kosmehl, H.2    Zardi, L.3    Neri, D.4
  • 31
    • 19344368532 scopus 로고    scopus 로고
    • Anti-phosphatidylserine monoclonal antibody 3G4 enhances the anti tumour effects of docetaxel against human breast carcinoma
    • [abstract 1498]
    • X. Huang M. B J. He L. Watkins P. Thorpe Anti-phosphatidylserine monoclonal antibody 3G4 enhances the anti tumour effects of docetaxel against human breast carcinoma [abstract 1498] Proc Am Assoc Cancer Res 45 2004
    • (2004) Proc. Am. Assoc. Cancer Res. , vol.45
    • Huang, X.1    Burg, M.2    He, J.3    Watkins, L.4    Thorpe, P.5
  • 32
  • 33
    • 18244407799 scopus 로고    scopus 로고
    • Steps toward mapping the human vasculature by phage display
    • W. Arap M.G. Kolonin M. Trepel et al. Steps toward mapping the human vasculature by phage display Nat Med 8 2002 121-127
    • (2002) Nat. Med. , vol.8 , pp. 121-127
    • Arap, W.1    Kolonin, M.G.2    Trepel, M.3
  • 34
    • 0023215827 scopus 로고
    • Flavone acetic acid (NSC 347512) induces haemorrhagic necrosis of mouse colon 26 and 38 tumours
    • [abstract 1498]
    • G.P. Smith S.B. Calveley M.J. Smith B.C. Baguley Flavone acetic acid (NSC 347512) induces haemorrhagic necrosis of mouse colon 26 and 38 tumours [abstract 1498] Eur J Cancer Clin Oncol 23 1987 1209-1211
    • (1987) Eur. J Cancer Clin. Oncol. , vol.23 , pp. 1209-1211
    • Smith, G.P.1    Calveley, S.B.2    Smith, M.J.3    Baguley, B.C.4
  • 35
    • 0022971018 scopus 로고
    • Activity of flavone acetic acid (NSC-347512) against solid tumors of mice
    • T.H. Corbett M.C. Bissery A. Wozniak et al. Activity of flavone acetic acid (NSC-347512) against solid tumors of mice Invest New Drugs 4 1986 207-220
    • (1986) Invest. New Drugs , vol.4 , pp. 207-220
    • Corbett, T.H.1    Bissery, M.C.2    Wozniak, A.3
  • 36
    • 0024330132 scopus 로고
    • Flavone acetic acid - Preclinical and clinical activity
    • D.J. Kerr S.B. Kaye Flavone acetic acid - preclinical and clinical activity Eur J Cancer Clin Oncol 25 1989 1271-1272
    • (1989) Eur. J. Cancer Clin. Oncol. , vol.25 , pp. 1271-1272
    • Kerr, D.J.1    Kaye, S.B.2
  • 37
    • 0026100365 scopus 로고
    • Potential antitumor agents. 61. Structure-activity relationships for in vivo colon 38 activity among disubstituted 9-oxo-9H-xanthene-4-acetic acids
    • G.W. Rewcastle G.J. Atwell Z.A. Li B.C. Baguley W.A. Denny Potential antitumor agents. 61. Structure-activity relationships for in vivo colon 38 activity among disubstituted 9-oxo-9H-xanthene-4-acetic acids J Med Chem 34 1991 217-222
    • (1991) J. Med. Chem. , vol.34 , pp. 217-222
    • Rewcastle, G.W.1    Atwell, G.J.2    Li, Z.A.3    Baguley, B.C.4    Denny, W.A.5
  • 38
    • 0031858141 scopus 로고    scopus 로고
    • Enhancement of the anti-tumour effects of the antivascular agent 5,6-dimethylxanthenone-4-acetic acid (DMXAA) by combination with 5-hydroxytryptamine and bioreductive drugs
    • C.J. Lash A.E. Li M. Rutland B.C. Baguley L.J. Zwi W.R. Wilson Enhancement of the anti-tumour effects of the antivascular agent 5,6-dimethylxanthenone-4-acetic acid (DMXAA) by combination with 5-hydroxytryptamine and bioreductive drugs Br J Cancer 78 1998 439-445
    • (1998) Br. J. Cancer , vol.78 , pp. 439-445
    • Lash, C.J.1    Li, A.E.2    Rutland, M.3    Baguley, B.C.4    Zwi, L.J.5    Wilson, W.R.6
  • 39
    • 0037125028 scopus 로고    scopus 로고
    • Induction of endothelial cell apoptosis by the antivascular agent 5,6-dimethylxanthenone-4-acetic acid
    • L.M. Ching Z. Cao C. Kieda S. Zwain M.B. Jameson B.C. Baguley Induction of endothelial cell apoptosis by the antivascular agent 5,6-dimethylxanthenone-4-acetic acid Br J Cancer 86 2002 1937-1942
    • (2002) Br. J. Cancer , vol.86 , pp. 1937-1942
    • Ching, L.M.1    Cao, Z.2    Kieda, C.3    Zwain, S.4    Jameson, M.B.5    Baguley, B.C.6
  • 40
    • 0030625644 scopus 로고    scopus 로고
    • Increased plasma serotonin following treatment with flavone-8-acetic acid, 5,6-dimethylxanthenone-4-acetic acid, vinblastine, and colchicine: Relation to vascular effects
    • B.C. Baguley L. Zhuang P. Kestell Increased plasma serotonin following treatment with flavone-8-acetic acid, 5,6-dimethylxanthenone-4-acetic acid, vinblastine, and colchicine: Relation to vascular effects Oncol Res 9 1997 55-60
    • (1997) Oncol. Res. , vol.9 , pp. 55-60
    • Baguley, B.C.1    Zhuang, L.2    Kestell, P.3
  • 41
    • 0026089375 scopus 로고
    • Tumor-dependent increased plasma nitrate concentrations as an indication of the antitumor effect of flavone-8-acetic acid and analogues in mice
    • L.L. Thomsen L.M. Ching L. Zhuang J.B. Gavin B.C. Baguley Tumor-dependent increased plasma nitrate concentrations as an indication of the antitumor effect of flavone-8-acetic acid and analogues in mice Cancer Res 51 1991 77-81
    • (1991) Cancer Res. , vol.51 , pp. 77-81
    • Thomsen, L.L.1    Ching, L.M.2    Zhuang, L.3    Gavin, J.B.4    Baguley, B.C.5
  • 42
    • 0034812637 scopus 로고    scopus 로고
    • The antitumour agent 5,6-dimethylxanthenone-4-acetic acid acts in vitro on human mononuclear cells as a co-stimulator with other inducers of tumour necrosis factor
    • M. Philpott L.M. Ching B.C. Baguley The antitumour agent 5,6-dimethylxanthenone-4-acetic acid acts in vitro on human mononuclear cells as a co-stimulator with other inducers of tumour necrosis factor Eur J Cancer 37 2001 1930-1937
    • (2001) Eur. J. Cancer , vol.37 , pp. 1930-1937
    • Philpott, M.1    Ching, L.M.2    Baguley, B.C.3
  • 43
    • 0028124643 scopus 로고
    • Correlation between immune and vascular activities of xanthenone acetic acid antitumor agents
    • L.J. Zwi B.C. Baguley J.B. Gavin W.R. Wilson Correlation between immune and vascular activities of xanthenone acetic acid antitumor agents Oncol Res 6 1994 79-85
    • (1994) Oncol. Res. , vol.6 , pp. 79-85
    • Zwi, L.J.1    Baguley, B.C.2    Gavin, J.B.3    Wilson, W.R.4
  • 44
    • 0031876881 scopus 로고    scopus 로고
    • Pulse treatment of human vascular endothelial cells with high doses of tumor necrosis factor and interferon-gamma results in simultaneous synergistic and reversible effects on proliferation and morphology
    • A. Yilmaz G. Bieler O. Spertini F.J. Lejeune C. Ruegg Pulse treatment of human vascular endothelial cells with high doses of tumor necrosis factor and interferon-gamma results in simultaneous synergistic and reversible effects on proliferation and morphology Int J Cancer 77 1998 592-599
    • (1998) Int. J. Cancer , vol.77 , pp. 592-599
    • Yilmaz, A.1    Bieler, G.2    Spertini, O.3    Lejeune, F.J.4    Ruegg, C.5
  • 45
    • 84938043079 scopus 로고
    • Inhibitory effects of cytokines on vascular endothelial cells: Synergistic interactions among interferon-gamma, tumor necrosis factor-alpha, and interleukin-1
    • K. Norioka E.C. Borden R. Auerbach Inhibitory effects of cytokines on vascular endothelial cells: Synergistic interactions among interferon-gamma, tumor necrosis factor-alpha, and interleukin-1 J Immunother 12 1992 13-18
    • (1992) J. Immunother. , vol.12 , pp. 13-18
    • Norioka, K.1    Borden, E.C.2    Auerbach, R.3
  • 46
    • 0025076479 scopus 로고
    • Role of tumor necrosis factor in flavone acetic acid-induced tumor vasculature shutdown
    • V. Mahadevan S.T. Malik A. Meager W. Fiers G.P. Lewis I.R. Hart Role of tumor necrosis factor in flavone acetic acid-induced tumor vasculature shutdown Cancer Res 50 1990 5537-5542
    • (1990) Cancer Res. , vol.50 , pp. 5537-5542
    • Mahadevan, V.1    Malik, S.T.2    Meager, A.3    Fiers, W.4    Lewis, G.P.5    Hart, I.R.6
  • 47
    • 0031973829 scopus 로고    scopus 로고
    • Persistent induction of nitric oxide synthase in tumours from mice treated with the anti-tumour agent 5,6-dimethylxanthenone-4-acetic acid
    • E. Moilanen L.L. Thomsen D.W. Miles D.W. Happerfield R.G. Knowles S. Moncada Persistent induction of nitric oxide synthase in tumours from mice treated with the anti-tumour agent 5,6-dimethylxanthenone-4-acetic acid Br J Cancer 77 1998 426-433
    • (1998) Br. J. Cancer , vol.77 , pp. 426-433
    • Moilanen, E.1    Thomsen, L.L.2    Miles, D.W.3    Happerfield, D.W.4    Knowles, R.G.5    Moncada, S.6
  • 48
    • 0038575250 scopus 로고    scopus 로고
    • Clinical aspects of a phase I trial of 5,6-dimethylxanthenone-4-acetic acid (DMXAA), a novel antivascular agent
    • M.B. Jameson P.I. Thompson B.C. Baguley et al. Clinical aspects of a phase I trial of 5,6-dimethylxanthenone-4-acetic acid (DMXAA), a novel antivascular agent Br J Cancer 88 2003 1844-1850
    • (2003) Br. J. Cancer , vol.88 , pp. 1844-1850
    • Jameson, M.B.1    Thompson, P.I.2    Baguley, B.C.3
  • 49
    • 0038576231 scopus 로고    scopus 로고
    • 5,6-dimethylxanthenone-4-acetic acid (DMXAA), a novel antivascular agent: Phase I clinical and pharmacokinetic study
    • G.J. Rustin C. Bradley S. Galbraith 5,6-dimethylxanthenone-4-acetic acid (DMXAA), a novel antivascular agent: Phase I clinical and pharmacokinetic study Br J Cancer 88 2003 1160-1167
    • (2003) Br. J. Cancer , vol.88 , pp. 1160-1167
    • Rustin, G.J.1    Bradley, C.2    Galbraith, S.3
  • 50
    • 0000226885 scopus 로고    scopus 로고
    • Phase I pharmacokinetic and pharmacodynamic study of 5,6-dimethylxanthenone-4-acetic acid (DMXAA), a novel anti vascular agent
    • [abstract 705]
    • M. Jameson P. Thompson B. Baguley et al. Phase I pharmacokinetic and pharmacodynamic study of 5,6-dimethylxanthenone-4-acetic acid (DMXAA), a novel anti vascular agent [abstract 705] Proc Am Soc Clin Oncol 2000
    • (2000) Proc. Am. Soc. Clin. Oncol.
    • Jameson, M.1    Thompson, P.2    Baguley, B.3
  • 51
    • 0037106501 scopus 로고    scopus 로고
    • Effects of 5,6-dimethylxanthenone-4-acetic acid on human tumor microcirculation assessed by dynamic contrast-enhanced magnetic resonance imaging
    • S.M. Galbraith G.J. Rustin M.A. Lodge et al. Effects of 5,6-dimethylxanthenone-4-acetic acid on human tumor microcirculation assessed by dynamic contrast-enhanced magnetic resonance imaging J Clin Oncol 20 2002 3826-3840
    • (2002) J. Clin. Oncol. , vol.20 , pp. 3826-3840
    • Galbraith, S.M.1    Rustin, G.J.2    Lodge, M.A.3
  • 52
    • 0028234390 scopus 로고
    • Combining bioreductive drugs (SR 4233 or SN 23862) with the vasoactive agents flavone acetic acid or 5,6-dimethylxanthenone acetic acid
    • S. Cliffe M.L. Taylor M. Rutland B.C. Baguley R.P. Hill W.R. Wilson Combining bioreductive drugs (SR 4233 or SN 23862) with the vasoactive agents flavone acetic acid or 5,6-dimethylxanthenone acetic acid Int J Radiat Oncol Biol Phys 29 1994 373-377
    • (1994) Int. J. Radiat. Oncol. Biol. Phys. , vol.29 , pp. 373-377
    • Cliffe, S.1    Taylor, M.L.2    Rutland, M.3    Baguley, B.C.4    Hill, R.P.5    Wilson, W.R.6
  • 53
    • 0031016945 scopus 로고    scopus 로고
    • Mechanisms of enhancement of the antitumour activity of melphalan by the tumour-blood-flow inhibitor 5,6-dimethylxanthenone-4-acetic acid
    • F.B. Pruijn M. van Daalen N.H. Holford W.R. Wilson Mechanisms of enhancement of the antitumour activity of melphalan by the tumour-blood-flow inhibitor 5,6-dimethylxanthenone-4-acetic acid Cancer Chemother Pharmacol 39 1997 541-546
    • (1997) Cancer Chemother. Pharmacol. , vol.39 , pp. 541-546
    • Pruijn, F.B.1    van Daalen, M.2    Holford, N.H.3    Wilson, W.R.4
  • 54
    • 0031775298 scopus 로고    scopus 로고
    • Enhancement of tumor radiation response by the antivascular agent 5,6-dimethylxanthenone-4-acetic acid
    • W.R. Wilson A.E. Li D.S. Cowan B.G. Siim Enhancement of tumor radiation response by the antivascular agent 5,6-dimethylxanthenone-4-acetic acid Int J Radiat Oncol Biol Phys 42 1998 905-908
    • (1998) Int. J. Radiat. Oncol. Biol. Phys. , vol.42 , pp. 905-908
    • Wilson, W.R.1    Li, A.E.2    Cowan, D.S.3    Siim, B.G.4
  • 55
    • 0030002174 scopus 로고    scopus 로고
    • Ablation of colorectal xenografts with combined radioimmunotherapy and tumor blood flow-modifying agents
    • R.B. Pedley J.A. Boden R. Boden et al. Ablation of colorectal xenografts with combined radioimmunotherapy and tumor blood flow-modifying agents Cancer Res 56 1996 3293-3300
    • (1996) Cancer Res. , vol.56 , pp. 3293-3300
    • Pedley, R.B.1    Boden, J.A.2    Boden, R.3
  • 56
    • 0033567097 scopus 로고    scopus 로고
    • Enhancement of antibody-directed enzyme prodrug therapy in colorectal xenografts by an antivascular agent
    • R.B. Pedley S.K. Sharma G.M. Boxer et al. Enhancement of antibody-directed enzyme prodrug therapy in colorectal xenografts by an antivascular agent Cancer Res 59 1999 3998-4003
    • (1999) Cancer Res. , vol.59 , pp. 3998-4003
    • Pedley, R.B.1    Sharma, S.K.2    Boxer, G.M.3
  • 57
    • 0029902597 scopus 로고    scopus 로고
    • Antivascular approaches to solid tumour therapy: Evaluation of tubulin binding agents
    • D.J. Chaplin G.R. Pettit C.S. Parkins S.A. Hill Antivascular approaches to solid tumour therapy: Evaluation of tubulin binding agents Br J Cancer Suppl 27 1996 S86-S88
    • (1996) Br. J. Cancer , vol.27 , Issue.SUPPL.
    • Chaplin, D.J.1    Pettit, G.R.2    Parkins, C.S.3    Hill, S.A.4
  • 58
    • 0035937376 scopus 로고    scopus 로고
    • Combretastatin-A4 disrupts neovascular development in non-neoplastic tissue
    • J. Griggs R. Hesketh G.A. Smith et al. Combretastatin-A4 disrupts neovascular development in non-neoplastic tissue Br J Cancer 84 2001 832-835
    • (2001) Br. J. Cancer , vol.84 , pp. 832-835
    • Griggs, J.1    Hesketh, R.2    Smith, G.A.3
  • 59
    • 0035064594 scopus 로고    scopus 로고
    • Effects of combretastatin A4 phosphate on endothelial cell morphology in vitro and relationship to tumour vascular targeting activity in vivo
    • S.M. Galbraith D.J. Chaplin F. Lee et al. Effects of combretastatin A4 phosphate on endothelial cell morphology in vitro and relationship to tumour vascular targeting activity in vivo Anticancer Res 21 2001 93-102
    • (2001) Anticancer. Res. , vol.21 , pp. 93-102
    • Galbraith, S.M.1    Chaplin, D.J.2    Lee, F.3
  • 60
    • 0032773566 scopus 로고    scopus 로고
    • Tumour vasculature as a target for cancer therapy
    • D.J. Chaplin G.J. Dougherty Tumour vasculature as a target for cancer therapy Br J Cancer 80 suppl 1 1999 57-64
    • (1999) Br. J. Cancer , vol.80 , Issue.SUPPL. 1 , pp. 57-64
    • Chaplin, D.J.1    Dougherty, G.J.2
  • 61
    • 0024427745 scopus 로고
    • Antimitotic natural products combretastatin A-4 and combretastatin A-2: Studies on the mechanism of their inhibition of the binding of colchicine to tubulin
    • C.M. Lin H.H. Ho G.R. Pettit E. Hamel Antimitotic natural products combretastatin A-4 and combretastatin A-2: Studies on the mechanism of their inhibition of the binding of colchicine to tubulin Biochemistry 28 1989 6984-6991
    • (1989) Biochemistry , vol.28 , pp. 6984-6991
    • Lin, C.M.1    Ho, H.H.2    Pettit, G.R.3    Hamel, E.4
  • 62
    • 0029044610 scopus 로고
    • Antineoplastic agents 322. Synthesis of combretastatin A-4 prodrugs
    • G.R. Pettit C. Temple Jr. V.L. Narayanan et al. Antineoplastic agents 322. Synthesis of combretastatin A-4 prodrugs Anticancer Drug Des 10 1995 299-309
    • (1995) Anticancer. Drug Des. , vol.10 , pp. 299-309
    • Pettit, G.R.1    Temple Jr., C.2    Narayanan, V.L.3
  • 64
    • 0032532391 scopus 로고    scopus 로고
    • Induction of apoptosis in proliferating human endothelial cells by the tumor-specific antiangiogenesis agent combretastatin A-4
    • S. Iyer D.J. Chaplin D.S. Rosenthal A.H. Boulares L.Y. Li M.E. Smulson Induction of apoptosis in proliferating human endothelial cells by the tumor-specific antiangiogenesis agent combretastatin A-4 Cancer Res 58 1998 4510-4514
    • (1998) Cancer Res. , vol.58 , pp. 4510-4514
    • Iyer, S.1    Chaplin, D.J.2    Rosenthal, D.S.3    Boulares, A.H.4    Li, L.Y.5    Smulson, M.E.6
  • 65
    • 0037085753 scopus 로고    scopus 로고
    • The tumor vascular targeting agent combretastatin A-4-phosphate induces reorganization of the actin cytoskeleton and early membrane blebbing in human endothelial cells
    • C. Kanthou G.M. Tozer The tumor vascular targeting agent combretastatin A-4-phosphate induces reorganization of the actin cytoskeleton and early membrane blebbing in human endothelial cells Blood 99 2002 2060-2069
    • (2002) Blood , vol.99 , pp. 2060-2069
    • Kanthou, C.1    Tozer, G.M.2
  • 66
    • 0036324914 scopus 로고    scopus 로고
    • Preclinical evaluation of the antitumour activity of the novel vascular targeting agent Oxi4503
    • S.A. Hill G.M. Tozer G.R. Pettit D. Chaplin Preclinical evaluation of the antitumour activity of the novel vascular targeting agent Oxi4503 Anticancer Res 22 2002 1453-1458
    • (2002) Anticancer. Res. , vol.22 , pp. 1453-1458
    • Hill, S.A.1    Tozer, G.M.2    Pettit, G.R.3    Chaplin, D.4
  • 67
    • 0032950870 scopus 로고    scopus 로고
    • Anti-vascular approaches to solid tumour therapy: Evaluation of combretastatin A4 phosphate
    • D.J. Chaplin G.R. Pettit S.A. Hill Anti-vascular approaches to solid tumour therapy: Evaluation of combretastatin A4 phosphate Anticancer Res 19 1999 189-195
    • (1999) Anticancer. Res. , vol.19 , pp. 189-195
    • Chaplin, D.J.1    Pettit, G.R.2    Hill, S.A.3
  • 68
    • 0032758736 scopus 로고    scopus 로고
    • In vivo and in vitro evaluation of combretastatin A-4 and its sodium phosphate prodrug
    • K. Grosios S.E. Holwell A.T. McGown G.R. Pettit M.C. Bibby In vivo and in vitro evaluation of combretastatin A-4 and its sodium phosphate prodrug Br J Cancer 81 1999 1318-1327
    • (1999) Br. J. Cancer , vol.81 , pp. 1318-1327
    • Grosios, K.1    Holwell, S.E.2    McGown, A.T.3    Pettit, G.R.4    Bibby, M.C.5
  • 69
    • 0034109559 scopus 로고    scopus 로고
    • Combination chemotherapy with combretastatin A-4 phosphate and 5-fluorouracil in an experimental murine colon adenocarcinoma
    • K. Grosios P.M. Loadman D.J. Swaine G.R. Pettit M.C. Bibby Combination chemotherapy with combretastatin A-4 phosphate and 5-fluorouracil in an experimental murine colon adenocarcinoma Anticancer Res 20 2000 229-233
    • (2000) Anticancer. Res. , vol.20 , pp. 229-233
    • Grosios, K.1    Loadman, P.M.2    Swaine, D.J.3    Pettit, G.R.4    Bibby, M.C.5
  • 70
    • 0030951899 scopus 로고    scopus 로고
    • Combretastatin A-4, an agent that displays potent and selective toxicity toward tumor vasculature
    • G.G. Dark S.A. Hill V.E. Prise G.M. Tozer G.R. Pettit D.J. Chaplin Combretastatin A-4, an agent that displays potent and selective toxicity toward tumor vasculature Cancer Res 57 1997 1829-1834
    • (1997) Cancer Res. , vol.57 , pp. 1829-1834
    • Dark, G.G.1    Hill, S.A.2    Prise, V.E.3    Tozer, G.M.4    Pettit, G.R.5    Chaplin, D.J.6
  • 71
    • 0031770618 scopus 로고    scopus 로고
    • The effect of combretastatin A-4 disodium phosphate in a C3H mouse mammary carcinoma and a variety of murine spontaneous tumors
    • M.R. Horsman E. Ehrnrooth M. Ladekarl J. Overgaard The effect of combretastatin A-4 disodium phosphate in a C3H mouse mammary carcinoma and a variety of murine spontaneous tumors Int J Radiat Oncol Biol Phys 42 1998 895-898
    • (1998) Int. J. Radiat. Oncol. Biol. Phys. , vol.42 , pp. 895-898
    • Horsman, M.R.1    Ehrnrooth, E.2    Ladekarl, M.3    Overgaard, J.4
  • 72
    • 0035417875 scopus 로고    scopus 로고
    • Mechanisms associated with tumor vascular shut-down induced by combretastatin A-4 phosphate: Intravital microscopy and measurement of vascular permeability
    • G.M. Tozer V.E. Prise J. Wilson et al. Mechanisms associated with tumor vascular shut-down induced by combretastatin A-4 phosphate: Intravital microscopy and measurement of vascular permeability Cancer Res 61 2001 6413-6422
    • (2001) Cancer Res. , vol.61 , pp. 6413-6422
    • Tozer, G.M.1    Prise, V.E.2    Wilson, J.3
  • 73
    • 0031748452 scopus 로고    scopus 로고
    • Magnetic resonance imaging and spectroscopy of combretastatin A4 prodrug-induced disruption of tumour perfusion and energetic status
    • D.A. Beauregard P.E. Thelwall D.J. Chaplin S.A. Hill G.E. Adams K.M. Brindle Magnetic resonance imaging and spectroscopy of combretastatin A4 prodrug-induced disruption of tumour perfusion and energetic status Br J Cancer 77 1998 1761-1767
    • (1998) Br. J. Cancer , vol.77 , pp. 1761-1767
    • Beauregard, D.A.1    Thelwall, P.E.2    Chaplin, D.J.3    Hill, S.A.4    Adams, G.E.5    Brindle, K.M.6
  • 74
    • 0033119771 scopus 로고    scopus 로고
    • Combretastatin A-4 phosphate as a tumor vascular-targeting agent: Early effects in tumors and normal tissues
    • G.M. Tozer V.E. Prise J. Wilson R.J. Locke et al. Combretastatin A-4 phosphate as a tumor vascular-targeting agent: Early effects in tumors and normal tissues Cancer Res 59 1999 1626-1634
    • (1999) Cancer Res. , vol.59 , pp. 1626-1634
    • Tozer, G.M.1    Prise, V.E.2    Wilson, J.3    Locke, R.J.4
  • 75
    • 0027215198 scopus 로고
    • Modification of tumour blood flow using the hypertensive agent, angiotensin II
    • G.M. Tozer K.M. Shaffi Modification of tumour blood flow using the hypertensive agent, angiotensin II Br J Cancer 67 1993 981-988
    • (1993) Br. J. Cancer , vol.67 , pp. 981-988
    • Tozer, G.M.1    Shaffi, K.M.2
  • 76
    • 0026600356 scopus 로고
    • Relationship between the hydralazine-induced changes in murine tumor blood supply and mouse blood pressure
    • M.R. Horsman K.L. Christensen J. Overgaard Relationship between the hydralazine-induced changes in murine tumor blood supply and mouse blood pressure Int J Radiat Oncol Biol Phys 22 1992 455-458
    • (1992) Int. J. Radiat. Oncol. Biol. Phys. , vol.22 , pp. 455-458
    • Horsman, M.R.1    Christensen, K.L.2    Overgaard, J.3
  • 77
    • 0042887593 scopus 로고    scopus 로고
    • Assessment of pharmacodynamic vascular response in a phase I trial of combretastatin A4 phosphate
    • H.L. Anderson J.T. Yap M.P. Miller A. Robbins T. Jones P.M. Price Assessment of pharmacodynamic vascular response in a phase I trial of combretastatin A4 phosphate J Clin Oncol 21 2003 2823-2830
    • (2003) J. Clin. Oncol. , vol.21 , pp. 2823-2830
    • Anderson, H.L.1    Yap, J.T.2    Miller, M.P.3    Robbins, A.4    Jones, T.5    Price, P.M.6
  • 78
    • 0037096814 scopus 로고    scopus 로고
    • A phase I pharmacokinetic and translational study of the novel vascular targeting agent combretastatin a-4 phosphate on a single-dose intravenous schedule in patients with advanced cancer
    • A. Dowlati K. Robertson M. Cooney et al. A phase I pharmacokinetic and translational study of the novel vascular targeting agent combretastatin a-4 phosphate on a single-dose intravenous schedule in patients with advanced cancer Cancer Res 62 2002 3408-3416
    • (2002) Cancer Res. , vol.62 , pp. 3408-3416
    • Dowlati, A.1    Robertson, K.2    Cooney, M.3
  • 79
    • 0029851988 scopus 로고    scopus 로고
    • A novel K+ channel blocker isolated from 'hiccup nut' toxin
    • E. Guatteo L. Bianchi L. Faravelli et al. A novel K+ channel blocker isolated from 'hiccup nut' toxin Neuroreport 7 1996 2575-2579
    • (1996) Neuroreport. , vol.7 , pp. 2575-2579
    • Guatteo, E.1    Bianchi, L.2    Faravelli, L.3
  • 80
    • 0042386700 scopus 로고    scopus 로고
    • Phase I clinical trial of weekly combretastatin A4 phosphate: Clinical and pharmacokinetic results
    • G.J. Rustin S.M. Galbraith H. Anderson et al. Phase I clinical trial of weekly combretastatin A4 phosphate: Clinical and pharmacokinetic results J Clin Oncol 21 2003 2815-2822
    • (2003) J. Clin. Oncol. , vol.21 , pp. 2815-2822
    • Rustin, G.J.1    Galbraith, S.M.2    Anderson, H.3
  • 81
    • 0042386691 scopus 로고    scopus 로고
    • Combretastatin A4 phosphate has tumor antivascular activity in rat and man as demonstrated by dynamic magnetic resonance imaging
    • S.M. Galbraith R.J. Maxwell M.A. Lodge et al. Combretastatin A4 phosphate has tumor antivascular activity in rat and man as demonstrated by dynamic magnetic resonance imaging J Clin Oncol 21 2003 2831-2842
    • (2003) J. Clin. Oncol. , vol.21 , pp. 2831-2842
    • Galbraith, S.M.1    Maxwell, R.J.2    Lodge, M.A.3
  • 83
    • 0642307227 scopus 로고    scopus 로고
    • Phase I trial of the antivascular agent combretastatin A4 phosphate on a 5-day schedule to patients with cancer: Magnetic resonance imaging evidence for altered tumor blood flow
    • J.P. Stevenson M. Rosen W. Sun et al. Phase I trial of the antivascular agent combretastatin A4 phosphate on a 5-day schedule to patients with cancer: Magnetic resonance imaging evidence for altered tumor blood flow J Clin Oncol 21 2003 4428-4438
    • (2003) J. Clin. Oncol. , vol.21 , pp. 4428-4438
    • Stevenson, J.P.1    Rosen, M.2    Sun, W.3
  • 85
    • 0031923033 scopus 로고    scopus 로고
    • Early activation of vascular endothelium in nonobese, nondiabetic essential hypertensive patients with multiple metabolic abnormalities
    • C. Ferri G. Desideri R. Baldoncini et al. Early activation of vascular endothelium in nonobese, nondiabetic essential hypertensive patients with multiple metabolic abnormalities Diabetes 47 1998 660-667
    • (1998) Diabetes , vol.47 , pp. 660-667
    • Ferri, C.1    Desideri, G.2    Baldoncini, R.3
  • 88
    • 0037115398 scopus 로고    scopus 로고
    • ZD6126: A novel vascular-targeting agent that causes selective destruction of tumor vasculature
    • P.D. Davis G.J. Dougherty D.C. Blakey et al. ZD6126: A novel vascular-targeting agent that causes selective destruction of tumor vasculature Cancer Res 62 2002 7247-7253
    • (2002) Cancer Res. , vol.62 , pp. 7247-7253
    • Davis, P.D.1    Dougherty, G.J.2    Blakey, D.C.3
  • 89
    • 0142155561 scopus 로고    scopus 로고
    • Vascular targeting effects of ZD6126 in a C3H mouse mammary carcinoma and the enhancement of radiation response
    • M.R. Horsman R. Murata Vascular targeting effects of ZD6126 in a C3H mouse mammary carcinoma and the enhancement of radiation response Int J Radiat Oncol Biol Phys 57 2003 1047-1055
    • (2003) Int. J. Radiat. Oncol. Biol. Phys. , vol.57 , pp. 1047-1055
    • Horsman, M.R.1    Murata, R.2
  • 90
    • 2342548069 scopus 로고    scopus 로고
    • Vascular targeting: Clinical experience
    • Anon Meniscus Philadelphia
    • Anon Vascular targeting: Clinical experience In: Horizons inc cancer therapeutics: From bench to bedside 3 2002 Meniscus Philadelphia 16-23
    • (2002) Horizons Inc Cancer Therapeutics: From Bench to Bedside , vol.3 , pp. 16-23
  • 91
    • 0012692946 scopus 로고    scopus 로고
    • A dose escalation study of the novel vascular targeting agent ZD6126 in patients with solid tumours
    • [abstract 438]
    • S.M. Gadgeel P. LoRusso A.J. Wozniak C. Wheeler A dose escalation study of the novel vascular targeting agent ZD6126 in patients with solid tumours [abstract 438] Proc Am Soc Clin Oncol 21 2002
    • (2002) Proc. Am. Soc. Clin. Oncol. , vol.21
    • Gadgeel, S.M.1    LoRusso, P.2    Wozniak, A.J.3    Wheeler, C.4
  • 92
    • 19344377818 scopus 로고    scopus 로고
    • A phase I dose escalation trial of ZD6126, a novel vascular targeting agent, in patients with cancer refractory to other treatments
    • [abstract 36]
    • S. LoRusso S. Gadgeel A. Wozniak et al. A phase I dose escalation trial of ZD6126, a novel vascular targeting agent, in patients with cancer refractory to other treatments [abstract 36] Proc AACR-NCI-EORTC 2001
    • (2001) Proc AACR-NCI-EORTC
    • LoRusso, S.1    Gadgeel, S.2    Wozniak, A.3
  • 93
    • 0013405842 scopus 로고    scopus 로고
    • MRI evaluation of the effects of the vascular targeting agent ZD6126 on tumor vasculature
    • [abstract 440]
    • Z. DelProposto P. LoRusso Z Latif et al. MRI evaluation of the effects of the vascular targeting agent ZD6126 on tumor vasculature [abstract 440] Proc Am Soc Clin Oncol 21 2002
    • (2002) Proc. Am. Soc. Clin. Oncol. , vol.21
    • DelProposto, Z.1    LoRusso, P.2    Latif, Z.3
  • 94
    • 0038599016 scopus 로고    scopus 로고
    • Clinical evaluation of the novel vascular targeting agent ZD6126: Assessment of toxicity and surrogate markers of vascular damage
    • [abstract 439]
    • S.A. Radema L. Beerepoot P.O. Witteveen et al. Clinical evaluation of the novel vascular targeting agent ZD6126: Assessment of toxicity and surrogate markers of vascular damage [abstract 439] Proc Am Soc Clin Oncol 21 2002
    • (2002) Proc. Am. Soc. Clin. Oncol. , vol.21
    • Radema, S.A.1    Beerepoot, L.2    Witteveen, P.O.3
  • 95
    • 0242329757 scopus 로고    scopus 로고
    • Microvascular mechanisms by which the combretastatin A-4 derivative AC7700 (AVE8062) induces tumour blood flow stasis
    • K. Hori S. Saito Microvascular mechanisms by which the combretastatin A-4 derivative AC7700 (AVE8062) induces tumour blood flow stasis Br J Cancer 89 2003 1334-1344
    • (2003) Br. J. Cancer , vol.89 , pp. 1334-1344
    • Hori, K.1    Saito, S.2
  • 96
    • 0032729686 scopus 로고    scopus 로고
    • Antitumor effects due to irreversible stoppage of tumor tissue blood flow: Evaluation of a novel combretastatin A-4 derivative, AC7700
    • K. Hori S. Saito Y. Nihei M. Suzuki Y. Sato Antitumor effects due to irreversible stoppage of tumor tissue blood flow: Evaluation of a novel combretastatin A-4 derivative, AC7700 Jpn J Cancer Res 90 1999 1026-1038
    • (1999) Jpn. J. Cancer Res. , vol.90 , pp. 1026-1038
    • Hori, K.1    Saito, S.2    Nihei, Y.3    Suzuki, M.4    Sato, Y.5
  • 97
    • 16844365863 scopus 로고    scopus 로고
    • In vivo antitumour activity and tumor necrosis induced by AVE8062A, a tumour vascular targeting agent
    • [abstract 781]
    • P. Lejeune T. H P. Vrignaud et al. In vivo antitumour activity and tumor necrosis induced by AVE8062A, a tumour vascular targeting agent [abstract 781] Proc Am Assoc Cancer Res 43 2002
    • (2002) Proc. Am. Assoc. Cancer Res. , vol.43
    • Lejeune, P.1    Vrignaud, T.H.P.2
  • 98
    • 0842265381 scopus 로고    scopus 로고
    • Phase I, pharmacokinetic, and DCE-MRI correlative study of AVE8062A, an antivascular combretastatin analogue, administered weekly for 3 weeks every 28 days
    • [abstract 834]
    • A.W. Tolcher L. Forero P. Celio L.A. Hammond E.K. Rowinsky et al. Phase I, pharmacokinetic, and DCE-MRI correlative study of AVE8062A, an antivascular combretastatin analogue, administered weekly for 3 weeks every 28 days [abstract 834] Proc Am Soc Clin Oncol 22 2003
    • (2003) Proc. Am. Soc. Clin. Oncol. , vol.22
    • Tolcher, A.W.1    Forero, L.2    Celio, P.3    Hammond, L.A.4    Rowinsky, E.K.5
  • 99
    • 84900098241 scopus 로고    scopus 로고
    • In vivo synergy between cytotoxic agents and AVE8062A: A tumour vascular targeting agent
    • [abstract 8]. Miami, Florida
    • Vrignaud P. In vivo synergy between cytotoxic agents and AVE8062A: A tumour vascular targeting agent [abstract 8]. Proc 2nd international conference on vascular targeting, Miami, Florida 2004.
    • (2004) Proc 2nd International Conference on Vascular Targeting
    • Vrignaud, P.1
  • 100
    • 0036140378 scopus 로고    scopus 로고
    • Enhanced antitumor activities of TZT-1027 against TNF-alpha or IL-6 secreting Lewis lung carcinoma in vivo
    • T. Natsume Y. Koh M. Kobayashi Enhanced antitumor activities of TZT-1027 against TNF-alpha or IL-6 secreting Lewis lung carcinoma in vivo Cancer Chemother Pharmacol 49 2002 35-47
    • (2002) Cancer Chemother. Pharmacol. , vol.49 , pp. 35-47
    • Natsume, T.1    Koh, Y.2    Kobayashi, M.3
  • 101
    • 0033857963 scopus 로고    scopus 로고
    • TZT-1027, an antimicrotubule agent, attacks tumor vasculature and induces tumor cell death
    • M. Otani T. Natsume J.I. Watanabe et al. TZT-1027, an antimicrotubule agent, attacks tumor vasculature and induces tumor cell death Jpn J Cancer Res 91 2000 837-844
    • (2000) Jpn. J. Cancer Res. , vol.91 , pp. 837-844
    • Otani, M.1    Natsume, T.2    Watanabe, J.I.3
  • 103
    • 19344372663 scopus 로고    scopus 로고
    • The novel vascular disrupting agent, MN-029, shows potent and selective anti-tumour activity in preclinical animal models
    • abstract 23 Miami, Florida
    • McCreedy BK, Locke T, K W. The novel vascular disrupting agent, MN-029, shows potent and selective anti-tumour activity in preclinical animal models [abstract 23]. Proc 2nd international conference on vascular targeting, Miami, Florida 2004.
    • (2004) Proc 2nd International Conference on Vascular Targeting
    • McCreedy, B.K.1    Locke, T.K.W.2
  • 104
    • 0035428054 scopus 로고    scopus 로고
    • Dynamic contrast-enhanced MRI studies in oncology with an emphasis on quantification, validation and human studies
    • A.R. Padhani J.E. Husband Dynamic contrast-enhanced MRI studies in oncology with an emphasis on quantification, validation and human studies Clin Radiol 56 2001 607-620
    • (2001) Clin. Radiol. , vol.56 , pp. 607-620
    • Padhani, A.R.1    Husband, J.E.2
  • 105
    • 0036794518 scopus 로고    scopus 로고
    • Dynamic contrast-enhanced MRI in clinical oncology: Current status and future directions
    • A.R. Padhani Dynamic contrast-enhanced MRI in clinical oncology: Current status and future directions J Magn Reson Imaging 16 2002 407-422
    • (2002) J. Magn. Reson. Imaging , vol.16 , pp. 407-422
    • Padhani, A.R.1
  • 106
    • 0032828135 scopus 로고    scopus 로고
    • Estimating kinetic parameters from dynamic contrast-enhanced T(1)-weighted MRI of a diffusible tracer: Standardized quantities and symbols
    • P.S. Tofts G. Brix D.L. Buckley et al. Estimating kinetic parameters from dynamic contrast-enhanced T(1)-weighted MRI of a diffusible tracer: standardized quantities and symbols J Magn Reson Imaging 10 1999 223-232
    • (1999) J. Magn. Reson. Imaging , vol.10 , pp. 223-232
    • Tofts, P.S.1    Brix, G.2    Buckley, D.L.3
  • 107
    • 0036198715 scopus 로고    scopus 로고
    • Reproducibility of dynamic contrast-enhanced MRI in human muscle and tumours: Comparison of quantitative and semi-quantitative analysis
    • S.M. Galbraith M.A. Lodge N.J. Taylor et al. Reproducibility of dynamic contrast-enhanced MRI in human muscle and tumours: Comparison of quantitative and semi-quantitative analysis NMR Biomed 15 2002 132-142
    • (2002) NMR Biomed , vol.15 , pp. 132-142
    • Galbraith, S.M.1    Lodge, M.A.2    Taylor, N.J.3
  • 108
    • 0010918579 scopus 로고    scopus 로고
    • Reproducibility of dynamic contrast enhanced (DCE-MRI) assessment of tumor vascularity
    • [abstract 399]
    • J.L.P. Evelhoch Z. Latif P. Morton et al. Reproducibility of dynamic contrast enhanced (DCE-MRI) assessment of tumor vascularity [abstract 399] Proc Am Soc Clin Oncol 20 2001
    • (2001) Proc. Am. Soc. Clin. Oncol. , vol.20
    • Evelhoch, J.L.P.1    Latif, Z.2    Morton, P.3
  • 109
    • 0034045183 scopus 로고    scopus 로고
    • Utility of simultaneously acquired gradient-echo and spin-echo cerebral blood volume and morphology maps in brain tumor patients
    • K.M. Donahue H.G. Krouwer S.D. Rand et al. Utility of simultaneously acquired gradient-echo and spin-echo cerebral blood volume and morphology maps in brain tumor patients Magn Reson Med 43 2000 845-853
    • (2000) Magn. Reson. Med. , vol.43 , pp. 845-853
    • Donahue, K.M.1    Krouwer, H.G.2    Rand, S.D.3
  • 110
    • 0033860453 scopus 로고    scopus 로고
    • MRI characterization of tumors and grading angiogenesis using macromolecular contrast media: Status report
    • R. Brasch K. Turetschek MRI characterization of tumors and grading angiogenesis using macromolecular contrast media: Status report Eur J Radiol 34 2000 148-155
    • (2000) Eur. J. Radiol. , vol.34 , pp. 148-155
    • Brasch, R.1    Turetschek, K.2
  • 111
    • 0036099568 scopus 로고    scopus 로고
    • Clinical measurement of blood flow in tumours using PET: A review
    • H. Anderson P.M. Price Clinical measurement of blood flow in tumours using PET: A review Nucl Med Commun 23 2002 131-138
    • (2002) Nucl. Med. Commun. , vol.23 , pp. 131-138
    • Anderson, H.1    Price, P.M.2
  • 112
    • 0346023954 scopus 로고    scopus 로고
    • Combretastatin A-4 phosphate enhances CPT-11 activity independently of the administration sequence
    • H. Wildiers B. Ahmed G. Guetens et al. Combretastatin A-4 phosphate enhances CPT-11 activity independently of the administration sequence Eur J Cancer 40 2004 284-290
    • (2004) Eur. J. Cancer , vol.40 , pp. 284-290
    • Wildiers, H.1    Ahmed, B.2    Guetens, G.3
  • 113
    • 0035233996 scopus 로고    scopus 로고
    • Combretastatin A-4 and doxorubicin combination treatment is effective in a preclinical model of human medullary thyroid carcinoma
    • B.D. Nelkin D.W. Ball Combretastatin A-4 and doxorubicin combination treatment is effective in a preclinical model of human medullary thyroid carcinoma Oncol Rep 8 2001 157-160
    • (2001) Oncol. Rep. , vol.8 , pp. 157-160
    • Nelkin, B.D.1    Ball, D.W.2
  • 114
    • 0031742231 scopus 로고    scopus 로고
    • Targeting the tumor vasculature with combretastatin A-4 disodium phosphate: Effects on radiation therapy
    • L. Li A. Rojiani D.W. Siemann Targeting the tumor vasculature with combretastatin A-4 disodium phosphate: Effects on radiation therapy Int J Radiat Oncol Biol Phys 42 1998 899-903
    • (1998) Int. J. Radiat. Oncol. Biol. Phys. , vol.42 , pp. 899-903
    • Li, L.1    Rojiani, A.2    Siemann, D.W.3
  • 115
    • 0035874889 scopus 로고    scopus 로고
    • Eradication of colorectal xenografts by combined radioimmunotherapy and combretastatin a-4 3-O-phosphate
    • R.B. Pedley S.A. Hill G.M. Boxer et al. Eradication of colorectal xenografts by combined radioimmunotherapy and combretastatin a-4 3-O-phosphate Cancer Res 61 2001 4716-4722
    • (2001) Cancer Res. , vol.61 , pp. 4716-4722
    • Pedley, R.B.1    Hill, S.A.2    Boxer, G.M.3
  • 116
    • 0036891507 scopus 로고    scopus 로고
    • Synergy between vascular targeting agents and antibody-directed therapy
    • R.B. Pedley E. El-Emir A.A. Flynn et al. Synergy between vascular targeting agents and antibody-directed therapy Int J Radiat Oncol Biol Phys 54 2002 1524-1531
    • (2002) Int. J. Radiat. Oncol. Biol. Phys. , vol.54 , pp. 1524-1531
    • Pedley, R.B.1    El-Emir, E.2    Flynn, A.A.3
  • 117
    • 0036568457 scopus 로고    scopus 로고
    • Vascular targeting agents enhance chemotherapeutic agent activities in solid tumor therapy
    • D.W. Siemann E. Mercer S. Lepler A.M. Rojiani Vascular targeting agents enhance chemotherapeutic agent activities in solid tumor therapy Int J Cancer 99 2002 1-6
    • (2002) Int. J. Cancer , vol.99 , pp. 1-6
    • Siemann, D.W.1    Mercer, E.2    Lepler, S.3    Rojiani, A.M.4
  • 118
    • 0033573982 scopus 로고    scopus 로고
    • Synergy between an antiangiogenic integrin alphav antagonist and an antibody-cytokine fusion protein eradicates spontaneous tumor metastases
    • H.N. Lode T. Moehler R. Xiang et al. Synergy between an antiangiogenic integrin alphav antagonist and an antibody-cytokine fusion protein eradicates spontaneous tumor metastases Proc Natl Acad Sci U S A 96 1999 1591-1596
    • (1999) Proc. Natl. Acad. Sci. U S A , vol.96 , pp. 1591-1596
    • Lode, H.N.1    Moehler, T.2    Xiang, R.3
  • 119
    • 18244419396 scopus 로고    scopus 로고
    • Combined effects of angiostatin and ionizing radiation in antitumour therapy
    • H.J. Mauceri N.N. Hanna M.A. Beckett et al. Combined effects of angiostatin and ionizing radiation in antitumour therapy Nature 394 1998 287-291
    • (1998) Nature , vol.394 , pp. 287-291
    • Mauceri, H.J.1    Hanna, N.N.2    Beckett, M.A.3
  • 120
    • 0036891440 scopus 로고    scopus 로고
    • Combination of vascular targeting agents with thermal or radiation therapy
    • M.R. Horsman R. Murata Combination of vascular targeting agents with thermal or radiation therapy Int J Radiat Oncol Biol Phys 54 2002 1518-1523
    • (2002) Int. J. Radiat. Oncol. Biol. Phys. , vol.54 , pp. 1518-1523
    • Horsman, M.R.1    Murata, R.2
  • 121
    • 0034958723 scopus 로고    scopus 로고
    • Combretastatin A-4 and hyperthermia; a potent combination for the treatment of solid tumors
    • H.P. Eikesdal R. Bjerkvig O. Mella O. Dahl Combretastatin A-4 and hyperthermia; a potent combination for the treatment of solid tumors Radiother Oncol 60 2001 147-154
    • (2001) Radiother. Oncol. , vol.60 , pp. 147-154
    • Eikesdal, H.P.1    Bjerkvig, R.2    Mella, O.3    Dahl, O.4
  • 122
    • 0036569804 scopus 로고    scopus 로고
    • Enhancement of radiation therapy by the novel vascular targeting agent ZD6126
    • D.W. Siemann A.M. Rojiani Enhancement of radiation therapy by the novel vascular targeting agent ZD6126 Int J Radiat Oncol Biol Phys 53 2002 164-171
    • (2002) Int. J. Radiat. Oncol. Biol. Phys. , vol.53 , pp. 164-171
    • Siemann, D.W.1    Rojiani, A.M.2
  • 123
    • 0037267544 scopus 로고    scopus 로고
    • Targeting the tumor blood vessel network to enhance the efficacy of radiation therapy
    • D.W. Siemann W. Shi Targeting the tumor blood vessel network to enhance the efficacy of radiation therapy Semin Radiat Oncol 13 2003 53-61
    • (2003) Semin. Radiat. Oncol. , vol.13 , pp. 53-61
    • Siemann, D.W.1    Shi, W.2
  • 124
    • 0035254653 scopus 로고    scopus 로고
    • In vivo antitumor effect of vascular targeting combined with either ionizing radiation or anti-angiogenesis treatment
    • W. Landuyt B. Ahmed S. Nuyts et al. In vivo antitumor effect of vascular targeting combined with either ionizing radiation or anti-angiogenesis treatment Int J Radiat Oncol Biol Phys 49 2001 443-450
    • (2001) Int. J. Radiat. Oncol. Biol. Phys. , vol.49 , pp. 443-450
    • Landuyt, W.1    Ahmed, B.2    Nuyts, S.3
  • 125
    • 0034759198 scopus 로고    scopus 로고
    • Improved tumor response by combining radiation and the vascular-damaging drug 5,6-dimethylxanthenone-4-acetic acid
    • R. Murata D.W. Siemann J. Overgaard M.R. Horsman Improved tumor response by combining radiation and the vascular-damaging drug 5,6-dimethylxanthenone-4-acetic acid Radiat Res 156 2001 503-509
    • (2001) Radiat. Res. , vol.156 , pp. 503-509
    • Murata, R.1    Siemann, D.W.2    Overgaard, J.3    Horsman, M.R.4
  • 126
    • 0035889331 scopus 로고    scopus 로고
    • Combretastatin A-4 disodium phosphate: A vascular targeting agent that improves that improves the anti-tumor effects of hyperthermia, radiation, and mild thermoradiotherapy
    • R. Murata J. Overgaard M.R. Horsman Combretastatin A-4 disodium phosphate: A vascular targeting agent that improves that improves the anti-tumor effects of hyperthermia, radiation, and mild thermoradiotherapy Int J Radiat Oncol Biol Phys 51 2001 1018-1024
    • (2001) Int. J. Radiat. Oncol. Biol. Phys. , vol.51 , pp. 1018-1024
    • Murata, R.1    Overgaard, J.2    Horsman, M.R.3
  • 127
    • 19344374931 scopus 로고    scopus 로고
    • Acute anti vascular effects of combretastatin A4 phosphate (CA4P) on The SW1222 tumour as measured by dynamic contrast enhanced MRI (DCE-MRI)
    • Lankester K, P B. Acute anti vascular effects of combretastatin A4 phosphate (CA4P) on The SW1222 tumour as measured by dynamic contrast enhanced MRI (DCE-MRI) 2004.
    • (2004)
    • Lankester, K.P.B.1
  • 128
    • 0141653353 scopus 로고    scopus 로고
    • Phase Ib trial of combretastatin A4 phosphate (CA4P) in combination with carboplatin in patients with advanced cancer
    • [abstract 889]
    • J.H. Bilenker J. Stevenson M.A. Rosen M. Gallagher et al. Phase Ib trial of combretastatin A4 phosphate (CA4P) in combination with carboplatin in patients with advanced cancer [abstract 889] Proc Am Soc Clin Oncol 2003 22
    • (2003) Proc. Am. Soc. Clin. Oncol. , pp. 22
    • Bilenker, J.H.1    Stevenson, J.2    Rosen, M.A.3    Gallagher, M.4
  • 131
    • 0000996268 scopus 로고    scopus 로고
    • Combination of the VEGF receptor tyrosine kinase inhibitor ZD6474 and vascular targeting agent ZD6126 produces an enhanced anti-tumor response
    • S.R. Wedge J. Kendrew D.J. Ogilvie et al. Combination of the VEGF receptor tyrosine kinase inhibitor ZD6474 and vascular targeting agent ZD6126 produces an enhanced anti-tumor response Proc Am Assoc Cancer Res 43 2002 1081
    • (2002) Proc. Am. Assoc. Cancer Res. , vol.43 , pp. 1081
    • Wedge, S.R.1    Kendrew, J.2    Ogilvie, D.J.3
  • 133
    • 0033962101 scopus 로고    scopus 로고
    • Relationship of vascular maturation in breast cancer blood vessels to vascular density and metastasis, assessed by expression of a novel basement membrane component, LH39
    • S. Kakolyris S.B. Fox M. Koukourakis et al. Relationship of vascular maturation in breast cancer blood vessels to vascular density and metastasis, assessed by expression of a novel basement membrane component, LH39 Br J Cancer 82 2000 844-851
    • (2000) Br. J. Cancer , vol.82 , pp. 844-851
    • Kakolyris, S.1    Fox, S.B.2    Koukourakis, M.3
  • 134
    • 0034648765 scopus 로고    scopus 로고
    • Angiogenesis in cancer and other diseases
    • P. Carmeliet R.K. Jain Angiogenesis in cancer and other diseases Nature 407 2000 249-257
    • (2000) Nature , vol.407 , pp. 249-257
    • Carmeliet, P.1    Jain, R.K.2
  • 135
    • 19344362849 scopus 로고    scopus 로고
    • Website NCI
    • Website NCI. http://www.cancer.gov/clinicaltrials/developments/ anti-angio-table.


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