Cardiac fibrosis and vascular remodeling are attenuated by metformin in obese rats

International Journal of Cardiology

Volumn 165, Issue 3, 2013, Pages 483-487

  Burlá, Adriana K ^a   Lobato, Núbia S ^a   Fortes, Zuleica B ^a   Oigman, Wille ^a   Neves, Mario Fritsch ^a  

^a STATE UNIVERSITY OF RIO DE JANEIRO   (Brazil)

Author keywords

Cardiac fibrosis; Collagen; Insulin resistance; Metformin; Obesity; Vascular remodeling

Indexed keywords

COLLAGEN; GLUTAMATE SODIUM; INSULIN; METFORMIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTERIAL WALL THICKNESS; ARTICLE; BLOOD PRESSURE MEASUREMENT; CARDIOVASCULAR DISEASE; CARDIOVASCULAR PARAMETERS; COLLAGEN DISEASE; CONTROLLED STUDY; DISEASE ASSOCIATION; DRUG EFFICACY; DRUG MECHANISM; HEART MUSCLE FIBROSIS; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; MALE; MORPHOLOGY; NONHUMAN; OBESITY; PRIORITY JOURNAL; RAT; SYSTOLIC BLOOD PRESSURE; VASCULAR REMODELING; ANIMAL TISSUE; ARTERIOLE; HEART LEFT VENTRICLE;

ANIMALS; ENDOMYOCARDIAL FIBROSIS; HYPOGLYCEMIC AGENTS; MALE; METFORMIN; OBESITY; RATS; RATS, WISTAR; VENTRICULAR REMODELING;

EID: 84877057639     PISSN: 01675273     EISSN: 18741754     Source Type: Journal    
DOI: 10.1016/j.ijcard.2011.09.012     Document Type: Article

References (53)

1. K. Marinou, D. Tousoulis, A.S. Antonopoulos, E. Stefanadi, and C. Stefanadis Obesity and cardiovascular disease: from pathophysiology to risk stratification Int J Cardiol 138 2010 3 8
2. S.M. Ayatollahi, and Z. Ghoreshizadeh Prevalence of obesity and overweight among adults in Iran Obes Rev 11 2010 335 337
3. S. Yusuf, S. Hawken, and S. Ounpuu Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEART study): case-control study Lancet 364 2004 937 952
4. E. Ingelsson, L.M. Sullivan, and C.S. Fox Burden and prognostic importance of subclinical cardiovascular disease in overweight and obese individuals Circulation 116 2007 375 384
5. P.E. Zebekakis, T. Nawrot, and L. Thijs Obesity is associated with increased arterial stiffness from adolescence until old age J Hypertens 23 2005 1839 1846
6. B.I. Levy, E.L. Schiffrin, and J.J. Mourad Impaired tissue perfusion: a pathology common to hypertension, obesity, and diabetes mellitus Circulation 118 2008 968 976
7. C. De Ciuceis, E. Porteri, and D. Rizzoni Structural alterations of subcutaneous small-resistance arteries may predict major cardiovascular events in patients with hypertension Am J Hypertens 20 2007 846 852
8. G. Grassi, and E.L. Schiffrin Media-to-lumen ratio as predictor of renal abnormalities in hypertension: new findings, new questions J Hypertens 28 2010 1811 1813
9. G. Grassi, G. Seravalle, and F. Scopelliti Structural and functional alterations of subcutaneous small resistance arteries in severe human obesity Obesity (Silver Spring) 18 2010 92 98
10. R. Dawson, M.A. Pelleymounter, W.J. Millard, S. Liu, and B. Eppler Attenuation of leptin-mediated effects by monosodium glutamate-induced arcuate nucleus damage Am J Physiol 273 1997 E202 E206
11. L. Macho, M. Fickova, Jezova, and S. Zorad Late effects of postnatal administration of monosodium glutamate on insulin action in adult rats Physiol Res 49 Suppl 1 2000 S79 S85
12. M. Nagata, W. Suzuki, and S. Iizuka Type 2 diabetes mellitus in obese mouse model induced by monosodium glutamate Exp Anim 55 2006 109 115
13. N.S. Lobato, F.P. Filgueira, and E.H. Akamine Obesity induced by neonatal treatment with monosodium glutamate impairs microvascular reactivity in adult rats: role of NO and prostanoids Nutr Metab Cardiovasc Dis 21 10 2011 Oct 808 816
14. P.V. Katakam, M.R. Ujhelyi, M. Hoenig, and A.W. Miller Metformin improves vascular function in insulin-resistant rats Hypertension 35 2000 108 112
15. J.P. Kay, R. Alemzadeh, G. Langley, L. D'Angelo, P. Smith, and S. Holshouser Beneficial effects of metformin in normoglycemic morbidly obese adolescents Metabolism 50 2001 1457 1461
16. F.L. Carson, J.H. Martin, and J.A. Lynn Formalin fixation for electron microscopy: a re-evaluation Am J Clin Pathol 59 1973 365 373
17. H.E. Lebovitz Insulin resistance - a common link between type 2 diabetes and cardiovascular disease Diabetes Obes Metab 8 2006 237 249
18. K. Tokuyama, and J. Himms-Hagen Adrenalectomy prevents obesity in glutamate-treated mice Am J Physiol 257 1989 E139 E144
19. N.V. Cunha, S.B. de Abreu, and C. Panis Cox-2 inhibition attenuates cardiovascular and inflammatory aspects in monosodium glutamate-induced obese rats Life Sci 87 2010 375 381
20. U. Scherrer, and C. Sartori Insulin as a vascular and sympathoexcitatory hormone: implications for blood pressure regulation, insulin sensitivity, and cardiovascular morbidity Circulation 96 1997 4104 4113
21. B. Gustafson, A. Hammarstedt, C.X. Andersson, and U. Smith Inflamed adipose tissue: a culprit underlying the metabolic syndrome and atherosclerosis Arterioscler Thromb Vasc Biol 27 2007 2276 2283
22. G.E. Alvarez, S.D. Beske, T.P. Ballard, and K.P. Davy Sympathetic neural activation in visceral obesity Circulation 106 2002 2533 2536
23. G. Grassi, R. Dell'Oro, A. Facchini, F. Quarti Trevano, G.B. Bolla, and G. Mancia Effect of central and peripheral body fat distribution on sympathetic and baroreflex function in obese normotensives J Hypertens 22 2004 2363 2369
24. C.X. Andersson, B. Gustafson, A. Hammarstedt, S. Hedjazifar, and U. Smith Inflamed adipose tissue, insulin resistance and vascular injury Diabetes Metab Res Rev 24 2008 595 603
25. A.E. Malavazos, M.M. Corsi, and F. Ermetici Proinflammatory cytokines and cardiac abnormalities in uncomplicated obesity: relationship with abdominal fat deposition Nutr Metab Cardiovasc Dis 17 2007 294 302
26. A.E. Malavazos, F. Ermetici, C. Coman, M.M. Corsi, L. Morricone, and B. Ambrosi Influence of epicardial adipose tissue and adipocytokine levels on cardiac abnormalities in visceral obesity Int J Cardiol 121 2007 132 134
27. G. Iacobellis, F. Leonetti, N. Singh, and A MS Relationship of epicardial adipose tissue with atrial dimensions and diastolic function in morbidly obese subjects Int J Cardiol 115 2007 272 273
28. H.C. McGill Jr., C.A. McMahan, and E.E. Herderick Obesity accelerates the progression of coronary atherosclerosis in young men Circulation 105 2002 2712 2718
29. A. Must, P.F. Jacques, G.E. Dallal, C.J. Bajema, and W.H. Dietz Long-term morbidity and mortality of overweight adolescents. A follow-up of the Harvard Growth Study of 1922 to 1935 N Engl J Med 327 1992 1350 1355
30. D.J. Gunnell, S.J. Frankel, K. Nanchahal, T.J. Peters, and G. Davey Smith Childhood obesity and adult cardiovascular mortality: a 57-y follow-up study based on the Boyd Orr cohort Am J Clin Nutr 67 1998 1111 1118
31. J.P. Despres, B. Lamarche, and P. Mauriege Hyperinsulinemia as an independent risk factor for ischemic heart disease N Engl J Med 334 1996 952 957
32. J.B. Ruige, W.J. Assendelft, J.M. Dekker, P.J. Kostense, R.J. Heine, and L.M. Bouter Insulin and risk of cardiovascular disease: a meta-analysis Circulation 97 1998 996 1001
33. T. Smiley, P. Oh, and L.G. Shane The relationship of insulin resistance measured by reliable indexes to coronary artery disease risk factors and outcomes - a systematic review Can J Cardiol 17 2001 797 805
34. J.E. Toblli, G. Cao, G. DeRosa, and P. Forcada Reduced cardiac expression of plasminogen activator inhibitor 1 and transforming growth factor beta1 in obese Zucker rats by perindopril Heart 91 2005 80 86
35. A. Cittadini, C.S. Mantzoros, and T.G. Hampton Cardiovascular abnormalities in transgenic mice with reduced brown fat: an animal model of human obesity Circulation 100 1999 2177 2183
36. A.K. Zaman, S. Fujii, and D. Goto Salutary effects of attenuation of angiotensin II on coronary perivascular fibrosis associated with insulin resistance and obesity J Mol Cell Cardiol 37 2004 525 535
37. A.K. Zaman, S. Fujii, and H. Sawa Angiotensin-converting enzyme inhibition attenuates hypofibrinolysis and reduces cardiac perivascular fibrosis in genetically obese diabetic mice Circulation 103 2001 3123 3128
38. D.P. Relling, L.B. Esberg, and C.X. Fang High-fat diet-induced juvenile obesity leads to cardiomyocyte dysfunction and upregulation of Foxo3a transcription factor independent of lipotoxicity and apoptosis J Hypertens 24 2006 549 561
39. E.D. Abel, S.E. Litwin, and G. Sweeney Cardiac remodeling in obesity Physiol Rev 88 2008 389 419
40. D. Quilliot, F. Alla, and P. Bohme Myocardial collagen turnover in normotensive obese patients: relation to insulin resistance Int J Obes (Lond) 29 2005 1321 1328
41. K.S. Moshal, N. Tyagi, and V. Moss Early induction of matrix metalloproteinase-9 transduces signaling in human heart end stage failure J Cell Mol Med 9 2005 704 713
42. S. Madani, S. De Girolamo, D.M. Munoz, R.K. Li, and G. Sweeney Direct effects of leptin on size and extracellular matrix components of human pediatric ventricular myocytes Cardiovasc Res 69 2006 716 725
43. R.J. Sidell, M.A. Cole, N.J. Draper, M. Desrois, R.E. Buckingham, and K. Clarke Thiazolidinedione treatment normalizes insulin resistance and ischemic injury in the zucker fatty rat heart Diabetes 51 2002 1110 1117
44. T.L. Yue, W. Bao, and J.L. Gu Rosiglitazone treatment in Zucker diabetic Fatty rats is associated with ameliorated cardiac insulin resistance and protection from ischemia/reperfusion-induced myocardial injury Diabetes 54 2005 554 562
45. H. Xiao, X. Ma, and W. Feng Metformin attenuates cardiac fibrosis by inhibiting the TGFbeta1-Smad3 signalling pathway Cardiovasc Res 87 2010 504 513
46. X.F. Wang, J.Y. Zhang, L. Li, X.Y. Zhao, H.L. Tao, and L. Zhang Metformin improves cardiac function in rats via activation of AMP-activated protein kinase Clin Exp Pharmacol Physiol 38 2 2011 Feb 94 101
47. C.X. Zhang, S.N. Pan, and R.S. Meng Metformin attenuates ventricular hypertrophy by activating the AMPK-eNOS pathway in rats Clin Exp Pharmacol Physiol 38 1 2011 Jan 55 62
48. C.J. Bailey Metformin: effects on micro and macrovascular complications in type 2 diabetes Cardiovasc Drugs Ther 22 2008 215 224
49. S.E. Kahn, S.M. Haffner, and G. Viberti Rosiglitazone decreases C-reactive protein to a greater extent relative to glyburide and metformin over 4 years despite greater weight gain: observations from a Diabetes Outcome Progression Trial (ADOPT) Diabetes Care 33 2010 177 183
50. M.H. Park, S. Kinra, K.J. Ward, B. White, and R.M. Viner Metformin for obesity in children and adolescents: a systematic review Diabetes Care 32 2009 1743 1745
51. S. Wiegand, D. l'Allemand, and H. Hubel Metformin and placebo therapy both improve weight management and fasting insulin in obese insulin-resistant adolescents: a prospective, placebo-controlled, randomized study Eur J Endocrinol 163 2010 585 592
52. S. Verma, S. Bhanot, and J.H. McNeill Decreased vascular reactivity in metformin-treated fructose-hypertensive rats Metabolism 45 1996 1053 1055
53. P.J. Little, N. Osman, S.T. de Dios, N. Cemerlang, M. Ballinger, and J. Nigro Anti-proliferative activity of oral anti-hyperglycemic agents on human vascular smooth muscle cells: thiazolidinediones (glitazones) have enhanced activity under high glucose conditions Cardiovasc Diabetol 6 2007 33