Collagenase increases the transcapillary pressure gradient and improves the uptake and distribution of monoclonal antibodies in human osteosarcoma xenografts

Cancer Research

Volumn 64, Issue 14, 2004, Pages 4768-4773

  Eikenes, Live ^a   Bruland, Øyvind S ^b   Brekken, Christian ^a   De Lange Davies, Catharina ^a  

^a NORWEGIAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Norway)

^b OSLO UNIVERSITY HOSPITAL   (Norway)

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGENASE; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY TP 3; UNCLASSIFIED DRUG;

ADOLESCENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD VESSEL PERMEABILITY; CANCER THERAPY; CAPILLARY PRESSURE; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; DRUG DISTRIBUTION; DRUG PENETRATION; DRUG UPTAKE; EXTRACELLULAR MATRIX; FEMALE; HUMAN; KINETICS; MACROMOLECULE; MEAN ARTERIAL PRESSURE; METASTASIS; MICROPIPETTE; MOUSE; NONHUMAN; OSTEOSARCOMA; PRESSURE GRADIENT; PRIORITY JOURNAL; SOLID TUMOR; TECHNIQUE; TISSUE PRESSURE; TRANSCAPILLARY PRESSURE GRADIENT; TUMOR XENOGRAFT; VASCULAR RESISTANCE; WICK IN NEEDLE METHOD;

ANIMALS; ANTIBODIES, MONOCLONAL; BLOOD PRESSURE; CAPILLARIES; COLLAGEN TYPE I; COLLAGENASES; EXTRACELLULAR FLUID; FEMALE; HUMANS; MICE; MICE, INBRED BALB C; MICROSCOPY, CONFOCAL; NEOPLASM TRANSPLANTATION; OSTEOSARCOMA; TISSUE DISTRIBUTION; TRANSPLANTATION, HETEROLOGOUS;

EID: 3142660422     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-03-1472     Document Type: Article

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