Expression of CYP3A in chronic ethanol-fed mice is mediated by endogenous pregnane X receptor ligands formed by enhanced cholesterol metabolism

Archives of Toxicology

Volumn 89, Issue 4, 2015, Pages 579-589

  Je, Young Tae ^a   Sim, Woo Cheol ^a   Kim, Dong Gwang ^a   Jung, Byung Hwa ^b   Shin, Ho Sang ^c   Lee, Byung Hoon ^a  

^a Seoul National University   (South Korea)

^b Korea Institute of Science and Technology   (South Korea)

^c Kongju National University   (South Korea)

Author keywords

Cholesterol; CYP3A; Ethanol; Lieber DeCarli; Metabolism; PXR

Indexed keywords

3,7,12-TRIHYDROXYCOPROSTANE; 7 ALPHA-HYDROXY-4-CHOLESTEN-3-ONE; ALCOHOL; CHOLEST 4 EN 3 ONE; CHOLESTANOL; CHOLESTEROL; CYP3A11 PROTEIN, MOUSE; CYTOCHROME P450 3A; LIGAND; LITHOCHOLIC ACID; MEMBRANE PROTEIN; PREGNANE X RECEPTOR; STEROID RECEPTOR;

ANIMAL; CHROMATIN IMMUNOPRECIPITATION; DOSE RESPONSE; DRUG DETOXIFICATION; DRUG EFFECTS; ENZYME ACTIVE SITE; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETICS; INSTITUTE FOR CANCER RESEARCH MOUSE; LIVER; MALE; METABOLISM; TIME; WESTERN BLOTTING;

ANIMALS; BLOTTING, WESTERN; CATALYTIC DOMAIN; CHOLESTANOLS; CHOLESTENONES; CHOLESTEROL; CHROMATIN IMMUNOPRECIPITATION; CYTOCHROME P-450 CYP3A; DOSE-RESPONSE RELATIONSHIP, DRUG; ETHANOL; GENE EXPRESSION REGULATION; LIGANDS; LITHOCHOLIC ACID; LIVER; MALE; MEMBRANE PROTEINS; METABOLIC DETOXICATION, PHASE I; METABOLIC DETOXICATION, PHASE II; MICE, INBRED ICR; RECEPTORS, STEROID; TIME FACTORS;

EID: 84939888073     PISSN: 03405761     EISSN: 14320738     Source Type: Journal    
DOI: 10.1007/s00204-014-1268-9     Document Type: Article

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