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Volumn 34, Issue 20, 2015, Pages 2586-2596

MutT Homolog 1 (MTH1) maintains multiple KRAS-driven pro-malignant pathways

Author keywords

[No Author keywords available]

Indexed keywords

8-OXODGTPASE; DNA LIGASE; KRAS PROTEIN, HUMAN; ONCOPROTEIN; PHOSPHATASE; PROTEIN P53; RAS PROTEIN; TP53 PROTEIN, HUMAN;

EID: 84939883772     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2014.195     Document Type: Article
Times cited : (77)

References (53)
  • 1
    • 1242340431 scopus 로고    scopus 로고
    • Oncogenic Ras and its role in tumor cell invasion and metastasis
    • Campbell PM, Der CJ. Oncogenic Ras and its role in tumor cell invasion and metastasis. Semin Cancer Biol 2004; 14: 105-114.
    • (2004) Semin Cancer Biol , vol.14 , pp. 105-114
    • Campbell, P.M.1    Der, C.J.2
  • 3
    • 2442693092 scopus 로고    scopus 로고
    • The superoxide-generating oxidase Nox1 is functionally required for Ras oncogene transformation
    • Mitsushita J, Lambeth JD, Kamata T. The superoxide-generating oxidase Nox1 is functionally required for Ras oncogene transformation. Cancer Res 2004; 64: 3580-3585.
    • (2004) Cancer Res , vol.64 , pp. 3580-3585
    • Mitsushita, J.1    Lambeth, J.D.2    Kamata, T.3
  • 6
    • 0030980641 scopus 로고    scopus 로고
    • Mitogenic signaling mediated by oxidants in ras-transformed fibroblasts
    • Irani K, Xia Y, Zweier JL, Sollott SJ, Der CJ, Fearon ER et al. Mitogenic signaling mediated by oxidants in ras-transformed fibroblasts. Science 1997; 275: 1649-1652.
    • (1997) Science , vol.275 , pp. 1649-1652
    • Irani, K.1    Xia, Y.2    Zweier, J.L.3    Sollott, S.J.4    Der, C.J.5    Fearon, E.R.6
  • 8
    • 33750900751 scopus 로고    scopus 로고
    • Intracellular redox regulation by the family of small GTPases
    • Finkel T. Intracellular redox regulation by the family of small GTPases. Antioxid Redox Signal 2006; 8: 1857-1863.
    • (2006) Antioxid Redox Signal , vol.8 , pp. 1857-1863
    • Finkel, T.1
  • 9
    • 79953033356 scopus 로고    scopus 로고
    • Enhanced elimination of oxidized guanine nucleotides inhibits oncogenic RAS-induced DNA damage and premature senescence
    • Rai P, Young JJ, Burton DG, Giribaldi MG, Onder TT, Weinberg RA. Enhanced elimination of oxidized guanine nucleotides inhibits oncogenic RAS-induced DNA damage and premature senescence. Oncogene 2011; 30: 1489-1496.
    • (2011) Oncogene , vol.30 , pp. 1489-1496
    • Rai, P.1    Young, J.J.2    Burton, D.G.3    Giribaldi, M.G.4    Onder, T.T.5    Weinberg, R.A.6
  • 10
    • 33846128155 scopus 로고    scopus 로고
    • The DNA damage signaling pathway is a critical mediator of oncogene-induced senescence
    • Mallette FA, Gaumont-Leclerc M-F, Ferbeyre G. The DNA damage signaling pathway is a critical mediator of oncogene-induced senescence. Genes Dev 2007; 21: 43-48.
    • (2007) Genes Dev , vol.21 , pp. 43-48
    • Mallette, F.A.1    Gaumont-Leclerc, M.-F.2    Ferbeyre, G.3
  • 11
    • 33845269825 scopus 로고    scopus 로고
    • Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication
    • Di Micco R, Fumagalli M, Cicalese A, Piccinin S, Gasparini P, Luise C et al. Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication. Nature 2006; 444: 638-642.
    • (2006) Nature , vol.444 , pp. 638-642
    • Di Micco, R.1    Fumagalli, M.2    Cicalese, A.3    Piccinin, S.4    Gasparini, P.5    Luise, C.6
  • 12
    • 0034671502 scopus 로고    scopus 로고
    • Oncogenic ras mediates apoptosis in response to protein kinase C inhibition through the generation of reactive oxygen species
    • Liou JS, Chen CY, Chen JS, Faller DV. Oncogenic ras mediates apoptosis in response to protein kinase C inhibition through the generation of reactive oxygen species. J Biol Chem 2000; 275: 39001-39011.
    • (2000) J Biol Chem , vol.275 , pp. 39001-39011
    • Liou, J.S.1    Chen, C.Y.2    Chen, J.S.3    Faller, D.V.4
  • 13
    • 0031771114 scopus 로고    scopus 로고
    • Correlation of genetic instability and apoptosis in the presence of oncogenic Ki-Ras
    • Chen CY, Liou J, Forman LW, Faller DV. Correlation of genetic instability and apoptosis in the presence of oncogenic Ki-Ras. Cell Death Differ 1998; 5: 984-995.
    • (1998) Cell Death Differ , vol.5 , pp. 984-995
    • Chen, C.Y.1    Liou, J.2    Forman, L.W.3    Faller, D.V.4
  • 14
    • 0035796057 scopus 로고    scopus 로고
    • Molecular genetics and structural biology of human MutT homolog MTH1
    • Nakabeppu Y. Molecular genetics and structural biology of human MutT homolog, MTH1. Mutat Res 2001; 477: 59-70.
    • (2001) Mutat Res , vol.477 , pp. 59-70
    • Nakabeppu, Y.1
  • 15
    • 58549087616 scopus 로고    scopus 로고
    • Continuous elimination of oxidized nucleotides is necessary to prevent rapid onset of cellular senescence
    • Rai P, Onder TT, Young JJ, McFaline JL, Pang B, Dedon PC et al. Continuous elimination of oxidized nucleotides is necessary to prevent rapid onset of cellular senescence. Proc Natl Acad Sci USA 2009; 106: 169-174.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 169-174
    • Rai, P.1    Onder, T.T.2    Young, J.J.3    McFaline, J.L.4    Pang, B.5    Dedon, P.C.6
  • 16
    • 0037717023 scopus 로고    scopus 로고
    • Expression of human MutT homologue (hMTH1) protein in primary non-small-cell lung carcinomas and histologically normal surrounding tissue
    • Kennedy CH, Pass HI, Mitchell JB. Expression of human MutT homologue (hMTH1) protein in primary non-small-cell lung carcinomas and histologically normal surrounding tissue. Free Radic Biol Med 2003; 34: 1447-1457.
    • (2003) Free Radic Biol Med , vol.34 , pp. 1447-1457
    • Kennedy, C.H.1    Pass, H.I.2    Mitchell, J.B.3
  • 17
    • 85011937497 scopus 로고    scopus 로고
    • MiR-145 inhibits cell proliferation of human lung adenocarcinoma by targeting EGFR and NUDT1
    • Cho WC, Chow AS, Au JS. MiR-145 inhibits cell proliferation of human lung adenocarcinoma by targeting EGFR and NUDT1. RNA Biol 2011; 8: 125-131.
    • (2011) RNA Biol , vol.8 , pp. 125-131
    • Cho, W.C.1    Chow, A.S.2    Au, J.S.3
  • 18
    • 59449092185 scopus 로고    scopus 로고
    • Single-vector inducible lentiviral RNAi system for oncology target validation
    • Wiederschain D, Wee S, Chen L, Loo A, Yang G, Huang A et al. Single-vector inducible lentiviral RNAi system for oncology target validation. Cell Cycle 2009; 8: 498-504.
    • (2009) Cell Cycle , vol.8 , pp. 498-504
    • Wiederschain, D.1    Wee, S.2    Chen, L.3    Loo, A.4    Yang, G.5    Huang, A.6
  • 19
    • 0030944985 scopus 로고    scopus 로고
    • Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a
    • Serrano M, Lin AW, McCurrach ME, Beach D, Lowe SW. Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a. Cell 1997; 88: 593-602.
    • (1997) Cell , vol.88 , pp. 593-602
    • Serrano, M.1    Lin, A.W.2    McCurrach, M.E.3    Beach, D.4    Lowe, S.W.5
  • 20
    • 0034698170 scopus 로고    scopus 로고
    • Inhibition of the phosphoinositide 3-kinase pathway induces a senescence-like arrest mediated by p27Kip1
    • Collado M, Medema RH, Garcia-Cao I, Dubuisson ML, Barradas M, Glassford J et al. Inhibition of the phosphoinositide 3-kinase pathway induces a senescence-like arrest mediated by p27Kip1. J Biol Chem 2000; 275: 21960-21968.
    • (2000) J Biol Chem , vol.275 , pp. 21960-21968
    • Collado, M.1    Medema, R.H.2    Garcia-Cao, I.3    Dubuisson, M.L.4    Barradas, M.5    Glassford, J.6
  • 21
    • 0033583242 scopus 로고    scopus 로고
    • Ras proteins induce senescence by altering the intracellular levels of reactive oxygen species
    • Lee AC, Fenster BE, Ito H, Takeda K, Bae NS, Hirai T et al. Ras proteins induce senescence by altering the intracellular levels of reactive oxygen species. J Biol Chem 1999; 274: 7936-7940.
    • (1999) J Biol Chem , vol.274 , pp. 7936-7940
    • Lee, A.C.1    Fenster, B.E.2    Ito, H.3    Takeda, K.4    Bae, N.S.5    Hirai, T.6
  • 22
    • 33750510904 scopus 로고    scopus 로고
    • Mitogenic signalling and the p16INK4a-Rb pathway cooperate to enforce irreversible cellular senescence
    • Takahashi A, Ohtani N, Yamakoshi K, Iida S-i, Tahara H, Nakayama K et al. Mitogenic signalling and the p16INK4a-Rb pathway cooperate to enforce irreversible cellular senescence. Nat Cell Biol 2006; 8: 1291-1297.
    • (2006) Nat Cell Biol , vol.8 , pp. 1291-1297
    • Takahashi, A.1    Ohtani, N.2    Yamakoshi, K.3    Iida, S.-I.4    Tahara, H.5    Nakayama, K.6
  • 23
    • 56849118516 scopus 로고    scopus 로고
    • Akt determines replicative senescence and oxidative or oncogenic premature senescence and sensitizes cells to oxidative apoptosis
    • Nogueira V, Park Y, Chen CC, Xu PZ, Chen ML, Tonic I et al. Akt determines replicative senescence and oxidative or oncogenic premature senescence and sensitizes cells to oxidative apoptosis. Cancer Cell 2008; 14: 458-470.
    • (2008) Cancer Cell , vol.14 , pp. 458-470
    • Nogueira, V.1    Park, Y.2    Chen, C.C.3    Xu, P.Z.4    Chen, M.L.5    Tonic, I.6
  • 24
    • 79954589566 scopus 로고    scopus 로고
    • 8-Oxoguanine incision activity is impaired in lung tissues of NSCLC patients with the polymorphism of OGG1 and XRCC1 genes
    • Janik J, Swoboda M, Janowska B, Ciesla JM, Gackowski D, Kowalewski J et al. 8-Oxoguanine incision activity is impaired in lung tissues of NSCLC patients with the polymorphism of OGG1 and XRCC1 genes. Mutat Res 2011; 709-710: 21-31.
    • (2011) Mutat Res , vol.709-710 , pp. 21-31
    • Janik, J.1    Swoboda, M.2    Janowska, B.3    Ciesla, J.M.4    Gackowski, D.5    Kowalewski, J.6
  • 25
    • 0034672199 scopus 로고    scopus 로고
    • HOGG1 polymorphism and loss of heterozygosity (LOH): Significance for lung cancer susceptibility in a caucasian population
    • Wikman H, Risch A, Klimek F, Schmezer P, Spiegelhalder B, Dienemann H et al. hOGG1 polymorphism and loss of heterozygosity (LOH): Significance for lung cancer susceptibility in a caucasian population. Int J Cancer 2000; 88: 932-937.
    • (2000) Int J Cancer , vol.88 , pp. 932-937
    • Wikman, H.1    Risch, A.2    Klimek, F.3    Schmezer, P.4    Spiegelhalder, B.5    Dienemann, H.6
  • 26
    • 14544296619 scopus 로고    scopus 로고
    • Contribution of hMTH1 to the maintenance of 8-oxoguanine levels in lung dna of non-small-cell lung cancer patients
    • Speina E, Arczewska KD, Gackowski D, Zielinska M, Siomek A, Kowalewski J et al. Contribution of hMTH1 to the maintenance of 8-oxoguanine levels in lung dna of non-small-cell lung cancer patients. J Natl Cancer Inst 2005; 97: 384-395.
    • (2005) J Natl Cancer Inst , vol.97 , pp. 384-395
    • Speina, E.1    Arczewska, K.D.2    Gackowski, D.3    Zielinska, M.4    Siomek, A.5    Kowalewski, J.6
  • 27
    • 46649102827 scopus 로고    scopus 로고
    • Interplay of two major repair pathways in the processing of complex double-strand DNA breaks
    • Dobbs TA, Palmer P, Maniou Z, Lomax ME, O'Neill P. Interplay of two major repair pathways in the processing of complex double-strand DNA breaks. DNA Repair (Amst) 2008; 7: 1372-1383.
    • (2008) DNA Repair (Amst) , vol.7 , pp. 1372-1383
    • Dobbs, T.A.1    Palmer, P.2    Maniou, Z.3    Lomax, M.E.4    O'Neill, P.5
  • 28
    • 84863759637 scopus 로고    scopus 로고
    • Tumor cells require thymidylate kinase to prevent dUTP incorporation during DNA repair
    • Hu CM, Yeh MT, Tsao N, Chen CW, Gao QZ, Chang CY et al. Tumor cells require thymidylate kinase to prevent dUTP incorporation during DNA repair. Cancer Cell 2012; 22: 36-50.
    • (2012) Cancer Cell , vol.22 , pp. 36-50
    • Hu, C.M.1    Yeh, M.T.2    Tsao, N.3    Chen, C.W.4    Gao, Q.Z.5    Chang, C.Y.6
  • 30
    • 0035865399 scopus 로고    scopus 로고
    • A role for p53 in base excision repair
    • Zhou J, Ahn J, Wilson SH, Prives C. A role for p53 in base excision repair. EMBO J 2001; 20: 914-923.
    • (2001) EMBO J , vol.20 , pp. 914-923
    • Zhou, J.1    Ahn, J.2    Wilson, S.H.3    Prives, C.4
  • 31
    • 0028171454 scopus 로고
    • P53 gene mutations are associated with decreased sensitivity of human lymphoma cells to DNA damaging agents
    • Fan S, el-Deiry WS, Bae I, Freeman J, Jondle D, Bhatia K et al. p53 gene mutations are associated with decreased sensitivity of human lymphoma cells to DNA damaging agents. Cancer Res 1994; 54: 5824-5830.
    • (1994) Cancer Res , vol.54 , pp. 5824-5830
    • Fan Sel-Deiry, W.S.1    Bae, I.2    Freeman, J.3    Jondle, D.4    Bhatia, K.5
  • 32
    • 0027285380 scopus 로고
    • P53 mutations increase resistance to ionizing radiation
    • Lee JM, Bernstein A. p53 mutations increase resistance to ionizing radiation. Proc Natl Acad Sci USA 1993; 90: 5742-5746.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 5742-5746
    • Lee, J.M.1    Bernstein, A.2
  • 33
    • 0033626566 scopus 로고    scopus 로고
    • Prognostic significance of p27KIP1 protein and ki-67 growth fraction in non-small cell lung cancers
    • Hommura F, Dosaka-Akita H, Mishina T, Nishi M, Kojima T, Hiroumi H et al. Prognostic significance of p27KIP1 protein and ki-67 growth fraction in non-small cell lung cancers. Clin Cancer Res 2000; 6: 4073-4081.
    • (2000) Clin Cancer Res , vol.6 , pp. 4073-4081
    • Hommura, F.1    Dosaka-Akita, H.2    Mishina, T.3    Nishi, M.4    Kojima, T.5    Hiroumi, H.6
  • 34
    • 0036726313 scopus 로고    scopus 로고
    • Stable suppression of tumorigenicity by virus-mediated RNA interference
    • Brummelkamp TR, Bernards R, Agami R. Stable suppression of tumorigenicity by virus-mediated RNA interference. Cancer Cell 2002; 2: 243-247.
    • (2002) Cancer Cell , vol.2 , pp. 243-247
    • Brummelkamp, T.R.1    Bernards, R.2    Agami, R.3
  • 35
    • 79951823579 scopus 로고    scopus 로고
    • Knockdown of oncogenic KRAS in non-small cell lung cancers suppresses tumor growth and sensitizes tumor cells to targeted therapy
    • Sunaga N, Shames DS, Girard L, Peyton M, Larsen JE, Imai H et al. Knockdown of oncogenic KRAS in non-small cell lung cancers suppresses tumor growth and sensitizes tumor cells to targeted therapy. Mol Cancer Ther 2011; 10: 336-346.
    • (2011) Mol Cancer Ther , vol.10 , pp. 336-346
    • Sunaga, N.1    Shames, D.S.2    Girard, L.3    Peyton, M.4    Larsen, J.E.5    Imai, H.6
  • 36
    • 0027905014 scopus 로고
    • Sasazuki T.Altered growth of human colon cancer cell lines disrupted at activated Ki-ras
    • Shirasawa S, Furuse M, Yokoyama N, Sasazuki T.Altered growth of human colon cancer cell lines disrupted at activated Ki-ras. Science 1993; 260: 85-88.
    • (1993) Science , vol.260 , pp. 85-88
    • Shirasawa, S.1    Furuse, M.2    Yokoyama, N.3
  • 37
    • 0025868669 scopus 로고
    • Specific inhibition of K-ras expression and tumorigenicity of lung cancer cells by antisense RNA
    • Mukhopadhyay T, Tainsky M, Cavender AC, Roth JA. Specific inhibition of K-ras expression and tumorigenicity of lung cancer cells by antisense RNA. Cancer Res 1991; 51: 1744-1748.
    • (1991) Cancer Res , vol.51 , pp. 1744-1748
    • Mukhopadhyay, T.1    Tainsky, M.2    Cavender, A.C.3    Roth, J.A.4
  • 39
    • 84882973107 scopus 로고    scopus 로고
    • Molecular pathways: Reactive oxygen species homeostasis in cancer cells and implications for cancer therapy
    • Nogueira V, Hay N. Molecular pathways: Reactive oxygen species homeostasis in cancer cells and implications for cancer therapy. Clin Cancer Res 2013; 19: 4309-4314.
    • (2013) Clin Cancer Res , vol.19 , pp. 4309-4314
    • Nogueira, V.1    Hay, N.2
  • 40
    • 33744472232 scopus 로고    scopus 로고
    • G-quadruplex formation within the promoter of the KRAS proto-oncogene and its effect on transcription
    • Cogoi S, Xodo LE. G-quadruplex formation within the promoter of the KRAS proto-oncogene and its effect on transcription. Nucleic Acids Res 2006; 34: 2536-2549.
    • (2006) Nucleic Acids Res , vol.34 , pp. 2536-2549
    • Cogoi, S.1    Xodo, L.E.2
  • 41
    • 84861584060 scopus 로고    scopus 로고
    • Promoter G-quadruplex sequences are targets for base oxidation and strand cleavage during hypoxia-induced transcription
    • Clark DW, Phang T, Edwards MG, Geraci MW, Gillespie MN. Promoter G-quadruplex sequences are targets for base oxidation and strand cleavage during hypoxia-induced transcription. Free Radic Biol Med 2012; 53: 51-59.
    • (2012) Free Radic Biol Med , vol.53 , pp. 51-59
    • Clark, D.W.1    Phang, T.2    Edwards, M.G.3    Geraci, M.W.4    Gillespie, M.N.5
  • 42
    • 0037181064 scopus 로고    scopus 로고
    • Site-specific probing of oxidative reactivity and telomerase function using 7,8-dihydro-8-oxoguanine in telomeric DNA
    • Szalai VA, Singer MJ, Thorp HH. Site-specific probing of oxidative reactivity and telomerase function using 7,8-dihydro-8-oxoguanine in telomeric DNA. J Am Chem Soc 2002; 124: 1625-1631.
    • (2002) J Am Chem Soc , vol.124 , pp. 1625-1631
    • Szalai, V.A.1    Singer, M.J.2    Thorp, H.H.3
  • 43
    • 71449125359 scopus 로고    scopus 로고
    • Telomeric D-loops containing 8-oxo-2'-deoxyguanosine are preferred substrates for Werner and Bloom syndrome helicases and are bound by POT1
    • Ghosh A, Rossi ML, Aulds J, Croteau D, Bohr VA. Telomeric D-loops containing 8-oxo-2'-deoxyguanosine are preferred substrates for Werner and Bloom syndrome helicases and are bound by POT1. J Biol Chem 2009; 284: 31074-31084.
    • (2009) J Biol Chem , vol.284 , pp. 31074-31084
    • Ghosh, A.1    Rossi, M.L.2    Aulds, J.3    Croteau, D.4    Bohr, V.A.5
  • 44
    • 0037264633 scopus 로고    scopus 로고
    • Targeting RAS signalling pathways in cancer therapy
    • Downward J. Targeting RAS signalling pathways in cancer therapy. Nat Rev Cancer 2003; 3: 11-22.
    • (2003) Nat Rev Cancer , vol.3 , pp. 11-22
    • Downward, J.1
  • 45
    • 84899619048 scopus 로고    scopus 로고
    • Stereospecific targeting of MTH1 by (S)-crizotinib as an anticancer strategy
    • Huber KV, Salah E, Radic B, Gridling M, Elkins JM, Stukalov A et al. Stereospecific targeting of MTH1 by (S)-crizotinib as an anticancer strategy. Nature 2014; 508: 222-227.
    • (2014) Nature , vol.508 , pp. 222-227
    • Huber, K.V.1    Salah, E.2    Radic, B.3    Gridling, M.4    Elkins, J.M.5    Stukalov, A.6
  • 46
    • 84899619506 scopus 로고    scopus 로고
    • MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool
    • Gad H, Koolmeister T, Jemth AS, Eshtad S, Jacques SA, Strom CE et al. MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool. Nature 2014; 508: 215-221.
    • (2014) Nature , vol.508 , pp. 215-221
    • Gad, H.1    Koolmeister, T.2    Jemth, A.S.3    Eshtad, S.4    Jacques, S.A.5    Strom, C.E.6
  • 47
    • 84855789039 scopus 로고    scopus 로고
    • Creation and validation of a ligationindependent cloning (LIC) retroviral vector for stable gene transduction in mammalian cells
    • Patel A, Munoz A, Halvorsen K, Rai P. Creation and validation of a ligationindependent cloning (LIC) retroviral vector for stable gene transduction in mammalian cells. BMC Biotechnol 2012; 12: 3.
    • (2012) BMC Biotechnol , vol.12 , pp. 3
    • Patel, A.1    Munoz, A.2    Halvorsen, K.3    Rai, P.4
  • 49
    • 77950237428 scopus 로고    scopus 로고
    • Activation of Hedgehog signaling by the environmental toxicant arsenic may contribute to the etiology of arsenic-induced tumors
    • Fei DL, Li H, Kozul CD, Black KE, Singh S, Gosse JA et al. Activation of Hedgehog signaling by the environmental toxicant arsenic may contribute to the etiology of arsenic-induced tumors. Cancer Res 2010; 70: 1981-1988.
    • (2010) Cancer Res , vol.70 , pp. 1981-1988
    • Fei, D.L.1    Li, H.2    Kozul, C.D.3    Black, K.E.4    Singh, S.5    Gosse, J.A.6
  • 50
    • 44949231424 scopus 로고    scopus 로고
    • Analyzing real-time PCR data by the comparative C (T) method
    • Schmittgen TD, Livak KJ. Analyzing real-time PCR data by the comparative C (T) method. Nat Protoc 2008; 3: 1101-1108.
    • (2008) Nat Protoc , vol.3 , pp. 1101-1108
    • Schmittgen, T.D.1    Livak, K.J.2
  • 51
    • 84879526156 scopus 로고    scopus 로고
    • Androgen deprivation-induced senescence promotes outgrowth of androgen-refractory prostate cancer cells
    • Burton DG, Giribaldi MG, Munoz A, Halvorsen K, Patel A, Jorda M et al. Androgen deprivation-induced senescence promotes outgrowth of androgen-refractory prostate cancer cells. PLoS ONE 2013; 8: E68003.
    • (2013) PLoS ONE , vol.8 , pp. e68003
    • Burton, D.G.1    Giribaldi, M.G.2    Munoz, A.3    Halvorsen, K.4    Patel, A.5    Jorda, M.6
  • 52
    • 0029047362 scopus 로고
    • A biomarker that identifies senescent human cells in culture and in aging skin in vivo
    • Dimri G, Lee X, Basile G, Acosta M, Scott G, Roskelley C et al. A biomarker that identifies senescent human cells in culture and in aging skin in vivo. PNAS 1995; 92: 9363-9367.
    • (1995) PNAS , vol.92 , pp. 9363-9367
    • Dimri, G.1    Lee, X.2    Basile, G.3    Acosta, M.4    Scott, G.5    Roskelley, C.6
  • 53
    • 33749076241 scopus 로고    scopus 로고
    • Sequential combinations of flavopiridol and docetaxel inhibit prostate tumors, induce apoptosis, and decrease angiogenesis in the Ggamma/T-15 transgenic mouse model of prostate cancer
    • Reiner T, De las Pozas A, Perez-Stable C. Sequential combinations of flavopiridol and docetaxel inhibit prostate tumors, induce apoptosis, and decrease angiogenesis in the Ggamma/T-15 transgenic mouse model of prostate cancer. Prostate 2006; 66: 1487-1497.
    • (2006) Prostate , vol.66 , pp. 1487-1497
    • Reiner, T.1    De Las Pozas, A.2    Perez-Stable, C.3


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