Expression of human MutT homologue (hMTH1) protein in primary non-small-cell lung carcinomas and histologically normal surrounding tissue

Free Radical Biology and Medicine

Volumn 34, Issue 11, 2003, Pages 1447-1457

  Kennedy, Christopher H ^a   Pass, Harvey I ^b   Mitchell, James B ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b WAYNE STATE UNIVERSITY   (United States)

Author keywords

8 Oxo dGTPase; Carcinogenesis; DNA repair; Free radicals; hMTH1; Human MutT homologue; Lung cancer; Oxidative DNA damage; Oxidative stress

Indexed keywords

BIOLOGICAL MARKER; MESSENGER RNA; NUCLEOTIDE; PROTEIN; PROTEIN MTH1; UNCLASSIFIED DRUG;

ADENOCARCINOMA; ARTICLE; CONTROLLED STUDY; HISTOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LUNG NON SMALL CELL CANCER; LUNG PARENCHYMA; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; SEQUENCE HOMOLOGY; SQUAMOUS CELL CARCINOMA; TISSUE DISTRIBUTION; WESTERN BLOTTING;

EID: 0037717023     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0891-5849(03)00176-X     Document Type: Article

References (61)

1. Edwards B.K., Howe H.L., Ries L.A., Thun M.J., Rosenberg H.M., Yancik R., Wingo P.A., Jemal A., Feigal E.G. Annual report to the nation on the status of cancer, 1973-1999, featuring implications of age and aging on U.S. cancer burden. Cancer. 94:2002;2766-2792.
2. Dreher D., Junod A.F. Role of oxygen free radicals in cancer development. Eur. J. Cancer. 32A:1996;30-38.
3. Sies H. Oxidative stress from basic research to clinical application . Am. J. Med. 91:1991;31S-38S.
4. Church D.F., Pryor W.A. Free-radical chemistry of cigarette smoke and its toxicological implications. Environ. Health Perspect. 64:1985;111-126.
5. Pryor W.A., Hales B.J., Premovic P.I., Church D.F. The radicals in cigarette tar their nature and suggested physiological implications . Science. 220:1983;425-427.
6. Pryor W.A., Stone K. Oxidants in cigarette smoke. Radicals, hydrogen peroxide, peroxynitrate, and peroxynitrite. Ann. N. Y. Acad. Sci. 686:1993;12-27.
7. Cerutti P.A. Oxy-radicals and cancer. Lancet. 344:1994;862-863.
8. Halliwell B., Aruoma O.I. DNA damage by oxygen-derived species. Its mechanism and measurement in mammalian systems. FEBS Lett. 281:1991;9-19.
9. Toyokuni S., Mori T., Dizdaroglu M. DNA base modifications in renal chromatin of Wistar rats treated with a renal carcinogen, ferric nitrilotriacetate. Int. J. Cancer. 57:1994;123-128.
10. Kuchino Y., Mori F., Kasai H., Inoue H., Iwai S., Miura K., Ohtsuka E., Nishimura S. Misreading of DNA templates containing 8-hydroxydeoxyguanosine at the modified base and at adjacent residues. Nature. 327:1987;77-79.
11. Shibutani S., Takeshita M., Grollman A.P. Insertion of specific bases during DNA synthesis past the oxidation-damaged base 8-oxodG. Nature. 349:1991;431-434.
12. Malins D.C., Haimanot R. Major alterations in the nucleotide structure of DNA in cancer of the female breast. Cancer Res. 51:1991;5430-5432.
13. Matsui A., Ikeda T., Enomoto K., Hosoda K., Nakashima H., Omae K., Watanabe M., Hibi T., Kitajima M. Increased formation of oxidative DNA damage, 8-hydroxy-2′-deoxyguanosine, in human breast cancer tissue and its relationship to GSTP1 and COMT genotypes. Cancer Lett. 151:2000;87-95.
14. Lee B.M., Jang J.J., Kim H.S. Benzo[a]pyrene diol-epoxide-I-DNA and oxidative DNA adducts associated with gastric adenocarcinoma. Cancer Lett. 125:1998;61-68.
15. Jaruga P., Zastawny T.H., Skokowski J., Dizdaroglu M., Olinski R. Oxidative DNA base damage and antioxidant enzyme activities in human lung cancer. FEBS Lett. 341:1994;59-64.
16. Olinski R., Zastawny T., Budzbon J., Skokowski J., Zegarski W., Dizdaroglu M. DNA base modifications in chromatin of human cancerous tissues. FEBS Lett. 309:1992;193-198.
17. Okamoto K., Toyokuni S., Uchida K., Ogawa O., Takenewa J., Kakehi Y., Kinoshita H., Hattori-Nakakuki Y., Hiai H., Yoshida O. Formation of 8-hydroxy-2′-deoxyguanosine and 4-hydroxy-2-nonenal-modified proteins in human renal-cell carcinoma. Int. J. Cancer. 58:1994;825-829.
18. Toyokuni S., Okamoto K., Yodoi J., Hiai H. Persistent oxidative stress in cancer. FEBS Lett. 358:1995;1-3.
19. Maki H., Sekiguchi M. MutT protein specifically hydrolyses a potent mutagenic substrate for DNA synthesis. Nature. 355:1992;273-275.
20. Cheng K.C., Cahill D.S., Kasai H., Nishimura S., Loeb L.A. 8-Hydroxyguanine, an abundant form of oxidative DNA damage, causes G→T and A→C substitutions. J. Biol. Chem. 267:1992;166-172.
21. Mo J.Y., Maki H., Sekiguchi M. Hydrolytic elimination of a mutagenic nucleotide, 8-oxodGTP, by human 18-kilodalton protein sanitization of nucleotide pool . Proc. Natl. Acad. Sci. USA. 89:1992;11021-11025.
22. Okamoto K., Toyokuni S., Kim W.J., Ogawa O., Kakehi Y., Arao S., Hiai H., Yoshida O. Overexpression of human mutT homologue gene messenger RNA in renal-cell carcinoma evidence of persistent oxidative stress in cancer . Int. J. Cancer. 65:1996;437-441.
23. Wani G., Milo G.E., D'Ambrosio S.M. Enhanced expression of the 8-oxo-7,8-dihydrodeoxyguanosine triphosphatase gene in human breast tumor cells. Cancer Lett. 125:1998;123-130.
24. Hibi K., Liu Q., Beaudry G.A., Madden S.L., Westra W.H., Wehage S.L., Yang S.C., Heitmiller R.F., Bertelsen A.H., Sidransky D., Jen J. Serial analysis of gene expression in non-small cell lung cancer. Cancer Res. 58:1998;5690-5694.
25. Kennedy C.H., Cueto R., Belinsky S.A., Lechner J.F., Pryor W.A. Overexpression of hMTH1 mRNA a molecular marker of oxidative stress in lung cancer cells . FEBS Lett. 429:1998;17-20.
26. Iida T., Furuta A., Kawashima M., Nishida J., Nakabeppu Y., Iwaki T. Accumulation of 8-oxo-2′-deoxyguanosine and increased expression of hMTH1 protein in brain tumors. Neuro-oncology. 3:2001;73-81.
27. Kanamoto T., Hellman U., Heldin C.H., Souchelnytskyi S. Functional proteomics of transforming growth factor-beta1-stimulated Mv1Lu epithelial cells Rad51 as a target of TGFbeta1-dependent regulation of DNA repair . EMBO J. 21:2002;1219-1230.
28. Tilleman K., Van den Haute C., Geerts H., van Leuven F., Esmans E.L., Moens L. Proteomics analysis of the neurodegeneration in the brain of tau transgenic mice. Proteomics. 2:2002;656-665.
29. Wulfkuhle J.D., Sgroi D.C., Krutzsch H., McLean K., McGarvey K., Knowlton M., Chen S., Shu H., Sahin A., Kurek R., Wallwiener D., Merino M.J., Petricoin III E.F., Zhao Y., Steeg P.S. Proteomics of human breast ductal carcinoma. in situ. Cancer Res. 62:2002;6740-6749.
30. Ames B.N., Gold L.S., Willett W.C. The causes and prevention of cancer. Proc. Natl. Acad. Sci. USA. 92:1995;5258-5265.
31. Jackson A.L., Loeb L.A. The contribution of endogenous sources of DNA damage to the multiple mutations in cancer. Mutat. Res. 477:2001;7-21.
32. Loft S., Poulsen H.E. Cancer risk and oxidative DNA damage in man. J. Mol. Med. 74:1996;297-312.
33. Pryor W.A. Cancer and free radicals. Basic Life Sci. 39:1986;45-59.
34. Simic M.G. DNA markers of oxidative processes in vivo relevance to carcinogenesis and anticarcinogenesis . Cancer Res. 54:(7 Suppl.):1994;1918s-1923s.
35. Simic M.G., Bergtold D.S., Karam L.R. Generation of oxy radicals in biosystems. Mutat. Res. 214:1989;3-12.
36. Kovacic P., Jacintho J.D. Mechanisms of carcinogenesis focus on oxidative stress and electron transfer . Curr. Med. Chem. 8:2001;773-796.
37. Cerutti P., Ghosh R., Oya Y., Amstad P. The role of the cellular antioxidant defense in oxidant carcinogenesis. Environ. Health Perspect. 102:(Suppl. 10):1994;123-129.
38. Szatrowski T.P., Nathan C.F. Production of large amounts of hydrogen peroxide by human tumor cells. Cancer Res. 51:1991;794-798.
39. Aust S.D., Morehouse L.A., Thomas C.E. Role of metals in oxygen radical reactions. J. Free Radic. Biol. Med. 1:1985;3-25.
40. Pryor W.A. Why is the hydroxyl radical the only radical that commonly adds to DNA? Hypothesis it has a rare combination of high electrophilicity, high thermochemical reactivity, and a mode of production that can occur near DNA . Free Radic. Biol. Med. 4:1988;219-223.
41. Simandan T., Sun J., Dix T.A. Oxidation of DNA bases, deoxyribonucleosides and homopolymers by peroxyl radicals. Biochem. J. 335:1998;233-240.
42. Barciszewski J., Barciszewska M.Z., Siboska G., Rattan S.I., Clark B.F. Some unusual nucleic acid bases are products of hydroxyl radical oxidation of DNA and RNA. Mol. Biol. Rep. 26:1999;231-238.
43. Kasai H. Analysis of a form of oxidative DNA damage, 8-hydroxy-2′-deoxyguanosine, as a marker of cellular oxidative stress during carcinogenesis. Mutat. Res. 387:1997;147-163.
44. Cadet J., D'Ham C., Douki T., Pouget J.P., Ravanat J.L., Sauvaigo S. Facts and artifacts in the measurement of oxidative base damage to DNA. Free Radic. Res. 29:1998;541-550.
45. Cadet J., Bourdat A.G., D'Ham C., Duarte V., Gasparutto D., Romieu A., Ravanat J.L. Oxidative base damage to DNA specificity of base excision repair enzymes . Mutat. Res. 462:2000;121-128.
46. Davies K.J. Oxidative stress, antioxidant defenses, and damage removal, repair, and replacement systems. IUBMB Life. 50:2000;279-289.
47. Lu A.L., Li X., Gu Y., Wright P.M., Chang D.Y. Repair of oxidative DNA damage mechanisms and functions . Cell Biochem. Biophys. 35:2001;141-170.
48. Mitra S., Boldogh I., Izumi T., Hazra T.K. Complexities of the DNA base excision repair pathway for repair of oxidative DNA damage. Environ. Mol. Mutagen. 38:2001;180-190.
49. Boiteux S., Radicella J.P. The human OGG1 gene structure, functions, and its implication in the process of carcinogenesis . Arch. Biochem. Biophys. 377:2000;1-8.
50. Nakabeppu Y. Regulation of intracellular localization of human MTH1, OGG1, and MYH proteins for repair of oxidative DNA damage. Prog. Nucleic Acid Res. Mol. Biol. 68:2001;75-94.
51. Pavlov Y.I., Minnick D.T., Izuta S., Kunkel T.A. DNA replication fidelity with 8-oxodeoxyguanosine triphosphate. Biochemistry. 33:1994;4695-4701.
52. Colussi C., Parlanti E., Degan P., Aquilina G., Barnes D., Macpherson P., Karran P., Crescenzi M., Dogliotti E., Bignami M. The mammalian mismatch repair pathway removes DNA 8-oxodGMP incorporated from the oxidized dNTP pool. Curr. Biol. 12:2002;912-918.
53. Hayakawa H., Taketomi A., Sakumi K., Kuwano M., Sekiguchi M. Generation and elimination of 8-oxo-7,8-dihydro-2′-deoxyguanosine 5′-triphosphate, a mutagenic substrate for DNA synthesis, in human cells. Biochemistry. 34:1995;89-95.
54. Oda H., Nakabeppu Y., Furuichi M., Sekiguchi M. Regulation of expression of the human MTH1 gene encoding 8-oxo-dGTPase. Alternative splicing of transcription products. J. Biol. Chem. 272:1997;17843-17850.
55. Bialkowski K., Kasprzak K.S. Activity of the antimutagenic enzyme 8-oxo-2′-deoxyguanosine 5′-triphosphate pyrophosphohydrolase (8-oxo-dGTPase) in cultured chinese hamster ovary cells effects of cell cycle, proliferation rate, and population density . Free Radic. Biol. Med. 28:2000;337-344.
56. Tanaka T., Kondo S., Iwasa Y., Hiai H., Toyokuni S. Expression of stress-response and cell proliferation genes in renal cell carcinoma induced by oxidative stress. Am. J. Pathol. 156:2000;2149-2157.
57. Meyer F., Fiala E., Westendorf J. Induction of 8-oxo-dGTPase activity in human lymphoid cells and normal fibroblasts by oxidative stress. Toxicology. 146:2000;83-92.
58. Kim H.N., Morimoto Y., Tsuda T., Ootsuyama Y., Hirohashi M., Hirano T., Tanaka I., Lim Y., Yun I.G., Kasai H. Changes in DNA 8-hydroxyguanine levels, 8-hydroxyguanine repair activity, and hOGG1 and hMTH1 mRNA expression in human lung alveolar epithelial cells induced by crocidolite asbestos. Carcinogenesis. 22:2001;265-269.
59. Mossman B.T., Marsh J.P. Evidence supporting a role for active oxygen species in asbestos-induced toxicity and lung disease. Environ. Health Perspect. 81:1989;91-94.
60. Inoue M., Osaki T., Noguchi M., Hirohashi S., Yasumoto K., Kasai H. Lung cancer patients have increased 8-hydroxydeoxyguanosine levels in peripheral lung tissue DNA. Jpn. J. Cancer Res. 89:1998;691-695.
61. Asami S., Manabe H., Miyake J., Tsurudome Y., Hirano T., Yamaguchi R., Itoh H., Kasai H. Cigarette smoking induces an increase in oxidative DNA damage, 8-hydroxydeoxyguanosine, in a central site of the human lung. Carcinogenesis. 18:1997;1763-1766.