Prognostic significance of p27KIP1 protein and Ki-67 growth fraction in non-small cell lung cancers

Clinical Cancer Research

Volumn 6, Issue 10, 2000, Pages 4073-4081

  Hommura, Fumihiro ^a   Dosaka Akita, Hirotoshi ^a   Mishina, Takayuki ^a   Nishi, Motoi ^c   Kojima, Tetsuya ^a   Hiroumi, Hiromitsu ^a   Ogura, Shigeaki ^a   Shimizu, Michio ^b   Katoh, Hiroyuki ^a   Kawakami, Yoshikazu ^a  

^a HOKKAIDO UNIVERSITY   (Japan)

^b HOKKAIDO UNIVERSITY HOSPITAL   (Japan)

^c SAPPORO MEDICAL UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CELL CYCLE PROTEIN; CYCLIN DEPENDENT KINASE INHIBITOR 1B; KI 67 ANTIGEN; MICROTUBULE ASSOCIATED PROTEIN; RAS PROTEIN; TUMOR SUPPRESSOR PROTEIN; PROTEIN KI67; PROTEIN P27; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; BIOSYNTHESIS; CELL DIVISION; DISEASE FREE SURVIVAL; FEMALE; HUMAN; IMMUNOHISTOCHEMISTRY; LUNG NON SMALL CELL CANCER; LUNG TUMOR; MALE; METABOLISM; MIDDLE AGED; MORTALITY; MULTIVARIATE ANALYSIS; PATHOLOGY; PROGNOSIS; SEX DIFFERENCE; SMOKING; SQUAMOUS CELL CARCINOMA; TIME; CANCER STATISTICS; CIGARETTE SMOKING; GENETIC HETEROGENEITY; HUMAN TISSUE; LABELING INDEX; MAJOR CLINICAL STUDY; ONCOGENE RAS; PRIORITY JOURNAL; PROTEIN EXPRESSION; SURVIVAL RATE; TREATMENT OUTCOME; TUMOR GROWTH;

ADULT; AGED; CARCINOMA, NON-SMALL-CELL LUNG; CARCINOMA, SQUAMOUS CELL; CELL CYCLE PROTEINS; CELL DIVISION; CYCLIN-DEPENDENT KINASE INHIBITOR P27; DISEASE-FREE SURVIVAL; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; KI-67 ANTIGEN; LUNG NEOPLASMS; MALE; MICROTUBULE-ASSOCIATED PROTEINS; MIDDLE AGED; MULTIVARIATE ANALYSIS; PROGNOSIS; RAS PROTEINS; SEX FACTORS; SMOKING; TIME FACTORS; TUMOR SUPPRESSOR PROTEINS;

EID: 0033626566     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (43)

1. Staging and prognostic factors: Non-small cell lung cancer
2. Molecular biology of lung cancer
3. Non-small cell lung cancer
4. Cyclins and cancer. II. Cyclin D and CDK inhibitors come of age
5. Cancer cell cycles
6. Principles of CDK regulation
7. 1 phase progression: Cycling on cue
8. 1 cyclin-dependent kinases
9. 1 control in mammalian cells
10. Role of the ubiquitin-proteasome pathway in regulating abundance of the cyclin-dependent kinase inhibitor p27
11. p27(kip1): A multifunctional cyclin-dependent kinase inhibitor with prognostic significance in human cancers
12. Value of Ki-67 immunostaining in preoperative biopsies of carcinomas of the lung
13. Role of p27(Kip1) and cyclin-dependent kinase 2 in the proliferation of non-small cell lung cancer
14. Prognostic significance of Ki-67 immunostaining and symptoms in resected stage I and II non-small cell lung cancer
15. Prognostic significance of p53 and ras p21 expression in nonsmall cell lung cancer
16. Altered p16(INK4) and retinoblastoma protein status in non-small cell lung cancer: Potential synergistic effect with altered p53 protein on proliferative activity
17. Altered retinoblastoma protein expression in nonsmall cell lung cancer: Its synergistic effects with altered ras and p53 protein status on prognosis
18. Predictive value of expression of p16(INK4A), retinoblastoma and p53 proteins for the prognosis of non-small-cell lung cancers
19. Cyclin D1 expression in non-small cell lung cancers: Its association with altered p53 expression, cell proliferation and clinical outcome
20. Cyclin E expression, a potential prognostic marker for non-small cell lung cancers
21. Prognostic significance of the expression of ras oncogene product in non-small cell lung cancer
22. 1 phase required for p27(kip1) down-regulation, passage through the restriction point, and entry into S phase in growth factor-stimulated NIH3T3 fibroblasts
23. The World Health Organization histological typing of lung tumours. Second edition
24. Lung
25. Prognostic role of the cyclin-dependent kinase inhibitor p27 in non-small cell lung cancer
26. p27(KIP1) in human lung cancers: Differential changes in small cell and non-small cell carcinomas
27. Protein expression of the cell-cycle inhibitor p27(Kip1) in malignant melanoma: Inverse correlation with disease-free survival
28. Frequent loss of expression of the cyclin-dependent kinase inhibitor p27 in epithelial ovarian cancer
29. Reduced expression of the cell cycle inhibitor p27(Kip1) in non-small cell lung carcinoma: A prognostic factor independent of ras
30. Increased proteasome-dependent degradation of the cyclin-dependent kinase inhibitor p27 in aggressive colorectal carcinomas
31. The cell cycle inhibitor p27 is an independent prognostic marker in small (T(1a. b)) invasive breast carcinomas
32. High level expression of p27(kip1) and cyclin D1 in some human breast cancer cells: Inverse correlation between the expression of p27(kip1) and degree of malignancy in human breast and colorectal cancers
33. Increased expression of the p27(KIP1) protein in human esophageal cancer cell lines that over-express cyclin D1
34. Localization and expression of p27(KIP1) in multistage colorectal carcinogenesis
35. The concurrent expression of p27(kip1) and cyclin D1 in epithelial ovarian tumors
36. Promoting apoptosis: A novel activity associated with the cyclin-dependent kinase inhibitor p27
37. Cleavage of p21(cip1/waf1) and p27(kip1) mediates apoptosis in endothelial cells through activation of Cdk2: Role of a caspase cascade
38. Overexpression of cyclin E in the HCl 1 mouse mammary epithelial cell line is associated with growth inhibition and increased expression of p27(Kip1)
39. Overexpression of p27(Kip1) inhibits the growth of both normal and transformed human mammary epithelial cells
40. A biologic risk model for stage I lung cancer: Immunohistochemical analysis of 408 patients with the use of ten molecular markers
41. Prognostic value of nuclear DNA content and expression of the ras oncogene product in lung cancer
42. Molecular pathologic substaging in 244 stage I non-small-cell lung cancer patients: Clinical implications