Loss of liver kinase B1 (LKB1) in beta cells enhances glucose-stimulated insulin secretion despite profound mitochondrial defects

Journal of Biological Chemistry

Volumn 290, Issue 34, 2015, Pages 20934-20946

  Swisa, Avital ^a   Granot, Zvi ^a   Tamarina, Natalia ^b   Sayers, Sophie ^c   Bardeesy, Nabeel ^d   Philipson, Louis ^b   Hodson, David J ^c   Wikstrom, Jakob D ^e,f   Rutter, Guy A ^c   Leibowitz, Gil ^e   Glaser, Benjamin ^e   Dor, Yuval ^a  

^a HEBREW UNIVERSITY   (Israel)

^b UNIVERSITY OF CHICAGO   (United States)

^c IMPERIAL COLLEGE LONDON   (United Kingdom)

^d HARVARD MEDICAL SCHOOL   (United States)

^e HADASSAH HEBREW UNIVERSITY MEDICAL CENTER   (Israel)

^f KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; DEFECTS; ENZYMES; INSULIN; MITOCHONDRIA; PHYSIOLOGY;

ACTIVATED PROTEINS; ADENOSINE MONOPHOSPHATE; GLUCOSE-STIMULATED INSULIN SECRETIONS; INSULIN SECRETION; MEMBRANE DEPOLARIZATION; MITOCHONDRIAL DEFECTS; NEGATIVE REGULATORS; PANCREATIC BETA CELLS;

CYTOLOGY;

GLUCOSE; LIVER KINASE B1; REGULATOR PROTEIN; UNCLASSIFIED DRUG; GLUTAMIC ACID; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; INSULIN; PROTEIN SERINE THREONINE KINASE; RECOMBINANT PROTEIN; STK11 PROTEIN, MOUSE; TAMOXIFEN;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; CALCIUM TRANSPORT; CELL MEMBRANE DEPOLARIZATION; CELL POLARITY; CELL SIZE; CONTROLLED STUDY; IN VITRO STUDY; INSULIN RELEASE; MITOCHONDRIAL DYNAMICS; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN EXPRESSION; REVIEW; SIGNAL TRANSDUCTION; AGONISTS; ANIMAL; DEFICIENCY; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; HUMAN; METABOLISM; MITOCHONDRION; PATHOLOGY; PHOSPHORYLATION; SECRETION (PROCESS); TISSUE CULTURE TECHNIQUE; TRANSGENIC MOUSE;

AMP-ACTIVATED PROTEIN KINASES; ANIMALS; GENE EXPRESSION REGULATION; GLUCOSE; GLUTAMIC ACID; HUMANS; INSULIN; INSULIN-SECRETING CELLS; MICE; MICE, TRANSGENIC; MITOCHONDRIA; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; RECOMBINANT PROTEINS; SIGNAL TRANSDUCTION; TAMOXIFEN; TISSUE CULTURE TECHNIQUES;

EID: 84939864428     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M115.639237     Document Type: Review

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