LKB1 couples glucose metabolism to insulin secretion in mice

Diabetologia

Volumn 58, Issue 7, 2015, Pages 1513-1522

  Fu, Accalia ^a,b   Robitaille, Karine ^a   Faubert, Brandon ^c   Reeks, Courtney ^a   Dai, Xiao Qing ^d   Hardy, Alexandre B ^e   Sankar, Krishana S ^f   Ogrel, Svetlana ^a   Al Dirbashi, Osama Y ^a,b   Rocheleau, Jonathan V ^f   Wheeler, Michael B ^c   MacDonald, Patrick E ^d   Jones, Russell ^c   Screaton, Robert A ^a,b,g  

^a CHILDREN S HOSPITAL OF EASTERN ONTARIO   (Canada)

^b UNIVERSITY OF OTTAWA   (Canada)

^c MCGILL UNIVERSITY   (Canada)

^d UNIVERSITY OF ALBERTA   (Canada)

^e UNIVERSITY OF TORONTO   (Canada)

^f UNIVERSITY OF TORONTO   (Canada)

^g Sunnybrook Health Sciences Centre   (Canada)

Author keywords

ACC1; AMPK; Glucose metabolism; Glutamine metabolism; Insulin secretion; LKB1; Pancreatic beta cells

Indexed keywords

ACETYL COENZYME A CARBOXYLASE; CITRIC ACID; GLUCOSE; GLUTAMINE; PROTEIN KINASE LKB1; TOLBUTAMIDE; ANTIDIABETIC AGENT; FATTY ACID; INSULIN; PROTEIN SERINE THREONINE KINASE; SMALL INTERFERING RNA; STK11 PROTEIN, MOUSE;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ELECTROPHYSIOLOGY; GAS CHROMATOGRAPHY; GENE DELETION; GLUCOSE BLOOD LEVEL; GLUCOSE METABOLISM; INSULIN RELEASE; LIPOGENESIS; MASS SPECTROMETRY; MITOCHONDRIAL RESPIRATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; UPREGULATION; ANIMAL; BIOSYNTHESIS; BLOOD; DEFICIENCY; DRUG EFFECTS; GENETICS; KNOCKOUT MOUSE; METABOLISM; METABOLOMICS; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; PANCREAS ISLET BETA CELL; SECRETION (PROCESS);

ACETYL-COA CARBOXYLASE; ANIMALS; FATTY ACIDS, NONESTERIFIED; GLUCOSE; GLUTAMINE; HYPOGLYCEMIC AGENTS; INSULIN; INSULIN-SECRETING CELLS; MEMBRANE POTENTIAL, MITOCHONDRIAL; METABOLOMICS; MICE; MICE, KNOCKOUT; MITOCHONDRIA; PROTEIN-SERINE-THREONINE KINASES; RNA, SMALL INTERFERING;

EID: 84931570323     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-015-3579-7     Document Type: Article

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