Transamination is required for α-ketoisocaproate but not leucine to stimulate insulin secretion

Journal of Biological Chemistry

Volumn 285, Issue 44, 2010, Pages 33718-33726

  Zhou, Yingsheng ^a,c   Jetton, Thomas L ^b   Goshorn, Stephanie ^a   Lynch, Christopher J ^a   She, Pengxiang ^a  

^a PENN STATE COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF VERMONT COLLEGE OF MEDICINE   (United States)

^c BEIJING HOSPITAL   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMICAL MECHANISMS; BRANCHED-CHAIN AMINOTRANSFERASE; DOSE-DEPENDENT; GLUTAMATE DEHYDROGENASE; INSULIN RELEASE; INSULIN SECRETION; INTRACELLULAR SIGNALS; KETOGLUTARATE;

GLUCOSE; INSULIN; METABOLISM; OXIDATION; PHYSIOLOGY;

AMINO ACIDS;

2 OXOGLUTARIC ACID; 2 OXOISOCAPROIC ACID; 3 METHYL 2 OXOVALERIC ACID; ADENOSINE TRIPHOSPHATE; ARGININE; GLUCOSE; GLUTAMATE DEHYDROGENASE; GLUTAMINE; INSULIN; LEUCINE; MALIC ACID; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CATABOLISM; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME ACTIVATION; INSULIN RELEASE; INTRACELLULAR SIGNALING; MOUSE; NONHUMAN; OXIDATION; PANCREAS ISLET; PANCREAS PERFUSION; PRIORITY JOURNAL; TRANSAMINATION;

ADENOSINE TRIPHOSPHATE; ANIMALS; FEMALE; GLUCOSE; GLUTAMINE; INSULIN; ISLETS OF LANGERHANS; KETO ACIDS; KETOGLUTARIC ACIDS; LEUCINE; MICE; MICE, TRANSGENIC; MITOCHONDRIA; OXYGEN; TRANSAMINASES;

MUS;

EID: 77958541533     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.136846     Document Type: Article

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