Universal allosteric mechanism for Gα activation by GPCRs

Nature

Volumn 524, Issue 7564, 2015, Pages 173-179

  Flock, Tilman ^a   Ravarani, Charles N J ^a   Sun, Dawei ^b,c   Venkatakrishnan, A J ^a,d   Kayikci, Melis ^a   Tate, Christopher G ^a   Veprintsev, Dmitry B ^b,c   Babu, M Madan ^a  

^a MRC LABORATORY OF MOLECULAR BIOLOGY   (United Kingdom)

^b PAUL SCHERRER INSTITUTE   (Switzerland)

^c ETH ZURICH   (Switzerland)

^d STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

G PROTEIN COUPLED RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA SUBUNIT; GUANOSINE DIPHOSPHATE; RAS PROTEIN;

CHEMICAL BINDING; GENE EXPRESSION; GENETIC ANALYSIS; PROTEIN;

ALLOSTERISM; ARTICLE; HUMAN; MOLECULAR EVOLUTION; MOLECULAR INTERACTION; MOLECULAR MECHANICS; PRIORITY JOURNAL; PROTEIN DOMAIN; RECEPTOR BINDING; ANIMAL; BINDING SITE; BIOLOGY; CHEMICAL STRUCTURE; CHEMISTRY; ENZYME ACTIVATION; ENZYME SPECIFICITY; GENETIC ENGINEERING; GENETICS; METABOLISM; MUTATION; NUCLEOTIDE SEQUENCE; PROTEIN SECONDARY STRUCTURE; PROTEIN TERTIARY STRUCTURE; SIGNAL TRANSDUCTION;

ALLOSTERIC REGULATION; ANIMALS; BINDING SITES; COMPUTATIONAL BIOLOGY; CONSERVED SEQUENCE; ENZYME ACTIVATION; EVOLUTION, MOLECULAR; GENETIC ENGINEERING; GTP-BINDING PROTEIN ALPHA SUBUNITS; GUANOSINE DIPHOSPHATE; HUMANS; MODELS, MOLECULAR; MUTATION; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; RAS PROTEINS; RECEPTORS, G-PROTEIN-COUPLED; SIGNAL TRANSDUCTION; SUBSTRATE SPECIFICITY;

EID: 84939522532     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature14663     Document Type: Article

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