Structural basis of G protein-coupled receptor-Gi protein interaction: Formation of the cannabinoid CB2 receptor-Gi protein complex

Journal of Biological Chemistry

Volumn 289, Issue 29, 2014, Pages 20259-20272

  Mnpotra, Jagjeet S ^a   Qiao, Zhuanhong ^b   Cai, Jian ^b   Lynch, Diane L ^a   Grossfield, Alan ^c   Leioatts, Nicholas ^c   Hurst, Dow P ^a   Pitman, Michael C ^a,d   Song, Zhao Hui ^b   Reggio, Patricia H ^a  

^a UNIVERSITY OF NORTH CAROLINA AT GREENSBORO   (United States)

^b University of Louisville School of Medicine   (United States)

^c UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

^d IBM T J WATSON RESEARCH CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; CROSSLINKING; ELECTROSPRAY IONIZATION; MOLECULAR DYNAMICS; ROTATION;

CANNABINOID RECEPTORS; CHEMICAL CROSS-LINKING; COMPLEX FORMATIONS; CONFORMATIONAL CHANGE; G PROTEIN COUPLED RECEPTORS; HYDROPHOBIC POCKETS; MOLECULAR DYNAMICS SIMULATIONS; PROTEIN INTERACTION;

PROTEINS;

1 PALMITOYL 2 OLEOYL PHOSPHATIDYLCHOLINE; CANNABINOID 2 RECEPTOR; G PROTEIN COUPLED RECEPTOR; INHIBITORY GUANINE NUCLEOTIDE BINDING PROTEIN; ISOLEUCINE; LEUCINE; PHENYLALANINE; PHOSPHATIDYLCHOLINE; THREONINE; UNCLASSIFIED DRUG; VALINE;

ALPHA HELIX; ARTICLE; COMPLEX FORMATION; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; ELECTROSPRAY MASS SPECTROMETRY; HEK293 CELL LINE; HUMAN; HUMAN CELL; HYDROPHOBICITY; LIQUID CHROMATOGRAPHY; MOLECULAR DYNAMICS; MOLECULAR MODEL; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN CROSS LINKING; PROTEIN INTERACTION; PROTEIN STRUCTURE;

CANNABINOID RECEPTOR; G PROTEIN-COUPLED RECEPTOR (GPCR); MASS SPECTROMETRY (MS); MOLECULAR DYNAMICS; SIGNAL TRANSDUCTION;

CHROMATOGRAPHY, LIQUID; CROSS-LINKING REAGENTS; GTP-BINDING PROTEIN ALPHA SUBUNITS, GI-GO; HEK293 CELLS; HUMANS; MODELS, MOLECULAR; MOLECULAR DYNAMICS SIMULATION; MULTIPROTEIN COMPLEXES; PROTEIN CONFORMATION; PROTEIN INTERACTION DOMAINS AND MOTIFS; PROTEIN INTERACTION MAPPING; PROTEIN STRUCTURE, SECONDARY; RECEPTOR, CANNABINOID, CB2; RECOMBINANT PROTEINS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TANDEM MASS SPECTROMETRY;

EID: 84904488770     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.539916     Document Type: Article

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