메뉴 건너뛰기




Volumn 48, Issue , 2015, Pages 62-81

Pharmacological approaches to retinitis pigmentosa: A laboratory perspective

Author keywords

Apoptosis; Ceramide; Environmental enrichment; Inflammation; Microglia; Neurotrophic factors; Orphan disease; Photoreceptors; Rare disease

Indexed keywords

9 CIS RETINOL ACETATE; ANTIOXIDANT; CILIARY NEUROTROPHIC FACTOR; DOCOSAHEXAENOIC ACID; RETINOL; ROD DERIVED CONE VIABILITY FACTOR; SPHINGOLIPID; VALPROIC ACID; NERVE GROWTH FACTOR; NEUROPROTECTIVE AGENT; NXNL1 PROTEIN, HUMAN; THIOREDOXIN;

EID: 84939264496     PISSN: 13509462     EISSN: 18731635     Source Type: Journal    
DOI: 10.1016/j.preteyeres.2015.06.005     Document Type: Article
Times cited : (79)

References (187)
  • 1
    • 13244255551 scopus 로고    scopus 로고
    • Enzymes of sphingolipid metabolism in Drosophila melanogaster
    • Acharya U., Acharya J.K. Enzymes of sphingolipid metabolism in Drosophila melanogaster. Cell. Mol. Life Sci. 2005, 62:128-142.
    • (2005) Cell. Mol. Life Sci. , vol.62 , pp. 128-142
    • Acharya, U.1    Acharya, J.K.2
  • 2
    • 0037436579 scopus 로고    scopus 로고
    • Modulating sphingolipid biosynthetic pathway rescues photoreceptor degeneration
    • Acharya U., Patel S., Koundakjian E., Nagashima K., Han X., Acharya J.K. Modulating sphingolipid biosynthetic pathway rescues photoreceptor degeneration. Science 2003, 299:1740-1743.
    • (2003) Science , vol.299 , pp. 1740-1743
    • Acharya, U.1    Patel, S.2    Koundakjian, E.3    Nagashima, K.4    Han, X.5    Acharya, J.K.6
  • 6
    • 38549111184 scopus 로고    scopus 로고
    • Acommon founder mutation of CERKL underlies autosomal recessive retinal degeneration with early macular involvement among Yemenite Jews
    • Auslender N., Sharon D., Abbasi A.H., Garzozi H.J., Banin E., Ben-Yosef T. Acommon founder mutation of CERKL underlies autosomal recessive retinal degeneration with early macular involvement among Yemenite Jews. Investig. Ophthalmol. Vis. Sci. 2007, 48:5431-5438.
    • (2007) Investig. Ophthalmol. Vis. Sci. , vol.48 , pp. 5431-5438
    • Auslender, N.1    Sharon, D.2    Abbasi, A.H.3    Garzozi, H.J.4    Banin, E.5    Ben-Yosef, T.6
  • 13
    • 84870318786 scopus 로고    scopus 로고
    • Environmental enrichment extends photoreceptor survival and visual function in a mouse model of retinitis pigmentosa
    • Barone I., Novelli E., Piano I., Gargini C., Strettoi E. Environmental enrichment extends photoreceptor survival and visual function in a mouse model of retinitis pigmentosa. PLoS One 2012, 7:e50726.
    • (2012) PLoS One , vol.7 , pp. e50726
    • Barone, I.1    Novelli, E.2    Piano, I.3    Gargini, C.4    Strettoi, E.5
  • 14
    • 84908696173 scopus 로고    scopus 로고
    • Long-term preservation of cone photoreceptors and visual acuity in rd10 mutant mice exposed to continuous environmental enrichment
    • Barone I., Novelli E., Strettoi E. Long-term preservation of cone photoreceptors and visual acuity in rd10 mutant mice exposed to continuous environmental enrichment. Mol. Vis. 2014, 20:1545-1556.
    • (2014) Mol. Vis. , vol.20 , pp. 1545-1556
    • Barone, I.1    Novelli, E.2    Strettoi, E.3
  • 15
    • 77957235392 scopus 로고    scopus 로고
    • Transmission electron microscopy of lipid vesicles for drug delivery: comparison between positive and negative staining
    • Bello V., Mattei G., Mazzoldi P., Vivenza N., Gasco P., Idee J.M., Robic C., Borsella E. Transmission electron microscopy of lipid vesicles for drug delivery: comparison between positive and negative staining. Microsc. Microanal. 2010, 16:456-461.
    • (2010) Microsc. Microanal. , vol.16 , pp. 456-461
    • Bello, V.1    Mattei, G.2    Mazzoldi, P.3    Vivenza, N.4    Gasco, P.5    Idee, J.M.6    Robic, C.7    Borsella, E.8
  • 16
    • 0020284388 scopus 로고
    • Nutrition and retinal degenerations. Vitamin A, taurine, ornithine, and phytanic acid
    • Berson E.L. Nutrition and retinal degenerations. Vitamin A, taurine, ornithine, and phytanic acid. Retina 1982, 2:236-255.
    • (1982) Retina , vol.2 , pp. 236-255
    • Berson, E.L.1
  • 19
  • 20
    • 84879416452 scopus 로고    scopus 로고
    • Long-term follow-up for efficacy and safety of treatment of retinitis pigmentosa with valproic acid
    • Bhalla S., Joshi D., Bhullar S., Kasuga D., Park Y., Kay C.N. Long-term follow-up for efficacy and safety of treatment of retinitis pigmentosa with valproic acid. Br. J. Ophthalmol. 2013, 97:895-899.
    • (2013) Br. J. Ophthalmol. , vol.97 , pp. 895-899
    • Bhalla, S.1    Joshi, D.2    Bhullar, S.3    Kasuga, D.4    Park, Y.5    Kay, C.N.6
  • 21
    • 84880571547 scopus 로고    scopus 로고
    • Randomized trial of ciliary neurotrophic factor delivered by encapsulated cell intraocular implants for retinitis pigmentosa
    • 283-292 e281
    • Birch D.G., Weleber R.G., Duncan J.L., Jaffe G.J., Tao W. Randomized trial of ciliary neurotrophic factor delivered by encapsulated cell intraocular implants for retinitis pigmentosa. Am. J. Ophthalmol. 2013, 156. 283-292 e281.
    • (2013) Am. J. Ophthalmol. , vol.156
    • Birch, D.G.1    Weleber, R.G.2    Duncan, J.L.3    Jaffe, G.J.4    Tao, W.5
  • 24
  • 26
    • 84880413477 scopus 로고    scopus 로고
    • Novel chemotherapeutic drugs in sphingolipid cancer research
    • Canals D., Hannun Y.A. Novel chemotherapeutic drugs in sphingolipid cancer research. Handb. Exp. Pharmacol. 2013, 211-238.
    • (2013) Handb. Exp. Pharmacol. , pp. 211-238
    • Canals, D.1    Hannun, Y.A.2
  • 29
    • 84860684969 scopus 로고    scopus 로고
    • Emerging gene therapies for retinal degenerations
    • Cepko C.L. Emerging gene therapies for retinal degenerations. J.Neurosci. 2012, 32:6415-6420.
    • (2012) J.Neurosci. , vol.32 , pp. 6415-6420
    • Cepko, C.L.1
  • 30
    • 0036186946 scopus 로고    scopus 로고
    • Animal models in research on retinal degenerations: past progress and future hope
    • Chader G.J. Animal models in research on retinal degenerations: past progress and future hope. Vis. Res. 2002, 42:393-399.
    • (2002) Vis. Res. , vol.42 , pp. 393-399
    • Chader, G.J.1
  • 38
    • 65649106136 scopus 로고    scopus 로고
    • Mechanisms of apoptosis in retinitis pigmentosa
    • Cottet S., Schorderet D.F. Mechanisms of apoptosis in retinitis pigmentosa. Curr. Mol. Med. 2009, 9:375-383.
    • (2009) Curr. Mol. Med. , vol.9 , pp. 375-383
    • Cottet, S.1    Schorderet, D.F.2
  • 41
    • 84880161275 scopus 로고    scopus 로고
    • Genes and mutations causing retinitis pigmentosa
    • Daiger S.P., Sullivan L.S., Bowne S.J. Genes and mutations causing retinitis pigmentosa. Clin. Genet. 2013, 84:132-141.
    • (2013) Clin. Genet. , vol.84 , pp. 132-141
    • Daiger, S.P.1    Sullivan, L.S.2    Bowne, S.J.3
  • 42
    • 84920824525 scopus 로고    scopus 로고
    • Gene therapy for the eye focus on mutation-independent approaches
    • Dalkara D., Duebel J., Sahel J.A. Gene therapy for the eye focus on mutation-independent approaches. Curr. Opin. Neurol. 2015, 28:51-60.
    • (2015) Curr. Opin. Neurol. , vol.28 , pp. 51-60
    • Dalkara, D.1    Duebel, J.2    Sahel, J.A.3
  • 46
    • 53249147453 scopus 로고    scopus 로고
    • NT-501: an ophthalmic implant of polymer-encapsulated ciliary neurotrophic factor-producing cells
    • Emerich D.F., Thanos C.G. NT-501: an ophthalmic implant of polymer-encapsulated ciliary neurotrophic factor-producing cells. Curr. Opin. Mol. Ther. 2008, 10:506-515.
    • (2008) Curr. Opin. Mol. Ther. , vol.10 , pp. 506-515
    • Emerich, D.F.1    Thanos, C.G.2
  • 48
    • 80051618338 scopus 로고    scopus 로고
    • Allelic heterogeneity and genetic modifier loci contribute to clinical variation in males with X-linked retinitis pigmentosa due to RPGR mutations
    • Fahim A.T., Bowne S.J., Sullivan L.S., Webb K.D., Williams J.T., Wheaton D.K., Birch D.G., Daiger S.P. Allelic heterogeneity and genetic modifier loci contribute to clinical variation in males with X-linked retinitis pigmentosa due to RPGR mutations. PLoS One 2011, 6:e23021.
    • (2011) PLoS One , vol.6 , pp. e23021
    • Fahim, A.T.1    Bowne, S.J.2    Sullivan, L.S.3    Webb, K.D.4    Williams, J.T.5    Wheaton, D.K.6    Birch, D.G.7    Daiger, S.P.8
  • 51
    • 0037376674 scopus 로고    scopus 로고
    • Oxidant signals and oxidative stress
    • Finkel T. Oxidant signals and oxidative stress. Curr. Opin. Cell Biol. 2003, 15:247-254.
    • (2003) Curr. Opin. Cell Biol. , vol.15 , pp. 247-254
    • Finkel, T.1
  • 53
    • 33744970260 scopus 로고    scopus 로고
    • Enriched environment during adolescence changes brain-derived neurotrophic factor and TrkB levels in the rat visual system but does not offer neuroprotection to retinal ganglion cells following axotomy
    • Franklin T.B., Murphy J.A., Myers T.L., Clarke D.B., Currie R.W. Enriched environment during adolescence changes brain-derived neurotrophic factor and TrkB levels in the rat visual system but does not offer neuroprotection to retinal ganglion cells following axotomy. Brain Res. 2006, 1095:1-11.
    • (2006) Brain Res. , vol.1095 , pp. 1-11
    • Franklin, T.B.1    Murphy, J.A.2    Myers, T.L.3    Clarke, D.B.4    Currie, R.W.5
  • 54
    • 84925493743 scopus 로고    scopus 로고
    • The role of electrical stimulation therapy in ophthalmic diseases
    • Fu L., Lo A.C.Y., Lai J.S.M., Shih K.C. The role of electrical stimulation therapy in ophthalmic diseases. Graefes Arch. Clin. Exp. 2015, 253:171-176.
    • (2015) Graefes Arch. Clin. Exp. , vol.253 , pp. 171-176
    • Fu, L.1    Lo, A.C.Y.2    Lai, J.S.M.3    Shih, K.C.4
  • 56
    • 77953411221 scopus 로고    scopus 로고
    • Chapter 10-Solid lipid nanoparticles and microemulsions for drug delivery the CNS
    • Gasco M.R., Priano L., Zara G.P. Chapter 10-Solid lipid nanoparticles and microemulsions for drug delivery the CNS. Prog. Brain Res. 2009, 180:181-192.
    • (2009) Prog. Brain Res. , vol.180 , pp. 181-192
    • Gasco, M.R.1    Priano, L.2    Zara, G.P.3
  • 58
    • 56749180855 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor functions as a metabotrophin to mediate the effects of exercise on cognition
    • Gomez-Pinilla F., Vaynman S., Ying Z. Brain-derived neurotrophic factor functions as a metabotrophin to mediate the effects of exercise on cognition. Eur. J. Neurosci. 2008, 28:2278-2287.
    • (2008) Eur. J. Neurosci. , vol.28 , pp. 2278-2287
    • Gomez-Pinilla, F.1    Vaynman, S.2    Ying, Z.3
  • 62
    • 38549152194 scopus 로고    scopus 로고
    • Principles of bioactive lipid signalling: lessons from sphingolipids
    • Hannun Y.A., Obeid L.M. Principles of bioactive lipid signalling: lessons from sphingolipids. Nat. Rev. Mol. Cell Biol. 2008, 9:139-150.
    • (2008) Nat. Rev. Mol. Cell Biol. , vol.9 , pp. 139-150
    • Hannun, Y.A.1    Obeid, L.M.2
  • 64
    • 77953268102 scopus 로고    scopus 로고
    • Roles for dysfunctional sphingolipid metabolism in Alzheimer's disease neuropathogenesis
    • Haughey N.J., Bandaru V.V., Bae M., Mattson M.P. Roles for dysfunctional sphingolipid metabolism in Alzheimer's disease neuropathogenesis. Biochim. Biophys. Acta 2010, 1801:878-886.
    • (2010) Biochim. Biophys. Acta , vol.1801 , pp. 878-886
    • Haughey, N.J.1    Bandaru, V.V.2    Bae, M.3    Mattson, M.P.4
  • 65
    • 0030340608 scopus 로고    scopus 로고
    • Investigations of antiretinal antibodies in pigmentary retinopathy and other retinal degenerations
    • discussion 200-176
    • Heckenlively J.R., Aptsiauri N., Nusinowitz S., Peng C., Hargrave P.A. Investigations of antiretinal antibodies in pigmentary retinopathy and other retinal degenerations. Trans. Am. Ophthalmol. Soc. 1996, 94:179-200. discussion 200-176.
    • (1996) Trans. Am. Ophthalmol. Soc. , vol.94 , pp. 179-200
    • Heckenlively, J.R.1    Aptsiauri, N.2    Nusinowitz, S.3    Peng, C.4    Hargrave, P.A.5
  • 66
    • 0032911681 scopus 로고    scopus 로고
    • Association of antiretinal antibodies and cystoid macular edema in patients with retinitis pigmentosa
    • Heckenlively J.R., Jordan B.L., Aptsiauri N. Association of antiretinal antibodies and cystoid macular edema in patients with retinitis pigmentosa. Am. J. Ophthalmol. 1999, 127:565-573.
    • (1999) Am. J. Ophthalmol. , vol.127 , pp. 565-573
    • Heckenlively, J.R.1    Jordan, B.L.2    Aptsiauri, N.3
  • 68
    • 38349147618 scopus 로고    scopus 로고
    • Environmental enrichment counteracts Alzheimer's neurovascular dysfunction in TgCRND8 mice
    • Herring A., Yasin H., Ambree O., Sachser N., Paulus W., Keyvani K. Environmental enrichment counteracts Alzheimer's neurovascular dysfunction in TgCRND8 mice. Brain Pathol. 2008, 18:32-39.
    • (2008) Brain Pathol. , vol.18 , pp. 32-39
    • Herring, A.1    Yasin, H.2    Ambree, O.3    Sachser, N.4    Paulus, W.5    Keyvani, K.6
  • 71
    • 81155152766 scopus 로고    scopus 로고
    • Dendrimer-based targeted intravitreal therapy for sustained attenuation of neuroinflammation in retinal degeneration
    • Iezzi R., Guru B.R., Glybina I.V., Mishra M.K., Kennedy A., Kannan R.M. Dendrimer-based targeted intravitreal therapy for sustained attenuation of neuroinflammation in retinal degeneration. Biomaterials 2012, 33:979-988.
    • (2012) Biomaterials , vol.33 , pp. 979-988
    • Iezzi, R.1    Guru, B.R.2    Glybina, I.V.3    Mishra, M.K.4    Kennedy, A.5    Kannan, R.M.6
  • 75
    • 34248530339 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors exhibit anti-inflammatory and neuroprotective effects in a rat permanent ischemic model of stroke: multiple mechanisms of action
    • Kim H.J., Rowe M., Ren M., Hong J.S., Chen P.S., Chuang D.M. Histone deacetylase inhibitors exhibit anti-inflammatory and neuroprotective effects in a rat permanent ischemic model of stroke: multiple mechanisms of action. J.Pharmacol. Exp. Ther. 2007, 321:892-901.
    • (2007) J.Pharmacol. Exp. Ther. , vol.321 , pp. 892-901
    • Kim, H.J.1    Rowe, M.2    Ren, M.3    Hong, J.S.4    Chen, P.S.5    Chuang, D.M.6
  • 78
    • 84878264043 scopus 로고    scopus 로고
    • Photoreceptor proteins initiate microglial activation via Toll-like receptor 4 in retinal degeneration mediated by all-trans-retinal
    • Kohno H., Chen Y., Kevany B.M., Pearlman E., Miyagi M., Maeda T., Palczewski K., Maeda A. Photoreceptor proteins initiate microglial activation via Toll-like receptor 4 in retinal degeneration mediated by all-trans-retinal. J.Biol. Chem. 2013, 288:15326-15341.
    • (2013) J.Biol. Chem. , vol.288 , pp. 15326-15341
    • Kohno, H.1    Chen, Y.2    Kevany, B.M.3    Pearlman, E.4    Miyagi, M.5    Maeda, T.6    Palczewski, K.7    Maeda, A.8
  • 79
    • 84898627423 scopus 로고    scopus 로고
    • CCL3 production by microglial cells modulates disease severity in murine models of retinal degeneration
    • Kohno H., Maeda T., Perusek L., Pearlman E., Maeda A. CCL3 production by microglial cells modulates disease severity in murine models of retinal degeneration. J.Immunol. 2014, 192:3816-3827.
    • (2014) J.Immunol. , vol.192 , pp. 3816-3827
    • Kohno, H.1    Maeda, T.2    Perusek, L.3    Pearlman, E.4    Maeda, A.5
  • 80
    • 35248831880 scopus 로고    scopus 로고
    • Antioxidants slow photoreceptor cell death in mouse models of retinitis pigmentosa
    • Komeima K., Rogers B.S., Campochiaro P.A. Antioxidants slow photoreceptor cell death in mouse models of retinitis pigmentosa. J.Cell. Physiol. 2007, 213:809-815.
    • (2007) J.Cell. Physiol. , vol.213 , pp. 809-815
    • Komeima, K.1    Rogers, B.S.2    Campochiaro, P.A.3
  • 82
    • 55049106647 scopus 로고    scopus 로고
    • Blockade of neuronal nitric oxide synthase reduces cone cell death in a model of retinitis pigmentosa
    • Komeima K., Usui S., Shen J., Rogers B.S., Campochiaro P.A. Blockade of neuronal nitric oxide synthase reduces cone cell death in a model of retinitis pigmentosa. Free Radic. Biol. Med. 2008, 45:905-912.
    • (2008) Free Radic. Biol. Med. , vol.45 , pp. 905-912
    • Komeima, K.1    Usui, S.2    Shen, J.3    Rogers, B.S.4    Campochiaro, P.A.5
  • 85
    • 0020556070 scopus 로고
    • Role of autoimmunity in retinitis pigmentosa
    • Kumar M., Gupta R.M., Nema H.V. Role of autoimmunity in retinitis pigmentosa. Ann. Ophthalmol. 1983, 15:838-840.
    • (1983) Ann. Ophthalmol. , vol.15 , pp. 838-840
    • Kumar, M.1    Gupta, R.M.2    Nema, H.V.3
  • 86
    • 38349086976 scopus 로고    scopus 로고
    • Differential regulation of trophic and proinflammatory microglial effectors is dependent on severity of neuronal injury
    • Lai A.Y., Todd K.G. Differential regulation of trophic and proinflammatory microglial effectors is dependent on severity of neuronal injury. Glia 2008, 56:259-270.
    • (2008) Glia , vol.56 , pp. 259-270
    • Lai, A.Y.1    Todd, K.G.2
  • 88
    • 34347237872 scopus 로고    scopus 로고
    • NGF topical application in patients with corneal ulcer does not generate circulating NGF antibodies
    • Lambiase A., Coassin M., Sposato V., Micera A., Sacchetti M., Bonini S., Aloe L. NGF topical application in patients with corneal ulcer does not generate circulating NGF antibodies. Pharmacol. Res. 2007, 56:65-69.
    • (2007) Pharmacol. Res. , vol.56 , pp. 65-69
    • Lambiase, A.1    Coassin, M.2    Sposato, V.3    Micera, A.4    Sacchetti, M.5    Bonini, S.6    Aloe, L.7
  • 94
    • 77952962177 scopus 로고    scopus 로고
    • Rod-derived cone viability factor for treating blinding diseases: from clinic to redox signaling
    • 26ps16
    • Leveillard T., Sahel J.A. Rod-derived cone viability factor for treating blinding diseases: from clinic to redox signaling. Sci. Transl. Med. 2010, 2. 26ps16.
    • (2010) Sci. Transl. Med. , vol.2
    • Leveillard, T.1    Sahel, J.A.2
  • 96
    • 84944357914 scopus 로고    scopus 로고
    • The use of Argus(R) II retinal prosthesis by blind subjects to achieve localisation and prehension of objects in 3-dimensional space
    • Luo Y.H., Zhong J.J., da Cruz L. The use of Argus(R) II retinal prosthesis by blind subjects to achieve localisation and prehension of objects in 3-dimensional space. Graefes Arch. Clin. Exp. Ophthalmol. 2014.
    • (2014) Graefes Arch. Clin. Exp. Ophthalmol.
    • Luo, Y.H.1    Zhong, J.J.2    da Cruz, L.3
  • 98
    • 66149129178 scopus 로고    scopus 로고
    • Loss of cone photoreceptors caused by chromophore depletion is partially prevented by the artificial chromophore pro-drug, 9-cis-retinyl acetate
    • Maeda T., Cideciyan A.V., Maeda A., Golczak M., Aleman T.S., Jacobson S.G., Palczewski K. Loss of cone photoreceptors caused by chromophore depletion is partially prevented by the artificial chromophore pro-drug, 9-cis-retinyl acetate. Hum. Mol. Genet. 2009, 18:2277-2287.
    • (2009) Hum. Mol. Genet. , vol.18 , pp. 2277-2287
    • Maeda, T.1    Cideciyan, A.V.2    Maeda, A.3    Golczak, M.4    Aleman, T.S.5    Jacobson, S.G.6    Palczewski, K.7
  • 103
    • 34047207833 scopus 로고    scopus 로고
    • Programmed cell death in retinal degeneration: targeting apoptosis in photoreceptors as potential therapy for retinal degeneration
    • Marigo V. Programmed cell death in retinal degeneration: targeting apoptosis in photoreceptors as potential therapy for retinal degeneration. Cell Cycle 2007, 6:652-655.
    • (2007) Cell Cycle , vol.6 , pp. 652-655
    • Marigo, V.1
  • 104
    • 79959600571 scopus 로고    scopus 로고
    • Pharmacological manipulation of rhodopsin retinitis pigmentosa
    • Mendes H.F., Zaccarini R., Cheetham M.E. Pharmacological manipulation of rhodopsin retinitis pigmentosa. Adv. Exp. Med. Biol. 2010, 664:317-323.
    • (2010) Adv. Exp. Med. Biol. , vol.664 , pp. 317-323
    • Mendes, H.F.1    Zaccarini, R.2    Cheetham, M.E.3
  • 105
    • 78649780371 scopus 로고    scopus 로고
    • Alterations of the sphingolipid pathway in Alzheimer's disease: new biomarkers and treatment targets?
    • Mielke M.M., Lyketsos C.G. Alterations of the sphingolipid pathway in Alzheimer's disease: new biomarkers and treatment targets?. Neuromolecular Med. 2010, 12:331-340.
    • (2010) Neuromolecular Med. , vol.12 , pp. 331-340
    • Mielke, M.M.1    Lyketsos, C.G.2
  • 109
    • 84855998508 scopus 로고    scopus 로고
    • Steric volume exclusion sets soluble protein concentrations in photoreceptor sensory cilia
    • Najafi M., Maza N.A., Calvert P.D. Steric volume exclusion sets soluble protein concentrations in photoreceptor sensory cilia. Proc. Natl. Acad. Sci. U. S. A. 2012, 109:203-208.
    • (2012) Proc. Natl. Acad. Sci. U. S. A. , vol.109 , pp. 203-208
    • Najafi, M.1    Maza, N.A.2    Calvert, P.D.3
  • 110
    • 70450223117 scopus 로고    scopus 로고
    • The neurobiology of brain and cognitive reserve: mental and physical activity as modulators of brain disorders
    • Nithianantharajah J., Hannan A.J. The neurobiology of brain and cognitive reserve: mental and physical activity as modulators of brain disorders. Prog. Neurobiol. 2009, 89:369-382.
    • (2009) Prog. Neurobiol. , vol.89 , pp. 369-382
    • Nithianantharajah, J.1    Hannan, A.J.2
  • 111
    • 83455172618 scopus 로고    scopus 로고
    • Low-dose-rate, low-dose irradiation delays neurodegeneration in a model of retinitis pigmentosa
    • Otani A., Kojima H., Guo C., Oishi A., Yoshimura N. Low-dose-rate, low-dose irradiation delays neurodegeneration in a model of retinitis pigmentosa. Am. J. Pathol. 2012, 180:328-336.
    • (2012) Am. J. Pathol. , vol.180 , pp. 328-336
    • Otani, A.1    Kojima, H.2    Guo, C.3    Oishi, A.4    Yoshimura, N.5
  • 112
    • 84902144481 scopus 로고    scopus 로고
    • Constitutively active rhodopsin and retinal disease
    • Park P.S. Constitutively active rhodopsin and retinal disease. Adv. Pharmacol. 2014, 70:1-36.
    • (2014) Adv. Pharmacol. , vol.70 , pp. 1-36
    • Park, P.S.1
  • 115
    • 84926613939 scopus 로고    scopus 로고
    • Advances in drug delivery to the posterior segment
    • Pearce W., Hsu J., Yeh S. Advances in drug delivery to the posterior segment. Curr. Opin. Ophthalmol. 2015, 26:233-239.
    • (2015) Curr. Opin. Ophthalmol. , vol.26 , pp. 233-239
    • Pearce, W.1    Hsu, J.2    Yeh, S.3
  • 116
    • 84902143838 scopus 로고    scopus 로고
    • Suppression of microglial activation is neuroprotective in a mouse model of human retinitis pigmentosa
    • Peng B., Xiao J., Wang K., So K.F., Tipoe G.L., Lin B. Suppression of microglial activation is neuroprotective in a mouse model of human retinitis pigmentosa. J.Neurosci. 2014, 34:8139-8150.
    • (2014) J.Neurosci. , vol.34 , pp. 8139-8150
    • Peng, B.1    Xiao, J.2    Wang, K.3    So, K.F.4    Tipoe, G.L.5    Lin, B.6
  • 118
    • 84878484305 scopus 로고    scopus 로고
    • Cone survival and preservation of visual acuity in an animal model of retinal degeneration
    • Piano I., Novelli E., Gasco P., Ghidoni R., Strettoi E., Gargini C. Cone survival and preservation of visual acuity in an animal model of retinal degeneration. Eur. J. Neurosci. 2013, 37:1853-1862.
    • (2013) Eur. J. Neurosci. , vol.37 , pp. 1853-1862
    • Piano, I.1    Novelli, E.2    Gasco, P.3    Ghidoni, R.4    Strettoi, E.5    Gargini, C.6
  • 120
    • 84862834591 scopus 로고    scopus 로고
    • Signaling and regulatory functions of bioactive sphingolipids as therapeutic targets in multiple sclerosis
    • Podbielska M., Krotkiewski H., Hogan E.L. Signaling and regulatory functions of bioactive sphingolipids as therapeutic targets in multiple sclerosis. Neurochem. Res. 2012, 37:1154-1169.
    • (2012) Neurochem. Res. , vol.37 , pp. 1154-1169
    • Podbielska, M.1    Krotkiewski, H.2    Hogan, E.L.3
  • 122
    • 33845294076 scopus 로고    scopus 로고
    • Sphingolipids in apoptosis, survival and regeneration in the nervous system
    • Posse de Chaves E.I. Sphingolipids in apoptosis, survival and regeneration in the nervous system. Biochim. Biophys. Acta 2006, 1758:1995-2015.
    • (2006) Biochim. Biophys. Acta , vol.1758 , pp. 1995-2015
    • Posse de Chaves, E.I.1
  • 123
    • 58149141478 scopus 로고    scopus 로고
    • Stimulation of the insulin/mTOR pathway delays cone death in a mouse model of retinitis pigmentosa
    • Punzo C., Kornacker K., Cepko C.L. Stimulation of the insulin/mTOR pathway delays cone death in a mouse model of retinitis pigmentosa. Nat. Neurosci. 2009, 12:44-52.
    • (2009) Nat. Neurosci. , vol.12 , pp. 44-52
    • Punzo, C.1    Kornacker, K.2    Cepko, C.L.3
  • 124
    • 84855832566 scopus 로고    scopus 로고
    • Loss of daylight vision in retinal degeneration: are oxidative stress and metabolic dysregulation to blame?
    • Punzo C., Xiong W., Cepko C.L. Loss of daylight vision in retinal degeneration: are oxidative stress and metabolic dysregulation to blame?. J.Biol. Chem. 2012, 287:1642-1648.
    • (2012) J.Biol. Chem. , vol.287 , pp. 1642-1648
    • Punzo, C.1    Xiong, W.2    Cepko, C.L.3
  • 125
    • 77953966511 scopus 로고    scopus 로고
    • Sphingosine 1-phosphate and cancer
    • Pyne N.J., Pyne S. Sphingosine 1-phosphate and cancer. Nat. Rev. Cancer 2010, 10:489-503.
    • (2010) Nat. Rev. Cancer , vol.10 , pp. 489-503
    • Pyne, N.J.1    Pyne, S.2
  • 126
    • 38549125007 scopus 로고    scopus 로고
    • Long-term suppression of neurodegeneration in chronic experimental optic neuritis: antioxidant gene therapy
    • Qi X., Sun L., Lewin A.S., Hauswirth W.W., Guy J. Long-term suppression of neurodegeneration in chronic experimental optic neuritis: antioxidant gene therapy. Investig. Ophthalmol. Vis. Sci. 2007, 48:5360-5370.
    • (2007) Investig. Ophthalmol. Vis. Sci. , vol.48 , pp. 5360-5370
    • Qi, X.1    Sun, L.2    Lewin, A.S.3    Hauswirth, W.W.4    Guy, J.5
  • 128
    • 84885775437 scopus 로고    scopus 로고
    • Genetic architecture of retinal and macular degenerative diseases: the promise and challenges of next-generation sequencing
    • Ratnapriya R., Swaroop A. Genetic architecture of retinal and macular degenerative diseases: the promise and challenges of next-generation sequencing. Genome Med. 2013, 5.
    • (2013) Genome Med. , vol.5
    • Ratnapriya, R.1    Swaroop, A.2
  • 130
    • 84922482050 scopus 로고    scopus 로고
    • Potential benefits and limitations of enriched environments and cognitive activity on age-related behavioural decline
    • Redolat R., Mesa-Gresa P. Potential benefits and limitations of enriched environments and cognitive activity on age-related behavioural decline. Curr. Top. Behav. Neurosci. 2012, 10:293-316.
    • (2012) Curr. Top. Behav. Neurosci. , vol.10 , pp. 293-316
    • Redolat, R.1    Mesa-Gresa, P.2
  • 131
    • 84863311216 scopus 로고    scopus 로고
    • Gene expression changes within Muller glial cells in retinitis pigmentosa
    • Roesch K., Stadler M.B., Cepko C.L. Gene expression changes within Muller glial cells in retinitis pigmentosa. Mol. Vis. 2012, 18:1197-1214.
    • (2012) Mol. Vis. , vol.18 , pp. 1197-1214
    • Roesch, K.1    Stadler, M.B.2    Cepko, C.L.3
  • 132
    • 77952713295 scopus 로고    scopus 로고
    • Regulating survival and development in the retina: key roles for simple sphingolipids
    • Rotstein N.P., Miranda G.E., Abrahan C.E., German O.L. Regulating survival and development in the retina: key roles for simple sphingolipids. J.Lipid Res. 2010, 51:1247-1262.
    • (2010) J.Lipid Res. , vol.51 , pp. 1247-1262
    • Rotstein, N.P.1    Miranda, G.E.2    Abrahan, C.E.3    German, O.L.4
  • 137
    • 84891528250 scopus 로고    scopus 로고
    • Environment and brain plasticity: towards an endogenous pharmacotherapy
    • Sale A., Berardi N., Maffei L. Environment and brain plasticity: towards an endogenous pharmacotherapy. Physiol. Rev. 2014, 94:189-234.
    • (2014) Physiol. Rev. , vol.94 , pp. 189-234
    • Sale, A.1    Berardi, N.2    Maffei, L.3
  • 138
    • 43149123746 scopus 로고    scopus 로고
    • Maternal enrichment during pregnancy accelerates retinal development of the fetus
    • Sale A., Cenni M.C., Ciucci F., Putignano E., Chierzi S., Maffei L. Maternal enrichment during pregnancy accelerates retinal development of the fetus. PLoS One 2007, 2:e1160.
    • (2007) PLoS One , vol.2 , pp. e1160
    • Sale, A.1    Cenni, M.C.2    Ciucci, F.3    Putignano, E.4    Chierzi, S.5    Maffei, L.6
  • 140
    • 84873410053 scopus 로고    scopus 로고
    • Therapeutic targeting of the ceramide-to-sphingosine 1-phosphate pathway in pain
    • Salvemini D., Doyle T., Kress M., Nicol G. Therapeutic targeting of the ceramide-to-sphingosine 1-phosphate pathway in pain. Trends Pharmacol. Sci. 2013, 34:110-118.
    • (2013) Trends Pharmacol. Sci. , vol.34 , pp. 110-118
    • Salvemini, D.1    Doyle, T.2    Kress, M.3    Nicol, G.4
  • 142
  • 143
    • 33746874469 scopus 로고    scopus 로고
    • Ceramide is the key mediator of oxidative stress-induced apoptosis in retinal photoreceptor cells
    • Sanvicens N., Cotter T.G. Ceramide is the key mediator of oxidative stress-induced apoptosis in retinal photoreceptor cells. J.Neurochem. 2006, 98:1432-1444.
    • (2006) J.Neurochem. , vol.98 , pp. 1432-1444
    • Sanvicens, N.1    Cotter, T.G.2
  • 144
    • 0642364447 scopus 로고    scopus 로고
    • Resveratrol induces growth inhibition and apoptosis in metastatic breast cancer cells via de novo ceramide signaling
    • Scarlatti F., Sala G., Somenzi G., Signorelli P., Sacchi N., Ghidoni R. Resveratrol induces growth inhibition and apoptosis in metastatic breast cancer cells via de novo ceramide signaling. FASEB J. 2003, 17:2339-2341.
    • (2003) FASEB J. , vol.17 , pp. 2339-2341
    • Scarlatti, F.1    Sala, G.2    Somenzi, G.3    Signorelli, P.4    Sacchi, N.5    Ghidoni, R.6
  • 146
    • 84939258013 scopus 로고    scopus 로고
    • Effect of short-term oral valproic acid on vision and visual field in retinitis pigmentosa
    • Shanmugam P.M., Minija C.K., Ramanjulu R., Tekwani P., Saxena M. Effect of short-term oral valproic acid on vision and visual field in retinitis pigmentosa. Ophthalmol. Ther. 2012, 1:6.
    • (2012) Ophthalmol. Ther. , vol.1 , pp. 6
    • Shanmugam, P.M.1    Minija, C.K.2    Ramanjulu, R.3    Tekwani, P.4    Saxena, M.5
  • 148
    • 84864861561 scopus 로고    scopus 로고
    • Valproic acid treatment may be harmful in non-dominant forms of retinitis pigmentosa
    • Sisk R.A. Valproic acid treatment may be harmful in non-dominant forms of retinitis pigmentosa. Br. J. Ophthalmol. 2012, 96:1154-1155.
    • (2012) Br. J. Ophthalmol. , vol.96 , pp. 1154-1155
    • Sisk, R.A.1
  • 149
    • 1542286877 scopus 로고    scopus 로고
    • Environmental enrichment rescues protein deficits in a mouse model of Huntington's disease, indicating a possible disease mechanism
    • Spires T.L., Grote H.E., Varshney N.K., Cordery P.M., van Dellen A., Blakemore C., Hannan A.J. Environmental enrichment rescues protein deficits in a mouse model of Huntington's disease, indicating a possible disease mechanism. J.Neurosci. 2004, 24:2270-2276.
    • (2004) J.Neurosci. , vol.24 , pp. 2270-2276
    • Spires, T.L.1    Grote, H.E.2    Varshney, N.K.3    Cordery, P.M.4    van Dellen, A.5    Blakemore, C.6    Hannan, A.J.7
  • 151
    • 84888271500 scopus 로고    scopus 로고
    • Electronic approaches to restitute vision in patients with neurodegenerative diseases of the retina
    • Stingl K., Zrenner E. Electronic approaches to restitute vision in patients with neurodegenerative diseases of the retina. Ophthalmic Res. 2013, 50:215-220.
    • (2013) Ophthalmic Res. , vol.50 , pp. 215-220
    • Stingl, K.1    Zrenner, E.2
  • 152
    • 78649850282 scopus 로고    scopus 로고
    • Inhibition of ceramide biosynthesis preserves photoreceptor structure and function in a mouse model of retinitis pigmentosa
    • Strettoi E., Gargini C., Novelli E., Sala G., Piano I., Gasco P., Ghidoni R. Inhibition of ceramide biosynthesis preserves photoreceptor structure and function in a mouse model of retinitis pigmentosa. Proc. Natl. Acad. Sci. U. S. A. 2010, 107:18706-18711.
    • (2010) Proc. Natl. Acad. Sci. U. S. A. , vol.107 , pp. 18706-18711
    • Strettoi, E.1    Gargini, C.2    Novelli, E.3    Sala, G.4    Piano, I.5    Gasco, P.6    Ghidoni, R.7
  • 154
    • 84859369692 scopus 로고    scopus 로고
    • BK channels mediate pathway-specific modulation of visual signals in the invivo mouse retina
    • Tanimoto N., Sothilingam V., Euler T., Ruth P., Seeliger M.W., Schubert T. BK channels mediate pathway-specific modulation of visual signals in the invivo mouse retina. J.Neurosci. 2012, 32:4861-4866.
    • (2012) J.Neurosci. , vol.32 , pp. 4861-4866
    • Tanimoto, N.1    Sothilingam, V.2    Euler, T.3    Ruth, P.4    Seeliger, M.W.5    Schubert, T.6
  • 156
    • 84876269789 scopus 로고    scopus 로고
    • Improvement of central retinal sensitivity six months after topical isopropyl unoprostone in patients with retinitis pigmentosa
    • Tawada A., Sugawara T., Ogata K., Hagiwara A., Yamamoto S. Improvement of central retinal sensitivity six months after topical isopropyl unoprostone in patients with retinitis pigmentosa. Indian J. Ophthalmol. 2013, 61:95-99.
    • (2013) Indian J. Ophthalmol. , vol.61 , pp. 95-99
    • Tawada, A.1    Sugawara, T.2    Ogata, K.3    Hagiwara, A.4    Yamamoto, S.5
  • 157
    • 27644496187 scopus 로고    scopus 로고
    • Delivery of neurotrophic factors and therapeutic proteins for retinal diseases
    • Thanos C., Emerich D. Delivery of neurotrophic factors and therapeutic proteins for retinal diseases. Expert Opin. Biol. Ther. 2005, 5:1443-1452.
    • (2005) Expert Opin. Biol. Ther. , vol.5 , pp. 1443-1452
    • Thanos, C.1    Emerich, D.2
  • 161
    • 0346373649 scopus 로고    scopus 로고
    • Mutation of CERKL, a novel human ceramide kinase gene, causes autosomal recessive retinitis pigmentosa (RP26)
    • Tuson M., Marfany G., Gonzalez-Duarte R. Mutation of CERKL, a novel human ceramide kinase gene, causes autosomal recessive retinitis pigmentosa (RP26). Am. J. Hum. Genet. 2004, 74:128-138.
    • (2004) Am. J. Hum. Genet. , vol.74 , pp. 128-138
    • Tuson, M.1    Marfany, G.2    Gonzalez-Duarte, R.3
  • 163
    • 0031762302 scopus 로고    scopus 로고
    • Photoreceptor dystrophy in the RCS rat: roles of oxygen, debris, and bFGF
    • Valter K., Maslim J., Bowers F., Stone J. Photoreceptor dystrophy in the RCS rat: roles of oxygen, debris, and bFGF. Investig. Ophthalmol. Vis. Sci. 1998, 39:2427-2442.
    • (1998) Investig. Ophthalmol. Vis. Sci. , vol.39 , pp. 2427-2442
    • Valter, K.1    Maslim, J.2    Bowers, F.3    Stone, J.4
  • 168
    • 84912003078 scopus 로고    scopus 로고
    • Intravitreal controlled release of dexamethasone from engineered microparticles of porous silicon dioxide
    • Wang C., Hou H., Nan K., Sailor M.J., Freeman W.R., Cheng L. Intravitreal controlled release of dexamethasone from engineered microparticles of porous silicon dioxide. Exp. Eye Res. 2014, 129:74-82.
    • (2014) Exp. Eye Res. , vol.129 , pp. 74-82
    • Wang, C.1    Hou, H.2    Nan, K.3    Sailor, M.J.4    Freeman, W.R.5    Cheng, L.6
  • 169
    • 84890789300 scopus 로고    scopus 로고
    • Molecular complexes that direct rhodopsin transport to primary cilia
    • Wang J., Deretic D. Molecular complexes that direct rhodopsin transport to primary cilia. Prog. Retin. Eye Res. 2014, 38:1-19.
    • (2014) Prog. Retin. Eye Res. , vol.38 , pp. 1-19
    • Wang, J.1    Deretic, D.2
  • 171
    • 84877350585 scopus 로고    scopus 로고
    • Current advances in using neurotrophic factors to treat neurodegenerative disorders
    • Weissmiller A.M., Wu C. Current advances in using neurotrophic factors to treat neurodegenerative disorders. Transl. Neurodegener. 2012, 1:14.
    • (2012) Transl. Neurodegener. , vol.1 , pp. 14
    • Weissmiller, A.M.1    Wu, C.2
  • 174
    • 84857194991 scopus 로고    scopus 로고
    • Environmental enrichment alters glial antigen expression and neuroimmune function in the adult rat hippocampus
    • Williamson L.L., Chao A., Bilbo S.D. Environmental enrichment alters glial antigen expression and neuroimmune function in the adult rat hippocampus. Brain Behav. Immun. 2012, 26:500-510.
    • (2012) Brain Behav. Immun. , vol.26 , pp. 500-510
    • Williamson, L.L.1    Chao, A.2    Bilbo, S.D.3
  • 175
    • 34548043011 scopus 로고    scopus 로고
    • Retinal prostheses: current challenges and future outlook
    • Winter J.O., Cogan S.F., Rizzo J.F. Retinal prostheses: current challenges and future outlook. J.Biomater. Sci. Polym. Ed. 2007, 18:1031-1055.
    • (2007) J.Biomater. Sci. Polym. Ed. , vol.18 , pp. 1031-1055
    • Winter, J.O.1    Cogan, S.F.2    Rizzo, J.F.3
  • 177
    • 78649443884 scopus 로고    scopus 로고
    • Robust cell integration from co-transplantation of biodegradable MMP2-PLGA microspheres with retinal progenitor cells
    • Yao J., Tucker B.A., Zhang X., Checa-Casalengua P., Herrero-Vanrell R., Young M.J. Robust cell integration from co-transplantation of biodegradable MMP2-PLGA microspheres with retinal progenitor cells. Biomaterials 2011, 32:1041-1050.
    • (2011) Biomaterials , vol.32 , pp. 1041-1050
    • Yao, J.1    Tucker, B.A.2    Zhang, X.3    Checa-Casalengua, P.4    Herrero-Vanrell, R.5    Young, M.J.6
  • 181
    • 3042526482 scopus 로고    scopus 로고
    • Photoreceptor death, trophic factor expression, retinal oxygen status, and photoreceptor function in the P23H rat
    • Yu D.Y., Cringle S., Valter K., Walsh N., Lee D., Stone J. Photoreceptor death, trophic factor expression, retinal oxygen status, and photoreceptor function in the P23H rat. Investig. Ophthalmol. Vis. Sci. 2004, 45:2013-2019.
    • (2004) Investig. Ophthalmol. Vis. Sci. , vol.45 , pp. 2013-2019
    • Yu, D.Y.1    Cringle, S.2    Valter, K.3    Walsh, N.4    Lee, D.5    Stone, J.6
  • 182
    • 0033753749 scopus 로고    scopus 로고
    • Intraretinal oxygen levels before and after photoreceptor loss in the RCS rat
    • Yu D.Y., Cringle S.J., Su E.N., Yu P.K. Intraretinal oxygen levels before and after photoreceptor loss in the RCS rat. Investig. Ophthalmol. Vis. Sci. 2000, 41:3999-4006.
    • (2000) Investig. Ophthalmol. Vis. Sci. , vol.41 , pp. 3999-4006
    • Yu, D.Y.1    Cringle, S.J.2    Su, E.N.3    Yu, P.K.4
  • 183
    • 34547149529 scopus 로고    scopus 로고
    • Translational aspects of sphingolipid metabolism
    • Zeidan Y.H., Hannun Y.A. Translational aspects of sphingolipid metabolism. Trends Mol. Med. 2007, 13:327-336.
    • (2007) Trends Mol. Med. , vol.13 , pp. 327-336
    • Zeidan, Y.H.1    Hannun, Y.A.2
  • 186
    • 84855829483 scopus 로고    scopus 로고
    • Valproic acid-mediated neuroprotection in retinal ischemia injury via histone deacetylase inhibition and transcriptional activation
    • Zhang Z., Qin X., Tong N., Zhao X., Gong Y., Shi Y., Wu X. Valproic acid-mediated neuroprotection in retinal ischemia injury via histone deacetylase inhibition and transcriptional activation. Exp. Eye Res. 2012, 94:98-108.
    • (2012) Exp. Eye Res. , vol.94 , pp. 98-108
    • Zhang, Z.1    Qin, X.2    Tong, N.3    Zhao, X.4    Gong, Y.5    Shi, Y.6    Wu, X.7
  • 187
    • 84859921433 scopus 로고    scopus 로고
    • Valproic acid regulates antioxidant enzymes and prevents ischemia/reperfusion injury in the rat retina
    • Zhang Z., Qin X., Zhao X., Tong N., Gong Y., Zhang W., Wu X. Valproic acid regulates antioxidant enzymes and prevents ischemia/reperfusion injury in the rat retina. Curr. Eye Res. 2012, 37:429-437.
    • (2012) Curr. Eye Res. , vol.37 , pp. 429-437
    • Zhang, Z.1    Qin, X.2    Zhao, X.3    Tong, N.4    Gong, Y.5    Zhang, W.6    Wu, X.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.