The role of ceramide in major depressive disorder

European Archives of Psychiatry and Clinical Neuroscience

Volumn 259, Issue SUPPL. 2, 2009, Pages

  Kornhuber, Johannes ^a   Reichel, Martin ^a   Tripal, Philipp ^a   Groemer, Teja W ^a   Henkel, Andreas W ^a   Mühle, Christiane ^a   Gulbins, Erich ^b  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^b UNIVERSITY OF DUISBURG ESSEN   (Germany)

Author keywords

Acid sphingomyelinase; Amitriptyline; Ceramide; Fluoxetine; Lysosomes; Major depressive disorder; Neuroplasticity hypothesis; Pharmacokinetic hypothesis; Sphingolipids

Indexed keywords

ANTIDEPRESSANT AGENT; CERAMIDE; CITALOPRAM; CLOMIPRAMINE; CYTOKINE; CYTOTOXIC AGENT; DOXEPIN; FLUOXETINE; FLUVOXAMINE; MAPROTILINE; NORTRIPTYLINE; OPIPRAMOL; PAROXETINE; SERTRALINE; SPHINGOMYELIN PHOSPHODIESTERASE;

ARTICLE; BLOOD CELL; CARDIOVASCULAR DISEASE; DEPRESSION; DRUG ACCUMULATION; DRUG DISTRIBUTION; DRUG TARGETING; ENZYME ACTIVITY; HUMAN; IN VIVO STUDY; LYSOSOME; MAJOR DEPRESSION; NEUROBIOLOGY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; OXIDATIVE STRESS; PATHOLOGY; PREVALENCE; PRIORITY JOURNAL;

ANTIDEPRESSIVE AGENTS; BRAIN; CERAMIDES; DEPRESSIVE DISORDER, MAJOR; DOUBLE-BLIND METHOD; HUMANS; SPHINGOMYELIN PHOSPHODIESTERASE;

EID: 73449097161     PISSN: 09401334     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00406-009-0061-x     Document Type: Article

References (60)

1. AC Altamura AR Moro M Percudani 1994 Clinical pharmacokinetics of fluoxetine Clin Pharmacokinet 26 201 214 10.2165/00003088-199426030-00004 1:STN:280:DyaK2c3lt1SitA%3D%3D 8194283
2. R) Psychopharmacologia 11 174 178 10.1007/BF00401254 1:STN:280:DyaF1c3nslSmtQ%3D%3D 5588187
3. N Augé A Nègre-Salvayre R Salvayre T Levade 2000 Sphingomyelin metabolites in vascular cell signaling and atherogenesis Prog Lipid Res 39 207 229 10.1016/S0163-7827(00)00007-2 10799716 (Pubitemid 30224704)
4. K Balon BU Riebesehl BW Müller 1999 Drug liposome partitioning as a tool for the prediction of human passive intestinal absorption Pharm Res 16 882 888 10.1023/A:1018882221008 1:CAS:528:DyaK1MXktVyqsrk%3D 10397609 (Pubitemid 29284200)
5. P Baumann S Ulrich G Eckermann M Gerlach HJ Kuss G Laux B Müller-Oerlinghausen ML Rao P Riederer G Zernig C Hiemke 2005 The AGNP-TDM Expert Group Consensus Guidelines: focus on therapeutic monitoring of antidepressants Dialogues Clin Neurosci 7 231 247 16156382 (Pubitemid 41284688)
6. RH Belmaker G Agam 2008 Major depressive disorder N Engl J Med 358 55 68 10.1056/NEJMra073096 1:CAS:528:DC%2BD1cXisFWjsQ%3D%3D 18172175
7. F Bianco C Perrotta L Novellino M Francolini L Riganti E Menna L Saglietti EH Schuchman R Furlan E Clementi M Matteoli C Verderio 2009 Acid sphingomyelinase activity triggers microparticle release from glial cells EMBO J 28 1043 1054 10.1038/emboj.2009.45 1:CAS:528:DC%2BD1MXjtlyms7w%3D 19300439
8. G Cizza P Ravn GP Chrousos PW Gold 2001 Depression: a major, unrecognized risk factor for osteoporosis? Trends Endocrinol Metab 12 198 203 10.1016/S1043-2760(01)00407-6 1:CAS:528:DC%2BD3MXktVKktro%3D 11397644
9. S Corda C Laplace E Vicaut J Duranteau 2001 Rapid reactive oxygen species production by mitochondria in endothelial cells exposed to tumor necrosis factor-alpha is mediated by ceramide Am J Respir Cell Mol Biol 24 762 768 1:CAS:528:DC%2BD3MXltVWhtrg%3D 11415943
10. MA Coull S Lowther CLE Katona RW Horton 2000 Altered brain protein kinase C in depression: a post-mortem study Eur Neuropsychopharmacol 10 283 288 10.1016/S0924-977X(00)00084-5 1:CAS:528:DC%2BD3cXktlKrt70%3D 10871711
11. O Cuvillier G Pirianov B Kleuser PG Vanek OA Coso S Gutkind S Spiegel 1996 Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate Nature 381 800 803 10.1038/381800a0 1:CAS:528: DyaK28XjvVKnsro%3D 8657285 (Pubitemid 26243122)
12. C de Duve T de Barsy B Poole A Trouet P Tulkens F van Hoof 1974 Lysosomotropic agents Biochem Pharmacol 23 2495 2531 10.1016/0006-2952(74)90174- 9 4606365
13. MJ Forlenza GE Miller 2006 Increased serum levels of 8-hydroxy-2'- deoxyguanosine in clinical depression Psychosom Med 68 1 7 10.1097/01.psy. 0000195780.37277.2a 1:CAS:528:DC%2BD28Xmslajsg%3D%3D 16449405 (Pubitemid 43803209)
14. MG Frank SE Hendricks D Bessette DR Johnson JL Wieseler Frank WJ Burke 2001 Levels of monocyte reactive oxygen species are associated with reduced natural killer cell activity in major depressive disorder Neuropsychobiology 44 1 6 10.1159/000054906 1:CAS:528:DC%2BD3MXlt12htbs%3D 11408785 (Pubitemid 32624675)
15. K Fu RJ Konrad RW Hardy RM Brissie CA Robinson 2000 An unusual multiple drug intoxication case involving citalopram J Anal Toxicol 24 648 650 1:CAS:528:DC%2BD3cXntlOltrg%3D 11043674
16. I Goshen T Kreisel O Ben-Menachem-Zidon T Licht J Weidenfeld T Ben-Hur R Yirmiya 2008 Brain interleukin-1 mediates chronic stress-induced depression in mice via adrenocortical activation and hippocampal neurogenesis suppression Mol Psychiatry 13 717 728 10.1038/sj.mp.4002055 1:CAS:528:DC%2BD1cXnt1alt7w%3D 17700577 (Pubitemid 351861529)
17. I Goshen R Yirmiya 2009 Interleukin-1 (IL-1): a central regulator of stress responses Front Neuroendocrinol 30 30 45 10.1016/j.yfrne.2008.10.001 1:CAS:528:DC%2BD1MXhsVKnug%3D%3D 19017533
18. E Gulbins PL Li 2006 Physiological and pathophysiological aspects of ceramide Am J Physiol Regul Integr Comp Physiol 290 R11 R26 1:CAS:528: DC%2BD28XhsVKisL4%3D 16352856
19. E Gulbins I Szabo K Baltzer F Lang 1997 Ceramide-induced inhibition of T lymphocyte voltage-gated potassium channel is mediated by tyrosine kinases Proc Natl Acad Sci USA 94 7661 7666 10.1073/pnas.94.14.7661 1:CAS:528: DyaK2sXksFyls74%3D 9207149 (Pubitemid 27345373)
20. YA Hannun 1996 Functions of ceramide in coordinating cellular responses to stress Science 274 1855 1859 10.1126/science.274.5294.1855 1:CAS:528:DyaK28XnsFGisrc%3D 8943189 (Pubitemid 26424756)
21. ME Henry ME Schmidt J Hennen RA Villafuerte ML Butman P Tran LT Kerner B Cohen PF Renshaw 2005 A comparison of brain and serum pharmacokinetics of R-fluoxetine and racemic fluoxetine: a 19-F MRS study Neuropsychopharmacology 30 1576 1583 10.1038/sj.npp.1300749 1:CAS:528:DC%2BD2MXnvF2nur4%3D 15886723 (Pubitemid 41153130)
22. 2 a predisposing factor in affective illness? Biol Psychiatry 25 945 961 10.1016/0006-3223(89)90274-6 1:CAS:528:DyaL1MXktVGjtLY%3D 2566335 (Pubitemid 19122770)
23. R Hofmeister K Wiegmann C Korherr K Bernardo M Kronke W Falk 1997 Activation of acid sphingomyelinase by interleukin-1 (IL-1) requires the IL-1 receptor accessory protein J Biol Chem 272 27730 27736 10.1074/jbc.272.44.27730 1:CAS:528:DyaK2sXnt12ls7Y%3D 9346915 (Pubitemid 27473570)
24. MB Howren DM Lamkin J Suls 2009 Associations of depression with C-reactive protein, IL-1, and IL-6: a meta-analysis Psychosom Med 71 171 186 10.1097/PSY.0b013e3181907c1b 1:CAS:528:DC%2BD1MXhsFOkt7k%3D 19188531
25. 2 and facilitates its membrane docking and arachidonic acid release FASEB J 15 7 9 1:CAS:528:DC%2BD3MXht1SnsrY%3D 11099485
26. M Irie S Asami S Nagata M Miyata H Kasai 2001 Relationships between perceived workload, stress and oxidative DNA damage Int Arch Occup Environ Health 74 153 157 10.1007/s004200000209 1:CAS:528:DC%2BD3MXht1Ols7k%3D 11317710 (Pubitemid 32229220)
27. J Ishizaki K Yokogawa M Hirano E Nakashima Y Sai S Ohkuma T Ohshima F Ichimura 1996 Contribution of lysosomes to the subcellular distribution of basic drugs in the rat liver Pharm Res 13 902 906 10.1023/A:1016061330387 1:CAS:528:DyaK28Xjs1yrt7g%3D 8792430 (Pubitemid 26227748)
28. CN Karson JEO Newton R Livingston JB Jolly TB Cooper J Sprigg RA Komoroski 1993 Human brain fluoxetine concentrations J Neuropsychiatry Clin Neurosci 5 322 329 1:STN:280:DyaK3sznvFClsQ%3D%3D 8369643
29. M Kölzer N Werth K Sandhoff 2004 Interactions of acid sphingomyelinase and lipid bilayers in the presence of the tricyclic antidepressant desipramine FEBS Lett 559 96 98 10.1016/S0014-5793(04)00033-X 14960314 (Pubitemid 38186710)
30. JW Koo RS Duman 2008 IL-1beta is an essential mediator of the antineurogenic and anhedonic effects of stress Proc Natl Acad Sci USA 105 751 756 10.1073/pnas.0708092105 1:CAS:528:DC%2BD1cXpvFOhsw%3D%3D 18178625 (Pubitemid 351171780)
31. Kornhuber J, Henkel AW, Groemer TW, Städtler S, Welzel O, Tripal P, Rotter A, Bleich S, Trapp S (2009) Lipophilic cationic drugs increase the permeability of lysosomal membranes in a cell culture system (submitted)
32. J Kornhuber A Medlin S Bleich V Jendrossek AW Henkel J Wiltfang E Gulbins 2005 High activity of acid sphingomyelinase in major depression J Neural Transm 112 1583 1590 10.1007/s00702-005-0374-5 1:CAS:528:DC%2BD2MXhtFersLrO 16245071 (Pubitemid 41504272)
33. J Kornhuber W Retz P Riederer 1995 Slow accumulation of psychotropic substances in the human brain: relationship to therapeutic latency of neuroleptic and antidepressant drugs? J Neural Transm Suppl 46 311 319
34. J Kornhuber P Tripal M Reichel L Terfloth S Bleich J Wiltfang E Gulbins 2008 Identification of new functional inhibitors of acid sphingomyelinase using a structure-property-activity relation model J Med Chem 51 219 237 10.1021/jm070524a 1:CAS:528:DC%2BD2sXhtlejsbnP 18027916
35. 2 and alter its fatty acid specificity Biochem J 363 45 51 10.1042/0264-6021:3630045 1:CAS:528: DC%2BD38Xjt1aks74%3D 11903045 (Pubitemid 34280610)
36. A Lepple-Wienhues C Belka T Laun A Jekle B Walter U Wieland M Welz L Heil J Kun G Busch M Weller M Bamberg E Gulbins F Lang 1999 Stimulation of CD95 (Fas) blocks T lymphocyte calcium channels through sphingomyelinase and sphingolipids Proc Natl Acad Sci USA 96 13795 13800 10.1073/pnas.96.24.13795 1:CAS:528:DyaK1MXns1Oqt70%3D 10570152
37. F Lombardo RS Obach MY Shalaeva F Gao 2004 Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics J Med Chem 47 1242 1250 10.1021/jm030408h 1:CAS:528:DC%2BD2cXosFKrsQ%3D%3D 14971904 (Pubitemid 38229126)
38. M Maes R Smith A Christophe E Vandoolaeghe A Van Gastel H Neels P Demedts A Wauters HY Meltzer 1997 Lower serum high-density lipoprotein cholesterol (HDL-C) in major depression and in depressed men with serious suicidal attempts: relationship with immune-inflammatory markers Acta Psychiatr Scand 95 212 221 10.1111/j.1600-0447.1997.tb09622.x 1:STN:280:DyaK2s3ms1Smsg%3D%3D 9111854
39. S Marathe G Kuriakose KJ Williams I Tabas 1999 Sphingomyelinase, an enzyme implicated in atherogenesis, is present in atherosclerotic lesions and binds to specific components of the subendothelial extracellular matrix Arterioscler Thromb Vasc Biol 19 2648 2658 1:CAS:528:DyaK1MXnvVars7k%3D 10559007
40. G Müller M Ayoub P Storz J Rennecke D Fabbro K Pfizenmaier 1995 PKC ζ is a molecular switch in signal transduction of TNF-α, bifunctionally regulated by ceramide and arachidonic acid EMBO J 14 1961 1969 7744003
41. DL Musselman DL Evans CB Nemeroff 1998 The relationship of depression to cardiovascular disease: epidemiology, biology, and treatment Arch Gen Psychiatry 55 580 592 10.1001/archpsyc.55.7.580 1:STN:280:DyaK1czjsFOluw%3D%3D 9672048 (Pubitemid 28340345)
42. ME Ozcan M Gulec E Ozerol R Polat O Akyol 2004 Antioxidant enzyme activities and oxidative stress in affective disorders Int Clin Psychopharmacol 19 89 95 10.1097/00004850-200403000-00006 15076017 (Pubitemid 38316767)
43. GN Pandey Y Dwivedi HS Rizavi X Ren RR Conley 2004 Decreased catalytic activity and expression of protein kinase C isozymes in teenage suicide victims: a postmortem brain study Arch Gen Psychiatry 61 685 693 10.1001/archpsyc.61.7. 685 1:CAS:528:DC%2BD2cXms1ahu7s%3D 15237080 (Pubitemid 38890802)
44. G Parker NA Gibson H Brotchie G Heruc AM Rees D Hadzi-Pavlovic 2006 Omega-3 fatty acids and mood disorders Am J Psychiatry 163 969 978 10.1176/appi.ajp.163.6.969 16741195 (Pubitemid 44464482)
45. M Pascual SL Valles J Renau-Piqueras C Guerri 2003 Ceramide pathways modulate ethanol-induced cell death in astrocytes J Neurochem 87 1535 1545 1:CAS:528:DC%2BD2cXit1yr 14713309
46. DC Phillips K Allen HR Griffiths 2002 Synthetic ceramides induce growth arrest or apoptosis by altering cellular redox status Arch Biochem Biophys 407 15 24 10.1016/S0003-9861(02)00496-4 1:CAS:528:DC%2BD38XnvVyhtb4%3D 12392710 (Pubitemid 35283577)
47. H Qiu T Edmunds J Baker-Malcolm KP Karey S Estes C Schwarz H Hughes SM Van Patten 2003 Activation of human acid sphingomyelinase through modification or deletion of C-terminal cysteine J Biol Chem 278 32744 32752 10.1074/jbc.M303022200 1:CAS:528:DC%2BD3sXms1amtbw%3D 12801930 (Pubitemid 37055714)
48. Y Ramu Y Xu Z Lu 2006 Enzymatic activation of voltage-gated potassium channels Nature 442 696 699 10.1038/nature04880 1:CAS:528:DC%2BD28XnvVynsrw%3D 16799569 (Pubitemid 44215325)
49. Reichel M, Greiner E, Richter-Schmdinger T, Yedibela Ö, Tripal P, Jacobi A, Bleich S, Gulbins E, Kornhuber J (2009) Increased acid sphingomyelinase activity in peripheral blood cells of acutely intoxicated patients with alcohol dependence. Alcohol Clin Exp Res (in press)
50. EL Riddle KS Rau MK Topham GR Hanson AE Fleckenstein 2003 Ceramide-induced alterations in dopamine transporter function Eur J Pharmacol 458 31 36 10.1016/S0014-2999(02)02727-9 1:CAS:528:DC%2BD38Xpslalt7w%3D 12498904 (Pubitemid 36050698)
51. S Schütze K Potthoff T Machleidt D Berkovic K Wiegmann M Krönke 1992 TNF activates NF-kappa B by phosphatidylcholine-specific phospholipase C-induced "acidic" sphingomyelin breakdown Cell 71 765 776 10.1016/0092-8674(92)90553-O
52. A Schwarz AH Futerman 1997 Distinct roles for ceramide and glucosylceramide at different stages of neuronal growth J Neurosci 17 2929 2938 1:CAS:528:DyaK2sXislaiur8%3D 9096129
53. H Sietsma RJ Veldman JW Kok 2001 The involvement of sphingolipids in multidrug resistance J Membr Biol 181 153 162 1:CAS:528:DC%2BD3MXks1amtbc%3D 11420602
54. EL Smith EH Schuchman 2008 The unexpected role of acid sphingomyelinase in cell death and the pathophysiology of common diseases FASEB J 22 3419 3431 10.1096/fj.08-108043 1:CAS:528:DC%2BD1cXht1SqsrnM 18567738
55. S Spiegel O Cuvillier LC Edsall T Kohama R Menzeleev Z Olah A Olivera G Pirianov DM Thomas Z Tu B Van Jr F Wang 1998 Sphingosine-1-phosphate in cell growth and cell death Ann N Y Acad Sci 845 11 18 10.1111/j.1749-6632.1998. tb09658.x 1:CAS:528:DyaK1cXks12htb0%3D 9668339 (Pubitemid 28365296)
56. S Trapp GR Rosania RW Horobin J Kornhuber 2008 Quantitative modeling of selective lysosomal targeting for drug design Eur Biophys J 37 1317 1328 10.1007/s00249-008-0338-4 1:CAS:528:DC%2BD1cXhtFajt7nK 18504571
57. P Videbech B Ravnkilde 2004 Hippocampal volume and depression: a meta-analysis of MRI studies Am J Psychiatry 161 1957 1966 10.1176/appi.ajp.161. 11.1957 15514393 (Pubitemid 39441394)
58. JS Won I Singh 2006 Sphingolipid signaling and redox regulation Free Radic Biol Med 40 1875 1888 10.1016/j.freeradbiomed.2006.01.035 1:CAS:528:DC%2BD28XkvVyjtbc%3D 16716889 (Pubitemid 43728861)
59. YH Zeidan YA Hannun 2007 Activation of acid sphingomyelinase by protein kinase Cδ-mediated phosphorylation J Biol Chem 282 11549 11561 10.1074/jbc.M609424200 1:CAS:528:DC%2BD2sXjvFagtbs%3D 17303575 (Pubitemid 47100781)
60. X Zha LM Pierini PL Leopold PJ Skiba I Tabas FR Maxfield 1998 Sphingomyelinase treatment induces ATP-independent endocytosis J Cell Biol 140 39 47 10.1083/jcb.140.1.39 1:CAS:528:DyaK1cXktFKnuw%3D%3D 9425152 (Pubitemid 28070892)