메뉴 건너뛰기




Volumn 98, Issue 5, 2006, Pages 1432-1444

Ceramide is the key mediator of oxidative stress-induced apoptosis in retinal photoreceptor cells

Author keywords

Apoptosis; Ceramide; Oxidative stress; Photoreceptor; Retina; Sphingomyelinase

Indexed keywords

CALCIUM ION; CALPAIN; CASPASE; CATHEPSIN D; CERAMIDE; NITRIC OXIDE; NITRIC OXIDE DONOR; NITROPRUSSIDE SODIUM; REACTIVE OXYGEN METABOLITE; SPHINGOLIPID; SPHINGOMYELIN; SPHINGOMYELIN PHOSPHODIESTERASE;

EID: 33746874469     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2006.03977.x     Document Type: Article
Times cited : (99)

References (68)
  • 1
    • 0037436579 scopus 로고    scopus 로고
    • Modulating sphingolipid biosynthetic pathway rescues photoreceptor degeneration
    • Acharya U., Patel S., Koundakjian E., Nagashima K., Han X. and Acharya J. (2003) Modulating sphingolipid biosynthetic pathway rescues photoreceptor degeneration. Science 299, 1740-1743.
    • (2003) Science , vol.299 , pp. 1740-1743
    • Acharya, U.1    Patel, S.2    Koundakjian, E.3    Nagashima, K.4    Han, X.5    Acharya, J.6
  • 2
    • 0027074996 scopus 로고
    • Bilateral retinal and brain tumors in transgenic mice expressing simian virus 40 large T antigen under control of the human interphotoreceptor retinoid-binding protein promoter
    • Al-Ubaidi M. R., Font R. L., Quiambao A. B., Keener M. J., Liou G. I., Overbeek P. A. and Baehr W. (1992) Bilateral retinal and brain tumors in transgenic mice expressing simian virus 40 large T antigen under control of the human interphotoreceptor retinoid-binding protein promoter. J. Cell Biol. 119, 1681-1687.
    • (1992) J. Cell Biol. , vol.119 , pp. 1681-1687
    • Al-Ubaidi, M.R.1    Font, R.L.2    Quiambao, A.B.3    Keener, M.J.4    Liou, G.I.5    Overbeek, P.A.6    Baehr, W.7
  • 4
    • 0038662790 scopus 로고    scopus 로고
    • The mitochondria-associated endoplasmic-reticulum subcompartment (MAM fraction) of rat liver contains highly active sphingolipid-specific glycosyltransferases
    • Ardail D., Popa I., Bodennec J., Louisot P., Schmitt D. and Portoukalian J. (2003) The mitochondria-associated endoplasmic-reticulum subcompartment (MAM fraction) of rat liver contains highly active sphingolipid-specific glycosyltransferases. Biochem. J. 371, 1013-1019.
    • (2003) Biochem. J. , vol.371 , pp. 1013-1019
    • Ardail, D.1    Popa, I.2    Bodennec, J.3    Louisot, P.4    Schmitt, D.5    Portoukalian, J.6
  • 5
    • 0036961878 scopus 로고    scopus 로고
    • Nitric oxide production stimulated by the basic fibroblast growth factor requires the synthesis of ceramide
    • Arena S., Pattarozzi A., Thellung S. et al. (2002) Nitric oxide production stimulated by the basic fibroblast growth factor requires the synthesis of ceramide. Ann. N Y Acad. Sci. 973, 94-104.
    • (2002) Ann. N Y Acad. Sci. , vol.973 , pp. 94-104
    • Arena, S.1    Pattarozzi, A.2    Thellung, S.3
  • 6
    • 33845261493 scopus 로고
    • A rapid method of total lipid extraction and purification
    • Bligh E. and Dyer W. (1959) A rapid method of total lipid extraction and purification. Can. J. Biochem. Physiol. 37, 911-917.
    • (1959) Can. J. Biochem. Physiol. , vol.37 , pp. 911-917
    • Bligh, E.1    Dyer, W.2
  • 7
    • 0037968385 scopus 로고    scopus 로고
    • Introduction to apoptosis in ophthalmology
    • Carella G. (2003) Introduction to apoptosis in ophthalmology. Eur. J. Ophthalmol. 3, S5-S10.
    • (2003) Eur. J. Ophthalmol. , vol.3
    • Carella, G.1
  • 8
    • 0034027927 scopus 로고    scopus 로고
    • Oxidative stress induces caspase-independent retinal apoptosis in vitro
    • Carmody R. J. and Cotter T. G. (2000) Oxidative stress induces caspase-independent retinal apoptosis in vitro. Cell Death Differ. 7, 282-291.
    • (2000) Cell Death Differ. , vol.7 , pp. 282-291
    • Carmody, R.J.1    Cotter, T.G.2
  • 9
    • 0027521914 scopus 로고
    • Apoptosis: Final common pathway of photoreceptor death in rd, rds, and rhodopsin mutant mice
    • Chang G. Q., Hao Y. and Wong F. (1993) Apoptosis: final common pathway of photoreceptor death in rd, rds, and rhodopsin mutant mice. Neuron 11, 595-605.
    • (1993) Neuron , vol.11 , pp. 595-605
    • Chang, G.Q.1    Hao, Y.2    Wong, F.3
  • 10
    • 0942265544 scopus 로고    scopus 로고
    • Selective disruption of lysosomes in HeLa cells triggers apoptosis mediated by cleavage of Bid by multiple papain-like lysosomal cathepsins
    • Cirman T., Oresic K., Mazovec G., Turk V., Reed J., Myers R., Salvesen G. and Turk B. (2004) Selective disruption of lysosomes in HeLa cells triggers apoptosis mediated by cleavage of Bid by multiple papain-like lysosomal cathepsins. J. Biol. Chem. 279, 3578-3587.
    • (2004) J. Biol. Chem. , vol.279 , pp. 3578-3587
    • Cirman, T.1    Oresic, K.2    Mazovec, G.3    Turk, V.4    Reed, J.5    Myers, R.6    Salvesen, G.7    Turk, B.8
  • 11
    • 2442711625 scopus 로고    scopus 로고
    • Mitochondrial ceramide increases in UV-irradiated HeLa cells and is mainly derived from hydrolysis of sphingomyelin
    • Dai Q., Liu J., Chen J., Durrant D., McIntyre T. and Lee R. (2004) Mitochondrial ceramide increases in UV-irradiated HeLa cells and is mainly derived from hydrolysis of sphingomyelin. Oncogene 23, 3650-3658.
    • (2004) Oncogene , vol.23 , pp. 3650-3658
    • Dai, Q.1    Liu, J.2    Chen, J.3    Durrant, D.4    McIntyre, T.5    Lee, R.6
  • 12
    • 0032479460 scopus 로고    scopus 로고
    • Mitochondria and cells produce reactive oxygen species in virtual anaerobiosis: Relevance to ceramide-induced apoptosis
    • Degli Esposti M. and McLennan H. (1998) Mitochondria and cells produce reactive oxygen species in virtual anaerobiosis: relevance to ceramide-induced apoptosis. FEBS Lett. 430, 338-342.
    • (1998) FEBS Lett. , vol.430 , pp. 338-342
    • Degli Esposti, M.1    McLennan, H.2
  • 13
    • 0036850537 scopus 로고    scopus 로고
    • Caspase-independent photoreceptor apoptosis in vivo and differential expression of apoptotic protease activating factor-1 and caspase-3 during retinal development
    • Donovan M. and Cotter T. G. (2002) Caspase-independent photoreceptor apoptosis in vivo and differential expression of apoptotic protease activating factor-1 and caspase-3 during retinal development. Cell Death Differ. 9, 1220-1231.
    • (2002) Cell Death Differ. , vol.9 , pp. 1220-1231
    • Donovan, M.1    Cotter, T.G.2
  • 14
    • 0035933741 scopus 로고    scopus 로고
    • Light-induced photoreceptor apoptosis in vivo requires neuronal nitric-oxide synthase and guanylate cyclase activity and is caspase-3- independent
    • Donovan M., Carmody R. J. and Cotter T. G. (2001) Light-induced photoreceptor apoptosis in vivo requires neuronal nitric-oxide synthase and guanylate cyclase activity and is caspase-3-independent. J. Biol. Chem. 276, 23 000-23 008.
    • (2001) J. Biol. Chem. , vol.276 , pp. 23000-23008
    • Donovan, M.1    Carmody, R.J.2    Cotter, T.G.3
  • 15
    • 0037707639 scopus 로고    scopus 로고
    • Caspase-independent photoreceptor apoptosis in mouse models of retinal degeneration
    • Doonan F., Donovan M. and Cotter T. G. (2003) Caspase-independent photoreceptor apoptosis in mouse models of retinal degeneration. J. Neurosci. 23, 5723-5731.
    • (2003) J. Neurosci. , vol.23 , pp. 5723-5731
    • Doonan, F.1    Donovan, M.2    Cotter, T.G.3
  • 16
    • 32944467645 scopus 로고    scopus 로고
    • Activation of multiple pathways during photoreceptor apoptosis in the rd mouse
    • Doonan F., Donovan M. and Cotter T. G. (2005) Activation of multiple pathways during photoreceptor apoptosis in the rd mouse. Invest. Ophthalmol. Vis. Sci. 46, 3550-3558.
    • (2005) Invest. Ophthalmol. Vis. Sci. , vol.46 , pp. 3550-3558
    • Doonan, F.1    Donovan, M.2    Cotter, T.G.3
  • 17
    • 0036875316 scopus 로고    scopus 로고
    • The role of apoptosis in age-related macular degeneration
    • Dunaief J. L., Dentchev T., Ying G. S. and Milam A. H. (2002) The role of apoptosis in age-related macular degeneration. Arch. Ophthalmol. 120, 1435-1442.
    • (2002) Arch. Ophthalmol. , vol.120 , pp. 1435-1442
    • Dunaief, J.L.1    Dentchev, T.2    Ying, G.S.3    Milam, A.H.4
  • 18
    • 19344363059 scopus 로고    scopus 로고
    • Endothelial apoptosis induced by inhibition of integrins alphavbeta3 and alphavbeta5 involves ceramide metabolic pathways
    • Erdreich-Epstein A., Tran L., Cox O., Huang E., Laug W., Shimada H. and Millard M. (2005) Endothelial apoptosis induced by inhibition of integrins alphavbeta3 and alphavbeta5 involves ceramide metabolic pathways. Blood 105, 4353-4361.
    • (2005) Blood , vol.105 , pp. 4353-4361
    • Erdreich-Epstein, A.1    Tran, L.2    Cox, O.3    Huang, E.4    Laug, W.5    Shimada, H.6    Millard, M.7
  • 19
    • 0035736259 scopus 로고    scopus 로고
    • Organelle-specific initiation of cell death pathways
    • Ferri K. F. and Kroemer G. (2001) Organelle-specific initiation of cell death pathways. Nat. Cell Biol. 3, E255-E263.
    • (2001) Nat. Cell Biol. , vol.3
    • Ferri, K.F.1    Kroemer, G.2
  • 20
    • 3142721782 scopus 로고    scopus 로고
    • Induction of phase 2 genes by sulforaphane protects retinal pigment epithelial cells against photooxidative damage
    • Gao X. and Talalay P. (2004) Induction of phase 2 genes by sulforaphane protects retinal pigment epithelial cells against photooxidative damage. Proc. Natl Acad. Sci. USA 101, 10 446-10 451.
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , pp. 10446-10451
    • Gao, X.1    Talalay, P.2
  • 21
    • 1842330849 scopus 로고    scopus 로고
    • Direct effect of ceramide on the mitochondrial electron transport chain leads to generation of reactive oxygen species. Role of mitochondrial glutathione
    • Garcia-Ruiz C., Colell A., Mari M., Morales A. and Fernandez-Checa J. (1997) Direct effect of ceramide on the mitochondrial electron transport chain leads to generation of reactive oxygen species. Role of mitochondrial glutathione. J. Biol. Chem. 272, 11 369-11 377.
    • (1997) J. Biol. Chem. , vol.272 , pp. 11369-11377
    • Garcia-Ruiz, C.1    Colell, A.2    Mari, M.3    Morales, A.4    Fernandez-Checa, J.5
  • 22
    • 21744460556 scopus 로고    scopus 로고
    • Multiple death pathways in retina-derived 661W cells following growth factor deprivation: Cross-talk between caspases and calpains
    • Gomez-Vicente V., Donovan M. and Cotter T. G. (2005) Multiple death pathways in retina-derived 661W cells following growth factor deprivation: cross-talk between caspases and calpains. Cell Death Differ. 12, 796-804.
    • (2005) Cell Death Differ. , vol.12 , pp. 796-804
    • Gomez-Vicente, V.1    Donovan, M.2    Cotter, T.G.3
  • 23
    • 0031027794 scopus 로고    scopus 로고
    • Role of peroxide and superoxide anion during tumour cell apoptosis
    • Gorman A., McGowan A. and Cotter T. G. (1997) Role of peroxide and superoxide anion during tumour cell apoptosis. FEBS Lett. 404, 27-33.
    • (1997) FEBS Lett. , vol.404 , pp. 27-33
    • Gorman, A.1    McGowan, A.2    Cotter, T.G.3
  • 24
    • 0032575752 scopus 로고    scopus 로고
    • Mitochondria and apoptosis
    • Green D. and Reed J. (1998) Mitochondria and apoptosis. Science 281, 1309-1312.
    • (1998) Science , vol.281 , pp. 1309-1312
    • Green, D.1    Reed, J.2
  • 25
    • 0030856714 scopus 로고    scopus 로고
    • Direct inhibition of mitochondrial respiratory chain complex III by cell-permeable ceramide
    • Gudz T., Tserng K. and Hoppel C. (1997) Direct inhibition of mitochondrial respiratory chain complex III by cell-permeable ceramide. J. Biol. Chem. 272, 24 154-24 158.
    • (1997) J. Biol. Chem. , vol.272 , pp. 24154-24158
    • Gudz, T.1    Tserng, K.2    Hoppel, C.3
  • 27
    • 0033214095 scopus 로고    scopus 로고
    • Cathepsin D targeted by acid sphingomyelinase-derived ceramide
    • Heinrich M., Wickel M., Schneider-Brachert W. et al. (1999) Cathepsin D targeted by acid sphingomyelinase-derived ceramide. EMBO J. 18, 5252-5263.
    • (1999) EMBO J. , vol.18 , pp. 5252-5263
    • Heinrich, M.1    Wickel, M.2    Schneider-Brachert, W.3
  • 28
    • 2442661614 scopus 로고    scopus 로고
    • Cathepsin D links TNF-induced acid sphingomyelinase to Bid-mediated caspase-9 and -3 activation
    • Heinrich M., Neumeyer J., Jakob M. et al. (2004) Cathepsin D links TNF-induced acid sphingomyelinase to Bid-mediated caspase-9 and -3 activation. Cell Death Differ. 11, 550-563.
    • (2004) Cell Death Differ. , vol.11 , pp. 550-563
    • Heinrich, M.1    Neumeyer, J.2    Jakob, M.3
  • 29
    • 0042090272 scopus 로고    scopus 로고
    • Oxidized low density lipoprotein inhibits macrophage apoptosis by blocking ceramide generation, thereby maintaining protein kinase B activation and Bcl-XL levels
    • Hundal R., Gomez-Munoz A., Kong J., Salh B., Marotta A., Duronio V. and Steinbrecher U. (2003) Oxidized low density lipoprotein inhibits macrophage apoptosis by blocking ceramide generation, thereby maintaining protein kinase B activation and Bcl-XL levels. J. Biol. Chem. 278, 24 399-24 408.
    • (2003) J. Biol. Chem. , vol.278 , pp. 24399-24408
    • Hundal, R.1    Gomez-Munoz, A.2    Kong, J.3    Salh, B.4    Marotta, A.5    Duronio, V.6    Steinbrecher, U.7
  • 30
    • 0028468309 scopus 로고
    • The tricyclic antidepressant desipramine causes proteolytic degradation of lysosomal sphingomyelinase in human.broblasts
    • Hurwitz R., Ferlinz K. and Sandhoff K. (1994) The tricyclic antidepressant desipramine causes proteolytic degradation of lysosomal sphingomyelinase in human .broblasts. Biol. Chem. Hoppe Seyler 375, 447-450.
    • (1994) Biol. Chem. Hoppe Seyler , vol.375 , pp. 447-450
    • Hurwitz, R.1    Ferlinz, K.2    Sandhoff, K.3
  • 31
    • 0033548599 scopus 로고    scopus 로고
    • Nitric oxide donors induce stress signaling via ceramide formation in rat renal mesangial cells
    • Huwiler A., Pfeilschifter J. and van den Bosch H. (1999) Nitric oxide donors induce stress signaling via ceramide formation in rat renal mesangial cells. J. Biol. Chem. 274, 7190-7195.
    • (1999) J. Biol. Chem. , vol.274 , pp. 7190-7195
    • Huwiler, A.1    Pfeilschifter, J.2    Van Den Bosch, H.3
  • 34
    • 0242609099 scopus 로고    scopus 로고
    • Cathepsin D mediates cytochrome c release and caspase activation in human fibroblast apoptosis induced by staurosporine
    • Johansson A., Steen H., Ollinger K. and Roberg K. (2003) Cathepsin D mediates cytochrome c release and caspase activation in human fibroblast apoptosis induced by staurosporine. Cell Death Differ. 10, 1253-1259.
    • (2003) Cell Death Differ. , vol.10 , pp. 1253-1259
    • Johansson, A.1    Steen, H.2    Ollinger, K.3    Roberg, K.4
  • 35
    • 0035408169 scopus 로고    scopus 로고
    • The lysosomal protease cathepsin D mediates apoptosis induced by oxidative stress
    • Kagedal K., Johansson U. and Ollinger K. (2001) The lysosomal protease cathepsin D mediates apoptosis induced by oxidative stress. FASEB J. 15, 1592-1594.
    • (2001) FASEB J. , vol.15 , pp. 1592-1594
    • Kagedal, K.1    Johansson, U.2    Ollinger, K.3
  • 36
    • 0035575679 scopus 로고    scopus 로고
    • Programmed cell death: Alive and well in the new millennium
    • Kaufmann S. H. and Hengartner M. O. (2001) Programmed cell death: alive and well in the new millennium. Trends Cell Biol. 11, 526-534.
    • (2001) Trends Cell Biol. , vol.11 , pp. 526-534
    • Kaufmann, S.H.1    Hengartner, M.O.2
  • 37
    • 0033524924 scopus 로고    scopus 로고
    • Photooxidative stress down-modulates the activity of nuclear factor-kappaB via involvement of caspase-1, leading to apoptosis of photoreceptor cells
    • Krishnamoorthy R. R., Crawford M. J., Chaturvedi M. M., Jain S. K., Aggarwal B. B., Al-Ubaidi M. R. and Agarwal N. (1999) Photooxidative stress down-modulates the activity of nuclear factor-kappaB via involvement of caspase-1, leading to apoptosis of photoreceptor cells. J. Biol. Chem. 274, 3734-3743.
    • (1999) J. Biol. Chem. , vol.274 , pp. 3734-3743
    • Krishnamoorthy, R.R.1    Crawford, M.J.2    Chaturvedi, M.M.3    Jain, S.K.4    Aggarwal, B.B.5    Al-Ubaidi, M.R.6    Agarwal, N.7
  • 38
    • 0037375044 scopus 로고    scopus 로고
    • Oxidative stress-induced mitochondrial DNA damage in human retinal pigment epithelial cells: A possible mechanism for RPE aging and age-related macular degeneration
    • Liang F. Q. and Godley B. F. (2003) Oxidative stress-induced mitochondrial DNA damage in human retinal pigment epithelial cells: a possible mechanism for RPE aging and age-related macular degeneration. Exp. Eye Res. 76, 397-403.
    • (2003) Exp. Eye Res. , vol.76 , pp. 397-403
    • Liang, F.Q.1    Godley, B.F.2
  • 39
    • 0036256178 scopus 로고    scopus 로고
    • Triggering caspase-independent cell death to combat cancer
    • Mathiasen I. and Jaattela M. (2002) Triggering caspase-independent cell death to combat cancer. Trends Mol. Med. 8, 212-220.
    • (2002) Trends Mol. Med. , vol.8 , pp. 212-220
    • Mathiasen, I.1    Jaattela, M.2
  • 40
    • 0041766297 scopus 로고    scopus 로고
    • Screening for nitric oxide-dependent protein-protein interactions
    • Matsumoto A., Comatas K. E., Liu L. and Stamler J. S. (2003) Screening for nitric oxide-dependent protein-protein interactions. Science 301, 657-661.
    • (2003) Science , vol.301 , pp. 657-661
    • Matsumoto, A.1    Comatas, K.E.2    Liu, L.3    Stamler, J.S.4
  • 41
    • 0037163856 scopus 로고    scopus 로고
    • New advances on structural and biological functions of ceramide in apoptotic/necrotic cell death and cancer
    • Mimeault M. (2002) New advances on structural and biological functions of ceramide in apoptotic/necrotic cell death and cancer. FEBS Lett. 530, 9-16.
    • (2002) FEBS Lett. , vol.530 , pp. 9-16
    • Mimeault, M.1
  • 42
    • 0033578378 scopus 로고    scopus 로고
    • Inhibition of nitric-oxide synthase 2 by aminoguanidine provides neuroprotection of retinal ganglion cells in a rat model of chronic glaucoma
    • Neufeld A., Sawada A. and Becker B. (1999) Inhibition of nitric-oxide synthase 2 by aminoguanidine provides neuroprotection of retinal ganglion cells in a rat model of chronic glaucoma. Proc. Natl Acad. Sci. USA 96, 9944-9948.
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 9944-9948
    • Neufeld, A.1    Sawada, A.2    Becker, B.3
  • 43
    • 0032785021 scopus 로고    scopus 로고
    • Caspase structure, proteolytic substrates, and function during apoptotic cell death
    • Nicholson D. W. (1999) Caspase structure, proteolytic substrates, and function during apoptotic cell death. Cell Death Differ. 6, 1028-1042.
    • (1999) Cell Death Differ. , vol.6 , pp. 1028-1042
    • Nicholson, D.W.1
  • 45
    • 0027511687 scopus 로고
    • Programmed cell death induced by ceramide
    • Obeid L., Linardic C., Karolak L. and Hannun Y. (1993) Programmed cell death induced by ceramide. Science 259, 1769-1771.
    • (1993) Science , vol.259 , pp. 1769-1771
    • Obeid, L.1    Linardic, C.2    Karolak, L.3    Hannun, Y.4
  • 46
    • 0034650786 scopus 로고    scopus 로고
    • Inhibition of cathepsin D prevents free-radical-induced apoptosis in rat cardiomyocytes
    • Ollinger K. (2000) Inhibition of cathepsin D prevents free-radical-induced apoptosis in rat cardiomyocytes. Arch. Biochem. Biophys. 373, 346-351.
    • (2000) Arch. Biochem. Biophys. , vol.373 , pp. 346-351
    • Ollinger, K.1
  • 48
    • 0037203342 scopus 로고    scopus 로고
    • Ceramide in apoptosis: An overview and current perspectives
    • Pettus B., Chalfant C. and Hannun Y. (2002) Ceramide in apoptosis: an overview and current perspectives. Biochim. Biophys. Acta 1585, 114-125.
    • (2002) Biochim. Biophys. Acta , vol.1585 , pp. 114-125
    • Pettus, B.1    Chalfant, C.2    Hannun, Y.3
  • 49
    • 0346577312 scopus 로고    scopus 로고
    • NO induced apoptosis of vascular smooth muscle cells accompanied by ceramide increase
    • Pilane C. M. and LaBelle E. F. (2004) NO induced apoptosis of vascular smooth muscle cells accompanied by ceramide increase. J. Cell Physiol. 199, 310-315.
    • (2004) J. Cell Physiol. , vol.199 , pp. 310-315
    • Pilane, C.M.1    LaBelle, E.F.2
  • 50
    • 0035355341 scopus 로고    scopus 로고
    • The Ca2+ concentration of the endoplasmic reticulum is a key determinant of ceramide-induced apoptosis: Significance for the molecular mechanism of Bcl-2 action
    • Pinton P., Ferrari D., Rapizzi E., Di Virgilio F., Pozzan T. and Rizzuto R. (2001) The Ca2+ concentration of the endoplasmic reticulum is a key determinant of ceramide-induced apoptosis: significance for the molecular mechanism of Bcl-2 action. EMBO J. 20, 2690-2701.
    • (2001) EMBO J. , vol.20 , pp. 2690-2701
    • Pinton, P.1    Ferrari, D.2    Rapizzi, E.3    Di Virgilio, F.4    Pozzan, T.5    Rizzuto, R.6
  • 51
    • 1842375100 scopus 로고    scopus 로고
    • Implication of mitochondrial hydrogen peroxide generation in ceramide-induced apoptosis
    • Quillet-Mary A., Jaffrezou J., Mansat V., Bordier C., Naval J. and Laurent G. (1997) Implication of mitochondrial hydrogen peroxide generation in ceramide-induced apoptosis. J. Biol. Chem. 272, 21 388-21 395.
    • (1997) J. Biol. Chem. , vol.272 , pp. 21388-21395
    • Quillet-Mary, A.1    Jaffrezou, J.2    Mansat, V.3    Bordier, C.4    Naval, J.5    Laurent, G.6
  • 52
    • 0034697378 scopus 로고    scopus 로고
    • Ceramide analysis utilizing gas chromatography-mass spectrometry
    • Raith K., Darius J. and Neubert R. (2000) Ceramide analysis utilizing gas chromatography-mass spectrometry. J. Chromatogr. 876, 229-233.
    • (2000) J. Chromatogr. , vol.876 , pp. 229-233
    • Raith, K.1    Darius, J.2    Neubert, R.3
  • 53
    • 0031897739 scopus 로고    scopus 로고
    • Oxidative stress causes relocation of the lysosomal enzyme cathepsin D with ensuing apoptosis in neonatal rat cardiomyocytes
    • Roberg K. and Ollinger K. (1998) Oxidative stress causes relocation of the lysosomal enzyme cathepsin D with ensuing apoptosis in neonatal rat cardiomyocytes. Am. J. Pathol. 152, 1151-1156.
    • (1998) Am. J. Pathol. , vol.152 , pp. 1151-1156
    • Roberg, K.1    Ollinger, K.2
  • 54
    • 0033436344 scopus 로고    scopus 로고
    • Lysosomal release of cathepsin D precedes relocation of cytochrome c and loss of mitochondrial transmembrane potential during apoptosis induced by oxidative stress
    • Roberg K., Johansson U. and Ollinger K. (1999) Lysosomal release of cathepsin D precedes relocation of cytochrome c and loss of mitochondrial transmembrane potential during apoptosis induced by oxidative stress. Free Radic. Biol. Med. 27, 1228-1237.
    • (1999) Free Radic. Biol. Med. , vol.27 , pp. 1228-1237
    • Roberg, K.1    Johansson, U.2    Ollinger, K.3
  • 55
    • 0033575320 scopus 로고    scopus 로고
    • Ceramide induces Bcl2 dephosphorylation via a mechanism involving mitochondrial PP2A
    • Ruvolo P., Deng X., Ito T., Carr B. and May W. (1999) Ceramide induces Bcl2 dephosphorylation via a mechanism involving mitochondrial PP2A. J. Biol. Chem. 274, 20 296-20 300.
    • (1999) J. Biol. Chem. , vol.274 , pp. 20296-20300
    • Ruvolo, P.1    Deng, X.2    Ito, T.3    Carr, B.4    May, W.5
  • 56
    • 4544326749 scopus 로고    scopus 로고
    • Oxidative stress-induced apoptosis in retinal photoreceptor cells is mediated by calpains and caspases and blocked by the oxygen radical scavenger CR-6
    • Sanvicens N., Gomez-Vicente V., Masip I., Messeguer A. and Cotter T. (2004) Oxidative stress-induced apoptosis in retinal photoreceptor cells is mediated by calpains and caspases and blocked by the oxygen radical scavenger CR-6. J.Biol. Chem. 279, 39 268-39 278.
    • (2004) J.Biol. Chem. , vol.279 , pp. 39268-39278
    • Sanvicens, N.1    Gomez-Vicente, V.2    Masip, I.3    Messeguer, A.4    Cotter, T.5
  • 58
    • 2442651256 scopus 로고    scopus 로고
    • Reduced expression of Bax in ceramide-resistant HL-60 subline
    • Sawai H., Kawai S. and Domae N. (2004) Reduced expression of Bax in ceramide-resistant HL-60 subline. Biochem. Biophys. Res. Commun. 319, 46-49.
    • (2004) Biochem. Biophys. Res. Commun. , vol.319 , pp. 46-49
    • Sawai, H.1    Kawai, S.2    Domae, N.3
  • 59
    • 0030791958 scopus 로고    scopus 로고
    • Anandamide and other N-acylethanolamines in mouse peritoneal macrophages
    • Schmid P., Kuwae T., Krebsbach R. and Schmid H. (1997) Anandamide and other N-acylethanolamines in mouse peritoneal macrophages. Chem. Phys. Lipids 87, 103-110.
    • (1997) Chem. Phys. Lipids , vol.87 , pp. 103-110
    • Schmid, P.1    Kuwae, T.2    Krebsbach, R.3    Schmid, H.4
  • 60
    • 8644278972 scopus 로고    scopus 로고
    • Interleukin-2-induced survival of natural killer (NK) cells involving phosphatidylinositol-3 kinase-dependent reduction of ceramide through acid sphingomyelinase, sphingomyelin synthase and glucosylceramide synthase
    • Taguchi Y., Kondo T., Watanabe M., Miyaji M., Umehara H., Kozutsumi Y. and Okazaki T. (2004) Interleukin-2-induced survival of natural killer (NK) cells involving phosphatidylinositol-3 kinase-dependent reduction of ceramide through acid sphingomyelinase, sphingomyelin synthase and glucosylceramide synthase. Blood 104, 3285-3293.
    • (2004) Blood , vol.104 , pp. 3285-3293
    • Taguchi, Y.1    Kondo, T.2    Watanabe, M.3    Miyaji, M.4    Umehara, H.5    Kozutsumi, Y.6    Okazaki, T.7
  • 61
    • 0033537839 scopus 로고    scopus 로고
    • Ceramide generation in nitric oxide-induced apoptosis. Activation of magnesium-dependent neutral sphingomyelinase via caspase-3
    • Takeda Y., Tashima M., Takahashi A., Uchiyama T. and Okazaki T. (1999) Ceramide generation in nitric oxide-induced apoptosis. Activation of magnesium-dependent neutral sphingomyelinase via caspase-3. J. Biol. Chem. 274, 10 654-10 660.
    • (1999) J. Biol. Chem. , vol.274 , pp. 10654-10660
    • Takeda, Y.1    Tashima, M.2    Takahashi, A.3    Uchiyama, T.4    Okazaki, T.5
  • 62
    • 1542742250 scopus 로고    scopus 로고
    • Expression of cone-photoreceptor-specific antigens in a cell line derived from retinal tumors in transgenic mice
    • Tan E., Ding X., Saadi A., Agarwal N., Naash M. and Al-Ubaidi M. (2004) Expression of cone-photoreceptor-specific antigens in a cell line derived from retinal tumors in transgenic mice. Invest. Ophthalmol. Vis. Sci. 45, 764-768.
    • (2004) Invest. Ophthalmol. Vis. Sci. , vol.45 , pp. 764-768
    • Tan, E.1    Ding, X.2    Saadi, A.3    Agarwal, N.4    Naash, M.5    Al-Ubaidi, M.6
  • 64
    • 0032575750 scopus 로고    scopus 로고
    • Caspases: Enemies within
    • Thornberry N. A. and Lazebnik Y. (1998) Caspases: enemies within. Science 281, 1312-1316.
    • (1998) Science , vol.281 , pp. 1312-1316
    • Thornberry, N.A.1    Lazebnik, Y.2
  • 66
    • 0346373649 scopus 로고    scopus 로고
    • Mutation of CERKL, a novel human ceramide kinase gene, causes autosomal recessive retinitis pigmentosa (RP26)
    • Tuson M., Marfany G. and Gonzalez-Duarte R. (2004) Mutation of CERKL, a novel human ceramide kinase gene, causes autosomal recessive retinitis pigmentosa (RP26). Am. J. Hum. Genet. 74, 128-138.
    • (2004) Am. J. Hum. Genet. , vol.74 , pp. 128-138
    • Tuson, M.1    Marfany, G.2    Gonzalez-Duarte, R.3
  • 67
    • 0034717903 scopus 로고    scopus 로고
    • Sphingolipid transport in eukaryotic cells
    • Van Meer G. and Holthuis J. C. (2000) Sphingolipid transport in eukaryotic cells. Biochim. Biophys. Acta 1486, 145-170.
    • (2000) Biochim. Biophys. Acta , vol.1486 , pp. 145-170
    • Van Meer, G.1    Holthuis, J.C.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.