Inhibition of ceramide biosynthesis preserves photoreceptor structure and function in a mouse model of retinitis pigmentosa

Proceedings of the National Academy of Sciences of the United States of America

Volumn 107, Issue 43, 2010, Pages 18706-18711

  Strettoi, Enrica ^a   Gargini, Claudia ^b   Novelli, Elena ^c   Sala, Giusy ^d   Piano, Ilaria ^b   Gasco, Paolo ^e   Ghidoni, Riccardo ^d  

^a CNR   (Italy)

^b UNIVERSITY OF PISA   (Italy)

^c IRCCS FONDAZIONE BIETTI   (Italy)

^d UNIVERSITY OF MILAN   (Italy)

^e NANOVECTOR S R L   (Italy)

Author keywords

Apoptosis; Electroretinography; Morphology; Sphingolipid

Indexed keywords

CERAMIDE; SOLID LIPID NANOPARTICLE; THERMOZYMOCIDIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BIOSYNTHESIS; CELL PROTECTION; CELL STRUCTURE; CELL SURVIVAL; CONTROLLED STUDY; DRUG ACTIVITY; DRUG DELIVERY SYSTEM; IN VIVO STUDY; MOUSE; NONHUMAN; PHOTORECEPTOR; PRIORITY JOURNAL; RETINITIS PIGMENTOSA; SIGNAL TRANSDUCTION; TISSUE LEVEL;

ANIMALS; CERAMIDES; DISEASE MODELS, ANIMAL; ENZYME INHIBITORS; FATTY ACIDS, MONOUNSATURATED; HUMANS; MICE; MICE, INBRED C57BL; MICE, MUTANT STRAINS; PHOTORECEPTOR CELLS, VERTEBRATE; RETINITIS PIGMENTOSA; SERINE C-PALMITOYLTRANSFERASE;

MUS;

EID: 78649850282     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1007644107     Document Type: Article

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