Modulating sphingolipid biosynthetic pathway rescues photoreceptor degeneration

Science

Volumn 299, Issue 5613, 2003, Pages 1740-1743

  Acharya, Usha ^a   Patel, Shetal ^a   Koundakjian, Edmund ^b   Nagashima, Kunio ^c   Han, Xianlin ^d   Acharya, Jairaj K ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c SAIC FREDERICK INC   (United States)

^d WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENZYMES; LIPIDS; MUTAGENESIS; OPHTHALMOLOGY; PHYSIOLOGICAL MODELS; PROTEINS; SIGNALING;

BIOSYNTHETIC PATHWAYS; PHOTORECEPTORS;

BIOSYNTHESIS;

ACYLSPHINGOSINE DEACYLASE; DYNAMIN; PHOSPHOLIPASE C; RETINA S ANTIGEN; SPHINGOLIPID;

MUTATION; PROTEIN;

ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; DROSOPHILA; GENE EXPRESSION; GENE MUTATION; MODULATION; NONHUMAN; PHOTORECEPTOR; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN SYNTHESIS; PROTEIN TRANSPORT; RETINA DEGENERATION; SIGNAL TRANSDUCTION; TRANSPORT KINETICS;

ACYLTRANSFERASES; AMIDOHYDROLASES; ANIMALS; ANIMALS, GENETICALLY MODIFIED; APOPTOSIS; ARRESTINS; CERAMIDES; CLATHRIN; CLONING, MOLECULAR; CROSSES, GENETIC; DROSOPHILA; DYNAMINS; ELECTRORETINOGRAPHY; ENDOCYTOSIS; GENES, INSECT; LIGHT; MUTATION; NECROSIS; PHOSPHATIDYLINOSITOL DIACYLGLYCEROL-LYASE; PHOSPHOLIPASE C; PHOSPHOPROTEINS; PHOTORECEPTORS, INVERTEBRATE; PHOTOTRANSDUCTION; RECEPTORS, CELL SURFACE; RETINAL DEGENERATION; RHODOPSIN; SERINE C-PALMITOYLTRANSFERASE; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; SPHINGOSINE;

ANIMALIA;

EID: 0037436579     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1080549     Document Type: Article

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