Berberine prevents nitric oxide-induced rat chondrocyte apoptosis and cartilage degeneration in a rat osteoarthritis model via AMPK and p38 MAPK signaling

Apoptosis

Volumn 20, Issue 9, 2015, Pages 1187-1199

  Zhou, Yan ^a   Liu, Shi Qing ^a   Yu, Ling ^a   He, Bin ^a   Wu, Shi Hao ^b   Zhao, Qi ^a   Xia, Shao Qiang ^a   Mei, Hong Jun ^b  

^a RENMIN HOSPITAL OF WUHAN UNIVERSITY   (China)

^b Wuhan No 4 Hospital   (China)

Author keywords

Apoptosis; Berberine; Chondrocyte; Osteoarthritis; Sodium nitroprusside

Indexed keywords

ADENOSINE MONOPHOSPHATE ACTIVATED PROTEIN KINASE; BERBERINE; CASPASE 3; COLLAGEN TYPE 2; CYCLIC AMP; INDUCIBLE NITRIC OXIDE SYNTHASE; MITOGEN ACTIVATED PROTEIN KINASE P38; NITRIC OXIDE; NITROPRUSSIDE SODIUM; PROTEIN BAX; PROTEIN BCL 2; PROTEIN KINASE; UNCLASSIFIED DRUG; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ALKALOID; APOPTOSIS REGULATORY PROTEIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; IMIDAZOLE DERIVATIVE; PROTEIN KINASE INHIBITOR; PYRIDINE DERIVATIVE; VIDARABINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; ARTICULAR CARTILAGE; CARTILAGE CELL; CARTILAGE DEGENERATION; CHONDROPROTECTION; CONTROLLED STUDY; CYTOSKELETON; DOWN REGULATION; DRUG MECHANISM; ENZYME ACTIVITY; HISTOPATHOLOGY; IN VITRO STUDY; IN VIVO STUDY; MALE; NEWBORN; NONHUMAN; OSTEOARTHRITIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION; UPREGULATION; ANIMAL; CELL SURVIVAL; CYTOLOGY; DISEASE MODEL; DRUG EFFECTS; KNEE; METABOLISM; PHOSPHORYLATION; SPRAGUE DAWLEY RAT;

ARA; RATTUS;

ALKALOIDS; AMP-ACTIVATED PROTEIN KINASES; ANIMALS; ANIMALS, NEWBORN; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; BERBERINE; CARTILAGE, ARTICULAR; CELL SURVIVAL; CHONDROCYTES; CYTOSKELETON; DISEASE MODELS, ANIMAL; IMIDAZOLES; KNEE JOINT; MALE; NITRIC OXIDE; NITROPRUSSIDE; OSTEOARTHRITIS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PROTEIN KINASE INHIBITORS; PYRIDINES; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION; VIDARABINE;

EID: 84938978957     PISSN: 13608185     EISSN: 1573675X     Source Type: Journal    
DOI: 10.1007/s10495-015-1152-y     Document Type: Article

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