Oxidative changes and signalling pathways are pivotal in initiating age-related changes in articular cartilage

Annals of the Rheumatic Diseases

Volumn 75, Issue 2, 2016, Pages 449-458

  Hui, Wang ^a   Young, David A ^a   Rowan, Andrew D ^a   Xu, Xin ^b   Cawston, Tim E ^a   Proctor, Carole J ^a  

^a NEWCASTLE UNIVERSITY   (United Kingdom)

^b NEWCASTLE UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

3 NITROTYROSINE; ACTIVIN RECEPTOR LIKE KINASE 1; COLLAGEN TYPE 2; COLLAGENASE 3; INTERLEUKIN 1; PROTEIN BCL 2; PROTEOGLYCAN; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 1; UBIQUITIN PROTEIN LIGASE; UBIQUITIN PROTEIN LIGASE LC 3B; UNCLASSIFIED DRUG; 3-NITROTYROSINE; ACTIVIN RECEPTOR 1; TYROSINE;

AGING; ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; ARTICULAR CARTILAGE; AUTOPHAGY; CARTILAGE MATRIX; COMPUTER MODEL; COMPUTER SIMULATION; CONTROLLED STUDY; DOWN REGULATION; EXTRACELLULAR MATRIX; HISTOPATHOLOGY; KNEE OSTEOARTHRITIS; MALE; MOLECULAR PATHOLOGY; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN DEPLETION; PROTEIN EXPRESSION; UPREGULATION; ANALOGS AND DERIVATIVES; ANIMAL; C57BL MOUSE; IMMUNOHISTOCHEMISTRY; KNEE; METABOLISM; PHYSIOLOGY; SIGNAL TRANSDUCTION;

ACTIVIN RECEPTORS, TYPE I; AGING; ANIMALS; CARTILAGE, ARTICULAR; COLLAGEN TYPE II; COMPUTER SIMULATION; EXTRACELLULAR MATRIX; IMMUNOHISTOCHEMISTRY; INTERLEUKIN-1; KNEE JOINT; MATRIX METALLOPROTEINASE 13; MICE; MICE, INBRED C57BL; OXIDATIVE STRESS; SIGNAL TRANSDUCTION; TRANSFORMING GROWTH FACTOR BETA; TYROSINE;

EID: 84954394949     PISSN: 00034967     EISSN: 14682060     Source Type: Journal    
DOI: 10.1136/annrheumdis-2014-206295     Document Type: Article

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