Endogenous cannabinoid anandamide impairs cell growth and induces apoptosis in chondrocytes

Journal of Orthopaedic Research

Volumn 32, Issue 9, 2014, Pages 1137-1146

  Gõmez, Rodolfo ^a   Conde, Javier ^a   Scotece, Morena ^a   Lõpez, Verõnica ^a   Lago, Francisca ^a   Gõmez Reino, Juan Jesús ^b   Gualillo, Oreste ^a  

^a Santiago University Clinical Hospital   (Spain)

^b UNIVERSITY OF SANTIAGO DE COMPOSTELA   (Spain)

Author keywords

apoptosis; cannabinoids; chondrocyte physiology; signal transduction; TNF

Indexed keywords

ANANDAMIDE; CANNABINOID 2 RECEPTOR; CASPASE 3; CASPASE 8; CASPASE 9; ENDOCANNABINOID; FATTY ACID AMIDASE; FOCAL ADHESION KINASE; LACTATE DEHYDROGENASE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MYC PROTEIN; STRESS ACTIVATED PROTEIN KINASE; SYNAPTOPHYSIN; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; APOPTOSIS; ARTICLE; CARTILAGE CELL; CELL GROWTH; CELL PROLIFERATION; CELL VIABILITY; CHROMATIN CONDENSATION; CONTROLLED STUDY; DRUG EFFECT; ENZYME ACTIVATION; ENZYME RELEASE; HUMAN; HUMAN CELL; MTT ASSAY; NONHUMAN; ONCOGENE C MYC; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

APOPTOSIS; CANNABINOIDS; CHONDROCYTE PHYSIOLOGY; SIGNAL TRANSDUCTION; TNF;

AMP-ACTIVATED PROTEIN KINASES; ANIMALS; APOPTOSIS; ARACHIDONIC ACIDS; CANNABINOIDS; CASPASES; CELL LINE; CELL PROLIFERATION; CHONDROCYTES; CHROMATIN; ENDOCANNABINOIDS; MAP KINASE SIGNALING SYSTEM; MICE; MODELS, ANIMAL; POLYUNSATURATED ALKAMIDES; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84904471164     PISSN: 07360266     EISSN: 1554527X     Source Type: Journal    
DOI: 10.1002/jor.22660     Document Type: Article

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