Activation of AMPK protects against hydrogen peroxide-induced osteoblast apoptosis through autophagy induction and NADPH maintenance: New implications for osteonecrosis treatment?

Cellular Signalling

Volumn 26, Issue 1, 2014, Pages 1-8

  She, Chang ^a   Zhu, Lun qing ^b   Zhen, Yun fang ^b   Wang, Xiao dong ^b   Dong, Qi rong ^a  

^a THE SECOND AFFILIATED HOSPITAL OF SOOCHOW UNIVERSITY   (China)

^b CHILDREN S HOSPITAL OF SOOCHOW UNIVERSITY   (China)

Author keywords

AMPK; Autophagy; Hydrogen peroxide; NADPH and osteonecrosis

Indexed keywords

HYDROGEN PEROXIDE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; SHORT HAIRPIN RNA;

ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; AUTOPHAGY; CELL DEATH; CELL STRAIN HEK293; CELL SURVIVAL; FEMUR HEAD NECROSIS; HUMAN; HUMAN CELL; HUMAN TISSUE; MOUSE; NONHUMAN; OSTEOBLAST; OSTEOBLASTOMA; OXIDATIVE STRESS; PRIORITY JOURNAL;

3-MA; 3-METHYLADENINE; ACC; ACETYL-COA CARBOXYLASE; ALKALINE PHOSPHOTASE; ALP; AMP-ACTIVATED PROTEIN KINASE; AMPK; AUTOPHAGY; H(2)O(2); HYDROGEN PEROXIDE; LC3B; LIGHT CHAIN 3B; NADPH; NADPH AND OSTEONECROSIS; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; REACTIVE OXYGEN SPECIES; ROS;

AMP-ACTIVATED PROTEIN KINASES; ANIMALS; APOPTOSIS; AUTOPHAGY; CELL LINE, TRANSFORMED; CYTOPROTECTION; ENZYME ACTIVATION; HEK293 CELLS; HUMANS; HYDROGEN PEROXIDE; MICE; NADP; OSTEOBLASTS; OSTEONECROSIS; OXIDATIVE STRESS; PROTEIN KINASE INHIBITORS;

EID: 84886076523     PISSN: 08986568     EISSN: 18733913     Source Type: Journal    
DOI: 10.1016/j.cellsig.2013.08.046     Document Type: Article

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