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Volumn 15, Issue 9, 2015, Pages

Listening to Our Gut: Contribution of Gut Microbiota and Cardiovascular Risk in Diabetes Pathogenesis

Author keywords

Branched chain amino acids; Diabetes mellitus; Microbiome; Trimethylamine N oxide

Indexed keywords

BETAINE; CARNITINE; CHOLINE; GAMMA BUTYROBETAINE; PHOSPHATIDYLCHOLINE; SHORT CHAIN FATTY ACID; TRIMETHYLAMINE OXIDE; METHYLAMINE; TRIMETHYLAMINE;

EID: 84938843573     PISSN: 15344827     EISSN: 15390829     Source Type: Journal    
DOI: 10.1007/s11892-015-0634-1     Document Type: Review
Times cited : (27)

References (87)
  • 1
    • 20544444045 scopus 로고    scopus 로고
    • Diversity of the human intestinal microbial flora
    • PID: 1583171
    • Eckburg PB et al. Diversity of the human intestinal microbial flora. Science. 2005;308(5728):1635–8.
    • (2005) Science , vol.308 , Issue.5728 , pp. 1635-1638
    • Eckburg, P.B.1
  • 2
    • 69249109724 scopus 로고    scopus 로고
    • Comparative analysis of pyrosequencing and a phylogenetic microarray for exploring microbial community structures in the human distal intestine
    • PID: 1969327
    • Claesson MJ et al. Comparative analysis of pyrosequencing and a phylogenetic microarray for exploring microbial community structures in the human distal intestine. PLoS One. 2009;4(8):e6669.
    • (2009) PLoS One , vol.4 , Issue.8 , pp. 6669
    • Claesson, M.J.1
  • 3
    • 35348968286 scopus 로고    scopus 로고
    • The human microbiome project
    • COI: 1:CAS:528:DC%2BD2sXhtFOjt7nP, PID: 1794311
    • Turnbaugh PJ et al. The human microbiome project. Nature. 2007;449(7164):804–10.
    • (2007) Nature , vol.449 , Issue.7164 , pp. 804-810
    • Turnbaugh, P.J.1
  • 4
    • 8144226856 scopus 로고    scopus 로고
    • The gut microbiota as an environmental factor that regulates fat storage
    • PID: 1550521
    • Backhed F et al. The gut microbiota as an environmental factor that regulates fat storage. Proc Natl Acad Sci U S A. 2004;101(44):15718–23.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , Issue.44 , pp. 15718-15723
    • Backhed, F.1
  • 5
    • 33846542071 scopus 로고    scopus 로고
    • Mechanisms underlying the resistance to diet-induced obesity in germ-free mice
    • COI: 1:CAS:528:DC%2BD2sXhtVSitbo%3D, PID: 1721091
    • Backhed F et al. Mechanisms underlying the resistance to diet-induced obesity in germ-free mice. Proc Natl Acad Sci U S A. 2007;104(3):979–84.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , Issue.3 , pp. 979-984
    • Backhed, F.1
  • 6
    • 33845874101 scopus 로고    scopus 로고
    • An obesity-associated gut microbiome with increased capacity for energy harvest
    • PID: 1718331
    • Turnbaugh PJ et al. An obesity-associated gut microbiome with increased capacity for energy harvest. Nature. 2006;444(7122):1027–31.
    • (2006) Nature , vol.444 , Issue.7122 , pp. 1027-1031
    • Turnbaugh, P.J.1
  • 7
    • 82455171885 scopus 로고    scopus 로고
    • Involvement of tissue bacteria in the onset of diabetes in humans: evidence for a concept
    • COI: 1:CAS:528:DC%2BC3MXhsVGgu7nO, PID: 2197614
    • Amar J et al. Involvement of tissue bacteria in the onset of diabetes in humans: evidence for a concept. Diabetologia. 2011;54(12):3055–61.
    • (2011) Diabetologia , vol.54 , Issue.12 , pp. 3055-3061
    • Amar, J.1
  • 8
    • 84869087622 scopus 로고    scopus 로고
    • Circulating lipopolysaccharide-binding protein (LBP) as a marker of obesity-related insulin resistance
    • COI: 1:CAS:528:DC%2BC38Xhs1ynu7f
    • Moreno-Navarrete JM et al. Circulating lipopolysaccharide-binding protein (LBP) as a marker of obesity-related insulin resistance. Int J Obes (Lond). 2012;36(11):1442–9.
    • (2012) Int J Obes (Lond) , vol.36 , Issue.11 , pp. 1442-1449
    • Moreno-Navarrete, J.M.1
  • 9
    • 34347399563 scopus 로고    scopus 로고
    • Metabolic endotoxemia initiates obesity and insulin resistance
    • COI: 1:CAS:528:DC%2BD2sXnvVWjurk%3D, PID: 1745685
    • Cani PD et al. Metabolic endotoxemia initiates obesity and insulin resistance. Diabetes. 2007;56(7):1761–72.
    • (2007) Diabetes , vol.56 , Issue.7 , pp. 1761-1772
    • Cani, P.D.1
  • 10
    • 0034959553 scopus 로고    scopus 로고
    • Short-chain fatty acids and human colonic function: roles of resistant starch and nonstarch polysaccharides
    • COI: 1:CAS:528:DC%2BD3MXlt1Ohsr4%3D, PID: 1142769
    • Topping DL, Clifton PM. Short-chain fatty acids and human colonic function: roles of resistant starch and nonstarch polysaccharides. Physiol Rev. 2001;81(3):1031–64.
    • (2001) Physiol Rev , vol.81 , Issue.3 , pp. 1031-1064
    • Topping, D.L.1    Clifton, P.M.2
  • 11
    • 0018718884 scopus 로고
    • The effect of meat protein and dietary fiber on colonic function and metabolism. II. Bacterial metabolites in feces and urine
    • COI: 1:CAS:528:DyaL3cXltFam, PID: 48452
    • Cummings JH et al. The effect of meat protein and dietary fiber on colonic function and metabolism. II. Bacterial metabolites in feces and urine. Am J Clin Nutr. 1979;32(10):2094–101.
    • (1979) Am J Clin Nutr , vol.32 , Issue.10 , pp. 2094-2101
    • Cummings, J.H.1
  • 12
    • 84887903682 scopus 로고    scopus 로고
    • Butyrate and colorectal cancer: the role of butyrate transport
    • COI: 1:CAS:528:DC%2BC3sXhslSmu7jN, PID: 2416029
    • Goncalves P, Martel F. Butyrate and colorectal cancer: the role of butyrate transport. Curr Drug Metab. 2013;14(9):994–1008.
    • (2013) Curr Drug Metab , vol.14 , Issue.9 , pp. 994-1008
    • Goncalves, P.1    Martel, F.2
  • 13
    • 0031840660 scopus 로고    scopus 로고
    • Review article: short chain fatty acids in health and disease
    • COI: 1:CAS:528:DyaK1cXksVSnsbc%3D, PID: 967880
    • Cook SI, Sellin JH. Review article: short chain fatty acids in health and disease. Aliment Pharmacol Ther. 1998;12(6):499–507.
    • (1998) Aliment Pharmacol Ther , vol.12 , Issue.6 , pp. 499-507
    • Cook, S.I.1    Sellin, J.H.2
  • 14
    • 0034897133 scopus 로고    scopus 로고
    • Acetate, propionate and butyrate in plasma: determination of the concentration and isotopic enrichment by gas chromatography/mass spectrometry with positive chemical ionization
    • COI: 1:CAS:528:DC%2BD3MXlvFyks7g%3D, PID: 1147340
    • Pouteau E et al. Acetate, propionate and butyrate in plasma: determination of the concentration and isotopic enrichment by gas chromatography/mass spectrometry with positive chemical ionization. J Mass Spectrom. 2001;36(7):798–805.
    • (2001) J Mass Spectrom , vol.36 , Issue.7 , pp. 798-805
    • Pouteau, E.1
  • 15
    • 0020581521 scopus 로고
    • Long-term effects of dietary fiber on glucose tolerance and gastric emptying in noninsulin-dependent diabetic patients
    • COI: 1:STN:280:DyaL3s7kvFOjsA%3D%3D, PID: 629908
    • Ray TK et al. Long-term effects of dietary fiber on glucose tolerance and gastric emptying in noninsulin-dependent diabetic patients. Am J Clin Nutr. 1983;37(3):376–81.
    • (1983) Am J Clin Nutr , vol.37 , Issue.3 , pp. 376-381
    • Ray, T.K.1
  • 16
    • 0017692450 scopus 로고
    • Dietary fiber and human health
    • COI: 1:CAS:528:DyaE2sXlvVaquro%3D, PID: 89582
    • Mendeloff AI. Dietary fiber and human health. N Engl J Med. 1977;297(15):811–4.
    • (1977) N Engl J Med , vol.297 , Issue.15 , pp. 811-814
    • Mendeloff, A.I.1
  • 17
    • 0038310186 scopus 로고    scopus 로고
    • Prior short-term consumption of resistant starch enhances postprandial insulin sensitivity in healthy subjects
    • COI: 1:CAS:528:DC%2BD3sXksFKmu7Y%3D, PID: 1271224
    • Robertson MD et al. Prior short-term consumption of resistant starch enhances postprandial insulin sensitivity in healthy subjects. Diabetologia. 2003;46(5):659–65.
    • (2003) Diabetologia , vol.46 , Issue.5 , pp. 659-665
    • Robertson, M.D.1
  • 18
    • 84878709716 scopus 로고    scopus 로고
    • Karlsson FH et al. Gut metagenome in European women with normal, impaired and diabetic glucose control. These two studies (18,19) provide the first metagenomic evidence of differing profiles between diabetes and normal individuals and suggest the potential to predict development of disease from metagenomic sequences
    • Karlsson FH et al. Gut metagenome in European women with normal, impaired and diabetic glucose control. Nature. 2013;498(7452):99–103. These two studies (18,19) provide the first metagenomic evidence of differing profiles between diabetes and normal individuals and suggest the potential to predict development of disease from metagenomic sequences.
    • (2013) Nature , vol.498 , Issue.7452 , pp. 99-103
  • 19
    • 84867074831 scopus 로고    scopus 로고
    • A metagenome-wide association study of gut microbiota in type 2 diabetes
    • COI: 1:CAS:528:DC%2BC38XhsVaqt7fJ, PID: 23023125, These two studies (18,19) provide the first metagenomic evidence of differing profiles between diabetes and normal individuals and suggest the potential to predict development of disease from metagenomic sequences
    • Qin J et al. A metagenome-wide association study of gut microbiota in type 2 diabetes. Nature. 2012;490(7418):55–60. These two studies (18,19) provide the first metagenomic evidence of differing profiles between diabetes and normal individuals and suggest the potential to predict development of disease from metagenomic sequences.
    • (2012) Nature , vol.490 , Issue.7418 , pp. 55-60
    • Qin, J.1
  • 20
    • 0038491435 scopus 로고    scopus 로고
    • Functional characterization of human receptors for short chain fatty acids and their role in polymorphonuclear cell activation
    • PID: 1271160
    • Le Poul E et al. Functional characterization of human receptors for short chain fatty acids and their role in polymorphonuclear cell activation. J Biol Chem. 2003;278(28):25481–9.
    • (2003) J Biol Chem , vol.278 , Issue.28 , pp. 25481-25489
    • Le Poul, E.1
  • 21
    • 0038363378 scopus 로고    scopus 로고
    • The Orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids
    • COI: 1:CAS:528:DC%2BD3sXit1Kgsbc%3D, PID: 1249628
    • Brown AJ et al. The Orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids. J Biol Chem. 2003;278(13):11312–9.
    • (2003) J Biol Chem , vol.278 , Issue.13 , pp. 11312-11319
    • Brown, A.J.1
  • 22
    • 84878579044 scopus 로고    scopus 로고
    • The gut microbiota suppresses insulin-mediated fat accumulation via the short-chain fatty acid receptor GPR43
    • PID: 2365201
    • Kimura I et al. The gut microbiota suppresses insulin-mediated fat accumulation via the short-chain fatty acid receptor GPR43. Nat Commun. 2013;4:1829.
    • (2013) Nat Commun , vol.4 , pp. 1829
    • Kimura, I.1
  • 23
    • 55949091259 scopus 로고    scopus 로고
    • Effects of the gut microbiota on host adiposity are modulated by the short-chain fatty-acid binding G protein-coupled receptor, Gpr41
    • COI: 1:CAS:528:DC%2BD1cXhtlersrvP, PID: 1893130
    • Samuel BS et al. Effects of the gut microbiota on host adiposity are modulated by the short-chain fatty-acid binding G protein-coupled receptor, Gpr41. Proc Natl Acad Sci U S A. 2008;105(43):16767–72.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , Issue.43 , pp. 16767-16772
    • Samuel, B.S.1
  • 24
    • 84856509724 scopus 로고    scopus 로고
    • Short-chain fatty acids stimulate glucagon-like peptide-1 secretion via the G-protein-coupled receptor FFAR2
    • COI: 1:CAS:528:DC%2BC38XltVOlt7Y%3D, PID: 2219064
    • Tolhurst G et al. Short-chain fatty acids stimulate glucagon-like peptide-1 secretion via the G-protein-coupled receptor FFAR2. Diabetes. 2012;61(2):364–71.
    • (2012) Diabetes , vol.61 , Issue.2 , pp. 364-371
    • Tolhurst, G.1
  • 25
    • 35748957503 scopus 로고    scopus 로고
    • The physiology of glucagon-like peptide 1
    • COI: 1:CAS:528:DC%2BD2sXhtlaqu7jI, PID: 1792858
    • Holst JJ. The physiology of glucagon-like peptide 1. Physiol Rev. 2007;87(4):1409–39.
    • (2007) Physiol Rev , vol.87 , Issue.4 , pp. 1409-1439
    • Holst, J.J.1
  • 26
    • 77449157340 scopus 로고    scopus 로고
    • Acute effects of intravenous and rectal acetate on glucagon-like peptide-1, peptide YY, ghrelin, adiponectin and tumour necrosis factor-alpha
    • COI: 1:CAS:528:DC%2BC3cXhtVOnsLk%3D, PID: 1981819
    • Freeland KR, Wolever TM. Acute effects of intravenous and rectal acetate on glucagon-like peptide-1, peptide YY, ghrelin, adiponectin and tumour necrosis factor-alpha. Br J Nutr. 2010;103(3):460–6.
    • (2010) Br J Nutr , vol.103 , Issue.3 , pp. 460-466
    • Freeland, K.R.1    Wolever, T.M.2
  • 27
    • 84866738529 scopus 로고    scopus 로고
    • Transfer of intestinal microbiota from lean donors increases insulin sensitivity in individuals with metabolic syndrome
    • COI: 1:CAS:528:DC%2BC38Xht1GlurzE, PID: 22728514, e
    • Vrieze A et al. Transfer of intestinal microbiota from lean donors increases insulin sensitivity in individuals with metabolic syndrome. Gastroenterology. 2012;143(4):913–6. e7.
    • (2012) Gastroenterology , vol.143 , Issue.4 , pp. 913-916
    • Vrieze, A.1
  • 28
    • 43549107065 scopus 로고    scopus 로고
    • Energy intake is associated with endotoxemia in apparently healthy men
    • COI: 1:CAS:528:DC%2BD1cXmtFWjsr8%3D, PID: 1846924
    • Amar J et al. Energy intake is associated with endotoxemia in apparently healthy men. Am J Clin Nutr. 2008;87(5):1219–23.
    • (2008) Am J Clin Nutr , vol.87 , Issue.5 , pp. 1219-1223
    • Amar, J.1
  • 29
    • 33750584214 scopus 로고    scopus 로고
    • TLR4 links innate immunity and fatty acid-induced insulin resistance
    • COI: 1:CAS:528:DC%2BD28XhtFyrsLfE, PID: 1705383
    • Shi H et al. TLR4 links innate immunity and fatty acid-induced insulin resistance. J Clin Invest. 2006;116(11):3015–25.
    • (2006) J Clin Invest , vol.116 , Issue.11 , pp. 3015-3025
    • Shi, H.1
  • 30
    • 0034566956 scopus 로고    scopus 로고
    • Anti-inflammatory effects of sodium butyrate on human monocytes: potent inhibition of IL-12 and up-regulation of IL-10 production
    • COI: 1:CAS:528:DC%2BD3MXht1Sntrs%3D, PID: 1102400
    • Saemann MD et al. Anti-inflammatory effects of sodium butyrate on human monocytes: potent inhibition of IL-12 and up-regulation of IL-10 production. FASEB J. 2000;14(15):2380–2.
    • (2000) FASEB J , vol.14 , Issue.15 , pp. 2380-2382
    • Saemann, M.D.1
  • 31
    • 82455193850 scopus 로고    scopus 로고
    • The interaction of short-chain fatty acids with adipose tissue: relevance for prevention of type 2 diabetes
    • COI: 1:CAS:528:DC%2BC3MXhsFGru7n
    • Roelofsen H, Priebe MG, Vonk RJ. The interaction of short-chain fatty acids with adipose tissue: relevance for prevention of type 2 diabetes. Benefic Microbes. 2010;1(4):433–7.
    • (2010) Benefic Microbes , vol.1 , Issue.4 , pp. 433-437
    • Roelofsen, H.1    Priebe, M.G.2    Vonk, R.J.3
  • 32
    • 69549114504 scopus 로고    scopus 로고
    • Butyrate enhances the intestinal barrier by facilitating tight junction assembly via activation of AMP-activated protein kinase in Caco-2 cell monolayers
    • COI: 1:CAS:528:DC%2BD1MXhtlWrt7nM, PID: 1962569
    • Peng L et al. Butyrate enhances the intestinal barrier by facilitating tight junction assembly via activation of AMP-activated protein kinase in Caco-2 cell monolayers. J Nutr. 2009;139(9):1619–25.
    • (2009) J Nutr , vol.139 , Issue.9 , pp. 1619-1625
    • Peng, L.1
  • 33
    • 84910129274 scopus 로고    scopus 로고
    • gamma-Butyrobetaine is a proatherogenic intermediate in gut microbial metabolism of L-carnitine to TMAO
    • COI: 1:CAS:528:DC%2BC2cXhvVSnu7fM, PID: 25440057, This study and reference [47] provide novel insights into the metabolism of TMAO and its associations with various gut microbiome profiles
    • Koeth RA et al. gamma-Butyrobetaine is a proatherogenic intermediate in gut microbial metabolism of L-carnitine to TMAO. Cell Metab. 2014;20(5):799–812. This study and reference [47] provide novel insights into the metabolism of TMAO and its associations with various gut microbiome profiles.
    • (2014) Cell Metab , vol.20 , Issue.5 , pp. 799-812
    • Koeth, R.A.1
  • 34
    • 84907486084 scopus 로고    scopus 로고
    • The contributory role of gut microbiota in cardiovascular disease
    • COI: 1:CAS:528:DC%2BC2cXhslGgtr%2FF, PID: 2527172
    • Tang WH, Hazen SL. The contributory role of gut microbiota in cardiovascular disease. J Clin Invest. 2014;124(10):4204–11.
    • (2014) J Clin Invest , vol.124 , Issue.10 , pp. 4204-4211
    • Tang, W.H.1    Hazen, S.L.2
  • 35
    • 84923913674 scopus 로고    scopus 로고
    • Transmission of atherosclerosis susceptibility with gut microbial transplantation
    • PID: 2555016
    • Gregory JC et al. Transmission of atherosclerosis susceptibility with gut microbial transplantation. J Biol Chem. 2014;290:5647–60.
    • (2014) J Biol Chem , vol.290 , pp. 5647-5660
    • Gregory, J.C.1
  • 36
    • 79953733693 scopus 로고    scopus 로고
    • Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease
    • COI: 1:CAS:528:DC%2BC3MXksVCrsrw%3D, PID: 21475195, In this study, Wang et al. uses a metabolomic screen to identify TMAO as a novel gut microbiota-dependent metabolite that is a potential modifiable risk factor for cardiovascular disease
    • Wang Z et al. Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease. Nature. 2011;472(7341):57–63. In this study, Wang et al. uses a metabolomic screen to identify TMAO as a novel gut microbiota-dependent metabolite that is a potential modifiable risk factor for cardiovascular disease.
    • (2011) Nature , vol.472 , Issue.7341 , pp. 57-63
    • Wang, Z.1
  • 37
    • 84908377019 scopus 로고    scopus 로고
    • Prognostic value of elevated levels of intestinal microbe-generated metabolite trimethylamine-N-oxide in patients with heart failure: refining the gut hypothesis
    • COI: 1:CAS:528:DC%2BC2cXhvVGisb3N, PID: 2544414
    • Tang WH et al. Prognostic value of elevated levels of intestinal microbe-generated metabolite trimethylamine-N-oxide in patients with heart failure: refining the gut hypothesis. J Am Coll Cardiol. 2014;64(18):1908–14.
    • (2014) J Am Coll Cardiol , vol.64 , Issue.18 , pp. 1908-1914
    • Tang, W.H.1
  • 38
    • 84876563088 scopus 로고    scopus 로고
    • Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk
    • COI: 1:CAS:528:DC%2BC3sXntVCmsrc%3D, PID: 23614584, In this clinical study with over 4000 participants, the authors reconfirmed the gut microbiota dependence of TMAO in human subjects and found that serum TMAO levels predicted 3-year incident cardiovascular risk in a dose-dependent manner
    • Tang WH et al. Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk. N Engl J Med. 2013;368(17):1575–84. In this clinical study with over 4000 participants, the authors reconfirmed the gut microbiota dependence of TMAO in human subjects and found that serum TMAO levels predicted 3-year incident cardiovascular risk in a dose-dependent manner.
    • (2013) N Engl J Med , vol.368 , Issue.17 , pp. 1575-1584
    • Tang, W.H.1
  • 39
    • 84921863158 scopus 로고    scopus 로고
    • Intestinal microbiota-dependent phosphatidylcholine metabolites, diastolic dysfunction and adverse clinical outcomes in chronic systolic heart failure
    • PID: 2545968
    • Tang WH et al. Intestinal microbiota-dependent phosphatidylcholine metabolites, diastolic dysfunction and adverse clinical outcomes in chronic systolic heart failure. J Card Fail. 2014;21:91–6.
    • (2014) J Card Fail , vol.21 , pp. 91-96
    • Tang, W.H.1
  • 40
    • 84898859680 scopus 로고    scopus 로고
    • Prognostic value of choline and betaine depends on intestinal microbiota-generated metabolite trimethylamine-N-oxide
    • COI: 1:CAS:528:DC%2BC2cXmsFertbg%3D, PID: 2449733
    • Wang Z et al. Prognostic value of choline and betaine depends on intestinal microbiota-generated metabolite trimethylamine-N-oxide. Eur Heart J. 2014;35(14):904–10.
    • (2014) Eur Heart J , vol.35 , Issue.14 , pp. 904-910
    • Wang, Z.1
  • 41
    • 79953737332 scopus 로고    scopus 로고
    • Metabolite profiles and the risk of developing diabetes
    • PID: 2142318
    • Wang TJ et al. Metabolite profiles and the risk of developing diabetes. Nat Med. 2011;17(4):448–53.
    • (2011) Nat Med , vol.17 , Issue.4 , pp. 448-453
    • Wang, T.J.1
  • 42
    • 84918565300 scopus 로고    scopus 로고
    • Betaine and trimethylamine-N-oxide as predictors of cardiovascular outcomes show different patterns in diabetes mellitus: an observational study
    • PID: 2549343
    • Lever M et al. Betaine and trimethylamine-N-oxide as predictors of cardiovascular outcomes show different patterns in diabetes mellitus: an observational study. PLoS ONE. 2014;9(12), e114969.
    • (2014) PLoS ONE , vol.9 , Issue.12
    • Lever, M.1
  • 43
    • 84921636319 scopus 로고    scopus 로고
    • Dietary trimethylamine N-oxide exacerbates impaired glucose tolerance in mice fed a high fat diet
    • COI: 1:CAS:528:DC%2BC2cXlslWksro%3D, PID: 2472112
    • Gao X et al. Dietary trimethylamine N-oxide exacerbates impaired glucose tolerance in mice fed a high fat diet. J Biosci Bioeng. 2014;118(4):476–81.
    • (2014) J Biosci Bioeng , vol.118 , Issue.4 , pp. 476-481
    • Gao, X.1
  • 44
    • 84927126803 scopus 로고    scopus 로고
    • Flavin-containing monooxygenase 3 as a potential player in diabetes-associated atherosclerosis
    • COI: 1:CAS:528:DC%2BC2MXhtF2itLbF, PID: 25849138, This study shows that knockdown of FMO3 and subsequently TMAO levels can prevent the development of hyperglycemia, hyperlipidemia, and atherosclerosis in a diabetes mouse model
    • Miao J et al. Flavin-containing monooxygenase 3 as a potential player in diabetes-associated atherosclerosis. Nat Commun. 2015;6:6498. This study shows that knockdown of FMO3 and subsequently TMAO levels can prevent the development of hyperglycemia, hyperlipidemia, and atherosclerosis in a diabetes mouse model.
    • (2015) Nat Commun , vol.6 , pp. 6498
    • Miao, J.1
  • 45
    • 84920704729 scopus 로고    scopus 로고
    • Flavin containing monooxygenase 3 exerts broad effects on glucose and lipid metabolism and atherosclerosis
    • COI: 1:CAS:528:DC%2BC2MXktFaruw%3D%3D, PID: 2537865
    • Shih DM et al. Flavin containing monooxygenase 3 exerts broad effects on glucose and lipid metabolism and atherosclerosis. J Lipid Res. 2015;56(1):22–37.
    • (2015) J Lipid Res , vol.56 , Issue.1 , pp. 22-37
    • Shih, D.M.1
  • 46
    • 84925862053 scopus 로고    scopus 로고
    • Gut microbiota-dependent trimethylamine N-oxide (TMAO) pathway contributes to both development of renal insufficiency and mortality risk in chronic kidney disease
    • COI: 1:CAS:528:DC%2BC2MXhs12kt7o%3D, PID: 2559933
    • Tang WH et al. Gut microbiota-dependent trimethylamine N-oxide (TMAO) pathway contributes to both development of renal insufficiency and mortality risk in chronic kidney disease. Circ Res. 2015;116(3):448–55.
    • (2015) Circ Res , vol.116 , Issue.3 , pp. 448-455
    • Tang, W.H.1
  • 47
    • 84877331372 scopus 로고    scopus 로고
    • Intestinal microbiota metabolism of L-carnitine, a nutrient in red meat, promotes atherosclerosis
    • COI: 1:CAS:528:DC%2BC3sXlsVCqu7w%3D, PID: 23563705, See reference 33
    • Koeth RA et al. Intestinal microbiota metabolism of L-carnitine, a nutrient in red meat, promotes atherosclerosis. Nat Med. 2013;19(5):576–85. See reference 33.
    • (2013) Nat Med , vol.19 , Issue.5 , pp. 576-585
    • Koeth, R.A.1
  • 48
    • 74949113912 scopus 로고    scopus 로고
    • Choline: an essential nutrient for public health
    • PID: 1990624
    • Zeisel SH, da Costa KA. Choline: an essential nutrient for public health. Nutr Rev. 2009;67(11):615–23.
    • (2009) Nutr Rev , vol.67 , Issue.11 , pp. 615-623
    • Zeisel, S.H.1    da Costa, K.A.2
  • 49
    • 84871863545 scopus 로고    scopus 로고
    • Choline and betaine food sources and intakes in Taiwanese
    • COI: 1:CAS:528:DC%2BC38XhvVCisbbL, PID: 2301731
    • Chu DM et al. Choline and betaine food sources and intakes in Taiwanese. Asia Pac J Clin Nutr. 2012;21(4):547–57.
    • (2012) Asia Pac J Clin Nutr , vol.21 , Issue.4 , pp. 547-557
    • Chu, D.M.1
  • 50
    • 43249110882 scopus 로고    scopus 로고
    • Phosphatidylcholine and choline homeostasis
    • COI: 1:CAS:528:DC%2BD1cXmslWntL0%3D, PID: 1820409
    • Li Z, Vance DE. Phosphatidylcholine and choline homeostasis. J Lipid Res. 2008;49(6):1187–94.
    • (2008) J Lipid Res , vol.49 , Issue.6 , pp. 1187-1194
    • Li, Z.1    Vance, D.E.2
  • 51
    • 80052096256 scopus 로고    scopus 로고
    • Role of phosphatidylcholine during neuronal differentiation
    • COI: 1:CAS:528:DC%2BC3MXhtVKlsbjO, PID: 2181883
    • Paoletti L et al. Role of phosphatidylcholine during neuronal differentiation. IUBMB Life. 2011;63(9):714–20.
    • (2011) IUBMB Life , vol.63 , Issue.9 , pp. 714-720
    • Paoletti, L.1
  • 52
    • 77952951396 scopus 로고    scopus 로고
    • The clinical significance of betaine, an osmolyte with a key role in methyl group metabolism
    • COI: 1:CAS:528:DC%2BC3cXmsVSmsLk%3D, PID: 2034693
    • Lever M, Slow S. The clinical significance of betaine, an osmolyte with a key role in methyl group metabolism. Clin Biochem. 2010;43(9):732–44.
    • (2010) Clin Biochem , vol.43 , Issue.9 , pp. 732-744
    • Lever, M.1    Slow, S.2
  • 53
    • 84859766869 scopus 로고    scopus 로고
    • Variability of plasma and urine betaine in diabetes mellitus and its relationship to methionine load test responses: an observational study
    • COI: 1:CAS:528:DC%2BC38XhtVyju7bO, PID: 2251029
    • Lever M et al. Variability of plasma and urine betaine in diabetes mellitus and its relationship to methionine load test responses: an observational study. Cardiovasc Diabetol. 2012;11:34.
    • (2012) Cardiovasc Diabetol , vol.11 , pp. 34
    • Lever, M.1
  • 54
    • 84861387300 scopus 로고    scopus 로고
    • Betaine and secondary events in an acute coronary syndrome cohort
    • COI: 1:CAS:528:DC%2BC38XnvFGrtb0%3D, PID: 2264956
    • Lever M et al. Betaine and secondary events in an acute coronary syndrome cohort. PLoS One. 2012;7(5), e37883.
    • (2012) PLoS One , vol.7 , Issue.5
    • Lever, M.1
  • 55
    • 36749104412 scopus 로고    scopus 로고
    • Homocysteine metabolism in diabetes
    • COI: 1:CAS:528:DC%2BD2sXht1eru7vF, PID: 1795630
    • Wijekoon EP, Brosnan ME, Brosnan JT. Homocysteine metabolism in diabetes. Biochem Soc Trans. 2007;35(Pt 5):1175–9.
    • (2007) Biochem Soc Trans , vol.35 , pp. 1175-1179
    • Wijekoon, E.P.1    Brosnan, M.E.2    Brosnan, J.T.3
  • 56
    • 42449163324 scopus 로고    scopus 로고
    • Divergent associations of plasma choline and betaine with components of metabolic syndrome in middle age and elderly men and women
    • COI: 1:CAS:528:DC%2BD1cXltFOnt7w%3D, PID: 1842460
    • Konstantinova SV et al. Divergent associations of plasma choline and betaine with components of metabolic syndrome in middle age and elderly men and women. J Nutr. 2008;138(5):914–20.
    • (2008) J Nutr , vol.138 , Issue.5 , pp. 914-920
    • Konstantinova, S.V.1
  • 57
    • 84881138347 scopus 로고    scopus 로고
    • Assessment of urinary betaine as a marker of diabetes mellitus in cardiovascular patients
    • COI: 1:CAS:528:DC%2BC3sXhtlajs7jE, PID: 2393633
    • Schartum-Hansen H et al. Assessment of urinary betaine as a marker of diabetes mellitus in cardiovascular patients. PLoS One. 2013;8(8), e69454.
    • (2013) PLoS One , vol.8 , Issue.8
    • Schartum-Hansen, H.1
  • 58
    • 79959794451 scopus 로고    scopus 로고
    • Plasma lipids and betaine are related in an acute coronary syndrome cohort
    • COI: 1:CAS:528:DC%2BC3MXptFyntbs%3D, PID: 2174794
    • Lever M et al. Plasma lipids and betaine are related in an acute coronary syndrome cohort. PLoS One. 2011;6(7), e21666.
    • (2011) PLoS One , vol.6 , Issue.7
    • Lever, M.1
  • 59
    • 84858118626 scopus 로고    scopus 로고
    • Dietary choline and betaine intakes and risk of cardiovascular diseases: review of epidemiological evidence
    • PID: 2257745
    • Rajaie S, Esmaillzadeh A. Dietary choline and betaine intakes and risk of cardiovascular diseases: review of epidemiological evidence. ARYA Atheroscler. 2011;7(2):78–86.
    • (2011) ARYA Atheroscler , vol.7 , Issue.2 , pp. 78-86
    • Rajaie, S.1    Esmaillzadeh, A.2
  • 60
    • 34347404326 scopus 로고    scopus 로고
    • Whole blood choline and plasma choline in acute coronary syndromes: prognostic and pathophysiological implications
    • COI: 1:CAS:528:DC%2BD2sXnsFWlsr8%3D, PID: 1755347
    • Danne O et al. Whole blood choline and plasma choline in acute coronary syndromes: prognostic and pathophysiological implications. Clin Chim Acta. 2007;383(1–2):103–9.
    • (2007) Clin Chim Acta , vol.383 , Issue.1-2 , pp. 103-109
    • Danne, O.1
  • 61
    • 0037407389 scopus 로고    scopus 로고
    • Prognostic implications of elevated whole blood choline levels in acute coronary syndromes
    • COI: 1:CAS:528:DC%2BD3sXjtFWqsrc%3D, PID: 1271414
    • Danne O et al. Prognostic implications of elevated whole blood choline levels in acute coronary syndromes. Am J Cardiol. 2003;91(9):1060–7.
    • (2003) Am J Cardiol , vol.91 , Issue.9 , pp. 1060-1067
    • Danne, O.1
  • 62
    • 68749095208 scopus 로고    scopus 로고
    • Usefulness of elevations in serum choline and free F2)-isoprostane to predict 30-day cardiovascular outcomes in patients with acute coronary syndrome
    • COI: 1:CAS:528:DC%2BD1MXhtVaqs77M, PID: 1969933
    • LeLeiko RM et al. Usefulness of elevations in serum choline and free F2-isoprostane to predict 30-day cardiovascular outcomes in patients with acute coronary syndrome. Am J Cardiol. 2009;104(5):638–43.
    • (2009) Am J Cardiol , vol.104 , Issue.5 , pp. 638-643
    • LeLeiko, R.M.1
  • 63
    • 34547750947 scopus 로고    scopus 로고
    • Usual choline and betaine dietary intake and incident coronary heart disease: the Atherosclerosis Risk in Communities (ARIC) study
    • PID: 1762990
    • Bidulescu A et al. Usual choline and betaine dietary intake and incident coronary heart disease: the Atherosclerosis Risk in Communities (ARIC) study. BMC Cardiovasc Disord. 2007;7:20.
    • (2007) BMC Cardiovasc Disord , vol.7 , pp. 20
    • Bidulescu, A.1
  • 64
    • 62149099618 scopus 로고    scopus 로고
    • Repeatability and measurement error in the assessment of choline and betaine dietary intake: the Atherosclerosis Risk in Communities (ARIC) study
    • PID: 1923210
    • Bidulescu A et al. Repeatability and measurement error in the assessment of choline and betaine dietary intake: the Atherosclerosis Risk in Communities (ARIC) study. Nutr J. 2009;8:14.
    • (2009) Nutr J , vol.8 , pp. 14
    • Bidulescu, A.1
  • 65
    • 33747618036 scopus 로고    scopus 로고
    • Metabolic profiling reveals a contribution of gut microbiota to fatty liver phenotype in insulin-resistant mice
    • COI: 1:CAS:528:DC%2BD28Xos12qu7s%3D, PID: 1689599
    • Dumas ME et al. Metabolic profiling reveals a contribution of gut microbiota to fatty liver phenotype in insulin-resistant mice. Proc Natl Acad Sci U S A. 2006;103(33):12511–6.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , Issue.33 , pp. 12511-12516
    • Dumas, M.E.1
  • 66
    • 10644280659 scopus 로고    scopus 로고
    • Carnitine in type 2 diabetes
    • COI: 1:CAS:528:DC%2BD2MXjvFOgtg%3D%3D, PID: 1559100
    • Mingrone G. Carnitine in type 2 diabetes. Ann N Y Acad Sci. 2004;1033:99–107.
    • (2004) Ann N Y Acad Sci , vol.1033 , pp. 99-107
    • Mingrone, G.1
  • 67
    • 0025748024 scopus 로고
    • Carnitine improves peripheral glucose disposal in non-insulin-dependent diabetic patients
    • COI: 1:STN:280:DyaK387jslShuw%3D%3D, PID: 177811
    • Capaldo B et al. Carnitine improves peripheral glucose disposal in non-insulin-dependent diabetic patients. Diabetes Res Clin Pract. 1991;14(3):191–5.
    • (1991) Diabetes Res Clin Pract , vol.14 , Issue.3 , pp. 191-195
    • Capaldo, B.1
  • 68
    • 0024268248 scopus 로고
    • Interaction of carnitine with insulin-stimulated glucose metabolism in humans
    • COI: 1:CAS:528:DyaL1MXovFSmsA%3D%3D, PID: 305982
    • Ferrannini E et al. Interaction of carnitine with insulin-stimulated glucose metabolism in humans. Am J Physiol. 1988;255(6 Pt 1):E946–52.
    • (1988) Am J Physiol , vol.255 , Issue.6 , pp. 946-952
    • Ferrannini, E.1
  • 69
    • 73349102478 scopus 로고    scopus 로고
    • Carnitine and type 2 diabetes
    • COI: 1:CAS:528:DC%2BD1MXht1GntrzM, PID: 1966261
    • Mynatt RL. Carnitine and type 2 diabetes. Diabetes Metab Res Rev. 2009;25 Suppl 1:S45–9.
    • (2009) Diabetes Metab Res Rev , vol.25 , pp. 45-49
    • Mynatt, R.L.1
  • 70
    • 84876494766 scopus 로고    scopus 로고
    • Metabolic effects of L-carnitine on type 2 diabetes mellitus: systematic review and meta-analysis
    • COI: 1:CAS:528:DC%2BC3sXovFequ78%3D, PID: 2343057
    • Vidal-Casariego A et al. Metabolic effects of L-carnitine on type 2 diabetes mellitus: systematic review and meta-analysis. Exp Clin Endocrinol Diabetes. 2013;121(4):234–8.
    • (2013) Exp Clin Endocrinol Diabetes , vol.121 , Issue.4 , pp. 234-238
    • Vidal-Casariego, A.1
  • 71
    • 84880197534 scopus 로고    scopus 로고
    • L-carnitine in the secondary prevention of cardiovascular disease: systematic review and meta-analysis
    • COI: 1:CAS:528:DC%2BC3sXmtlehsr8%3D, PID: 2359787
    • DiNicolantonio JJ et al. L-carnitine in the secondary prevention of cardiovascular disease: systematic review and meta-analysis. Mayo Clin Proc. 2013;88(6):544–51.
    • (2013) Mayo Clin Proc , vol.88 , Issue.6 , pp. 544-551
    • DiNicolantonio, J.J.1
  • 72
    • 84904445760 scopus 로고    scopus 로고
    • Effective dosing of L-carnitine in the secondary prevention of cardiovascular disease: a systematic review and meta-analysis
    • PID: 2504403
    • Shang R, Sun Z, Li H. Effective dosing of L-carnitine in the secondary prevention of cardiovascular disease: a systematic review and meta-analysis. BMC Cardiovasc Disord. 2014;14:88.
    • (2014) BMC Cardiovasc Disord , vol.14 , pp. 88
    • Shang, R.1    Sun, Z.2    Li, H.3
  • 73
    • 84871837954 scopus 로고    scopus 로고
    • Microbial conversion of choline to trimethylamine requires a glycyl radical enzyme
    • COI: 1:CAS:528:DC%2BC3sXoslSgsQ%3D%3D, PID: 2315150
    • Craciun S, Balskus EP. Microbial conversion of choline to trimethylamine requires a glycyl radical enzyme. Proc Natl Acad Sci U S A. 2012;109(52):21307–12.
    • (2012) Proc Natl Acad Sci U S A , vol.109 , Issue.52 , pp. 21307-21312
    • Craciun, S.1    Balskus, E.P.2
  • 74
    • 84896537331 scopus 로고    scopus 로고
    • Carnitine metabolism to trimethylamine by an unusual Rieske-type oxygenase from human microbiota
    • COI: 1:CAS:528:DC%2BC2cXjtl2kt74%3D, PID: 2459161
    • Zhu Y et al. Carnitine metabolism to trimethylamine by an unusual Rieske-type oxygenase from human microbiota. Proc Natl Acad Sci U S A. 2014;111(11):4268–73.
    • (2014) Proc Natl Acad Sci U S A , vol.111 , Issue.11 , pp. 4268-4273
    • Zhu, Y.1
  • 75
    • 77950251400 scopus 로고    scopus 로고
    • A human gut microbial gene catalogue established by metagenomic sequencing
    • COI: 1:CAS:528:DC%2BC3cXislahsLc%3D, PID: 2020360
    • Qin J et al. A human gut microbial gene catalogue established by metagenomic sequencing. Nature. 2010;464(7285):59–65.
    • (2010) Nature , vol.464 , Issue.7285 , pp. 59-65
    • Qin, J.1
  • 76
    • 58749112734 scopus 로고    scopus 로고
    • A core gut microbiome in obese and lean twins
    • COI: 1:CAS:528:DC%2BD1MXotlOlsw%3D%3D, PID: 1904340
    • Turnbaugh PJ et al. A core gut microbiome in obese and lean twins. Nature. 2009;457(7228):480–4.
    • (2009) Nature , vol.457 , Issue.7228 , pp. 480-484
    • Turnbaugh, P.J.1
  • 77
    • 78650037263 scopus 로고    scopus 로고
    • Differential adaptation of human gut microbiota to bariatric surgery-induced weight loss: links with metabolic and low-grade inflammation markers
    • COI: 1:CAS:528:DC%2BC3MXlsVamtg%3D%3D, PID: 2087671
    • Furet JP et al. Differential adaptation of human gut microbiota to bariatric surgery-induced weight loss: links with metabolic and low-grade inflammation markers. Diabetes. 2010;59(12):3049–57.
    • (2010) Diabetes , vol.59 , Issue.12 , pp. 3049-3057
    • Furet, J.P.1
  • 78
    • 84883181684 scopus 로고    scopus 로고
    • Human gut microbiota changes reveal the progression of glucose intolerance
    • COI: 1:CAS:528:DC%2BC3sXhsVWhsbfP, PID: 2401313
    • Zhang X et al. Human gut microbiota changes reveal the progression of glucose intolerance. PLoS One. 2013;8(8), e71108.
    • (2013) PLoS One , vol.8 , Issue.8
    • Zhang, X.1
  • 79
    • 84892874108 scopus 로고    scopus 로고
    • Effects of short chain fatty acid producing bacteria on epigenetic regulation of FFAR3 in type 2 diabetes and obesity
    • COI: 1:CAS:528:DC%2BC2cXptF2gsw%3D%3D, PID: 2432590
    • Remely M et al. Effects of short chain fatty acid producing bacteria on epigenetic regulation of FFAR3 in type 2 diabetes and obesity. Gene. 2014;537(1):85–92.
    • (2014) Gene , vol.537 , Issue.1 , pp. 85-92
    • Remely, M.1
  • 80
    • 84868197954 scopus 로고    scopus 로고
    • The microbiota of the gut in preschool children with normal and excessive body weight
    • Karlsson CL et al. The microbiota of the gut in preschool children with normal and excessive body weight. Obesity (Silver Spring). 2012;20(11):2257–61.
    • (2012) Obesity (Silver Spring) , vol.20 , Issue.11 , pp. 2257-2261
    • Karlsson, C.L.1
  • 81
    • 80755152887 scopus 로고    scopus 로고
    • Responses of gut microbiota and glucose and lipid metabolism to prebiotics in genetic obese and diet-induced leptin-resistant mice
    • COI: 1:CAS:528:DC%2BC3MXhsVyisrfM, PID: 2193398
    • Everard A et al. Responses of gut microbiota and glucose and lipid metabolism to prebiotics in genetic obese and diet-induced leptin-resistant mice. Diabetes. 2011;60(11):2775–86.
    • (2011) Diabetes , vol.60 , Issue.11 , pp. 2775-2786
    • Everard, A.1
  • 82
    • 84878465280 scopus 로고    scopus 로고
    • Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity
    • COI: 1:CAS:528:DC%2BC3sXhtFait7rM, PID: 2367110
    • Everard A et al. Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity. Proc Natl Acad Sci U S A. 2013;110(22):9066–71.
    • (2013) Proc Natl Acad Sci U S A , vol.110 , Issue.22 , pp. 9066-9071
    • Everard, A.1
  • 83
    • 84897960120 scopus 로고    scopus 로고
    • An increase in the Akkermansia spp. population induced by metformin treatment improves glucose homeostasis in diet-induced obese mice
    • COI: 1:CAS:528:DC%2BC2cXpsVSltro%3D, PID: 2380456
    • Shin NR et al. An increase in the Akkermansia spp. population induced by metformin treatment improves glucose homeostasis in diet-induced obese mice. Gut. 2014;63(5):727–35.
    • (2014) Gut , vol.63 , Issue.5 , pp. 727-735
    • Shin, N.R.1
  • 84
    • 78751580602 scopus 로고    scopus 로고
    • Dominant and diet-responsive groups of bacteria within the human colonic microbiota
    • COI: 1:CAS:528:DC%2BC3MXmsVGjtw%3D%3D, PID: 2068651
    • Walker AW et al. Dominant and diet-responsive groups of bacteria within the human colonic microbiota. ISME J. 2011;5(2):220–30.
    • (2011) ISME J , vol.5 , Issue.2 , pp. 220-230
    • Walker, A.W.1
  • 85
    • 80053618114 scopus 로고    scopus 로고
    • Linking long-term dietary patterns with gut microbial enterotypes
    • COI: 1:CAS:528:DC%2BC3MXht1Gms77K, PID: 2188573
    • Wu GD et al. Linking long-term dietary patterns with gut microbial enterotypes. Science. 2011;334(6052):105–8.
    • (2011) Science , vol.334 , Issue.6052 , pp. 105-108
    • Wu, G.D.1
  • 86
    • 84892828465 scopus 로고    scopus 로고
    • Diet rapidly and reproducibly alters the human gut microbiome
    • COI: 1:CAS:528:DC%2BC2cXhtFOls78%3D, PID: 2433621
    • David LA et al. Diet rapidly and reproducibly alters the human gut microbiome. Nature. 2014;505(7484):559–63.
    • (2014) Nature , vol.505 , Issue.7484 , pp. 559-563
    • David, L.A.1
  • 87
    • 84866146940 scopus 로고    scopus 로고
    • Diversity, stability and resilience of the human gut microbiota
    • COI: 1:CAS:528:DC%2BC38Xhtleru7jO, PID: 2297229
    • Lozupone CA et al. Diversity, stability and resilience of the human gut microbiota. Nature. 2012;489(7415):220–30.
    • (2012) Nature , vol.489 , Issue.7415 , pp. 220-230
    • Lozupone, C.A.1


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