Circulating lipopolysaccharide-binding protein (LBP) as a marker of obesity-related insulin resistance

International Journal of Obesity

Volumn 36, Issue 11, 2012, Pages 1442-1449

  Moreno Navarrete, J M ^a   Ortega, F ^a   Serino, M ^b   Luche, E ^b   Waget, A ^b   Pardo, G ^c   Salvador, J ^c   Ricart, W ^a   Fruhbeck G ^c   Burcelin, R ^b   Fernandez Real J M ^a  

^a HOSPITAL JOSEP TRUETA   (Spain)

^b CHU RANGUEIL   (France)

^c INSTITUTO DE SALUD CARLOS III   (Spain)

Author keywords

insulin resistance; LBP; LPS

Indexed keywords

ACETYLSALICYLIC ACID; ALLOPURINOL; GLUCAGON LIKE PEPTIDE 1 RECEPTOR; GLUCOSE; INSULIN; LIPOPOLYSACCHARIDE BINDING PROTEIN; METFORMIN; SULFONYLUREA; TUMOR NECROSIS FACTOR RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD PRESSURE MEASUREMENT; BODY COMPOSITION; BODY MASS; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; CROSS-SECTIONAL STUDY; DIASTOLIC BLOOD PRESSURE; DISEASE ASSOCIATION; DISEASE MARKER; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GLUCOSE BLOOD LEVEL; HUMAN; HUMAN TISSUE; INSULIN RESISTANCE; INSULIN SENSITIVITY; LIPID DIET; LIVER; MALE; MORBID OBESITY; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; ORAL GLUCOSE TOLERANCE TEST; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BLOOD LEVEL; SYSTOLIC BLOOD PRESSURE; WAIST HIP RATIO; WEIGHT REDUCTION; WILD TYPE;

ACUTE-PHASE PROTEINS; ADIPOSE TISSUE; ANIMALS; BIOLOGICAL MARKERS; BODY MASS INDEX; CARRIER PROTEINS; CROSS-SECTIONAL STUDIES; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMANS; INFLAMMATION; INSULIN RESISTANCE; MALE; MEMBRANE GLYCOPROTEINS; MICE; OBESITY; SPAIN; WEIGHT LOSS;

MUS;

EID: 84869087622     PISSN: 03070565     EISSN: 14765497     Source Type: Journal    
DOI: 10.1038/ijo.2011.256     Document Type: Article

References (28)

1. Weisberg SP, McCann D, Desai M, Rosenbaum M, Leibel RL, Ferrante Jr AW. Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest 2003; 112: 1796-1808.
2. Pickup JC, Crook MA. Is type II diabetes mellitus a disease of the innate immune system? Diabetologia 1998; 41: 1241-1248.
3. Festa A, D'Agostino Jr R, Howard G, Mykkanen L, Tracy RP, Haffner SM. Chronic subclinical inflammation as part of the insulin resistance syndrome: the Insulin Resistance Atherosclerosis Study (IRAS). Circulation 2000; 102: 42-47.
4. Ridker PM, Buring JE, Cook NR, Rifai N. C-reactive protein, the metabolic syndrome, and risk of incident cardiovascular events: an 8-year follow-up of 14719 initially healthy American women. Circulation 2003; 107: 391-397.
5. Fernandez-Real JM, Ricart W. Insulin resistance and chronic cardiovascular inflammatory syndrome. Endocr Rev 2003; 24: 278-301.
6. Lee JY, Hwang DH. The modulation of inflammatory gene expression by lipids: mediation through Toll-like receptors. Mol Cell 2006; 21: 174-185.
7. Song MJ, Kim KH, Yoon JM, Kim JB. Activation of Toll-like receptor 4 is associated with insulin resistance in adipocytes. Biochem Biophys Res Commun 2006; 346: 739-745.
8. Fernandez-Real JM, Lo pez-Bermejo A, Vendrell J, Ferri MJ, Recasens M, Ricart W. Burden of infection and insulin resistance in healthy middle-aged men. Diabetes Care 2006; 29: 1058-1064.
9. Ceriello A, Motz E. Is oxidative stress the pathogenic mechanism underlying insulin resistance, diabetes, and cardiovascular disease? The common soil hypothesis revisited. Arterioscler Thromb Vasc Biol 2004; 24: 816-823.
10. Grube BJ, Cochane CG, Ye RD, Green CE, McPhail ME, Ulevitch RJ et al. Lipopolysaccharide binding protein expression in primary human hepatocytes and HepG2 hepatoma cells. J Biol Chem 1994; 269: 8477-8482.
11. Tobias PS, Soldau K, Ulevitch RJ. Identification of a lipid A binding site in the acute phase reactant lipopolysaccharide binding protein. J Biol Chem 1989; 264: 10867-10871.
12. Hailman E, Lichenstein HS, Wurfel MM, Miller DS, Johnson DA, Kelley M et al. Lipopolysaccharide (LPS)-binding protein accelerates the binding of LPS to CD14. J Exp Med 1994; 179: 269-277.
13. Wurfel MM, Kunitake ST, Lichenstein H, Kane JP, Wright SD. Lipopolysaccharide (LPS)-binding protein is carried on lipoproteins and acts as a cofactor in the neutralization of LPS. J Exp Med 1994; 180: 1025-1035.
14. Gubern C, Lopez-Bermejo A, Biarnes J, Vendrell J, Ricart W, Fernandez-Real JM. Natural antibiotics and insulin sensitivity: the role of bactericidal/permeabilityincreasing protein. Diabetes 2006; 55: 216-224.
15. Lepper PM, Schumann C, Triantafilou K, Rasche FM, Schuster T, Frank H et al. Association of lipopolysaccharide-binding protein and coronary artery disease in men. J Am Coll Cardiol 2007; 50: 25-31.
16. Sun L, Yu Z, Ye X, Zou S, Li H, Yu D et al. A marker of endotoxemia is associated with obesity and related disorders in apparently healthy Chinese. Diabetes Care 2010; 33: 1925-1932.
17. Bergman RN, Prager R, Volund A, Olefsky JM. Equivalence of the insulin sensitivity index in man derived by the minimal model method and euglycaemic glucose clamp. J Clin Invest 1987; 79: 790-800.
18. Moreno-Navarrete JM, Mart?nez-Barricarte R, Catalan V, Sabater M, Gomez-Ambrosi J, Ortega FJ et al. Complement factor H is expressed in adipose tissue in association with insulin resistance. Diabetes 2010; 59: 200-209.
19. Gomez-Ambrosi J, Catalan V, Ram?rez B, Rodr?guez A, Colina I, Silva C et al. Plasma osteopontin levels and expresion in adipose tissue in obesity. J Clin Endocrinol Metab 2007; 92: 3719-3727.
20. Cani PD, Amar J, Iglesias MA, Poggi M, Knauf C, Bastelica D et al. Metabolic endotoxemia initiates obesity and insulin resistance. Diabetes 2007; 56: 1761-1772.
21. Cabou C, Campistron G, Marsollier N, Leloup C, Cruciani-Guglielmacci C, Penicaud L et al. Brain glucagon-like peptide-1 regulates arterial blood flow, heart rate, and insulin sensitivity. Diabetes 2008; 57: 2577-2587.
22. Cani PD, Bibiloni R, Knauf C, Waget A, Neyrinck AM, Delzenne NM et al. Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice. Diabetes 2008; 57: 1470-1481.
23. Zweigner J, Schumann RR, Weber JR. The role of lipopolysaccharide-binding protein in modulating the innate immune response. Microbes Infect 2006; 8: 946-952.
24. Zweigner J, Gramm HJ, Singer OC, Wegscheider K, Schumann RR. High concentrations of lipopolysaccharide-binding protein in serum of patients with severe sepsis or septic shock inhibit the lipopolysaccharide response in human monocytes. Blood 2001; 98: 3800-3808.
25. Naito E, Yoshida Y, Makino K, Kounoshi Y, Kunihiro S, Takahashi R et al. Benefitial effect of oral administration of Lactobacillus casei strain Shirota on insulin resistance in diet-induced obesity mice. J Appl Microbiol 2011; 110: 650-657.
26. Fernandez-Real JM, Broch M, Ricart W, Casamitjana R, Gutierrez C, Vendrell J et al. Plasma levels of the soluble fraction of tumor necrosis factor receptor 2 and insulin resistance. Diabetes 1998; 47: 1757-1762.
27. Ouellet V, Weisnagel SJ, Marois J, Bergeron J, Julien P, Gougeon R et al. Dietary cod protein reduces plasma C-reactive protein in insulin-resistant men and women. J Nutr 2008; 138: 2386-2391.
28. Mente A, Razak F, Blankenberg S, Vuksan V, Davis AD, Miller R et al. Ethnic variation in adiponectin and leptin levels and their association with adiposity and insulin resistance. Diabetes Care 2010; 33: 1629-1634.