miR-155 controls lymphoproliferation in LAT mutant mice by restraining T-cell apoptosis via SHIP-1/mTOR and PAK1/FOXO3/BIM pathways

PLoS ONE

Volumn 10, Issue 6, 2015, Pages

  Rouquette Jazdanian, Alexandre K ^a   Kortum, Robert L ^a,b   Li, Wenmei ^a   Merrill, Robert K ^a   Nguyen, Phan H ^a   Samelson, Lawrence E ^a   Sommers, Connie L ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b UNIFORMED SERVICES UNIVERSITY OF THE HEALTH SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIM PROTEIN; CASPASE 3; GAMMA INTERFERON; INTERLEUKIN 4; MICRORNA 155; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE 1; PROTEIN KINASE B; TRANSCRIPTION FACTOR FKHRL1; APOPTOSIS REGULATORY PROTEIN; BCL2L11 PROTEIN, HUMAN; BCL2L11 PROTEIN, MOUSE; FORKHEAD TRANSCRIPTION FACTOR; FOXO3 PROTEIN, MOUSE; INOSITOL POLYPHOSPHATE 5 PHOSPHATASE; INPP5D PROTEIN, HUMAN; INPP5D PROTEIN, MOUSE; LAT PROTEIN, MOUSE; MEMBRANE PROTEIN; MICRORNA; MIRN155 MICRORNA, MOUSE; ONCOPROTEIN; P21 ACTIVATED KINASE; PAK1 PROTEIN, MOUSE; PHOSPHATASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 5 PHOSPHATASE; PHOSPHOPROTEIN; SIGNAL TRANSDUCING ADAPTOR PROTEIN; TARGET OF RAPAMYCIN KINASE;

ANIMAL CELL; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; CD4 LYMPHOCYTE COUNT; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL CYCLE G1 PHASE; CELL CYCLE PROGRESSION; CELL EXPANSION; CELL SURVIVAL; CYTOKINE PRODUCTION; DOWN REGULATION; GENOTYPE; HUMAN; HUMAN CELL; LYMPHOCYTE ACTIVATION; LYMPHOCYTE PROLIFERATION; LYMPHOPROLIFERATIVE DISEASE; MOUSE; NONHUMAN; PHENOTYPE; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN TARGETING; T LYMPHOCYTE; TH2 CELL; ANIMAL; C57BL MOUSE; CELL PROLIFERATION; CYTOLOGY; GENETICS; IMMUNOLOGY; JURKAT CELL LINE; METABOLISM; MUTANT MOUSE STRAIN; MUTATION; PATHOLOGY; SIGNAL TRANSDUCTION;

MUS;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; BCL-2-LIKE PROTEIN 11; CELL PROLIFERATION; FORKHEAD BOX PROTEIN O3; FORKHEAD TRANSCRIPTION FACTORS; HUMANS; INOSITOL POLYPHOSPHATE 5-PHOSPHATASES; JURKAT CELLS; LYMPHOCYTE ACTIVATION; LYMPHOPROLIFERATIVE DISORDERS; MEMBRANE PROTEINS; MICE, INBRED C57BL; MICE, MUTANT STRAINS; MICRORNAS; MUTATION; P21-ACTIVATED KINASES; PHOSPHATIDYLINOSITOL-3,4,5-TRISPHOSPHATE 5-PHOSPHATASES; PHOSPHOPROTEINS; PHOSPHORIC MONOESTER HYDROLASES; PROTO-ONCOGENE PROTEINS; SIGNAL TRANSDUCTION; T-LYMPHOCYTES; TOR SERINE-THREONINE KINASES;

EID: 84938709272     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0131823     Document Type: Article

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