Actions of Rho family small G proteins and p21-activated protein kinases on mitogen-activated protein kinase family members

Molecular and Cellular Biology

Volumn 16, Issue 7, 1996, Pages 3707-3713

  Frost, Jeffrey A ^a   Xu, Shuichan ^a   Hutchison, Michele R ^a   Marcus, Stevan ^b   Cobb, Melanie H ^a,c  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b UNIVERSITY OF TEXAS   (United States)

^c UNIVERSITY OF TEXAS AT DALLAS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GUANINE NUCLEOTIDE BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN P21; RAF PROTEIN; RHO FACTOR;

ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME REGULATION; GENE EXPRESSION; HUMAN; HUMAN CELL; ONCOGENE C JUN; ONCOGENE RAS; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FAMILY; SIGNAL TRANSDUCTION;

EID: 0029950672     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.16.7.3707     Document Type: Article

References (54)

1. Cdc42/Racactivated kinase. J. Biol. Chem. 270: 22731-22737.
2. Burbelo, P. D., D. Drechsel, and A. Hall. 1995. A conserved binding motif defines numerous candidate target proteins for both Cdc42 and Rac GTPases. J. Biol. Chem. 270:29071-29074.
3. Cantor, S. B., T. Urano, and L. A. Feig. 1995. Identification and characterization of Ral-binding protein 1, a potential downstream target of Ral GTPases. Mol. Cell. Biol. 15:4578-4584.
4. Chen, S. Y., S. Y. Huff, C. C. Lai, C. J. Der, and S. Powers. 1994. Ras-15A protein shares highly similar dominant-negative biological properties with Ras-17N and forms a stable, guanine-nucleotide resistant complex with CDC25 exchange factor. Oncogene 9:2691-2698.
5. Cobb, M. H., and E. Goldsmith. 1995. How MAP kinases are regulated. J. Biol. Chem. 270:14843-14846.
6. Coso, O. A., M. Chiariello, J.-C. Yu, H. Teramoto, P. Crespo, N. Xu, T. Miki, and J. S. Gutkind. 1995. The small GTP-binding proteins Rac1 and Cdc42 regulate the activity of the JNK/SAPK signaling pathway. Cell 81:1137-1146.
7. Davis, R. 1994. MAPKS: new JNK expands the group. Trends Biochem. Sci. 19:470-473.
8. Davis, R. J. 1993. The mitogen-activated protein kinase signal transduction pathway. J. Biol. Chem. 268: 14553-14556.
9. Dent, P., T. Jelinek, D. K. Morrison, M. J. Weber, and T. W. Sturgill. 1995. Reversal of Raf-1 activation by purified and membrane-associated protein phosphatases. Science 268:1902-1906.
10. Dérijard, B., M. Hibi, I.-H. Wu, T. Barrett, B. Su, T. Deng, M. Karin, and R. J. Davis. 1994. JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain. Cell 76:1025-1037.
11. Dérijard, B., J. Raingeaud, T. Barrett, I. Wu, J. Han, R. J. Ulevitch, and R. J. Davis. 1995. Independent human MAP kinase signal transduction pathways defined by MEK and MKK isoforms. Science 267:682-685.
12. English, J. M., C. A. Vanderbilt, S. Xu, S. Marcus, and M. H. Cobb. 1995. Isolation of MEK5 and differential expression of alternatively spliced forms. J. Biol. Chem. 270:28897-28902.
13. Feig, L. A. 1994. Guanine-nucleotide exchange factors: a family of positive regulators of Ras and related GTPases. Curr. Opin. Cell Biol. 6:204-211.
14. Frost, J. A., A. S. Alberts, E. Sontag, K. Guan, M. C. Mumby, and J. R. Feramisco. 1994. Simian virus 40 small t antigen cooperates with mitogen-activated kinases to stimulate AP-1 activity. Mol. Cell. Biol. 14:6244-6252.
15. 14a.Frost, J. A., M. R. Hutchison, and M. H. Cobb. Unpublished data.
16. 14b.Frost, J. A., M. R. Hutchison, S. Marcus, and M. H. Cobb. Unpublished data.
17. 14c.Frost, J. A., S. Xu, A. Dang, S. J. Mansour, N. G. Ahn, and M. H. Cobb. Unpublished data.
18. 14d.Gilbreth, M., P. Yang, J. A. Frost, A. Polverino, M. H. Cobb, and S. Marcus. Submitted for publication.
19. Heidecker, G., M. Huleihel, J. L. Cleveland, W. Kolch, T. W. Beck, P. Lloyd, T. Pawson, and U. R. Kapp. 1990. Mutational activation of c-raf-1 and definition of the minimal transforming sequence. Mol. Cell. Biol. 10:2503-2512.
20. Hibi, M., A. Lin, T. Smeal, A. Minden, and M. Karin. 1993. Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain. Genes Dev. 7:2135-2148.
21. James, G. L., M. S. Brown, M. H. Cobb, and J. L. Goldstein. 1994 Benzodiazepine peptidomimetic interrupts the MAP kinase activation pathway in Ras-transformed Rat-1 cells, but not in untransformed cells. J. Biol. Chem. 269:27705-27714.
22. Khosravi-Far, R., P. A. Solski, G. J. Clark, M. S. Kinch, and C. J. Der. 1995. Activation of Rac1, RhoA, and mitogen-activated protein kinases is required for Ras transformation. Mol. Cell. Biol. 15:6443-6453.
23. Lange-Carter, C. A., C. M. Pleiman, A. M. Gardner, K. J. Blumer, and G. L. Johnson. 1993. A divergence in the MAP kinase regulatory network defined by MEK kinase and Raf. Science 260:315-319.
24. Leberer, E., D. Dignard, D. Harcus, D. V. Thomas, and M. Whiteway. 1992. The protein kinase homologue Ste20p is required to link the yeast pheromone response G-protein βτ subunits to downstream signalling components. EMBO J. 11:4815-4824.
25. Leevers, S. J., H. F. Paterson, and C. J. Marshall. 1994. Requirement for Ras in Raf activation is overcome by targeting Raf to the plasma membrane. Nature (London) 369:411-414.
26. Lin, A., A. Minden, H. Martinetto, F.-X. Claret, C. Lange-Carter, F. Mercurio, G. Johnson, and M. Karin. 1995. Identification of a dual specificity kinase that activates the Jun kinases and p38-Mpk2. Science 268:286-290.
27. Manser, E., C. Chong, Z.-S. Zhao, T. Leung, G. Michael, C. Hall, and L. Lim. 1995. Molecular cloning of a new member of the p21-Cdc42/Rac-activated kinase (PAK) family. J. Biol. Chem. 270:25070-25078.
28. Manser, E., T. Leung, H. Salihuddin, Z.-S. Zhao, and L. Lim. 1994. A brain serine/threonine protein kinase activated by Cdc42 and Rac1. Nature (London) 367:411-46.
29. PAK protein kinases, is a component of a Ras/Cdc42 signaling module in fission yeast Schizosaccharomyces pombe. Proc. Natl. Acad. Sci. USA 92:6180-6184.
30. Martin, G. A., G. Bollag, F. McCormick, and A. Abo. 1995. A novel serine kinase activated by Rac1/CDC42Hs-dependent autophosphorylation is related to PAK65 and STE20. EMBO J. 14:1970-1978.
31. Minden, A., A. Lin, F.-X. Claret, A. Abo, and M. Karin. 1995. Selective activation of the JNK signaling cascade and c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs. Cell 81:1147-1157.
32. Minden, A., A. Lin, M. McMahon, C. Lange-Carter, B. Dérijard, R. J. Davis, G. L. Johnson, and M. Karin. 1994. Differential activation of ERK and JNK mitogen-activated protein kinases by Raf-1 and MEKK. Science 266:1719-1723.
33. Polverino, A., J. Frost, P. Yang, M. Hutchison, A. M. Neiman, M. H. Cobb, and S. Marcus. 1995. Activation of MAPK cascades by p21-activated protein kinases in cell-free extracts of Xenopus oocytes. J. Biol. Chem. 270:26067-26070.
34. Pombo, C. M., J. H. Kehrl, I. Sánchez, P. Katz, J. Avruch, L. I. Zon, J. R. Woodgett, T. Force, and J. M. Kyriakis. 1995. Activation of the SAPK pathway by the human STE20 homologue germinal centre kinase. Nature (London) 377:750-754.
35. Qiu, R.-G., J. Chen, D. Kirn, F. McCormick, and M. Symons. 1995. An essential role for Rac in Ras transformation. Nature (London) 374:457-459.
36. Ramer, S. W., and R. W. Davis. 1993. A dominant truncation allele identifies a gene, STE20, that encodes a putative protein kinase necessary for mating in Saccharomyces cervisiae. Proc. Natl. Acad. Sci. USA 90:452-456.
37. Ridley, A. J., H. F. Paterson, C. L. Johnson, D. Diekmann, and A. Hall. 1992. The small GTP-binding protein rac regulates growth factor-induced membrane ruffling. Cell 70:401-410.
38. Sambrook, J.. E. F. Fritsch, and T. Maniatis. 1989. Molecular cloning: a laboratory manual, 2nd ed. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.
39. Settleman, J., C. F. Albright, L. C. Foster, and R. A. Weinberg. 1992. Association between GTPase activators for Rho and Ras families. Nature (London) 359:153-154.
40. Settleman, J., V. Narasimhan, L. C. Foster, and R. A. Weinberg. 1992. Molecular cloning of cDNAs encoding the GAP-associated protein p190: implications for a signaling pathway from Ras to the nucleus. Cell 69:539-549.
41. Shou, C., C. L. Farnsworth, B. G. Neel, and L. A. Feig. 1992. Molecular cloning of cDNAs encoding a guanine-nucleotide-releasing factor for Ras p21. Nature (London) 358:351-354.
42. Shubha, B., B. Dérijard, R. J. Davis, and R. A. Cerione. 1995 Cdc42 and PAK-mediated signaling leads to Jun kinase and p38 mitogen-activated protein kinase activation. J. Biol. Chem. 270:27998.
43. Stokoe, D., S. G. MacDonald, K. Cadwallader, M. Symons, and J. F. Hancock. 1994. Activation of Raf as a result of recruitment to plasma membrane. Science 264:1463-1467.
44. cds42/racl -activated serine/threonine kinase that is rapidly activated by thrombin in platelets. J. Biol. Chem. 270:26690-26697.
45. Thorburn, J., J. A. Frost, and A. Thorburn. 1994. Mitogen-activated protein kinases mediate changes in gene expression, but not cytoskeletal organization associated with cardiac muscle cell hypertrophy. J. Cell Biol. 126:1565-1572.
46. Valencia, A., P. Chardin, A. Wittinghofer, and C. Sander. 1991. The ras protein family: evolutionary tree and role of conserved amino acids. Biochemistry 30:4637-4648.
47. Vojtek, A. B., and J. A. Cooper. 1995. Rho family members: activators of MAP kinase cascades. Cell 82:527-529.
48. 43a.Whilehurst, C., and T. Geppert. Unpublished data.
49. Whilehurst, C. E., H. Owaki, J. T. Bruder, U. R. Rapp, and T. D. Geppert. 1995. The MEK kinase activity of the catalytic domain of RAF-1 is regulated independently of Ras binding in t cells. J. Biol. Chem. 270:5594-5599.
50. Xu, S., D. J. Robbins, L. B. Christerson, J. M. English, C. A. Vanderbilt, and M. H. Cobb. Cloning of Rat MEKK1 cDNA reveals an endogenous membrane-associated 195 kDa protein with a large regulatory domain. Proc. Natl. Acad. Sci. USA, in press.
51. 45a.Xu, S., D. J. Robbins, L. B. Christerson, J. M. English, C. A. Vanderbilt, and M. H. Cobb. Submitted for publication.
52. Xu, S., D. Robbins, J. Frost, A. Dang, C. Lange-Carter, and M. H. Cobb. 1995. MEKK1 phosphorylates MEK1 and MEK2 hut does not cause activation of MAP kinase. Proc. Natl. Acad. Sci. USA 92:6808-6812.
53. Van, M., T. Dal, J. C. Deak, J. M. Kyriakis, L. I. Zon, J. R. Woodgett, and D. J. Templeton. 1994. Activation of stress-activated protein kinase by MEKK1 phosphorylation of its activator SEK1. Nature (London) 372:798-800.
54. Zhang, S., J. Han, M. A. Sells, J. Chernoff, U. G. Knaus, R. J. Ulevitch, and G. M. Bokoch. 1995. Rho family GTPases regulate p38 mitogen-activated protein kinase through the downstream mediator Pakl. J. Biol. Chem. 270: 23934-23936.