-
1
-
-
0032212728
-
LAT is required for TCR-mediated activation of PLCγ1 and the Ras pathway
-
Finco, T. S., T. Kadlecek, W. Zhang, L. E. Samelson, and A. Weiss. 1998. LAT is required for TCR-mediated activation of PLCgamma1 and the Ras pathway. Immunity 9: 617-626. (Pubitemid 28557590)
-
(1998)
Immunity
, vol.9
, Issue.5
, pp. 617-626
-
-
Finco, T.S.1
Kadlecek, T.2
Zhang, W.3
Samelson, L.E.4
Weiss, A.5
-
2
-
-
0033103833
-
Essential role of LAT in T cell development
-
Zhang, W., C. L. Sommers, D. N. Burshtyn, C. C. Stebbins, J. B. DeJarnette, R. P. Trible, A. Grinberg, H. C. Tsay, H. M. Jacobs, C. M. Kessler, et al. 1999. Essential role of LAT in T cell development. Immunity 10: 323-332. (Pubitemid 29165287)
-
(1999)
Immunity
, vol.10
, Issue.3
, pp. 323-332
-
-
Zhang, W.1
Sommers, C.L.2
Burshtyn, D.N.3
Stebbins, C.C.4
DeJarnette, J.B.5
Trible, R.P.6
Grinberg, A.7
Tsay, H.C.8
Jacobs, H.M.9
Kessler, C.M.10
Long, E.O.11
Love, P.E.12
Samelson, L.E.13
-
3
-
-
0032498231
-
LAT: The ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation
-
DOI 10.1016/S0092-8674(00)80901-0
-
Zhang, W., J. Sloan-Lancaster, J. Kitchen, R. P. Trible, and L. E. Samelson. 1998. LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation. Cell 92: 83-92. (Pubitemid 28053300)
-
(1998)
Cell
, vol.92
, Issue.1
, pp. 83-92
-
-
Zhang, W.1
Sloan-Lancaster, J.2
Kitchen, J.3
Trible, R.P.4
Samelson, L.E.5
-
4
-
-
0034725625
-
Association of Grb2, Gads, and phospholipase C-γ1 with phosphorylated LAT tyrosine residues: Effect of LAT tyrosine mutations on T cell antigen receptor-mediated signaling
-
DOI 10.1074/jbc.M000404200
-
Zhang, W., R. P. Trible, M. Zhu, S. K. Liu, C. J. McGlade, and L. E. Samelson. 2000. Association of Grb2, Gads, and phospholipase C-gamma 1 with phosphorylated LAT tyrosine residues: effect of LAT tyrosine mutations on T cell antigen receptor-mediated signaling. J. Biol. Chem. 275: 23355-23361. (Pubitemid 30646238)
-
(2000)
Journal of Biological Chemistry
, vol.275
, Issue.30
, pp. 23355-23361
-
-
Zhang, W.1
Trible, R.P.2
Zhu, M.3
Liu, S.K.4
McGlade, C.J.5
Samelson, L.E.6
-
5
-
-
0343181431
-
The hematopoietic-specific adaptor protein Gads functions in T-cell signaling via interactions with the SLP-76 and LAT adaptors
-
DOI 10.1016/S0960-9822(99)80017-7
-
Liu, S. K., N. Fang, G. A. Koretzky, and C. J. McGlade. 1999. The hematopoietic-specific adaptor protein gads functions in T-cell signaling via interactions with the SLP-76 and LAT adaptors. Curr. Biol. 9: 67-75. (Pubitemid 29083530)
-
(1999)
Current Biology
, vol.9
, Issue.2
, pp. 67-75
-
-
Liu, S.K.1
Fang, N.2
Koretzky, G.A.3
McGlade, C.J.4
-
6
-
-
0035831340
-
Requirement for the SLP-76 adaptor GADS in T cell development
-
DOI 10.1126/science.1057176
-
Yoder, J., C. Pham, Y. M. Iizuka, O. Kanagawa, S. K. Liu, J. McGlade, and A. M. Cheng. 2001. Requirement for the SLP-76 adaptor GADS in T cell development. Science 291: 1987-1991. (Pubitemid 32217002)
-
(2001)
Science
, vol.291
, Issue.5510
, pp. 1987-1991
-
-
Yoder, J.1
Pham, C.2
Iizuka, Y.-M.3
Kanagawa, O.4
Liu, S.K.5
McGlade, J.6
Cheng, A.M.7
-
7
-
-
0032524389
-
RasGRP, a Ras guanyl nucleotide- releasing protein with calcium- and diacylglycerol-binding motifs
-
DOI 10.1126/science.280.5366.1082
-
Ebinu, J. O., D. A. Bottorff, E. Y. Chan, S. L. Stang, R. J. Dunn, and J. C. Stone. 1998. RasGRP, a Ras guanyl nucleotide-releasing protein with calcium- and diacylglycerol-binding motifs. Science 280: 1082-1086. (Pubitemid 28234950)
-
(1998)
Science
, vol.280
, Issue.5366
, pp. 1082-1086
-
-
Ebinu, J.O.1
Bottorff, D.A.2
Chan, E.Y.W.3
Stang, S.L.4
Dunn, R.J.5
Stone, J.C.6
-
8
-
-
0034658333
-
RasGRP links T-cell receptor signaling to Ras
-
Ebinu, J. O., S. L. Stang, C. Teixeira, D. A. Bottorff, J. Hooton, P. M. Blumberg, M. Barry, R. C. Bleakley, H. L. Ostergaard, and J. C. Stone. 2000. RasGRP links T-cell receptor signaling to Ras. Blood 95: 3199-3203. (Pubitemid 30321173)
-
(2000)
Blood
, vol.95
, Issue.10
, pp. 3199-3203
-
-
Ebinu, J.O.1
Stang, S.L.2
Teixeira, C.3
Bottorff, D.A.4
Hooton, J.5
Blumberg, P.M.6
Barry, M.7
Bleakley, R.C.8
Ostergaard, H.L.9
Stone, J.C.10
-
9
-
-
0034303371
-
RasGRP is essential for mouse thymocyte differentiation and TCR signaling
-
Dower, N. A., S. L. Stang, D. A. Bottorff, J. O. Ebinu, P. Dickie, H. L. Ostergaard, and J. C. Stone. 2000. RasGRP is essential for mouse thymocyte differentiation and TCR signaling. Nat. Immunol. 1: 317-321.
-
(2000)
Nat. Immunol.
, vol.1
, pp. 317-321
-
-
Dower, N.A.1
Stang, S.L.2
Bottorff, D.A.3
Ebinu, J.O.4
Dickie, P.5
Ostergaard, H.L.6
Stone, J.C.7
-
10
-
-
0037076975
-
A LAT mutation that inhibits T cell development yet induces lymphoproliferation
-
DOI 10.1126/science.1069066
-
Sommers, C. L., C. S. Park, J. Lee, C. Feng, C. L. Fuller, A. Grinberg, J. A. Hildebrand, E. Lacaná, R. K. Menon, E. W. Shores, et al. 2002. A LAT mutation that inhibits T cell development yet induces lymphoproliferation. Science 296: 2040-2043. (Pubitemid 34627529)
-
(2002)
Science
, vol.296
, Issue.5575
, pp. 2040-2043
-
-
Sommers, C.L.1
Park, C.-S.2
Lee, J.3
Feng, C.4
Fuller, C.L.5
Grinberg, A.6
Hildebrand, J.A.7
Lacana, E.8
Menon, R.K.9
Shores, E.W.10
Samelson, L.E.11
Love, P.E.12
-
11
-
-
0037077094
-
Induction of T helper type 2 immunity by a point mutation in the LAT adaptor
-
DOI 10.1126/science.1069057
-
Aguado, E., S. Richelme, S. Nuñez-Cruz, A. Miazek, A. M. Mura, M. Richelme, X. J. Guo, D. Sainty, H. T. He, B. Malissen, and M. Malissen. 2002. Induction of T helper type 2 immunity by a point mutation in the LAT adaptor. Science 296: 2036-2040. (Pubitemid 34627528)
-
(2002)
Science
, vol.296
, Issue.5575
, pp. 2036-2040
-
-
Aguado, E.1
Richelme, S.2
Nunez-Cruz, S.3
Miazek, A.4
Mura, A.-M.5
Richelme, M.6
Guo, X.-J.7
Sainty, D.8
He, H.-T.9
Malissen, B.10
Malissen, M.11
-
12
-
-
64849091388
-
STAT6 deletion converts the Th2 inflammatory pathology afflicting Lat(Y136F) mice into a lymphoproliferative disorder involving Th1 and CD8 effector T cells
-
Archambaud, C., A. Sansoni, M. Mingueneau, E. Devilard, G. Delsol, B. Malissen, and M. Malissen. 2009. STAT6 deletion converts the Th2 inflammatory pathology afflicting Lat(Y136F) mice into a lymphoproliferative disorder involving Th1 and CD8 effector T cells. J. Immunol. 182: 2680-2689.
-
(2009)
J. Immunol.
, vol.182
, pp. 2680-2689
-
-
Archambaud, C.1
Sansoni, A.2
Mingueneau, M.3
Devilard, E.4
Delsol, G.5
Malissen, B.6
Malissen, M.7
-
13
-
-
77951902637
-
The role of the LAT-PLC-gamma1 interaction in T regulatory cell function
-
Chuck, M. I., M. Zhu, S. Shen, and W. Zhang. 2010. The role of the LAT-PLC-gamma1 interaction in T regulatory cell function. J. Immunol. 184: 2476-2486.
-
(2010)
J. Immunol.
, vol.184
, pp. 2476-2486
-
-
Chuck, M.I.1
Zhu, M.2
Shen, S.3
Zhang, W.4
-
14
-
-
78149265961
-
The importance of LAT in the activation, homeostasis, and regulatory function of T cells
-
Shen, S., M. I. Chuck, M. Zhu, D. M. Fuller, C. W. Yang, and W. Zhang. 2010. The importance of LAT in the activation, homeostasis, and regulatory function of T cells. J. Biol. Chem. 285: 35393-35405.
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 35393-35405
-
-
Shen, S.1
Chuck, M.I.2
Zhu, M.3
Fuller, D.M.4
Yang, C.W.5
Zhang, W.6
-
15
-
-
66949162691
-
The essential role of LAT in thymocyte development during transition from the double-positive to single-positive stage
-
Shen, S., M. Zhu, J. Lau, M. Chuck, and W. Zhang. 2009. The essential role of LAT in thymocyte development during transition from the double-positive to single-positive stage. J. Immunol. 182: 5596-5604.
-
(2009)
J. Immunol.
, vol.182
, pp. 5596-5604
-
-
Shen, S.1
Zhu, M.2
Lau, J.3
Chuck, M.4
Zhang, W.5
-
16
-
-
0034292335
-
Effects of a constitutively active form of calcineurin on T cell activation and thymics selection
-
Hayden-Martinez, K., L. P. Kane, and S. M. Hedrick. 2000. Effects of a constitutively active form of calcineurin on T cell activation and thymic selection. J. Immunol. 165: 3713-3721. (Pubitemid 32057277)
-
(2000)
Journal of Immunology
, vol.165
, Issue.7
, pp. 3713-3721
-
-
Hayden-Martinez, K.1
Kane, L.P.2
Hedrick, S.M.3
-
17
-
-
0034972991
-
Identification of a phospholipase C-γ1 (PLC-γ1) SH3 domain-binding site in SLP-76 required for T-cell receptor-mediated activation of PLC-γ1 and NFAT
-
DOI 10.1128/MCB.21.13.4208-4218.2001
-
Yablonski, D., T. Kadlecek, and A. Weiss. 2001. Identification of a phospholipase C-gamma1 (PLC-gamma1) SH3 domain-binding site in SLP-76 required for T-cell receptor-mediated activation of PLC-gamma1 and NFAT. Mol. Cell. Biol. 21: 4208-4218. (Pubitemid 32565303)
-
(2001)
Molecular and Cellular Biology
, vol.21
, Issue.13
, pp. 4208-4218
-
-
Yablonski, D.1
Kadlecek, T.2
Weiss, A.3
-
18
-
-
2442517558
-
Roles of the Proline-rich Domain in SLP-76 Subcellular Localization and T Cell Function
-
DOI 10.1074/jbc.M313339200
-
Singer, A. L., S. C. Bunnell, A. E. Obstfeld, M. S. Jordan, J. N. Wu, P. S. Myung, L. E. Samelson, and G. A. Koretzky. 2004. Roles of the proline-rich domain in SLP-76 subcellular localization and T cell function. J. Biol. Chem. 279: 15481-15490. (Pubitemid 38618948)
-
(2004)
Journal of Biological Chemistry
, vol.279
, Issue.15
, pp. 15481-15490
-
-
Singer, A.L.1
Bunnell, S.C.2
Obstfeld, A.E.3
Jordan, M.S.4
Wu, J.N.5
Myung, P.S.6
Samelson, L.E.7
Koretzky, G.A.8
-
19
-
-
31344480633
-
+regulatory T cell development
-
DOI 10.1084/jem.20050903
-
Koonpaew, S., S. Shen, L. Flowers, and W. Zhang. 2006. LAT-mediated signaling in CD4+CD25+ regulatory T cell development. J. Exp. Med. 203: 119-129. (Pubitemid 43139651)
-
(2006)
Journal of Experimental Medicine
, vol.203
, Issue.1
, pp. 119-129
-
-
Koonpaew, S.1
Shen, S.2
Flowers, L.3
Zhang, W.4
-
20
-
-
0026643141
-
Identification of calcineurin as a key signalling enzyme in T-lymphocyte activation
-
Clipstone, N. A., and G. R. Crabtree. 1992. Identification of calcineurin as a key signalling enzyme in T-lymphocyte activation. Nature 357: 695-697.
-
(1992)
Nature
, vol.357
, pp. 695-697
-
-
Clipstone, N.A.1
Crabtree, G.R.2
-
21
-
-
0034084163
-
Phosphorylation meets ubiquitination: The control of NF-kappaB activity
-
DOI 10.1146/annurev.immunol.18.1.621
-
Karin, M., and Y. Ben-Neriah. 2000. Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity. Annu. Rev. Immunol. 18: 621-663. (Pubitemid 30365393)
-
(2000)
Annual Review of Immunology
, vol.18
, pp. 621-663
-
-
Karin, M.1
Ben-Neriah, Y.2
-
22
-
-
33744989924
-
Canonical NF-kappaB Activity, Dispensable for B Cell Development, Replaces BAFF-Receptor Signals and Promotes B Cell Proliferation upon Activation
-
DOI 10.1016/j.immuni.2006.04.005, PII S1074761306002627
-
Sasaki, Y., E. Derudder, E. Hobeika, R. Pelanda, M. Reth, K. Rajewsky, and M. Schmidt-Supprian. 2006. Canonical NF-kappaB activity, dispensable for B cell development, replaces BAFF-receptor signals and promotes B cell proliferation upon activation. Immunity 24: 729-739. (Pubitemid 43867365)
-
(2006)
Immunity
, vol.24
, Issue.6
, pp. 729-739
-
-
Sasaki, Y.1
Derudder, E.2
Hobeika, E.3
Pelanda, R.4
Reth, M.5
Rajewsky, K.6
Schmidt-Supprian, M.7
-
23
-
-
0030664126
-
Control of B cell development by Ras-mediated activation of Raf
-
Iritani, B. M., K. A. Forbush, M. A. Farrar, and R. M. Perlmutter. 1997. Control of B cell development by Ras-mediated activation of Raf. EMBO J. 16: 7019-7031. (Pubitemid 27520802)
-
(1997)
EMBO Journal
, vol.16
, Issue.23
, pp. 7019-7031
-
-
Iritani, B.M.1
Forbush, K.A.2
Farrar, M.A.3
Perlmutter, R.M.4
-
24
-
-
0012946420
-
Distinct signals mediate maturation and allelic exclusion in lymphocyte progenitors
-
DOI 10.1016/S1074-7613(00)80070-9
-
Iritani, B. M., J. Alberola-Ila, K. A. Forbush, and R. M. Perimutter. 1999. Distinct signals mediate maturation and allelic exclusion in lymphocyte progenitors. Immunity 10: 713-722. (Pubitemid 29302924)
-
(1999)
Immunity
, vol.10
, Issue.6
, pp. 713-722
-
-
Iritani, B.M.1
Alberola-Lla, J.2
Forbush, K.A.3
Perlmutter, R.M.4
-
25
-
-
40749113582
-
Th2 lymphoproliferative disorder of LatY136F mutant mice unfolds independently of TCR-MHC engagement and is insensitive to the action of Foxp3+ regulatory T cells
-
Wang, Y., A. Kissenpfennig, M. Mingueneau, S. Richelme, P. Perrin, S. Chevrier, C. Genton, B. Lucas, J. P. DiSanto, H. Acha-Orbea, et al. 2008. Th2 lymphoproliferative disorder of LatY136F mutant mice unfolds independently of TCR-MHC engagement and is insensitive to the action of Foxp3+ regulatory T cells. J. Immunol. 180: 1565-1575.
-
(2008)
J. Immunol.
, vol.180
, pp. 1565-1575
-
-
Wang, Y.1
Kissenpfennig, A.2
Mingueneau, M.3
Richelme, S.4
Perrin, P.5
Chevrier, S.6
Genton, C.7
Lucas, B.8
DiSanto, J.P.9
Acha-Orbea, H.10
-
26
-
-
68649087416
-
Loss of the LAT adaptor converts antigen-responsive T cells into pathogenic effectors that function independently of the T cell receptor
-
Mingueneau, M., R. Roncagalli, C. Grégoire, A. Kissenpfennig, A. Miazek, C. Archambaud, Y. Wang, P. Perrin, E. Bertosio, A. Sansoni, et al. 2009. Loss of the LAT adaptor converts antigen-responsive T cells into pathogenic effectors that function independently of the T cell receptor. Immunity 31: 197-208.
-
(2009)
Immunity
, vol.31
, pp. 197-208
-
-
Mingueneau, M.1
Roncagalli, R.2
Grégoire, C.3
Kissenpfennig, A.4
Miazek, A.5
Archambaud, C.6
Wang, Y.7
Perrin, P.8
Bertosio, E.9
Sansoni, A.10
-
27
-
-
71749094333
-
Development of Foxp3(+) regulatory T cells is driven by the c-Rel enhanceosome
-
Ruan, Q., V. Kameswaran, Y. Tone, L. Li, H. C. Liou, M. I. Greene, M. Tone, and Y. H. Chen. 2009. Development of Foxp3(+) regulatory T cells is driven by the c-Rel enhanceosome. Immunity 31: 932-940.
-
(2009)
Immunity
, vol.31
, pp. 932-940
-
-
Ruan, Q.1
Kameswaran, V.2
Tone, Y.3
Li, L.4
Liou, H.C.5
Greene, M.I.6
Tone, M.7
Chen, Y.H.8
-
28
-
-
71749088574
-
Nuclear factor-kappaB modulates regulatory T cell development by directly regulating expression of Foxp3 transcription factor
-
Long, M., S. G. Park, I. Strickland, M. S. Hayden, and S. Ghosh. 2009. Nuclear factor-kappaB modulates regulatory T cell development by directly regulating expression of Foxp3 transcription factor. Immunity 31: 921-931.
-
(2009)
Immunity
, vol.31
, pp. 921-931
-
-
Long, M.1
Park, S.G.2
Strickland, I.3
Hayden, M.S.4
Ghosh, S.5
-
29
-
-
33644844341
-
Molecular mechanisms underlying FOXP3 induction in human T cells
-
Mantel, P. Y., N. Ouaked, B. Rückert, C. Karagiannidis, R. Welz, K. Blaser, and C. B. Schmidt-Weber. 2006. Molecular mechanisms underlying FOXP3 induction in human T cells. J. Immunol. 176: 3593-3602.
-
(2006)
J. Immunol.
, vol.176
, pp. 3593-3602
-
-
Mantel, P.Y.1
Ouaked, N.2
Rückert, B.3
Karagiannidis, C.4
Welz, R.5
Blaser, K.6
Schmidt-Weber, C.B.7
-
30
-
-
70149103587
-
Genetic evidence for the role of Erk activation in a lymphoproliferative disease of mice
-
Miyaji, M., R. L. Kortum, R. Surana, W. Li, K. D. Woolard, R. M. Simpson, L. E. Samelson, and C. L. Sommers. 2009. Genetic evidence for the role of Erk activation in a lymphoproliferative disease of mice. Proc. Natl. Acad. Sci. USA 106: 14502-14507.
-
(2009)
Proc. Natl. Acad. Sci. USA
, vol.106
, pp. 14502-14507
-
-
Miyaji, M.1
Kortum, R.L.2
Surana, R.3
Li, W.4
Woolard, K.D.5
Simpson, R.M.6
Samelson, L.E.7
Sommers, C.L.8
-
31
-
-
0033566749
-
Phospho-LAT-independent activation of the Ras-mitogen-activated protein kinase pathway: A differential recruitment model of TCR partial agonist signaling
-
Chau, L. A., and J. Madrenas. 1999. Phospho-LAT-independent activation of the ras-mitogen-activated protein kinase pathway: a differential recruitment model of TCR partial agonist signaling. J. Immunol. 163: 1853-1858. (Pubitemid 29382185)
-
(1999)
Journal of Immunology
, vol.163
, Issue.4
, pp. 1853-1858
-
-
Chau, L.A.1
Madrenas, J.2
-
32
-
-
26644459229
-
The role of Erk1 and Erk2 in multiple stages of T cell development
-
DOI 10.1016/j.immuni.2005.08.013, PII S1074761305003043
-
Fischer, A. M., C. D. Katayama, G. Pagès, J. Pouysségur, and S. M. Hedrick. 2005. The role of erk1 and erk2 in multiple stages of T cell development. Immunity 23: 431-443. (Pubitemid 41443444)
-
(2005)
Immunity
, vol.23
, Issue.4
, pp. 431-443
-
-
Fischer, A.M.1
Katayama, C.D.2
Pages, G.3
Pouyssegur, J.4
Hedrick, S.M.5
-
33
-
-
0030018912
-
Positive and negative selection invoke distinct signaling pathways
-
DOI 10.1084/jem.184.1.9
-
Alberola-Ila, J., K. A. Hogquist, K. A. Swan, M. J. Bevan, and R. M. Perlmutter. 1996. Positive and negative selection invoke distinct signaling pathways. J. Exp. Med. 184: 9-18. (Pubitemid 26247210)
-
(1996)
Journal of Experimental Medicine
, vol.184
, Issue.1
, pp. 9-18
-
-
Alberola-Ila, J.1
Hogquist, K.A.2
Swan, K.A.3
Bevan, M.J.4
Perlmutter, R.M.5
|